Mutagenetix > Incidental Mutation

Incidental Mutation 'R5514:Or5t7'

440211

Institutional Source

Beutler Lab

Gene Symbol

Or5t7

Ensembl Gene

ENSMUSG00000075175

Gene Name

olfactory receptor family 5 subfamily T member 17

Synonyms

GA_x6K02T2Q125-48168771-48167839, MOR179-2, Olfr1086

MMRRC Submission

043074-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.292) question?

Stock #

R5514 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86506743-86507683 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86507225 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 151 (I151V)

Ref Sequence

ENSEMBL: ENSMUSP00000150094 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099878] [ENSMUST00000213198]

AlphaFold

Q8VFL9

Predicted Effect

probably benign
Transcript: ENSMUST00000099878
AA Change: I151V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000097463
Gene: ENSMUSG00000075175
AA Change: I151V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	3.3e-49	PFAM
Pfam:7tm_1	39	288	1.4e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213198
AA Change: I151V

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam17	T	C	12: 21,390,520 (GRCm39)	S382G	probably damaging	Het
Agr2	G	A	12: 36,046,090 (GRCm39)	V74I	probably benign	Het
Aldh3a1	T	C	11: 61,108,867 (GRCm39)	S423P	probably damaging	Het
Ampd1	C	T	3: 102,986,488 (GRCm39)	H56Y	possibly damaging	Het
Arhgef2	C	A	3: 88,550,304 (GRCm39)	P670T	probably benign	Het
Blk	T	G	14: 63,615,930 (GRCm39)	D333A	probably damaging	Het
Bmi1	T	C	2: 18,686,714 (GRCm39)	I31T	probably damaging	Het
Cacna1d	G	A	14: 30,072,790 (GRCm39)	Q62*	probably null	Het
Ccdc88c	A	G	12: 100,879,698 (GRCm39)	S1801P	probably damaging	Het
Cdkal1	C	T	13: 29,961,270 (GRCm39)	A100T	probably damaging	Het
Cfap251	G	T	5: 123,425,829 (GRCm39)		probably null	Het
Chst4	G	T	8: 110,756,606 (GRCm39)	S419Y	probably damaging	Het
Cntn4	T	C	6: 106,649,844 (GRCm39)	I680T	probably damaging	Het
Ddx55	T	C	5: 124,694,875 (GRCm39)	V101A	probably damaging	Het
Ddx60	A	T	8: 62,411,091 (GRCm39)	E451V	probably damaging	Het
Dffa	T	A	4: 149,190,772 (GRCm39)		probably null	Het
Dgkd	A	G	1: 87,861,832 (GRCm39)	R796G	probably damaging	Het
Dzank1	T	A	2: 144,323,605 (GRCm39)	M614L	probably benign	Het
Elf2	G	T	3: 51,215,555 (GRCm39)	Q52K	probably damaging	Het
Fcamr	T	A	1: 130,741,793 (GRCm39)	L522Q	probably damaging	Het
Fscn2	T	C	11: 120,258,858 (GRCm39)	Y468H	probably damaging	Het
Gm12689	T	C	4: 99,184,402 (GRCm39)	I85T	unknown	Het
Gm4787	A	G	12: 81,425,102 (GRCm39)	V352A	possibly damaging	Het
Gtsf1	T	C	15: 103,336,802 (GRCm39)	Q13R	probably benign	Het
Itpkb	G	A	1: 180,241,474 (GRCm39)	V715M	probably damaging	Het
Jmjd1c	T	A	10: 67,053,928 (GRCm39)	S263T	probably damaging	Het
Krba1	T	G	6: 48,390,429 (GRCm39)	L736R	probably damaging	Het
Lrrc8d	C	G	5: 105,960,650 (GRCm39)	F353L	probably damaging	Het
Lrrc8d	G	A	5: 105,960,651 (GRCm39)	E354K	probably benign	Het
Mtor	T	A	4: 148,630,901 (GRCm39)	V2286E	probably damaging	Het
Mybbp1a	T	A	11: 72,341,462 (GRCm39)	V1100E	possibly damaging	Het
Myo5a	G	A	9: 75,061,048 (GRCm39)	G518D	probably damaging	Het
Nalcn	A	T	14: 123,521,123 (GRCm39)	I1594N	probably benign	Het
Nav1	C	G	1: 135,398,299 (GRCm39)	G761A	probably benign	Het
Ncoa2	A	T	1: 13,251,445 (GRCm39)	L276H	probably damaging	Het
Ndufaf7	T	C	17: 79,245,051 (GRCm39)	Y57H	probably damaging	Het
Nfkb2	A	G	19: 46,299,847 (GRCm39)	Y807C	probably damaging	Het
Nid2	A	T	14: 19,852,535 (GRCm39)	Q1081L	probably damaging	Het
Nkain2	T	A	10: 31,827,189 (GRCm39)	I134F	probably damaging	Het
Nmu	A	C	5: 76,497,979 (GRCm39)	S69A	probably damaging	Het
Or4c15b	A	T	2: 89,112,817 (GRCm39)	I220N	probably damaging	Het
Pard3	A	G	8: 128,153,086 (GRCm39)	R886G	probably damaging	Het
Pde6b	G	T	5: 108,571,317 (GRCm39)	Q423H	probably benign	Het
Pip5k1b	A	T	19: 24,327,505 (GRCm39)	D450E	probably damaging	Het
Plcg1	T	C	2: 160,595,275 (GRCm39)		probably null	Het
Pnpt1	T	C	11: 29,103,246 (GRCm39)	S504P	possibly damaging	Het
Pomt2	A	T	12: 87,175,797 (GRCm39)	D312E	probably damaging	Het
Ppp1r1b	T	C	11: 98,246,228 (GRCm39)	L70P	probably damaging	Het
Prr5	C	A	15: 84,587,096 (GRCm39)	P282Q	probably benign	Het
Reln	A	T	5: 22,176,883 (GRCm39)	W1928R	possibly damaging	Het
Sacm1l	A	T	9: 123,415,419 (GRCm39)	R465*	probably null	Het
Sema7a	A	G	9: 57,863,046 (GRCm39)	Y239C	probably damaging	Het
Slc35e2	C	T	4: 155,694,483 (GRCm39)	P10L	probably benign	Het
Svep1	T	C	4: 58,044,054 (GRCm39)	T3531A	possibly damaging	Het
Tjp1	A	T	7: 65,004,609 (GRCm39)	W19R	probably damaging	Het
Tmc2	T	A	2: 130,083,564 (GRCm39)	M507K	possibly damaging	Het
Unc13a	A	G	8: 72,095,795 (GRCm39)	Y1241H	probably damaging	Het
Upp1	C	T	11: 9,081,771 (GRCm39)	P103S	probably damaging	Het
Vldlr	A	G	19: 27,221,624 (GRCm39)	E663G	probably damaging	Het
Vmn2r68	G	A	7: 84,886,767 (GRCm39)	T49I	possibly damaging	Het
Xirp2	A	T	2: 67,335,465 (GRCm39)	M95L	probably benign	Het

Other mutations in Or5t7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01783:Or5t7	APN	2	86,507,425 (GRCm39)	missense	probably benign	0.00
R0492:Or5t7	UTSW	2	86,506,834 (GRCm39)	missense	probably damaging	1.00
R0629:Or5t7	UTSW	2	86,506,873 (GRCm39)	missense	possibly damaging	0.65
R1114:Or5t7	UTSW	2	86,507,629 (GRCm39)	missense	possibly damaging	0.72
R1341:Or5t7	UTSW	2	86,507,507 (GRCm39)	missense	possibly damaging	0.86
R1868:Or5t7	UTSW	2	86,507,629 (GRCm39)	missense	possibly damaging	0.72
R2183:Or5t7	UTSW	2	86,507,380 (GRCm39)	missense	probably benign	0.21
R3159:Or5t7	UTSW	2	86,506,855 (GRCm39)	missense	probably benign	0.03
R4061:Or5t7	UTSW	2	86,507,162 (GRCm39)	missense	probably damaging	1.00
R4420:Or5t7	UTSW	2	86,507,263 (GRCm39)	missense	possibly damaging	0.95
R7066:Or5t7	UTSW	2	86,507,570 (GRCm39)	missense	possibly damaging	0.95
R7077:Or5t7	UTSW	2	86,507,236 (GRCm39)	missense	possibly damaging	0.78
R7246:Or5t7	UTSW	2	86,507,633 (GRCm39)	missense	probably benign	0.11
R7383:Or5t7	UTSW	2	86,507,263 (GRCm39)	missense	possibly damaging	0.95
R8062:Or5t7	UTSW	2	86,507,410 (GRCm39)	missense	probably benign	0.01
R8271:Or5t7	UTSW	2	86,507,218 (GRCm39)	missense	probably benign	0.12
R8417:Or5t7	UTSW	2	86,507,149 (GRCm39)	missense	probably damaging	1.00
R8927:Or5t7	UTSW	2	86,507,630 (GRCm39)	missense	probably benign	0.31
R8928:Or5t7	UTSW	2	86,507,630 (GRCm39)	missense	probably benign	0.31
R9029:Or5t7	UTSW	2	86,506,831 (GRCm39)	missense	probably damaging	1.00
R9342:Or5t7	UTSW	2	86,507,494 (GRCm39)	missense	probably damaging	1.00
R9384:Or5t7	UTSW	2	86,507,357 (GRCm39)	missense	probably benign	0.21
X0064:Or5t7	UTSW	2	86,507,543 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GCCATAGGACAGCAGGACAATC -3'
(R):5'- CACCCCACAAATGGTAGTTGAC -3'

Sequencing Primer
(F):5'- GGACAATCAGGATAGTGACTACCTC -3'
(R):5'- CCCCACAAATGGTAGTTGACTTTGTG -3'

Posted On

2016-11-08