Incidental Mutation 'R5646:Tas2r107'
ID441147
Institutional Source Beutler Lab
Gene Symbol Tas2r107
Ensembl Gene ENSMUSG00000053389
Gene Nametaste receptor, type 2, member 107
SynonymsT2R4, Tas2r7, mGR06, STC 5-1, mt2r43, T2R07
MMRRC Submission 043294-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock #R5646 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location131659118-131660149 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 131659708 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 126 (V126A)
Ref Sequence ENSEMBL: ENSMUSP00000067082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065781]
Predicted Effect probably benign
Transcript: ENSMUST00000065781
AA Change: V126A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000067082
Gene: ENSMUSG00000053389
AA Change: V126A

DomainStartEndE-ValueType
Pfam:TAS2R 1 297 4e-106 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik A G 10: 82,283,776 S4467P probably damaging Het
Add1 C A 5: 34,630,680 A691D probably benign Het
Agap3 C A 5: 24,483,397 D394E probably benign Het
Arhgef11 T C 3: 87,684,486 V59A possibly damaging Het
Atp2a1 A G 7: 126,453,105 V402A probably benign Het
Bbs9 T C 9: 22,578,715 F261L probably benign Het
Bsn A T 9: 108,110,432 probably benign Het
Camk1 A G 6: 113,339,340 V81A probably damaging Het
Cass4 T G 2: 172,416,245 C54W probably damaging Het
Ccdc39 A T 3: 33,825,550 F456L probably damaging Het
Cdc42bpa A G 1: 180,106,094 E766G probably damaging Het
Cdcp2 T C 4: 107,105,142 C171R probably damaging Het
Cdh9 G A 15: 16,823,285 E118K probably damaging Het
Col4a2 G A 8: 11,441,281 G1227R probably damaging Het
Cyp2d9 A G 15: 82,452,464 T5A probably benign Het
Dlg5 T A 14: 24,158,699 D813V probably damaging Het
Dmtf1 G A 5: 9,124,515 S405F possibly damaging Het
Drd2 A G 9: 49,404,912 K324R probably benign Het
Ergic1 T C 17: 26,614,358 S29P probably damaging Het
Fmnl1 A G 11: 103,196,512 probably benign Het
Foxd2 C T 4: 114,908,635 A63T unknown Het
Gfap T C 11: 102,891,456 I409M probably benign Het
Gfpt1 A G 6: 87,042,999 M1V probably null Het
H2-T23 C G 17: 36,031,803 E148Q possibly damaging Het
Hip1 G A 5: 135,428,741 R704W probably damaging Het
Kif19a A C 11: 114,779,654 D130A probably damaging Het
Lin7b T C 7: 45,369,193 D14G probably damaging Het
Meioc T A 11: 102,675,257 N510K possibly damaging Het
Mettl5 C A 2: 69,881,319 G68* probably null Het
Mitf A T 6: 98,013,694 I184F probably damaging Het
Mmp9 T A 2: 164,949,050 H119Q probably benign Het
Mycbp2 T A 14: 103,169,910 H2768L probably benign Het
Myh2 A T 11: 67,188,812 I1032F probably benign Het
Myo3b T C 2: 70,314,430 I1110T probably damaging Het
Nde1 T C 16: 14,169,514 F8L probably damaging Het
Olfr1317 T C 2: 112,142,683 V246A possibly damaging Het
Olfr202 C T 16: 59,283,979 V173I probably benign Het
Olfr432 C T 1: 174,051,287 Q305* probably null Het
Olfr447 A G 6: 42,911,523 probably null Het
Olfr550 A C 7: 102,579,305 Y270S possibly damaging Het
Olfr753-ps1 T C 17: 37,169,917 I244V probably benign Het
Olfr771 T C 10: 129,160,837 D49G possibly damaging Het
Pcdhga8 A G 18: 37,726,770 H293R probably benign Het
Pde7a A T 3: 19,233,773 L244Q probably damaging Het
Pex14 T C 4: 148,961,453 D340G probably benign Het
Pfkfb4 A T 9: 109,008,421 I195F probably damaging Het
Pik3c2a C A 7: 116,405,951 G361W probably damaging Het
Prkcg T A 7: 3,329,081 M517K probably damaging Het
Prob1 A T 18: 35,654,114 F362L probably benign Het
Rims4 C T 2: 163,864,017 W232* probably null Het
Robo2 T C 16: 73,961,819 D688G probably damaging Het
Sec24c C A 14: 20,679,573 A73E probably benign Het
Slc15a3 A G 19: 10,843,210 N64D probably benign Het
Smg1 A T 7: 118,212,559 N65K probably benign Het
Sptb G T 12: 76,587,441 D2165E probably benign Het
Sptbn5 A T 2: 120,048,811 noncoding transcript Het
Syt12 A T 19: 4,456,541 M192K possibly damaging Het
Thbs3 T C 3: 89,219,098 L242P probably damaging Het
Timp2 A T 11: 118,317,532 probably null Het
Tmtc1 G A 6: 148,246,831 A751V probably damaging Het
Tnni2 A T 7: 142,443,913 D85V probably damaging Het
Ttc39b G A 4: 83,244,070 P319L probably damaging Het
Ttc6 A T 12: 57,576,019 K68M probably damaging Het
Usp25 G A 16: 77,050,472 R156Q probably benign Het
Vill A T 9: 119,071,162 D365V probably damaging Het
Vmn1r65 T A 7: 6,009,224 T4S probably benign Het
Vmn2r76 C A 7: 86,226,053 C572F probably damaging Het
Vps26a A C 10: 62,468,298 N181K probably damaging Het
Xirp2 T C 2: 67,510,790 L1125P probably damaging Het
Zbtb41 T G 1: 139,423,763 S205A probably benign Het
Zfp438 T C 18: 5,214,526 D144G probably benign Het
Zfp600 T C 4: 146,195,100 S113P probably damaging Het
Zfp84 C T 7: 29,776,393 T170M probably benign Het
Zmiz2 T A 11: 6,402,837 D654E probably damaging Het
Zswim4 A T 8: 84,231,110 probably null Het
Other mutations in Tas2r107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02749:Tas2r107 APN 6 131659954 missense probably damaging 1.00
IGL02751:Tas2r107 APN 6 131659484 missense probably damaging 1.00
IGL02868:Tas2r107 APN 6 131659286 missense probably benign 0.11
IGL02943:Tas2r107 APN 6 131659406 missense probably damaging 0.99
R1564:Tas2r107 UTSW 6 131659822 missense probably damaging 0.96
R1905:Tas2r107 UTSW 6 131659988 missense probably benign 0.20
R1906:Tas2r107 UTSW 6 131659988 missense probably benign 0.20
R1907:Tas2r107 UTSW 6 131659988 missense probably benign 0.20
R2185:Tas2r107 UTSW 6 131659603 missense probably damaging 0.98
R3014:Tas2r107 UTSW 6 131660009 missense probably benign 0.30
R3824:Tas2r107 UTSW 6 131659330 missense probably benign 0.00
R4465:Tas2r107 UTSW 6 131660009 missense probably benign 0.30
R5058:Tas2r107 UTSW 6 131659742 missense probably damaging 1.00
R5975:Tas2r107 UTSW 6 131659780 missense probably benign 0.02
R6008:Tas2r107 UTSW 6 131659912 missense possibly damaging 0.82
R6144:Tas2r107 UTSW 6 131660003 missense possibly damaging 0.87
R6451:Tas2r107 UTSW 6 131660014 missense possibly damaging 0.81
R6662:Tas2r107 UTSW 6 131659489 missense possibly damaging 0.82
R6702:Tas2r107 UTSW 6 131659384 missense probably benign 0.12
R7032:Tas2r107 UTSW 6 131659190 missense possibly damaging 0.62
R7635:Tas2r107 UTSW 6 131659600 missense possibly damaging 0.92
R8303:Tas2r107 UTSW 6 131659622 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGATTCCCAGATTGGTCACAC -3'
(R):5'- CTTGGCGATTTCCAGAATTGG -3'

Sequencing Primer
(F):5'- GATTCCCAGATTGGTCACACTTTGG -3'
(R):5'- CGATTTCCAGAATTGGTGTTGTATG -3'
Posted On2016-11-08