Incidental Mutation 'R5637:Or14a260'
ID 440438
Institutional Source Beutler Lab
Gene Symbol Or14a260
Ensembl Gene ENSMUSG00000055610
Gene Name olfactory receptor family 14 subfamily A member 260
Synonyms Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R5637 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 85984661-85985602 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85984812 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 264 (T264I)
Ref Sequence ENSEMBL: ENSMUSP00000149779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069279] [ENSMUST00000213705] [ENSMUST00000217494]
AlphaFold Q8VFN8
Predicted Effect probably benign
Transcript: ENSMUST00000069279
AA Change: T264I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000063538
Gene: ENSMUSG00000055610
AA Change: T264I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Pfam:7tm_4 29 306 1.6e-42 PFAM
Pfam:7tm_1 39 288 9.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213705
AA Change: T264I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217494
AA Change: T264I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acmsd T C 1: 127,694,050 (GRCm39) F327L probably damaging Het
Adgrl3 C A 5: 81,841,391 (GRCm39) S824Y probably damaging Het
Arfip2 A G 7: 105,286,370 (GRCm39) M144T probably damaging Het
Arhgap32 A G 9: 32,158,502 (GRCm39) N179S probably damaging Het
Ash2l T C 8: 26,317,339 (GRCm39) Y249C probably damaging Het
Ccndbp1 A G 2: 120,842,165 (GRCm39) T141A probably benign Het
Cd177 T A 7: 24,455,748 (GRCm39) H258L probably benign Het
Celsr3 T C 9: 108,714,332 (GRCm39) W1956R probably damaging Het
Cep295 T C 9: 15,245,108 (GRCm39) probably null Het
Cngb1 T C 8: 95,984,549 (GRCm39) H420R probably damaging Het
Cobl C T 11: 12,246,531 (GRCm39) probably benign Het
Cobll1 T C 2: 64,956,247 (GRCm39) D337G possibly damaging Het
Dmrta1 A G 4: 89,577,068 (GRCm39) N175D probably benign Het
Dnah7b G T 1: 46,395,674 (GRCm39) V3859L possibly damaging Het
Dnah7c A G 1: 46,799,521 (GRCm39) probably null Het
Dusp4 C A 8: 35,284,451 (GRCm39) H255Q probably damaging Het
Evx1 T C 6: 52,292,751 (GRCm39) V134A possibly damaging Het
F12 T C 13: 55,570,228 (GRCm39) K93E possibly damaging Het
Fam186a A C 15: 99,839,628 (GRCm39) H2205Q possibly damaging Het
Fcgbpl1 A G 7: 27,852,277 (GRCm39) N1267D probably benign Het
Frem2 A G 3: 53,560,358 (GRCm39) I1383T probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gpr158 A G 2: 21,788,083 (GRCm39) I575V probably benign Het
Hdc A G 2: 126,458,109 (GRCm39) V71A probably benign Het
Helb G A 10: 119,941,353 (GRCm39) T445M probably benign Het
Inppl1 A T 7: 101,478,055 (GRCm39) S652R probably benign Het
Itpripl1 T C 2: 126,984,044 (GRCm39) D26G probably damaging Het
Klc1 T A 12: 111,740,842 (GRCm39) L106H probably damaging Het
Klhl25 T A 7: 75,515,540 (GRCm39) probably null Het
Krt6a T C 15: 101,600,714 (GRCm39) D318G probably benign Het
Lrp2 T C 2: 69,302,762 (GRCm39) N2989S probably damaging Het
Lta4h A G 10: 93,304,731 (GRCm39) probably null Het
Man1c1 A G 4: 134,318,735 (GRCm39) S251P probably damaging Het
Mapre2 T C 18: 23,886,919 (GRCm39) probably benign Het
Mfap3l A T 8: 61,109,821 (GRCm39) I66F probably damaging Het
Mvk A G 5: 114,594,003 (GRCm39) E286G possibly damaging Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or4f52 T A 2: 111,061,456 (GRCm39) K227N probably benign Het
Or7d11 A T 9: 19,966,279 (GRCm39) V160D possibly damaging Het
Pcdh9 A G 14: 94,123,198 (GRCm39) F991L possibly damaging Het
Pcdha9 T C 18: 37,131,426 (GRCm39) V165A probably benign Het
Pcsk6 A G 7: 65,618,745 (GRCm39) H437R probably damaging Het
Pfas C T 11: 68,884,149 (GRCm39) V589M probably damaging Het
Prpf40a A G 2: 53,046,746 (GRCm39) V288A possibly damaging Het
Rnf183 T C 4: 62,346,387 (GRCm39) D137G probably benign Het
Rsph6a A G 7: 18,788,820 (GRCm39) S51G probably benign Het
Scap G A 9: 110,210,640 (GRCm39) A991T possibly damaging Het
Sdk2 C A 11: 113,724,005 (GRCm39) V1222F probably damaging Het
Sdr16c6 T A 4: 4,063,232 (GRCm39) N181I possibly damaging Het
Semp2l2a A T 8: 13,887,713 (GRCm39) M126K possibly damaging Het
Serpinb7 A T 1: 107,356,037 (GRCm39) D20V probably damaging Het
Sh3bp2 C A 5: 34,718,392 (GRCm39) R531S possibly damaging Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Sox2 A G 3: 34,704,677 (GRCm39) N38S probably benign Het
Spg7 C A 8: 123,821,314 (GRCm39) Q680K possibly damaging Het
Styk1 T C 6: 131,277,381 (GRCm39) E331G possibly damaging Het
Tkfc G A 19: 10,571,897 (GRCm39) R380W probably benign Het
Trib3 A G 2: 152,180,410 (GRCm39) F261S probably damaging Het
Ubr1 T A 2: 120,793,998 (GRCm39) Q62L possibly damaging Het
Vmn2r54 T C 7: 12,349,296 (GRCm39) Y762C probably benign Het
Vmn2r97 T A 17: 19,167,628 (GRCm39) Y627* probably null Het
Zfp12 A G 5: 143,231,451 (GRCm39) K625E probably damaging Het
Zw10 T C 9: 48,968,950 (GRCm39) V38A probably damaging Het
Other mutations in Or14a260
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Or14a260 APN 7 85,985,269 (GRCm39) missense probably benign 0.00
IGL02419:Or14a260 APN 7 85,984,870 (GRCm39) missense probably damaging 0.98
IGL02519:Or14a260 APN 7 85,984,789 (GRCm39) missense probably benign 0.01
IGL02750:Or14a260 APN 7 85,984,752 (GRCm39) missense probably damaging 1.00
R0123:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0134:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0225:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R1025:Or14a260 UTSW 7 85,985,113 (GRCm39) missense probably benign 0.09
R1511:Or14a260 UTSW 7 85,985,553 (GRCm39) missense possibly damaging 0.49
R1674:Or14a260 UTSW 7 85,984,765 (GRCm39) missense probably damaging 1.00
R2011:Or14a260 UTSW 7 85,984,955 (GRCm39) nonsense probably null
R4588:Or14a260 UTSW 7 85,984,852 (GRCm39) missense probably benign 0.00
R6163:Or14a260 UTSW 7 85,985,592 (GRCm39) missense possibly damaging 0.84
R6407:Or14a260 UTSW 7 85,985,277 (GRCm39) missense possibly damaging 0.90
R7342:Or14a260 UTSW 7 85,985,295 (GRCm39) missense probably benign 0.00
R8066:Or14a260 UTSW 7 85,985,014 (GRCm39) missense probably benign 0.00
R8155:Or14a260 UTSW 7 85,985,386 (GRCm39) missense probably damaging 1.00
R8158:Or14a260 UTSW 7 85,984,885 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAATATGCTTTCCCACCTATTGACTG -3'
(R):5'- GCTCTGAAACACTTGTGGCC -3'

Sequencing Primer
(F):5'- CCCACCTATTGACTGATTTAACAATC -3'
(R):5'- CTGAAACACTTGTGGCCATTTAC -3'
Posted On 2016-11-08