Incidental Mutation 'R5642:Zfat'
| ID |
440783 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfat
|
| Ensembl Gene |
ENSMUSG00000022335 |
| Gene Name |
zinc finger and AT hook domain containing |
| Synonyms |
LOC380993, Zfp406, Zfat1 |
| MMRRC Submission |
043290-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5642 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
67955613-68130705 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 68052765 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 343
(V343E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124974
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159430]
[ENSMUST00000160248]
[ENSMUST00000162054]
[ENSMUST00000162173]
|
| AlphaFold |
Q7TS63 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159430
|
| SMART Domains |
Protein: ENSMUSP00000124420
Gene: ENSMUSG00000022335
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
12 |
35 |
2.45e0 |
SMART |
|
ZnF_C2H2
|
116 |
136 |
1.53e2 |
SMART |
|
low complexity region
|
158 |
174 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
209 |
231 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
237 |
259 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
264 |
287 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
292 |
315 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
396 |
419 |
2.05e-2 |
SMART |
|
low complexity region
|
539 |
555 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160248
AA Change: V343E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125257
Gene: ENSMUSG00000022335
AA Change: V343E
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
12 |
35 |
2.45e0 |
SMART |
|
ZnF_C2H2
|
116 |
136 |
1.53e2 |
SMART |
|
low complexity region
|
220 |
236 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
271 |
293 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
326 |
349 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
354 |
377 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
458 |
481 |
2.05e-2 |
SMART |
|
low complexity region
|
601 |
617 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
737 |
759 |
1.43e-1 |
SMART |
|
ZnF_C2H2
|
765 |
788 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
793 |
817 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
825 |
848 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
875 |
898 |
3.95e1 |
SMART |
|
ZnF_C2H2
|
904 |
926 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
932 |
954 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
961 |
983 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
989 |
1012 |
9.3e-1 |
SMART |
|
ZnF_C2H2
|
1036 |
1059 |
5.21e-4 |
SMART |
|
low complexity region
|
1073 |
1082 |
N/A |
INTRINSIC |
|
low complexity region
|
1139 |
1149 |
N/A |
INTRINSIC |
|
low complexity region
|
1218 |
1236 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162054
AA Change: V336E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125732
Gene: ENSMUSG00000022335
AA Change: V336E
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
12 |
35 |
2.45e0 |
SMART |
|
ZnF_C2H2
|
116 |
136 |
1.53e2 |
SMART |
|
low complexity region
|
213 |
229 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
264 |
286 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
319 |
342 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
347 |
370 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
397 |
419 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
425 |
447 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
451 |
474 |
2.05e-2 |
SMART |
|
low complexity region
|
594 |
610 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
730 |
752 |
1.43e-1 |
SMART |
|
ZnF_C2H2
|
758 |
781 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
786 |
810 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
818 |
841 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
868 |
891 |
3.95e1 |
SMART |
|
ZnF_C2H2
|
897 |
919 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
925 |
947 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
954 |
976 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
982 |
1005 |
9.3e-1 |
SMART |
|
ZnF_C2H2
|
1029 |
1052 |
5.21e-4 |
SMART |
|
low complexity region
|
1121 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1218 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162173
AA Change: V343E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124974
Gene: ENSMUSG00000022335
AA Change: V343E
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
12 |
35 |
2.45e0 |
SMART |
|
ZnF_C2H2
|
116 |
136 |
1.53e2 |
SMART |
|
low complexity region
|
220 |
236 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
271 |
293 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
326 |
349 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
354 |
377 |
4.4e-2 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
458 |
481 |
2.05e-2 |
SMART |
|
low complexity region
|
601 |
617 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
737 |
759 |
1.43e-1 |
SMART |
|
ZnF_C2H2
|
765 |
788 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
793 |
817 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
825 |
848 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
875 |
898 |
3.95e1 |
SMART |
|
ZnF_C2H2
|
904 |
926 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
932 |
954 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
961 |
983 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
989 |
1012 |
9.3e-1 |
SMART |
|
ZnF_C2H2
|
1036 |
1059 |
5.21e-4 |
SMART |
|
low complexity region
|
1133 |
1151 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc1 |
A |
G |
16: 14,261,319 (GRCm39) |
E699G |
probably damaging |
Het |
| Ap4e1 |
T |
A |
2: 126,906,899 (GRCm39) |
V1053D |
possibly damaging |
Het |
| Apobec1 |
T |
A |
6: 122,558,456 (GRCm39) |
I100F |
probably damaging |
Het |
| Atp6v1g3 |
G |
T |
1: 138,211,480 (GRCm39) |
K53N |
probably damaging |
Het |
| Bag3 |
C |
T |
7: 128,147,830 (GRCm39) |
R482W |
probably damaging |
Het |
| Brme1 |
C |
T |
8: 84,894,114 (GRCm39) |
T427I |
probably damaging |
Het |
| Cacna1i |
A |
G |
15: 80,279,279 (GRCm39) |
T2007A |
possibly damaging |
Het |
| Cd44 |
T |
C |
2: 102,731,687 (GRCm39) |
D2G |
probably damaging |
Het |
| Cdadc1 |
T |
A |
14: 59,827,372 (GRCm39) |
I100F |
possibly damaging |
Het |
| Cdh16 |
A |
G |
8: 105,344,677 (GRCm39) |
F485L |
probably damaging |
Het |
| Cdhr5 |
T |
A |
7: 140,849,110 (GRCm39) |
K817* |
probably null |
Het |
| Cfap46 |
G |
T |
7: 139,258,493 (GRCm39) |
P260Q |
probably damaging |
Het |
| Clec11a |
C |
T |
7: 43,955,832 (GRCm39) |
E72K |
possibly damaging |
Het |
| Cnr2 |
C |
A |
4: 135,644,076 (GRCm39) |
N51K |
probably damaging |
Het |
| Col3a1 |
T |
A |
1: 45,370,872 (GRCm39) |
|
probably benign |
Het |
| Cxcr1 |
G |
A |
1: 74,230,987 (GRCm39) |
T345M |
probably damaging |
Het |
| Cyp2s1 |
T |
C |
7: 25,515,744 (GRCm39) |
|
probably null |
Het |
| Dalrd3 |
C |
T |
9: 108,449,489 (GRCm39) |
T474M |
probably damaging |
Het |
| Ddit4 |
C |
T |
10: 59,787,327 (GRCm39) |
S3N |
probably benign |
Het |
| Ddx41 |
T |
C |
13: 55,683,708 (GRCm39) |
K108E |
possibly damaging |
Het |
| Dnaaf10 |
A |
G |
11: 17,177,263 (GRCm39) |
N207S |
possibly damaging |
Het |
| Ece2 |
A |
T |
16: 20,462,477 (GRCm39) |
H732L |
probably benign |
Het |
| Etv3 |
T |
G |
3: 87,443,322 (GRCm39) |
L302R |
possibly damaging |
Het |
| Fam135b |
A |
G |
15: 71,333,985 (GRCm39) |
S1070P |
probably damaging |
Het |
| Fhip1b |
A |
T |
7: 105,039,089 (GRCm39) |
I50N |
probably damaging |
Het |
| Gm11567 |
T |
A |
11: 99,770,437 (GRCm39) |
I125N |
unknown |
Het |
| Grm3 |
A |
G |
5: 9,620,536 (GRCm39) |
L236P |
probably benign |
Het |
| Hip1 |
T |
A |
5: 135,461,939 (GRCm39) |
R97* |
probably null |
Het |
| Hoxa5 |
T |
C |
6: 52,181,197 (GRCm39) |
Y45C |
probably damaging |
Het |
| Ighg1 |
T |
A |
12: 113,292,654 (GRCm39) |
H305L |
probably damaging |
Het |
| Inpp5b |
T |
A |
4: 124,676,229 (GRCm39) |
C362S |
probably benign |
Het |
| Kif1c |
A |
G |
11: 70,599,273 (GRCm39) |
K391E |
probably benign |
Het |
| Klf9 |
T |
C |
19: 23,119,246 (GRCm39) |
V43A |
probably benign |
Het |
| Krt28 |
T |
A |
11: 99,265,320 (GRCm39) |
I116F |
probably damaging |
Het |
| Lct |
A |
T |
1: 128,222,969 (GRCm39) |
D1439E |
probably damaging |
Het |
| Liph |
G |
A |
16: 21,784,745 (GRCm39) |
T284M |
possibly damaging |
Het |
| Lrrc75b |
T |
C |
10: 75,393,055 (GRCm39) |
K98R |
possibly damaging |
Het |
| Lypd4 |
T |
C |
7: 24,564,604 (GRCm39) |
Q178R |
probably benign |
Het |
| Map1a |
T |
A |
2: 121,136,524 (GRCm39) |
S2209T |
probably damaging |
Het |
| Map3k21 |
C |
T |
8: 126,665,563 (GRCm39) |
T584I |
probably benign |
Het |
| Map3k6 |
T |
C |
4: 132,972,855 (GRCm39) |
V338A |
probably damaging |
Het |
| Mapk8ip3 |
A |
T |
17: 25,122,285 (GRCm39) |
V699E |
possibly damaging |
Het |
| Mtarc1 |
A |
C |
1: 184,543,116 (GRCm39) |
S71A |
probably damaging |
Het |
| Nckap1l |
T |
C |
15: 103,363,452 (GRCm39) |
S53P |
probably benign |
Het |
| Nt5e |
T |
C |
9: 88,209,740 (GRCm39) |
M1T |
probably null |
Het |
| Nudt22 |
T |
C |
19: 6,972,896 (GRCm39) |
H64R |
probably damaging |
Het |
| Or1o11 |
A |
T |
17: 37,756,663 (GRCm39) |
T84S |
probably damaging |
Het |
| Or2t44 |
A |
T |
11: 58,677,654 (GRCm39) |
Y198F |
probably damaging |
Het |
| Or2w3 |
T |
C |
11: 58,557,225 (GRCm39) |
I280T |
possibly damaging |
Het |
| Or52b1 |
A |
T |
7: 104,978,772 (GRCm39) |
V209D |
probably damaging |
Het |
| Or5ac16 |
A |
G |
16: 59,022,369 (GRCm39) |
L140P |
probably damaging |
Het |
| Or8k17 |
T |
C |
2: 86,066,276 (GRCm39) |
N294S |
probably damaging |
Het |
| Otogl |
T |
C |
10: 107,722,413 (GRCm39) |
I314V |
probably benign |
Het |
| Pan2 |
G |
T |
10: 128,143,969 (GRCm39) |
E106D |
probably benign |
Het |
| Papss1 |
T |
A |
3: 131,337,565 (GRCm39) |
Y554* |
probably null |
Het |
| Pcnx1 |
T |
C |
12: 81,941,803 (GRCm39) |
V67A |
possibly damaging |
Het |
| Pdpk1 |
A |
C |
17: 24,325,829 (GRCm39) |
Y122* |
probably null |
Het |
| Pkd1l1 |
A |
T |
11: 8,829,202 (GRCm39) |
N1463K |
probably damaging |
Het |
| Ptgfrn |
C |
A |
3: 100,950,678 (GRCm39) |
M878I |
probably damaging |
Het |
| Ranbp3 |
G |
A |
17: 57,017,703 (GRCm39) |
G453E |
probably benign |
Het |
| Rapgef2 |
T |
C |
3: 79,002,157 (GRCm39) |
D261G |
probably damaging |
Het |
| Reep2 |
A |
G |
18: 34,979,271 (GRCm39) |
S199G |
probably benign |
Het |
| Rnpep |
G |
A |
1: 135,205,259 (GRCm39) |
T202I |
probably damaging |
Het |
| Sass6 |
T |
A |
3: 116,401,145 (GRCm39) |
|
probably null |
Het |
| Sema3e |
A |
G |
5: 14,212,257 (GRCm39) |
D111G |
probably damaging |
Het |
| Slc29a4 |
A |
G |
5: 142,697,727 (GRCm39) |
E60G |
probably damaging |
Het |
| Spata31g1 |
T |
C |
4: 42,971,831 (GRCm39) |
L388P |
possibly damaging |
Het |
| Spata31h1 |
T |
A |
10: 82,120,317 (GRCm39) |
Q4231L |
probably damaging |
Het |
| Sptlc3 |
T |
C |
2: 139,388,328 (GRCm39) |
Y107H |
probably damaging |
Het |
| Stx6 |
T |
C |
1: 155,073,925 (GRCm39) |
I245T |
probably benign |
Het |
| Syne2 |
T |
C |
12: 75,965,306 (GRCm39) |
S774P |
probably damaging |
Het |
| Tbc1d16 |
T |
A |
11: 119,049,617 (GRCm39) |
Q293L |
probably damaging |
Het |
| Tbc1d30 |
T |
C |
10: 121,132,692 (GRCm39) |
D224G |
probably damaging |
Het |
| Tbc1d32 |
T |
A |
10: 56,026,973 (GRCm39) |
N759Y |
possibly damaging |
Het |
| Tdrd12 |
G |
T |
7: 35,210,725 (GRCm39) |
A166E |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,405,046 (GRCm39) |
R653G |
probably benign |
Het |
| Them6 |
A |
T |
15: 74,593,654 (GRCm39) |
R171W |
probably null |
Het |
| Tln2 |
T |
C |
9: 67,203,640 (GRCm39) |
T489A |
probably benign |
Het |
| Tmem87a |
A |
G |
2: 120,234,427 (GRCm39) |
F39L |
probably benign |
Het |
| Toporsl |
T |
A |
4: 52,611,515 (GRCm39) |
C469* |
probably null |
Het |
| Tpr |
T |
C |
1: 150,299,569 (GRCm39) |
S1147P |
probably damaging |
Het |
| Trp53bp1 |
T |
C |
2: 121,067,143 (GRCm39) |
M528V |
probably benign |
Het |
| Trpm6 |
T |
A |
19: 18,807,571 (GRCm39) |
C1039S |
probably damaging |
Het |
| Ttc16 |
T |
A |
2: 32,665,348 (GRCm39) |
S5C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,617,412 (GRCm39) |
Y14607C |
probably damaging |
Het |
| Usp6nl |
T |
C |
2: 6,435,275 (GRCm39) |
F345L |
probably damaging |
Het |
| Vmn1r205 |
C |
T |
13: 22,776,206 (GRCm39) |
G299R |
probably benign |
Het |
| Vmn2r74 |
G |
A |
7: 85,606,588 (GRCm39) |
H253Y |
probably benign |
Het |
| Vps13d |
A |
T |
4: 144,896,872 (GRCm39) |
D343E |
possibly damaging |
Het |
| Vwf |
A |
G |
6: 125,580,381 (GRCm39) |
E543G |
|
Het |
| Zfp316 |
T |
C |
5: 143,249,846 (GRCm39) |
E139G |
unknown |
Het |
| Zfp943 |
T |
A |
17: 22,211,813 (GRCm39) |
C300S |
probably damaging |
Het |
| Zkscan16 |
A |
G |
4: 58,957,748 (GRCm39) |
K677E |
probably benign |
Het |
|
| Other mutations in Zfat |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00542:Zfat
|
APN |
15 |
68,042,071 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00862:Zfat
|
APN |
15 |
68,130,512 (GRCm39) |
splice site |
probably null |
|
|
IGL01021:Zfat
|
APN |
15 |
68,042,015 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01152:Zfat
|
APN |
15 |
67,982,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01733:Zfat
|
APN |
15 |
68,052,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01873:Zfat
|
APN |
15 |
68,096,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01990:Zfat
|
APN |
15 |
68,096,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02066:Zfat
|
APN |
15 |
68,052,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02664:Zfat
|
APN |
15 |
68,052,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02955:Zfat
|
APN |
15 |
68,052,963 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03201:Zfat
|
APN |
15 |
68,037,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0145:Zfat
|
UTSW |
15 |
68,058,948 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0408:Zfat
|
UTSW |
15 |
68,052,141 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0633:Zfat
|
UTSW |
15 |
68,052,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Zfat
|
UTSW |
15 |
68,084,432 (GRCm39) |
splice site |
probably benign |
|
|
R1508:Zfat
|
UTSW |
15 |
68,050,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Zfat
|
UTSW |
15 |
68,084,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1641:Zfat
|
UTSW |
15 |
68,051,959 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1889:Zfat
|
UTSW |
15 |
67,973,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1959:Zfat
|
UTSW |
15 |
68,018,392 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2030:Zfat
|
UTSW |
15 |
67,990,783 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2202:Zfat
|
UTSW |
15 |
68,051,709 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2340:Zfat
|
UTSW |
15 |
67,973,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3440:Zfat
|
UTSW |
15 |
67,956,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3442:Zfat
|
UTSW |
15 |
67,973,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3442:Zfat
|
UTSW |
15 |
67,956,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4406:Zfat
|
UTSW |
15 |
68,052,040 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4649:Zfat
|
UTSW |
15 |
68,056,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4710:Zfat
|
UTSW |
15 |
68,052,131 (GRCm39) |
missense |
probably benign |
|
|
R4712:Zfat
|
UTSW |
15 |
67,982,324 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4745:Zfat
|
UTSW |
15 |
68,052,223 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4862:Zfat
|
UTSW |
15 |
68,051,959 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5015:Zfat
|
UTSW |
15 |
68,050,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5075:Zfat
|
UTSW |
15 |
68,052,079 (GRCm39) |
missense |
probably benign |
|
|
R5208:Zfat
|
UTSW |
15 |
68,052,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Zfat
|
UTSW |
15 |
68,037,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5303:Zfat
|
UTSW |
15 |
67,982,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5328:Zfat
|
UTSW |
15 |
68,051,677 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5659:Zfat
|
UTSW |
15 |
67,990,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5947:Zfat
|
UTSW |
15 |
68,051,806 (GRCm39) |
missense |
probably benign |
|
|
R6046:Zfat
|
UTSW |
15 |
68,052,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6315:Zfat
|
UTSW |
15 |
67,956,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6342:Zfat
|
UTSW |
15 |
68,052,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6573:Zfat
|
UTSW |
15 |
68,037,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6789:Zfat
|
UTSW |
15 |
67,956,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7028:Zfat
|
UTSW |
15 |
68,052,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Zfat
|
UTSW |
15 |
68,052,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7039:Zfat
|
UTSW |
15 |
68,052,211 (GRCm39) |
missense |
probably benign |
|
|
R7065:Zfat
|
UTSW |
15 |
68,052,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7144:Zfat
|
UTSW |
15 |
68,050,631 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7208:Zfat
|
UTSW |
15 |
68,051,856 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7330:Zfat
|
UTSW |
15 |
68,084,600 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7345:Zfat
|
UTSW |
15 |
67,976,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Zfat
|
UTSW |
15 |
68,052,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7405:Zfat
|
UTSW |
15 |
68,056,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7481:Zfat
|
UTSW |
15 |
68,050,715 (GRCm39) |
nonsense |
probably null |
|
|
R7672:Zfat
|
UTSW |
15 |
68,130,535 (GRCm39) |
start codon destroyed |
probably null |
0.39 |
|
R7676:Zfat
|
UTSW |
15 |
68,096,693 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7701:Zfat
|
UTSW |
15 |
68,052,757 (GRCm39) |
nonsense |
probably null |
|
|
R7825:Zfat
|
UTSW |
15 |
68,051,769 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8152:Zfat
|
UTSW |
15 |
67,973,355 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8404:Zfat
|
UTSW |
15 |
67,976,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8405:Zfat
|
UTSW |
15 |
68,018,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8502:Zfat
|
UTSW |
15 |
67,976,916 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8534:Zfat
|
UTSW |
15 |
68,037,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8708:Zfat
|
UTSW |
15 |
67,956,278 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8887:Zfat
|
UTSW |
15 |
68,056,315 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Zfat
|
UTSW |
15 |
68,052,519 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8906:Zfat
|
UTSW |
15 |
67,956,404 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9117:Zfat
|
UTSW |
15 |
68,058,918 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9137:Zfat
|
UTSW |
15 |
68,051,794 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9310:Zfat
|
UTSW |
15 |
67,956,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9482:Zfat
|
UTSW |
15 |
68,084,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9610:Zfat
|
UTSW |
15 |
68,051,655 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9611:Zfat
|
UTSW |
15 |
68,051,655 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9630:Zfat
|
UTSW |
15 |
67,990,793 (GRCm39) |
missense |
probably benign |
0.37 |
|
Z1088:Zfat
|
UTSW |
15 |
68,058,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfat
|
UTSW |
15 |
68,051,677 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGTGGCAGTCGTAGAGCAG -3'
(R):5'- TGTGAGTACTGCAACAAGGTG -3'
Sequencing Primer
(F):5'- TAGAGCAGCTGCCGCTTG -3'
(R):5'- GGTGTTCAAGTTCAAGCACTC -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation