Incidental Mutation 'R5637:Klhl25'
ID 440437
Institutional Source Beutler Lab
Gene Symbol Klhl25
Ensembl Gene ENSMUSG00000055652
Gene Name kelch-like 25
Synonyms 2810402K13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R5637 (G1)
Quality Score 154
Status Not validated
Chromosome 7
Chromosomal Location 75498086-75523881 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 75515540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092073] [ENSMUST00000171155] [ENSMUST00000205612] [ENSMUST00000205887] [ENSMUST00000206019]
AlphaFold Q8R2P1
Predicted Effect probably damaging
Transcript: ENSMUST00000092073
AA Change: C149S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000089707
Gene: ENSMUSG00000055652
AA Change: C149S

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000171155
AA Change: C149S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000133175
Gene: ENSMUSG00000055652
AA Change: C149S

DomainStartEndE-ValueType
BTB 46 144 2.43e-28 SMART
BACK 149 251 1.06e-32 SMART
Blast:BTB 256 294 1e-9 BLAST
Kelch 296 340 1.4e0 SMART
Kelch 341 388 6.71e-10 SMART
Kelch 389 444 2.25e-11 SMART
Kelch 445 492 1.22e-1 SMART
Kelch 493 538 1.92e-5 SMART
Kelch 539 585 1.4e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000205612
Predicted Effect probably benign
Transcript: ENSMUST00000205887
Predicted Effect probably damaging
Transcript: ENSMUST00000206019
AA Change: C149S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206418
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd T C 1: 127,694,050 (GRCm39) F327L probably damaging Het
Adgrl3 C A 5: 81,841,391 (GRCm39) S824Y probably damaging Het
Arfip2 A G 7: 105,286,370 (GRCm39) M144T probably damaging Het
Arhgap32 A G 9: 32,158,502 (GRCm39) N179S probably damaging Het
Ash2l T C 8: 26,317,339 (GRCm39) Y249C probably damaging Het
Ccndbp1 A G 2: 120,842,165 (GRCm39) T141A probably benign Het
Cd177 T A 7: 24,455,748 (GRCm39) H258L probably benign Het
Celsr3 T C 9: 108,714,332 (GRCm39) W1956R probably damaging Het
Cep295 T C 9: 15,245,108 (GRCm39) probably null Het
Cngb1 T C 8: 95,984,549 (GRCm39) H420R probably damaging Het
Cobl C T 11: 12,246,531 (GRCm39) probably benign Het
Cobll1 T C 2: 64,956,247 (GRCm39) D337G possibly damaging Het
Dmrta1 A G 4: 89,577,068 (GRCm39) N175D probably benign Het
Dnah7b G T 1: 46,395,674 (GRCm39) V3859L possibly damaging Het
Dnah7c A G 1: 46,799,521 (GRCm39) probably null Het
Dusp4 C A 8: 35,284,451 (GRCm39) H255Q probably damaging Het
Evx1 T C 6: 52,292,751 (GRCm39) V134A possibly damaging Het
F12 T C 13: 55,570,228 (GRCm39) K93E possibly damaging Het
Fam186a A C 15: 99,839,628 (GRCm39) H2205Q possibly damaging Het
Fcgbpl1 A G 7: 27,852,277 (GRCm39) N1267D probably benign Het
Frem2 A G 3: 53,560,358 (GRCm39) I1383T probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gpr158 A G 2: 21,788,083 (GRCm39) I575V probably benign Het
Hdc A G 2: 126,458,109 (GRCm39) V71A probably benign Het
Helb G A 10: 119,941,353 (GRCm39) T445M probably benign Het
Inppl1 A T 7: 101,478,055 (GRCm39) S652R probably benign Het
Itpripl1 T C 2: 126,984,044 (GRCm39) D26G probably damaging Het
Klc1 T A 12: 111,740,842 (GRCm39) L106H probably damaging Het
Krt6a T C 15: 101,600,714 (GRCm39) D318G probably benign Het
Lrp2 T C 2: 69,302,762 (GRCm39) N2989S probably damaging Het
Lta4h A G 10: 93,304,731 (GRCm39) probably null Het
Man1c1 A G 4: 134,318,735 (GRCm39) S251P probably damaging Het
Mapre2 T C 18: 23,886,919 (GRCm39) probably benign Het
Mfap3l A T 8: 61,109,821 (GRCm39) I66F probably damaging Het
Mvk A G 5: 114,594,003 (GRCm39) E286G possibly damaging Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or14a260 G A 7: 85,984,812 (GRCm39) T264I probably benign Het
Or4f52 T A 2: 111,061,456 (GRCm39) K227N probably benign Het
Or7d11 A T 9: 19,966,279 (GRCm39) V160D possibly damaging Het
Pcdh9 A G 14: 94,123,198 (GRCm39) F991L possibly damaging Het
Pcdha9 T C 18: 37,131,426 (GRCm39) V165A probably benign Het
Pcsk6 A G 7: 65,618,745 (GRCm39) H437R probably damaging Het
Pfas C T 11: 68,884,149 (GRCm39) V589M probably damaging Het
Prpf40a A G 2: 53,046,746 (GRCm39) V288A possibly damaging Het
Rnf183 T C 4: 62,346,387 (GRCm39) D137G probably benign Het
Rsph6a A G 7: 18,788,820 (GRCm39) S51G probably benign Het
Scap G A 9: 110,210,640 (GRCm39) A991T possibly damaging Het
Sdk2 C A 11: 113,724,005 (GRCm39) V1222F probably damaging Het
Sdr16c6 T A 4: 4,063,232 (GRCm39) N181I possibly damaging Het
Semp2l2a A T 8: 13,887,713 (GRCm39) M126K possibly damaging Het
Serpinb7 A T 1: 107,356,037 (GRCm39) D20V probably damaging Het
Sh3bp2 C A 5: 34,718,392 (GRCm39) R531S possibly damaging Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Sox2 A G 3: 34,704,677 (GRCm39) N38S probably benign Het
Spg7 C A 8: 123,821,314 (GRCm39) Q680K possibly damaging Het
Styk1 T C 6: 131,277,381 (GRCm39) E331G possibly damaging Het
Tkfc G A 19: 10,571,897 (GRCm39) R380W probably benign Het
Trib3 A G 2: 152,180,410 (GRCm39) F261S probably damaging Het
Ubr1 T A 2: 120,793,998 (GRCm39) Q62L possibly damaging Het
Vmn2r54 T C 7: 12,349,296 (GRCm39) Y762C probably benign Het
Vmn2r97 T A 17: 19,167,628 (GRCm39) Y627* probably null Het
Zfp12 A G 5: 143,231,451 (GRCm39) K625E probably damaging Het
Zw10 T C 9: 48,968,950 (GRCm39) V38A probably damaging Het
Other mutations in Klhl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01068:Klhl25 APN 7 75,515,897 (GRCm39) nonsense probably null
IGL01142:Klhl25 APN 7 75,516,344 (GRCm39) missense probably damaging 1.00
IGL01295:Klhl25 APN 7 75,515,620 (GRCm39) missense probably benign 0.20
IGL02272:Klhl25 APN 7 75,516,368 (GRCm39) missense probably benign
IGL02721:Klhl25 APN 7 75,516,648 (GRCm39) missense probably damaging 1.00
R0196:Klhl25 UTSW 7 75,515,450 (GRCm39) missense probably damaging 1.00
R0365:Klhl25 UTSW 7 75,516,264 (GRCm39) missense probably damaging 1.00
R0828:Klhl25 UTSW 7 75,515,943 (GRCm39) missense probably damaging 0.99
R0881:Klhl25 UTSW 7 75,516,027 (GRCm39) missense probably damaging 1.00
R1061:Klhl25 UTSW 7 75,516,268 (GRCm39) nonsense probably null
R1228:Klhl25 UTSW 7 75,515,868 (GRCm39) missense probably benign
R1696:Klhl25 UTSW 7 75,516,591 (GRCm39) missense probably damaging 1.00
R1991:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R2118:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R4359:Klhl25 UTSW 7 75,516,480 (GRCm39) missense probably damaging 1.00
R4428:Klhl25 UTSW 7 75,515,162 (GRCm39) missense probably damaging 0.97
R4431:Klhl25 UTSW 7 75,515,162 (GRCm39) missense probably damaging 0.97
R4717:Klhl25 UTSW 7 75,516,528 (GRCm39) missense probably damaging 1.00
R4860:Klhl25 UTSW 7 75,516,798 (GRCm39) missense probably benign 0.03
R4860:Klhl25 UTSW 7 75,516,798 (GRCm39) missense probably benign 0.03
R5619:Klhl25 UTSW 7 75,516,602 (GRCm39) missense probably benign 0.22
R5652:Klhl25 UTSW 7 75,515,895 (GRCm39) missense probably benign 0.06
R5840:Klhl25 UTSW 7 75,516,440 (GRCm39) missense possibly damaging 0.92
R6693:Klhl25 UTSW 7 75,516,561 (GRCm39) missense possibly damaging 0.91
R6723:Klhl25 UTSW 7 75,515,739 (GRCm39) missense possibly damaging 0.64
R6875:Klhl25 UTSW 7 75,516,090 (GRCm39) missense probably damaging 1.00
R7239:Klhl25 UTSW 7 75,516,516 (GRCm39) missense probably benign 0.25
R8535:Klhl25 UTSW 7 75,515,843 (GRCm39) missense probably benign
R8712:Klhl25 UTSW 7 75,515,420 (GRCm39) missense probably damaging 0.99
R8768:Klhl25 UTSW 7 75,516,359 (GRCm39) missense probably damaging 1.00
R8827:Klhl25 UTSW 7 75,516,391 (GRCm39) missense possibly damaging 0.70
R9033:Klhl25 UTSW 7 75,516,681 (GRCm39) missense probably damaging 0.98
R9046:Klhl25 UTSW 7 75,515,337 (GRCm39) missense probably damaging 1.00
R9404:Klhl25 UTSW 7 75,515,153 (GRCm39) missense probably benign 0.01
R9480:Klhl25 UTSW 7 75,516,120 (GRCm39) missense probably damaging 0.99
R9601:Klhl25 UTSW 7 75,515,757 (GRCm39) missense probably damaging 1.00
R9762:Klhl25 UTSW 7 75,516,741 (GRCm39) missense probably damaging 1.00
Z1177:Klhl25 UTSW 7 75,515,870 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GATGATACGGTCAACTTCCAGGAC -3'
(R):5'- ACTGCAGGATGGCCTCAAAG -3'

Sequencing Primer
(F):5'- GACAACCTGCACCCCGAGG -3'
(R):5'- GGATGGCCTCAAAGACCACG -3'
Posted On 2016-11-08