Incidental Mutation 'R5638:Fndc7'
ID 440478
Institutional Source Beutler Lab
Gene Symbol Fndc7
Ensembl Gene ENSMUSG00000045326
Gene Name fibronectin type III domain containing 7
Synonyms E230011A21Rik
MMRRC Submission 043168-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5638 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 108760994-108797324 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108770208 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 659 (T659S)
Ref Sequence ENSEMBL: ENSMUSP00000136215 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053065] [ENSMUST00000102620] [ENSMUST00000180063]
AlphaFold A2AED3
Predicted Effect possibly damaging
Transcript: ENSMUST00000053065
AA Change: T573S

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000051172
Gene: ENSMUSG00000045326
AA Change: T573S

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
Blast:FN3 201 274 9e-44 BLAST
FN3 283 360 1.07e-1 SMART
FN3 457 530 5.1e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000102620
AA Change: T659S

PolyPhen 2 Score 0.665 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000099680
Gene: ENSMUSG00000045326
AA Change: T659S

DomainStartEndE-ValueType
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
FN3 201 275 2.44e-5 SMART
Blast:FN3 287 360 1e-43 BLAST
FN3 369 446 1.07e-1 SMART
FN3 543 616 5.1e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123018
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147002
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151713
Predicted Effect possibly damaging
Transcript: ENSMUST00000180063
AA Change: T659S

PolyPhen 2 Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000136215
Gene: ENSMUSG00000045326
AA Change: T659S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
FN3 29 102 2.62e-5 SMART
FN3 113 189 1.31e-5 SMART
FN3 201 275 2.44e-5 SMART
Blast:FN3 287 360 2e-43 BLAST
FN3 369 446 1.07e-1 SMART
FN3 543 616 5.1e1 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610028H24Rik G A 10: 76,288,729 (GRCm39) A96T probably benign Het
A930018M24Rik T C 14: 51,134,414 (GRCm39) D76G possibly damaging Het
Adamtsl3 A T 7: 82,260,958 (GRCm39) R1631W probably damaging Het
Alg5 C T 3: 54,646,254 (GRCm39) H40Y probably benign Het
B3galt1 T C 2: 67,949,095 (GRCm39) L270P probably damaging Het
Ceacam3 A G 7: 16,893,860 (GRCm39) Y457C probably damaging Het
Cenpa A T 5: 30,830,736 (GRCm39) R124W probably damaging Het
Cfap44 A G 16: 44,275,894 (GRCm39) T1385A possibly damaging Het
Chd9 A T 8: 91,738,078 (GRCm39) H1570L possibly damaging Het
Cmtm4 T C 8: 105,084,356 (GRCm39) I113V probably benign Het
Dmxl1 T C 18: 50,024,693 (GRCm39) I1789T possibly damaging Het
Dpf3 G A 12: 83,371,714 (GRCm39) R174W probably damaging Het
Dusp26 T C 8: 31,584,169 (GRCm39) L92P probably damaging Het
Fry A G 5: 150,282,546 (GRCm39) H357R possibly damaging Het
G0s2 A T 1: 192,954,859 (GRCm39) L75H probably damaging Het
Gm5493 A G 17: 22,969,065 (GRCm39) T82A probably benign Het
Herc2 T C 7: 55,854,164 (GRCm39) V3690A probably benign Het
Igf2bp3 C A 6: 49,064,734 (GRCm39) V537F probably damaging Het
Kntc1 C T 5: 123,956,538 (GRCm39) R2101W possibly damaging Het
Kpna2rt T C 17: 90,217,635 (GRCm39) E37G probably damaging Het
Mrgpra6 G T 7: 46,835,657 (GRCm39) P255T probably damaging Het
Ncor2 A G 5: 125,125,364 (GRCm39) V229A probably benign Het
Nos1ap T A 1: 170,176,968 (GRCm39) K145M probably damaging Het
Or6c210 T A 10: 129,495,969 (GRCm39) I98K possibly damaging Het
Or7g21 T A 9: 19,032,676 (GRCm39) C142S probably benign Het
Ppt2 C A 17: 34,844,823 (GRCm39) M140I probably benign Het
Ppwd1 A G 13: 104,356,906 (GRCm39) I203T probably damaging Het
Prpf6 A G 2: 181,287,381 (GRCm39) T589A probably benign Het
Psd4 T C 2: 24,287,427 (GRCm39) L453P probably benign Het
Ptpn14 A G 1: 189,519,038 (GRCm39) T23A probably damaging Het
Rxrb T C 17: 34,256,381 (GRCm39) L374P probably damaging Het
Scaf4 T C 16: 90,041,198 (GRCm39) E710G unknown Het
Sik1 C T 17: 32,069,802 (GRCm39) V216I probably damaging Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc30a5 T A 13: 100,950,380 (GRCm39) K236* probably null Het
Slc38a4 A C 15: 96,910,871 (GRCm39) S135A probably damaging Het
Slc9a1 T A 4: 133,139,571 (GRCm39) V263D probably damaging Het
Socs2 T C 10: 95,228,745 (GRCm39) I168M unknown Het
Spag9 C A 11: 93,959,838 (GRCm39) D342E probably damaging Het
Sspo T C 6: 48,469,825 (GRCm39) S4508P possibly damaging Het
Stat5b C A 11: 100,675,080 (GRCm39) E710* probably null Het
Stip1 G A 19: 7,009,883 (GRCm39) P213L probably damaging Het
Tarbp1 A T 8: 127,177,425 (GRCm39) L749Q probably damaging Het
Thsd7b T G 1: 129,523,270 (GRCm39) S24R probably benign Het
Upp2 T C 2: 58,680,107 (GRCm39) V293A probably damaging Het
Vmn2r65 C T 7: 84,590,047 (GRCm39) C623Y probably damaging Het
Vps54 T C 11: 21,258,799 (GRCm39) V742A probably damaging Het
Other mutations in Fndc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02077:Fndc7 APN 3 108,790,784 (GRCm39) missense probably benign 0.17
IGL02823:Fndc7 APN 3 108,776,487 (GRCm39) missense probably damaging 1.00
IGL02896:Fndc7 APN 3 108,770,247 (GRCm39) missense probably benign 0.04
IGL03196:Fndc7 APN 3 108,790,760 (GRCm39) missense probably damaging 1.00
IGL03343:Fndc7 APN 3 108,774,624 (GRCm39) missense probably damaging 1.00
IGL03377:Fndc7 APN 3 108,783,848 (GRCm39) missense probably benign 0.12
R0240:Fndc7 UTSW 3 108,766,235 (GRCm39) splice site probably benign
R0324:Fndc7 UTSW 3 108,784,015 (GRCm39) splice site probably null
R0457:Fndc7 UTSW 3 108,783,861 (GRCm39) missense probably benign 0.02
R0630:Fndc7 UTSW 3 108,783,931 (GRCm39) missense probably damaging 1.00
R0891:Fndc7 UTSW 3 108,777,904 (GRCm39) missense possibly damaging 0.54
R1752:Fndc7 UTSW 3 108,776,646 (GRCm39) missense probably benign 0.14
R1772:Fndc7 UTSW 3 108,777,850 (GRCm39) missense probably damaging 1.00
R1923:Fndc7 UTSW 3 108,784,003 (GRCm39) missense probably benign 0.00
R1957:Fndc7 UTSW 3 108,790,825 (GRCm39) missense probably damaging 0.98
R3801:Fndc7 UTSW 3 108,776,464 (GRCm39) missense possibly damaging 0.95
R4592:Fndc7 UTSW 3 108,766,218 (GRCm39) missense probably damaging 1.00
R4650:Fndc7 UTSW 3 108,770,135 (GRCm39) missense probably benign 0.15
R4652:Fndc7 UTSW 3 108,770,135 (GRCm39) missense probably benign 0.15
R4791:Fndc7 UTSW 3 108,783,975 (GRCm39) missense probably benign 0.00
R4933:Fndc7 UTSW 3 108,783,986 (GRCm39) missense probably benign 0.01
R5004:Fndc7 UTSW 3 108,790,789 (GRCm39) missense probably damaging 1.00
R5042:Fndc7 UTSW 3 108,770,102 (GRCm39) missense probably damaging 1.00
R5054:Fndc7 UTSW 3 108,788,663 (GRCm39) missense probably damaging 0.97
R5175:Fndc7 UTSW 3 108,776,482 (GRCm39) missense probably benign 0.04
R5325:Fndc7 UTSW 3 108,790,765 (GRCm39) missense probably damaging 1.00
R5571:Fndc7 UTSW 3 108,763,724 (GRCm39) missense possibly damaging 0.68
R5846:Fndc7 UTSW 3 108,788,707 (GRCm39) missense probably damaging 1.00
R6488:Fndc7 UTSW 3 108,777,891 (GRCm39) missense probably damaging 0.99
R6737:Fndc7 UTSW 3 108,779,594 (GRCm39) missense probably damaging 1.00
R6993:Fndc7 UTSW 3 108,783,907 (GRCm39) missense probably benign 0.00
R6998:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R6999:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7000:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7001:Fndc7 UTSW 3 108,783,964 (GRCm39) missense probably benign 0.02
R7181:Fndc7 UTSW 3 108,788,640 (GRCm39) critical splice donor site probably null
R7324:Fndc7 UTSW 3 108,779,537 (GRCm39) missense probably benign 0.06
R7425:Fndc7 UTSW 3 108,783,975 (GRCm39) missense probably benign 0.00
R7631:Fndc7 UTSW 3 108,776,568 (GRCm39) missense probably damaging 1.00
R7702:Fndc7 UTSW 3 108,770,129 (GRCm39) missense probably damaging 0.98
R7713:Fndc7 UTSW 3 108,777,979 (GRCm39) missense possibly damaging 0.90
R7909:Fndc7 UTSW 3 108,770,232 (GRCm39) missense probably benign 0.04
R7946:Fndc7 UTSW 3 108,779,452 (GRCm39) missense possibly damaging 0.78
R8023:Fndc7 UTSW 3 108,774,461 (GRCm39) missense probably damaging 1.00
R8694:Fndc7 UTSW 3 108,779,622 (GRCm39) nonsense probably null
R8708:Fndc7 UTSW 3 108,774,528 (GRCm39) missense probably benign 0.00
R9325:Fndc7 UTSW 3 108,790,834 (GRCm39) missense possibly damaging 0.55
R9608:Fndc7 UTSW 3 108,774,597 (GRCm39) missense probably damaging 1.00
Z1088:Fndc7 UTSW 3 108,790,816 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCCTAACTGCCTTTACCTGAG -3'
(R):5'- ACCTTGCTCTGTTCTAACTAGG -3'

Sequencing Primer
(F):5'- CATCACGGTGTAAACGTC -3'
(R):5'- CTGTGCAGAAGATTCTACTTGTC -3'
Posted On 2016-11-08