Mutagenetix > Incidental Mutation

Incidental Mutation 'R5642:Mapk8ip3'

440796

Institutional Source

Beutler Lab

Gene Symbol

Mapk8ip3

Ensembl Gene

ENSMUSG00000024163

Gene Name

mitogen-activated protein kinase 8 interacting protein 3

Synonyms

JSAP1, Syd2, JNK-interacting protein 3, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, D17Wsu15e, Jip3, JSAP1a, JSAP1b, JSAP1c, sunday driver 2, JSAP1d, JUN/SAPK-associated protein 1

MMRRC Submission

043290-MU

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.823) question?

Stock #

R5642 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

24892153-24936977 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 24903311 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 699 (V699E)

Ref Sequence

ENSEMBL: ENSMUSP00000114084 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088345] [ENSMUST00000115228] [ENSMUST00000115229] [ENSMUST00000117509] [ENSMUST00000119115] [ENSMUST00000120035] [ENSMUST00000121723] [ENSMUST00000121787] [ENSMUST00000146923] [ENSMUST00000178969] [ENSMUST00000146706]

AlphaFold

Q9ESN9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000088345
AA Change: V700E

PolyPhen 2 Score 0.492 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000085683
Gene: ENSMUSG00000024163
AA Change: V700E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.4e-72	PFAM
low complexity region	236	249	N/A	INTRINSIC
low complexity region	261	270	N/A	INTRINSIC
PDB:2W83\|D	417	472	6e-20	PDB
coiled coil region	525	555	N/A	INTRINSIC
low complexity region	582	596	N/A	INTRINSIC
low complexity region	754	769	N/A	INTRINSIC
low complexity region	893	901	N/A	INTRINSIC
low complexity region	928	940	N/A	INTRINSIC
SCOP:d1flga_	987	1167	4e-8	SMART
Blast:WD40	1075	1116	6e-18	BLAST
low complexity region	1260	1276	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115228
AA Change: V685E

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000110883
Gene: ENSMUSG00000024163
AA Change: V685E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.4e-72	PFAM
low complexity region	236	249	N/A	INTRINSIC
low complexity region	261	270	N/A	INTRINSIC
PDB:2W83\|D	411	466	7e-20	PDB
low complexity region	567	581	N/A	INTRINSIC
low complexity region	739	754	N/A	INTRINSIC
low complexity region	878	886	N/A	INTRINSIC
low complexity region	913	925	N/A	INTRINSIC
SCOP:d1flga_	972	1152	3e-8	SMART
Blast:WD40	1060	1101	6e-18	BLAST
low complexity region	1245	1261	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000115229
AA Change: V708E

PolyPhen 2 Score 0.492 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000110884
Gene: ENSMUSG00000024163
AA Change: V708E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	184	2.9e-60	PFAM
low complexity region	244	257	N/A	INTRINSIC
low complexity region	269	278	N/A	INTRINSIC
Pfam:JIP_LZII	423	493	3.1e-32	PFAM
coiled coil region	533	563	N/A	INTRINSIC
low complexity region	590	604	N/A	INTRINSIC
low complexity region	762	777	N/A	INTRINSIC
low complexity region	901	909	N/A	INTRINSIC
low complexity region	936	948	N/A	INTRINSIC
SCOP:d1flga_	995	1175	4e-8	SMART
Blast:WD40	1083	1124	7e-18	BLAST
low complexity region	1268	1284	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117509
AA Change: V677E

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000112712
Gene: ENSMUSG00000024163
AA Change: V677E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.4e-72	PFAM
low complexity region	238	247	N/A	INTRINSIC
PDB:2W83\|D	394	449	7e-20	PDB
coiled coil region	502	532	N/A	INTRINSIC
low complexity region	559	573	N/A	INTRINSIC
low complexity region	731	746	N/A	INTRINSIC
low complexity region	870	878	N/A	INTRINSIC
low complexity region	905	917	N/A	INTRINSIC
SCOP:d1flga_	964	1144	3e-8	SMART
Blast:WD40	1052	1093	6e-18	BLAST
low complexity region	1237	1253	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000119115
AA Change: V668E

PolyPhen 2 Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000112955
Gene: ENSMUSG00000024163
AA Change: V668E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.3e-72	PFAM
low complexity region	229	238	N/A	INTRINSIC
PDB:2W83\|D	385	440	7e-20	PDB
coiled coil region	493	523	N/A	INTRINSIC
low complexity region	550	564	N/A	INTRINSIC
low complexity region	722	737	N/A	INTRINSIC
low complexity region	861	869	N/A	INTRINSIC
low complexity region	896	908	N/A	INTRINSIC
SCOP:d1flga_	955	1135	3e-8	SMART
Blast:WD40	1043	1084	5e-18	BLAST
low complexity region	1228	1244	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000120035
AA Change: V699E

PolyPhen 2 Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000114084
Gene: ENSMUSG00000024163
AA Change: V699E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.4e-72	PFAM
low complexity region	235	248	N/A	INTRINSIC
low complexity region	260	269	N/A	INTRINSIC
PDB:2W83\|D	416	471	6e-20	PDB
coiled coil region	524	554	N/A	INTRINSIC
low complexity region	581	595	N/A	INTRINSIC
low complexity region	753	768	N/A	INTRINSIC
low complexity region	892	900	N/A	INTRINSIC
low complexity region	927	939	N/A	INTRINSIC
SCOP:d1flga_	986	1166	3e-8	SMART
Blast:WD40	1074	1115	6e-18	BLAST
low complexity region	1259	1275	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000121723
AA Change: V669E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000113698
Gene: ENSMUSG00000024163
AA Change: V669E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1e-72	PFAM
low complexity region	230	239	N/A	INTRINSIC
PDB:2W83\|D	386	441	7e-20	PDB
coiled coil region	494	524	N/A	INTRINSIC
low complexity region	551	565	N/A	INTRINSIC
low complexity region	723	738	N/A	INTRINSIC
low complexity region	862	870	N/A	INTRINSIC
low complexity region	897	909	N/A	INTRINSIC
SCOP:d1flga_	956	1136	3e-8	SMART
Blast:WD40	1044	1085	5e-18	BLAST
low complexity region	1229	1245	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000121787
AA Change: V663E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113753
Gene: ENSMUSG00000024163
AA Change: V663E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	3.8e-73	PFAM
low complexity region	230	239	N/A	INTRINSIC
PDB:2W83\|D	380	435	8e-20	PDB
coiled coil region	488	518	N/A	INTRINSIC
low complexity region	545	559	N/A	INTRINSIC
low complexity region	717	732	N/A	INTRINSIC
low complexity region	856	864	N/A	INTRINSIC
low complexity region	891	903	N/A	INTRINSIC
SCOP:d1flga_	950	1130	3e-8	SMART
Blast:WD40	1038	1079	6e-18	BLAST
low complexity region	1223	1239	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125648

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132258

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133198

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144336

Predicted Effect

possibly damaging
Transcript: ENSMUST00000146923
AA Change: V700E

PolyPhen 2 Score 0.492 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000114802
Gene: ENSMUSG00000024163
AA Change: V700E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.4e-72	PFAM
low complexity region	236	249	N/A	INTRINSIC
low complexity region	261	270	N/A	INTRINSIC
PDB:2W83\|D	417	472	6e-20	PDB
coiled coil region	525	555	N/A	INTRINSIC
low complexity region	582	596	N/A	INTRINSIC
low complexity region	754	769	N/A	INTRINSIC
low complexity region	893	901	N/A	INTRINSIC
low complexity region	928	940	N/A	INTRINSIC
SCOP:d1flga_	987	1167	4e-8	SMART
Blast:WD40	1075	1116	6e-18	BLAST
low complexity region	1260	1276	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000178969
AA Change: V700E

PolyPhen 2 Score 0.492 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000136924
Gene: ENSMUSG00000024163
AA Change: V700E

Domain	Start	End	E-Value	Type
Pfam:Jnk-SapK_ap_N	29	186	1.1e-72	PFAM
low complexity region	236	249	N/A	INTRINSIC
low complexity region	261	270	N/A	INTRINSIC
PDB:2W83\|D	417	472	6e-20	PDB
coiled coil region	525	555	N/A	INTRINSIC
low complexity region	582	596	N/A	INTRINSIC
low complexity region	754	769	N/A	INTRINSIC
low complexity region	893	901	N/A	INTRINSIC
low complexity region	928	940	N/A	INTRINSIC
SCOP:d1flga_	987	1167	3e-8	SMART
Blast:WD40	1075	1116	6e-18	BLAST
low complexity region	1260	1276	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156663

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147109

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145357

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152486

Predicted Effect

probably benign
Transcript: ENSMUST00000146706

SMART Domains

Protein: ENSMUSP00000118422
Gene: ENSMUSG00000024163

Domain	Start	End	E-Value	Type
low complexity region	55	64	N/A	INTRINSIC
Pfam:JIP_LZII	203	235	1.6e-17	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	T	C	4: 42,971,831	L388P	possibly damaging	Het
4930432K21Rik	C	T	8: 84,167,485	T427I	probably damaging	Het
4932415D10Rik	T	A	10: 82,284,483	Q4231L	probably damaging	Het
Abcc1	A	G	16: 14,443,455	E699G	probably damaging	Het
Ap4e1	T	A	2: 127,064,979	V1053D	possibly damaging	Het
Apobec1	T	A	6: 122,581,497	I100F	probably damaging	Het
Atp6v1g3	G	T	1: 138,283,742	K53N	probably damaging	Het
Bag3	C	T	7: 128,546,106	R482W	probably damaging	Het
Cacna1i	A	G	15: 80,395,078	T2007A	possibly damaging	Het
Cd44	T	C	2: 102,901,342	D2G	probably damaging	Het
Cdadc1	T	A	14: 59,589,923	I100F	possibly damaging	Het
Cdh16	A	G	8: 104,618,045	F485L	probably damaging	Het
Cdhr5	T	A	7: 141,269,197	K817*	probably null	Het
Cfap46	G	T	7: 139,678,577	P260Q	probably damaging	Het
Clec11a	C	T	7: 44,306,408	E72K	possibly damaging	Het
Cnr2	C	A	4: 135,916,765	N51K	probably damaging	Het
Col3a1	T	A	1: 45,331,712		probably benign	Het
Cxcr1	G	A	1: 74,191,828	T345M	probably damaging	Het
Cyp2s1	T	C	7: 25,816,319		probably null	Het
Dalrd3	C	T	9: 108,572,290	T474M	probably damaging	Het
Ddit4	C	T	10: 59,951,505	S3N	probably benign	Het
Ddx41	T	C	13: 55,535,895	K108E	possibly damaging	Het
Ece2	A	T	16: 20,643,727	H732L	probably benign	Het
Etv3	T	G	3: 87,536,015	L302R	possibly damaging	Het
Fam135b	A	G	15: 71,462,136	S1070P	probably damaging	Het
Fam160a2	A	T	7: 105,389,882	I50N	probably damaging	Het
Gm11567	T	A	11: 99,879,611	I125N	unknown	Het
Grm3	A	G	5: 9,570,536	L236P	probably benign	Het
Hip1	T	A	5: 135,433,085	R97*	probably null	Het
Hoxa5	T	C	6: 52,204,217	Y45C	probably damaging	Het
Ighg1	T	A	12: 113,329,034	H305L	probably damaging	Het
Inpp5b	T	A	4: 124,782,436	C362S	probably benign	Het
Kif1c	A	G	11: 70,708,447	K391E	probably benign	Het
Klf9	T	C	19: 23,141,882	V43A	probably benign	Het
Krt28	T	A	11: 99,374,494	I116F	probably damaging	Het
Lct	A	T	1: 128,295,232	D1439E	probably damaging	Het
Liph	G	A	16: 21,965,995	T284M	possibly damaging	Het
Lrrc75b	T	C	10: 75,557,221	K98R	possibly damaging	Het
Lypd4	T	C	7: 24,865,179	Q178R	probably benign	Het
Map1a	T	A	2: 121,306,043	S2209T	probably damaging	Het
Map3k21	C	T	8: 125,938,824	T584I	probably benign	Het
Map3k6	T	C	4: 133,245,544	V338A	probably damaging	Het
Marc1	A	C	1: 184,810,919	S71A	probably damaging	Het
Nckap1l	T	C	15: 103,455,025	S53P	probably benign	Het
Nt5e	T	C	9: 88,327,687	M1T	probably null	Het
Nudt22	T	C	19: 6,995,528	H64R	probably damaging	Het
Olfr1048	T	C	2: 86,235,932	N294S	probably damaging	Het
Olfr108	A	T	17: 37,445,772	T84S	probably damaging	Het
Olfr198	A	G	16: 59,202,006	L140P	probably damaging	Het
Olfr314	A	T	11: 58,786,828	Y198F	probably damaging	Het
Olfr322	T	C	11: 58,666,399	I280T	possibly damaging	Het
Olfr690	A	T	7: 105,329,565	V209D	probably damaging	Het
Otogl	T	C	10: 107,886,552	I314V	probably benign	Het
Pan2	G	T	10: 128,308,100	E106D	probably benign	Het
Papss1	T	A	3: 131,631,804	Y554*	probably null	Het
Pcnx	T	C	12: 81,895,029	V67A	possibly damaging	Het
Pdpk1	A	C	17: 24,106,855	Y122*	probably null	Het
Pkd1l1	A	T	11: 8,879,202	N1463K	probably damaging	Het
Ptgfrn	C	A	3: 101,043,362	M878I	probably damaging	Het
Ranbp3	G	A	17: 56,710,703	G453E	probably benign	Het
Rapgef2	T	C	3: 79,094,850	D261G	probably damaging	Het
Reep2	A	G	18: 34,846,218	S199G	probably benign	Het
Rnpep	G	A	1: 135,277,521	T202I	probably damaging	Het
Sass6	T	A	3: 116,607,496		probably null	Het
Sema3e	A	G	5: 14,162,243	D111G	probably damaging	Het
Slc29a4	A	G	5: 142,711,972	E60G	probably damaging	Het
Sptlc3	T	C	2: 139,546,408	Y107H	probably damaging	Het
Stx6	T	C	1: 155,198,179	I245T	probably benign	Het
Syne2	T	C	12: 75,918,532	S774P	probably damaging	Het
Tbc1d16	T	A	11: 119,158,791	Q293L	probably damaging	Het
Tbc1d30	T	C	10: 121,296,787	D224G	probably damaging	Het
Tbc1d32	T	A	10: 56,150,877	N759Y	possibly damaging	Het
Tdrd12	G	T	7: 35,511,300	A166E	probably damaging	Het
Tex14	A	G	11: 87,514,220	R653G	probably benign	Het
Them6	A	T	15: 74,721,805	R171W	probably null	Het
Tln2	T	C	9: 67,296,358	T489A	probably benign	Het
Tmem87a	A	G	2: 120,403,946	F39L	probably benign	Het
Toporsl	T	A	4: 52,611,515	C469*	probably null	Het
Tpr	T	C	1: 150,423,818	S1147P	probably damaging	Het
Trp53bp1	T	C	2: 121,236,662	M528V	probably benign	Het
Trpm6	T	A	19: 18,830,207	C1039S	probably damaging	Het
Ttc16	T	A	2: 32,775,336	S5C	probably damaging	Het
Ttn	T	C	2: 76,787,068	Y14607C	probably damaging	Het
Usp6nl	T	C	2: 6,430,464	F345L	probably damaging	Het
Vmn1r205	C	T	13: 22,592,036	G299R	probably benign	Het
Vmn2r74	G	A	7: 85,957,380	H253Y	probably benign	Het
Vps13d	A	T	4: 145,170,302	D343E	possibly damaging	Het
Vwf	A	G	6: 125,603,418	E543G		Het
Wdr92	A	G	11: 17,227,263	N207S	possibly damaging	Het
Zfat	A	T	15: 68,180,916	V343E	probably damaging	Het
Zfp316	T	C	5: 143,264,091	E139G	unknown	Het
Zfp943	T	A	17: 21,992,832	C300S	probably damaging	Het
Zkscan16	A	G	4: 58,957,748	K677E	probably benign	Het

Other mutations in Mapk8ip3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00578:Mapk8ip3	APN	17	24900819	missense	probably damaging	1.00
IGL01018:Mapk8ip3	APN	17	24899719	splice site	probably benign
IGL01066:Mapk8ip3	APN	17	24901718	missense	probably benign	0.00
IGL01656:Mapk8ip3	APN	17	24918029	missense	probably damaging	0.99
IGL01991:Mapk8ip3	APN	17	24927861	missense	possibly damaging	0.78
IGL02014:Mapk8ip3	APN	17	24903280	splice site	probably benign
IGL02219:Mapk8ip3	APN	17	24899558	missense	probably damaging	1.00
IGL03006:Mapk8ip3	APN	17	24901515	missense	probably benign
ANU74:Mapk8ip3	UTSW	17	24900577	missense	possibly damaging	0.94
FR4737:Mapk8ip3	UTSW	17	24902119	splice site	probably null
R0028:Mapk8ip3	UTSW	17	24904897	splice site	probably benign
R0401:Mapk8ip3	UTSW	17	24909171	intron	probably benign
R0496:Mapk8ip3	UTSW	17	24914450	splice site	probably benign
R1456:Mapk8ip3	UTSW	17	24906949	missense	probably damaging	1.00
R1503:Mapk8ip3	UTSW	17	24904923	missense	probably damaging	1.00
R1554:Mapk8ip3	UTSW	17	24903059	missense	probably benign	0.14
R1680:Mapk8ip3	UTSW	17	24901011	missense	probably damaging	1.00
R1733:Mapk8ip3	UTSW	17	24936850	missense	possibly damaging	0.70
R1741:Mapk8ip3	UTSW	17	24899854	missense	probably damaging	1.00
R1750:Mapk8ip3	UTSW	17	24914459	missense	probably null	1.00
R1774:Mapk8ip3	UTSW	17	24924145	critical splice donor site	probably null
R1845:Mapk8ip3	UTSW	17	24914583	missense	probably benign	0.29
R1911:Mapk8ip3	UTSW	17	24904051	missense	probably benign	0.00
R1993:Mapk8ip3	UTSW	17	24914588	missense	probably damaging	1.00
R2512:Mapk8ip3	UTSW	17	24914703	nonsense	probably null
R2656:Mapk8ip3	UTSW	17	24912807	missense	probably damaging	1.00
R2990:Mapk8ip3	UTSW	17	24905292	missense	probably benign	0.00
R4587:Mapk8ip3	UTSW	17	24904787	missense	probably damaging	1.00
R4617:Mapk8ip3	UTSW	17	24904787	missense	probably damaging	1.00
R4627:Mapk8ip3	UTSW	17	24903293	missense	probably benign
R4649:Mapk8ip3	UTSW	17	24904752	missense	probably damaging	1.00
R4868:Mapk8ip3	UTSW	17	24901415	missense	probably benign	0.04
R4903:Mapk8ip3	UTSW	17	24901209	missense	probably benign
R4915:Mapk8ip3	UTSW	17	24909153	missense	possibly damaging	0.75
R5447:Mapk8ip3	UTSW	17	24899189	missense	probably benign
R6320:Mapk8ip3	UTSW	17	24906905	missense	probably damaging	0.99
R6900:Mapk8ip3	UTSW	17	24909123	splice site	probably null
R7178:Mapk8ip3	UTSW	17	24901754	missense	probably benign	0.02
R7273:Mapk8ip3	UTSW	17	24906174	missense	probably benign	0.00
R7317:Mapk8ip3	UTSW	17	24901718	missense	probably benign	0.00
R7323:Mapk8ip3	UTSW	17	24901161	missense	probably benign
R7701:Mapk8ip3	UTSW	17	24901404	missense	possibly damaging	0.93
R7873:Mapk8ip3	UTSW	17	24906172	missense	probably benign	0.01
R8070:Mapk8ip3	UTSW	17	24901104	critical splice donor site	probably null
R8314:Mapk8ip3	UTSW	17	24901774	missense	probably benign	0.09
R8356:Mapk8ip3	UTSW	17	24904951	missense	probably damaging	1.00
R8441:Mapk8ip3	UTSW	17	24920500	intron	probably benign
R8537:Mapk8ip3	UTSW	17	24901678	nonsense	probably null
R8802:Mapk8ip3	UTSW	17	24905232	missense	probably damaging	1.00
R8864:Mapk8ip3	UTSW	17	24899518	missense	probably damaging	1.00
R8918:Mapk8ip3	UTSW	17	24912753	missense	probably damaging	1.00
R9312:Mapk8ip3	UTSW	17	24927951	critical splice acceptor site	probably null
R9599:Mapk8ip3	UTSW	17	24899150	missense	probably damaging	1.00
R9638:Mapk8ip3	UTSW	17	24899049	missense	probably benign
R9640:Mapk8ip3	UTSW	17	24936673	missense	possibly damaging	0.46
R9723:Mapk8ip3	UTSW	17	24913611	missense	possibly damaging	0.83
X0024:Mapk8ip3	UTSW	17	24903973	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- TACAGGCTTGGGTCCATTGC -3'
(R):5'- TGCACTGTGTACCAGAAGC -3'

Sequencing Primer
(F):5'- GGGTCCATTGCTAGAGTCCTC -3'
(R):5'- TGTGTACCAGAAGCCCGCAG -3'

Posted On

2016-11-08