Incidental Mutation 'R5640:Vmn2r107'
| ID |
440637 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r107
|
| Ensembl Gene |
ENSMUSG00000056910 |
| Gene Name |
vomeronasal 2, receptor 107 |
| Synonyms |
V2r6 |
| MMRRC Submission |
043289-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R5640 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20565687-20596034 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20595426 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 660
(T660A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048706
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042090]
|
| AlphaFold |
E9PZJ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042090
AA Change: T660A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: T660A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
466 |
3.6e-40 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
5.1e-21 |
PFAM |
|
Pfam:7tm_3
|
593 |
830 |
8e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ace |
A |
G |
11: 105,861,511 (GRCm39) |
Y220C |
probably damaging |
Het |
| Actl6a |
A |
G |
3: 32,772,199 (GRCm39) |
T170A |
probably damaging |
Het |
| Adamts8 |
T |
C |
9: 30,867,796 (GRCm39) |
V540A |
probably benign |
Het |
| Aga |
T |
C |
8: 53,964,919 (GRCm39) |
L27P |
probably damaging |
Het |
| Agmat |
T |
A |
4: 141,483,134 (GRCm39) |
H189Q |
probably damaging |
Het |
| Alx3 |
C |
A |
3: 107,507,977 (GRCm39) |
T162K |
probably damaging |
Het |
| Armc2 |
T |
A |
10: 41,887,894 (GRCm39) |
I30L |
possibly damaging |
Het |
| Atp10d |
T |
G |
5: 72,404,552 (GRCm39) |
Y487D |
probably damaging |
Het |
| Atp13a4 |
C |
T |
16: 29,234,649 (GRCm39) |
M908I |
probably damaging |
Het |
| B4galt2 |
T |
G |
4: 117,731,195 (GRCm39) |
N322T |
probably benign |
Het |
| Bmal1 |
C |
T |
7: 112,907,888 (GRCm39) |
P530L |
probably damaging |
Het |
| Brdt |
A |
T |
5: 107,507,174 (GRCm39) |
K525* |
probably null |
Het |
| Ccdc168 |
T |
C |
1: 44,101,087 (GRCm39) |
I4V |
probably benign |
Het |
| Ces3a |
T |
A |
8: 105,778,377 (GRCm39) |
M246K |
probably benign |
Het |
| Chd9 |
T |
A |
8: 91,763,190 (GRCm39) |
H2338Q |
probably damaging |
Het |
| Cyp3a16 |
T |
A |
5: 145,389,633 (GRCm39) |
D244V |
possibly damaging |
Het |
| Dhrs9 |
C |
A |
2: 69,224,822 (GRCm39) |
A170E |
probably damaging |
Het |
| Dlg5 |
T |
C |
14: 24,220,529 (GRCm39) |
N550D |
probably damaging |
Het |
| Dnah8 |
C |
T |
17: 31,022,082 (GRCm39) |
T3894I |
probably damaging |
Het |
| Dpys |
T |
C |
15: 39,705,462 (GRCm39) |
H217R |
probably damaging |
Het |
| Dpysl2 |
C |
T |
14: 67,071,817 (GRCm39) |
V108I |
probably benign |
Het |
| Eprs1 |
A |
G |
1: 185,106,381 (GRCm39) |
T199A |
probably benign |
Het |
| Fads1 |
A |
G |
19: 10,163,767 (GRCm39) |
D183G |
probably damaging |
Het |
| Fam110b |
T |
G |
4: 5,798,689 (GRCm39) |
Y36D |
probably damaging |
Het |
| Fbxl21 |
G |
A |
13: 56,685,194 (GRCm39) |
D407N |
probably benign |
Het |
| Fuca2 |
G |
A |
10: 13,383,174 (GRCm39) |
|
probably null |
Het |
| Gnas |
C |
A |
2: 174,126,764 (GRCm39) |
R100S |
probably benign |
Het |
| Gse1 |
A |
G |
8: 121,289,416 (GRCm39) |
H90R |
possibly damaging |
Het |
| Hoxc10 |
G |
T |
15: 102,875,702 (GRCm39) |
C137F |
probably benign |
Het |
| Ipp |
T |
G |
4: 116,377,886 (GRCm39) |
L252R |
possibly damaging |
Het |
| Jmjd1c |
T |
A |
10: 67,061,857 (GRCm39) |
S1403R |
probably benign |
Het |
| Kif19a |
A |
G |
11: 114,670,041 (GRCm39) |
M79V |
probably benign |
Het |
| Lipo4 |
T |
C |
19: 33,478,986 (GRCm39) |
T285A |
possibly damaging |
Het |
| Lrrc66 |
A |
T |
5: 73,765,977 (GRCm39) |
D355E |
probably benign |
Het |
| Lrsam1 |
T |
A |
2: 32,835,864 (GRCm39) |
Q301L |
probably benign |
Het |
| Med6 |
C |
T |
12: 81,628,628 (GRCm39) |
R138Q |
probably damaging |
Het |
| Nlrc5 |
A |
G |
8: 95,202,421 (GRCm39) |
T174A |
probably benign |
Het |
| Nrbp1 |
C |
T |
5: 31,406,929 (GRCm39) |
R322W |
possibly damaging |
Het |
| Or10ak14 |
T |
A |
4: 118,610,986 (GRCm39) |
T250S |
probably benign |
Het |
| Or11g24 |
C |
A |
14: 50,662,111 (GRCm39) |
A45D |
probably benign |
Het |
| Or4a47 |
T |
A |
2: 89,666,282 (GRCm39) |
E2D |
probably benign |
Het |
| Pde3a |
A |
G |
6: 141,429,641 (GRCm39) |
E734G |
probably damaging |
Het |
| Pgap6 |
C |
T |
17: 26,337,846 (GRCm39) |
T410I |
possibly damaging |
Het |
| Pnpla7 |
C |
T |
2: 24,893,013 (GRCm39) |
T167I |
possibly damaging |
Het |
| Pop7 |
T |
C |
5: 137,500,321 (GRCm39) |
N4S |
possibly damaging |
Het |
| Ppm1h |
C |
A |
10: 122,618,183 (GRCm39) |
P114Q |
probably benign |
Het |
| Prdm16 |
T |
C |
4: 154,426,367 (GRCm39) |
T473A |
probably benign |
Het |
| Prdm6 |
T |
C |
18: 53,669,813 (GRCm39) |
|
probably null |
Het |
| Prkdc |
T |
G |
16: 15,647,633 (GRCm39) |
W3686G |
possibly damaging |
Het |
| Ptchd4 |
C |
A |
17: 42,814,026 (GRCm39) |
H642Q |
possibly damaging |
Het |
| Rad1 |
A |
G |
15: 10,496,009 (GRCm39) |
Y228C |
possibly damaging |
Het |
| Rgs22 |
G |
A |
15: 36,107,101 (GRCm39) |
T56I |
probably benign |
Het |
| Rnf135 |
C |
A |
11: 80,084,733 (GRCm39) |
H169N |
probably benign |
Het |
| Rnft1 |
C |
T |
11: 86,377,319 (GRCm39) |
Q128* |
probably null |
Het |
| Sez6 |
T |
C |
11: 77,864,585 (GRCm39) |
|
probably benign |
Het |
| Sh3rf3 |
A |
G |
10: 58,649,769 (GRCm39) |
S125G |
probably benign |
Het |
| Sik2 |
T |
C |
9: 50,826,806 (GRCm39) |
E295G |
possibly damaging |
Het |
| Themis |
A |
G |
10: 28,739,372 (GRCm39) |
Q614R |
probably damaging |
Het |
| Thsd7b |
T |
A |
1: 130,044,408 (GRCm39) |
C1129* |
probably null |
Het |
| Tmem68 |
A |
T |
4: 3,569,512 (GRCm39) |
F59L |
probably benign |
Het |
| Vwa5b2 |
G |
T |
16: 20,416,292 (GRCm39) |
C484F |
probably damaging |
Het |
| Zfp418 |
T |
A |
7: 7,184,980 (GRCm39) |
C314* |
probably null |
Het |
|
| Other mutations in Vmn2r107 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01402:Vmn2r107
|
APN |
17 |
20,596,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01768:Vmn2r107
|
APN |
17 |
20,565,868 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02086:Vmn2r107
|
APN |
17 |
20,578,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02136:Vmn2r107
|
APN |
17 |
20,595,168 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r107
|
APN |
17 |
20,577,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02285:Vmn2r107
|
APN |
17 |
20,595,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02724:Vmn2r107
|
APN |
17 |
20,577,006 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02998:Vmn2r107
|
APN |
17 |
20,578,017 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03089:Vmn2r107
|
APN |
17 |
20,595,974 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03284:Vmn2r107
|
APN |
17 |
20,577,173 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03307:Vmn2r107
|
APN |
17 |
20,577,038 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03399:Vmn2r107
|
APN |
17 |
20,578,220 (GRCm39) |
splice site |
probably benign |
|
|
3-1:Vmn2r107
|
UTSW |
17 |
20,565,766 (GRCm39) |
missense |
probably benign |
|
|
BB006:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
BB016:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
R0285:Vmn2r107
|
UTSW |
17 |
20,565,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0455:Vmn2r107
|
UTSW |
17 |
20,595,085 (GRCm39) |
splice site |
probably benign |
|
|
R0497:Vmn2r107
|
UTSW |
17 |
20,595,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Vmn2r107
|
UTSW |
17 |
20,578,021 (GRCm39) |
missense |
probably benign |
|
|
R0621:Vmn2r107
|
UTSW |
17 |
20,595,252 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0667:Vmn2r107
|
UTSW |
17 |
20,575,916 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1118:Vmn2r107
|
UTSW |
17 |
20,576,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1204:Vmn2r107
|
UTSW |
17 |
20,578,031 (GRCm39) |
missense |
probably benign |
|
|
R1237:Vmn2r107
|
UTSW |
17 |
20,576,947 (GRCm39) |
nonsense |
probably null |
|
|
R1485:Vmn2r107
|
UTSW |
17 |
20,595,109 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1783:Vmn2r107
|
UTSW |
17 |
20,576,775 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1873:Vmn2r107
|
UTSW |
17 |
20,565,840 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1974:Vmn2r107
|
UTSW |
17 |
20,575,879 (GRCm39) |
splice site |
probably null |
|
|
R2009:Vmn2r107
|
UTSW |
17 |
20,595,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2029:Vmn2r107
|
UTSW |
17 |
20,595,549 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r107
|
UTSW |
17 |
20,595,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r107
|
UTSW |
17 |
20,595,817 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3087:Vmn2r107
|
UTSW |
17 |
20,580,607 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3740:Vmn2r107
|
UTSW |
17 |
20,595,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3961:Vmn2r107
|
UTSW |
17 |
20,595,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4031:Vmn2r107
|
UTSW |
17 |
20,595,483 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4270:Vmn2r107
|
UTSW |
17 |
20,576,041 (GRCm39) |
missense |
probably benign |
|
|
R4963:Vmn2r107
|
UTSW |
17 |
20,595,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5121:Vmn2r107
|
UTSW |
17 |
20,576,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6007:Vmn2r107
|
UTSW |
17 |
20,595,316 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6238:Vmn2r107
|
UTSW |
17 |
20,565,849 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6298:Vmn2r107
|
UTSW |
17 |
20,576,044 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6467:Vmn2r107
|
UTSW |
17 |
20,595,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6726:Vmn2r107
|
UTSW |
17 |
20,595,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6782:Vmn2r107
|
UTSW |
17 |
20,577,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7299:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7301:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7375:Vmn2r107
|
UTSW |
17 |
20,576,138 (GRCm39) |
missense |
probably benign |
|
|
R7448:Vmn2r107
|
UTSW |
17 |
20,595,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7495:Vmn2r107
|
UTSW |
17 |
20,595,271 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7589:Vmn2r107
|
UTSW |
17 |
20,595,634 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7594:Vmn2r107
|
UTSW |
17 |
20,580,635 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7678:Vmn2r107
|
UTSW |
17 |
20,576,901 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7929:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
R7974:Vmn2r107
|
UTSW |
17 |
20,577,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8040:Vmn2r107
|
UTSW |
17 |
20,595,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8263:Vmn2r107
|
UTSW |
17 |
20,580,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8426:Vmn2r107
|
UTSW |
17 |
20,577,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9175:Vmn2r107
|
UTSW |
17 |
20,577,051 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9537:Vmn2r107
|
UTSW |
17 |
20,595,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9642:Vmn2r107
|
UTSW |
17 |
20,580,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9711:Vmn2r107
|
UTSW |
17 |
20,577,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn2r107
|
UTSW |
17 |
20,577,230 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCTAGCCAGCATAGCTTTGTG -3'
(R):5'- GGTGGAGATATTGCCATCCATATTC -3'
Sequencing Primer
(F):5'- GCACTAACTGCCTTTGTTATTGG -3'
(R):5'- CCATATTCCACAAAGAAGAAGTTGG -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation