Incidental Mutation 'R5652:Adgrl1'
| ID |
441487 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl1
|
| Ensembl Gene |
ENSMUSG00000013033 |
| Gene Name |
adhesion G protein-coupled receptor L1 |
| Synonyms |
Lec2, 2900070I05Rik, lectomedin-2, Lphn1 |
| MMRRC Submission |
043298-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5652 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
84626734-84668583 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84656444 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 254
(Y254C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115295
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045393]
[ENSMUST00000098595]
[ENSMUST00000124355]
[ENSMUST00000131717]
[ENSMUST00000132500]
[ENSMUST00000141158]
[ENSMUST00000152978]
|
| AlphaFold |
Q80TR1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000045393
AA Change: Y254C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000048422
Gene: ENSMUSG00000013033
AA Change: Y254C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
6.6e-23 |
PFAM |
|
OLF
|
142 |
398 |
8.5e-138 |
SMART |
|
low complexity region
|
405 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
470 |
N/A |
INTRINSIC |
|
HormR
|
476 |
541 |
1.4e-23 |
SMART |
|
low complexity region
|
579 |
591 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
758 |
N/A |
INTRINSIC |
|
GPS
|
797 |
849 |
3.5e-27 |
SMART |
|
Pfam:7tm_2
|
856 |
1092 |
5.3e-66 |
PFAM |
|
Pfam:Latrophilin
|
1112 |
1470 |
1.7e-177 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098595
|
| SMART Domains |
Protein: ENSMUSP00000096195
Gene: ENSMUSG00000074219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
60 |
72 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124355
|
| SMART Domains |
Protein: ENSMUSP00000116064
Gene: ENSMUSG00000013033
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
1.1e-24 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131717
AA Change: Y78C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000118579
Gene: ENSMUSG00000013033
AA Change: Y78C
| Domain | Start | End | E-Value | Type |
|---|
|
OLF
|
1 |
222 |
4.51e-103 |
SMART |
|
low complexity region
|
229 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
279 |
294 |
N/A |
INTRINSIC |
|
HormR
|
300 |
365 |
2.26e-21 |
SMART |
|
low complexity region
|
403 |
415 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
582 |
N/A |
INTRINSIC |
|
GPS
|
621 |
673 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
680 |
916 |
7.9e-68 |
PFAM |
|
Pfam:Latrophilin
|
936 |
1295 |
2.7e-181 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000132500
AA Change: Y249C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000119100
Gene: ENSMUSG00000013033
AA Change: Y249C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
1.6e-25 |
PFAM |
|
OLF
|
137 |
393 |
1.39e-135 |
SMART |
|
low complexity region
|
400 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
450 |
465 |
N/A |
INTRINSIC |
|
HormR
|
471 |
536 |
2.26e-21 |
SMART |
|
low complexity region
|
574 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
742 |
753 |
N/A |
INTRINSIC |
|
GPS
|
792 |
844 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
851 |
1087 |
3.4e-68 |
PFAM |
|
Pfam:Latrophilin
|
1146 |
1511 |
6.4e-193 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139575
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000141158
AA Change: Y249C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000118452
Gene: ENSMUSG00000013033
AA Change: Y249C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
3.4e-25 |
PFAM |
|
OLF
|
137 |
393 |
1.39e-135 |
SMART |
|
low complexity region
|
400 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
450 |
465 |
N/A |
INTRINSIC |
|
HormR
|
471 |
536 |
2.26e-21 |
SMART |
|
low complexity region
|
574 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
742 |
753 |
N/A |
INTRINSIC |
|
GPS
|
792 |
844 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
851 |
1087 |
4.5e-68 |
PFAM |
|
Pfam:Latrophilin
|
1107 |
1466 |
1.1e-180 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000152978
AA Change: Y254C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000115295
Gene: ENSMUSG00000013033
AA Change: Y254C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
48 |
128 |
2.1e-25 |
PFAM |
|
OLF
|
142 |
398 |
1.39e-135 |
SMART |
|
low complexity region
|
405 |
441 |
N/A |
INTRINSIC |
|
low complexity region
|
455 |
470 |
N/A |
INTRINSIC |
|
HormR
|
476 |
541 |
2.26e-21 |
SMART |
|
Pfam:GAIN
|
544 |
773 |
4.1e-59 |
PFAM |
|
GPS
|
797 |
849 |
5.64e-25 |
SMART |
|
Pfam:7tm_2
|
856 |
1092 |
2.3e-69 |
PFAM |
|
Pfam:Latrophilin
|
1112 |
1516 |
7.3e-136 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200106
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199528
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150674
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for a targeted null allele at this locus are viable and fertile. Female homozygotes fail adequately to care for their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
C |
14: 118,856,339 (GRCm39) |
I334V |
probably benign |
Het |
| Adamts5 |
C |
T |
16: 85,696,156 (GRCm39) |
A334T |
probably damaging |
Het |
| Adcy4 |
G |
C |
14: 56,010,900 (GRCm39) |
F672L |
probably benign |
Het |
| Adnp2 |
A |
G |
18: 80,174,065 (GRCm39) |
S115P |
probably damaging |
Het |
| Aox1 |
A |
T |
1: 58,134,356 (GRCm39) |
S1110C |
probably damaging |
Het |
| Arhgap44 |
G |
T |
11: 64,915,064 (GRCm39) |
N401K |
probably damaging |
Het |
| Atp23 |
A |
T |
10: 126,735,494 (GRCm39) |
N63K |
possibly damaging |
Het |
| Atp8b1 |
G |
C |
18: 64,664,453 (GRCm39) |
I1238M |
probably benign |
Het |
| Ccdc38 |
A |
T |
10: 93,391,448 (GRCm39) |
|
probably null |
Het |
| Celsr2 |
T |
C |
3: 108,304,051 (GRCm39) |
D2364G |
probably null |
Het |
| Celsr3 |
G |
A |
9: 108,715,671 (GRCm39) |
D2116N |
probably benign |
Het |
| Cenpf |
A |
G |
1: 189,389,279 (GRCm39) |
S1518P |
probably damaging |
Het |
| Clcn3 |
C |
A |
8: 61,372,387 (GRCm39) |
V758L |
possibly damaging |
Het |
| Cmklr2 |
A |
G |
1: 63,222,626 (GRCm39) |
V203A |
probably benign |
Het |
| Ctsf |
T |
C |
19: 4,908,505 (GRCm39) |
L288P |
probably damaging |
Het |
| Cwh43 |
A |
G |
5: 73,575,484 (GRCm39) |
T334A |
probably damaging |
Het |
| Cyp3a57 |
A |
T |
5: 145,286,135 (GRCm39) |
|
probably null |
Het |
| Ddr1 |
C |
T |
17: 35,997,400 (GRCm39) |
A531T |
probably benign |
Het |
| Dennd1a |
A |
G |
2: 37,691,138 (GRCm39) |
I260T |
probably benign |
Het |
| Dgkh |
T |
C |
14: 78,865,201 (GRCm39) |
H47R |
probably damaging |
Het |
| Dync1h1 |
G |
A |
12: 110,632,422 (GRCm39) |
V4514I |
possibly damaging |
Het |
| Dync2h1 |
A |
T |
9: 7,116,638 (GRCm39) |
M66K |
probably benign |
Het |
| Fam186a |
T |
G |
15: 99,843,253 (GRCm39) |
Y997S |
possibly damaging |
Het |
| Fam8a1 |
T |
A |
13: 46,827,814 (GRCm39) |
L334H |
probably damaging |
Het |
| Fat4 |
C |
T |
3: 39,057,117 (GRCm39) |
T4271I |
probably damaging |
Het |
| Fdxacb1 |
T |
A |
9: 50,679,705 (GRCm39) |
L41Q |
probably damaging |
Het |
| Fgfr2 |
C |
T |
7: 129,863,593 (GRCm39) |
V18M |
probably damaging |
Het |
| Gpa33 |
A |
C |
1: 165,992,714 (GRCm39) |
|
probably null |
Het |
| Gpr107 |
A |
G |
2: 31,075,601 (GRCm39) |
I371V |
probably benign |
Het |
| H1f6 |
A |
G |
13: 23,880,219 (GRCm39) |
K124R |
probably benign |
Het |
| Hectd2 |
T |
C |
19: 36,581,720 (GRCm39) |
V420A |
probably damaging |
Het |
| Iglc3 |
A |
G |
16: 18,884,420 (GRCm39) |
|
probably benign |
Het |
| Igtp |
A |
G |
11: 58,097,455 (GRCm39) |
T209A |
probably benign |
Het |
| Itgb7 |
T |
A |
15: 102,124,638 (GRCm39) |
N793I |
possibly damaging |
Het |
| Kansl1 |
G |
A |
11: 104,228,992 (GRCm39) |
R870C |
probably damaging |
Het |
| Kcnh6 |
C |
T |
11: 105,899,811 (GRCm39) |
R27C |
probably damaging |
Het |
| Kif2b |
T |
A |
11: 91,466,656 (GRCm39) |
E542D |
possibly damaging |
Het |
| Klhl24 |
C |
A |
16: 19,938,997 (GRCm39) |
Y517* |
probably null |
Het |
| Klhl25 |
A |
G |
7: 75,515,895 (GRCm39) |
D267G |
probably benign |
Het |
| Krr1 |
C |
A |
10: 111,813,288 (GRCm39) |
F195L |
possibly damaging |
Het |
| Lsr |
C |
T |
7: 30,658,456 (GRCm39) |
G95D |
probably damaging |
Het |
| Matcap2 |
A |
G |
9: 22,335,786 (GRCm39) |
T135A |
probably benign |
Het |
| Med15 |
A |
T |
16: 17,473,055 (GRCm39) |
I504N |
probably damaging |
Het |
| Mug1 |
A |
G |
6: 121,817,140 (GRCm39) |
R70G |
probably benign |
Het |
| Mypn |
T |
A |
10: 62,971,580 (GRCm39) |
Q820L |
probably damaging |
Het |
| Nlrp4f |
A |
T |
13: 65,330,803 (GRCm39) |
H863Q |
probably benign |
Het |
| Nudt9 |
G |
A |
5: 104,207,646 (GRCm39) |
V213M |
probably benign |
Het |
| Or5ak4 |
T |
A |
2: 85,161,717 (GRCm39) |
N175I |
probably damaging |
Het |
| Or5k14 |
A |
G |
16: 58,692,847 (GRCm39) |
L222P |
probably damaging |
Het |
| Or7g16 |
A |
G |
9: 18,726,922 (GRCm39) |
S223P |
probably damaging |
Het |
| Or8c13 |
T |
C |
9: 38,092,111 (GRCm39) |
T3A |
probably benign |
Het |
| Orc2 |
A |
G |
1: 58,505,231 (GRCm39) |
F475L |
probably damaging |
Het |
| Oxa1l |
T |
A |
14: 54,604,289 (GRCm39) |
L183* |
probably null |
Het |
| Pcdh20 |
T |
C |
14: 88,704,760 (GRCm39) |
T847A |
probably damaging |
Het |
| Pcdha6 |
G |
A |
18: 37,101,889 (GRCm39) |
|
probably null |
Het |
| Pip5k1a |
T |
C |
3: 94,974,750 (GRCm39) |
N376S |
probably benign |
Het |
| Pkd1l1 |
T |
C |
11: 8,859,889 (GRCm39) |
E573G |
probably benign |
Het |
| Pkp1 |
T |
A |
1: 135,810,335 (GRCm39) |
|
probably null |
Het |
| Pum1 |
T |
C |
4: 130,491,438 (GRCm39) |
I643T |
possibly damaging |
Het |
| Rapgef3 |
A |
G |
15: 97,656,318 (GRCm39) |
S328P |
probably benign |
Het |
| Raver1 |
A |
G |
9: 21,001,608 (GRCm39) |
V75A |
probably damaging |
Het |
| Rbm28 |
T |
C |
6: 29,135,408 (GRCm39) |
E511G |
probably damaging |
Het |
| Satb1 |
T |
A |
17: 52,049,823 (GRCm39) |
T544S |
probably damaging |
Het |
| Sdcbp2 |
T |
C |
2: 151,431,135 (GRCm39) |
V248A |
probably benign |
Het |
| Sema7a |
A |
G |
9: 57,867,942 (GRCm39) |
D506G |
probably damaging |
Het |
| Septin8 |
A |
G |
11: 53,428,044 (GRCm39) |
E286G |
probably damaging |
Het |
| Sh3pxd2b |
A |
G |
11: 32,372,812 (GRCm39) |
I660V |
probably damaging |
Het |
| Stk38l |
G |
T |
6: 146,674,826 (GRCm39) |
D364Y |
possibly damaging |
Het |
| Sycp2 |
T |
C |
2: 178,000,498 (GRCm39) |
|
probably null |
Het |
| Tbc1d31 |
T |
A |
15: 57,815,062 (GRCm39) |
S580T |
probably damaging |
Het |
| Tcerg1l |
G |
A |
7: 137,881,775 (GRCm39) |
R305C |
probably damaging |
Het |
| Tek |
T |
A |
4: 94,743,561 (GRCm39) |
Y859N |
probably damaging |
Het |
| Tjp1 |
A |
T |
7: 64,962,191 (GRCm39) |
|
probably null |
Het |
| Tmem132d |
A |
T |
5: 127,861,859 (GRCm39) |
I754N |
possibly damaging |
Het |
| Togaram1 |
G |
A |
12: 65,063,424 (GRCm39) |
V1580I |
probably benign |
Het |
| Troap |
A |
G |
15: 98,980,145 (GRCm39) |
T442A |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,712,097 (GRCm39) |
|
probably benign |
Het |
| Twnk |
T |
A |
19: 44,995,732 (GRCm39) |
V55E |
possibly damaging |
Het |
| Uggt1 |
A |
T |
1: 36,255,234 (GRCm39) |
Y225* |
probably null |
Het |
| Vmn2r109 |
A |
G |
17: 20,760,781 (GRCm39) |
*859Q |
probably null |
Het |
| Vmn2r17 |
A |
T |
5: 109,577,430 (GRCm39) |
I494L |
probably benign |
Het |
| Vmn2r88 |
T |
C |
14: 51,656,029 (GRCm39) |
V746A |
probably damaging |
Het |
| Yae1d1 |
A |
G |
13: 18,166,291 (GRCm39) |
L57P |
probably damaging |
Het |
| Zfp26 |
G |
A |
9: 20,349,137 (GRCm39) |
R476* |
probably null |
Het |
| Zmynd8 |
T |
A |
2: 165,649,618 (GRCm39) |
Q816L |
probably damaging |
Het |
| Zswim8 |
A |
T |
14: 20,763,495 (GRCm39) |
H414L |
possibly damaging |
Het |
|
| Other mutations in Adgrl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Adgrl1
|
APN |
8 |
84,664,332 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01413:Adgrl1
|
APN |
8 |
84,656,486 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02020:Adgrl1
|
APN |
8 |
84,659,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02422:Adgrl1
|
APN |
8 |
84,664,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Adgrl1
|
APN |
8 |
84,665,143 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03169:Adgrl1
|
APN |
8 |
84,658,624 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03237:Adgrl1
|
APN |
8 |
84,656,312 (GRCm39) |
splice site |
probably null |
|
|
Swiss_rolls
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0375:Adgrl1
|
UTSW |
8 |
84,661,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0505:Adgrl1
|
UTSW |
8 |
84,661,279 (GRCm39) |
splice site |
probably benign |
|
|
R0681:Adgrl1
|
UTSW |
8 |
84,661,279 (GRCm39) |
splice site |
probably benign |
|
|
R0964:Adgrl1
|
UTSW |
8 |
84,661,041 (GRCm39) |
splice site |
probably benign |
|
|
R1182:Adgrl1
|
UTSW |
8 |
84,656,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Adgrl1
|
UTSW |
8 |
84,664,392 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1475:Adgrl1
|
UTSW |
8 |
84,664,979 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1610:Adgrl1
|
UTSW |
8 |
84,659,002 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1778:Adgrl1
|
UTSW |
8 |
84,656,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2089:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2091:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2091:Adgrl1
|
UTSW |
8 |
84,661,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2300:Adgrl1
|
UTSW |
8 |
84,656,746 (GRCm39) |
nonsense |
probably null |
|
|
R2403:Adgrl1
|
UTSW |
8 |
84,657,870 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2935:Adgrl1
|
UTSW |
8 |
84,661,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3772:Adgrl1
|
UTSW |
8 |
84,649,633 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4191:Adgrl1
|
UTSW |
8 |
84,665,569 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4393:Adgrl1
|
UTSW |
8 |
84,665,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4406:Adgrl1
|
UTSW |
8 |
84,656,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4445:Adgrl1
|
UTSW |
8 |
84,661,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Adgrl1
|
UTSW |
8 |
84,662,202 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4799:Adgrl1
|
UTSW |
8 |
84,662,202 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5214:Adgrl1
|
UTSW |
8 |
84,642,202 (GRCm39) |
splice site |
probably null |
|
|
R5242:Adgrl1
|
UTSW |
8 |
84,657,711 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5409:Adgrl1
|
UTSW |
8 |
84,656,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5522:Adgrl1
|
UTSW |
8 |
84,649,704 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5607:Adgrl1
|
UTSW |
8 |
84,663,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5608:Adgrl1
|
UTSW |
8 |
84,663,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5655:Adgrl1
|
UTSW |
8 |
84,665,230 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5919:Adgrl1
|
UTSW |
8 |
84,659,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Adgrl1
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6033:Adgrl1
|
UTSW |
8 |
84,645,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6129:Adgrl1
|
UTSW |
8 |
84,645,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Adgrl1
|
UTSW |
8 |
84,664,316 (GRCm39) |
nonsense |
probably null |
|
|
R7142:Adgrl1
|
UTSW |
8 |
84,663,829 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7181:Adgrl1
|
UTSW |
8 |
84,652,878 (GRCm39) |
splice site |
probably null |
|
|
R7238:Adgrl1
|
UTSW |
8 |
84,665,693 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7547:Adgrl1
|
UTSW |
8 |
84,665,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7709:Adgrl1
|
UTSW |
8 |
84,665,617 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7741:Adgrl1
|
UTSW |
8 |
84,656,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7852:Adgrl1
|
UTSW |
8 |
84,662,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7866:Adgrl1
|
UTSW |
8 |
84,664,564 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8146:Adgrl1
|
UTSW |
8 |
84,657,618 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8314:Adgrl1
|
UTSW |
8 |
84,665,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8829:Adgrl1
|
UTSW |
8 |
84,665,458 (GRCm39) |
missense |
|
|
|
R8857:Adgrl1
|
UTSW |
8 |
84,657,657 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8979:Adgrl1
|
UTSW |
8 |
84,665,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9204:Adgrl1
|
UTSW |
8 |
84,660,519 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9226:Adgrl1
|
UTSW |
8 |
84,656,426 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9302:Adgrl1
|
UTSW |
8 |
84,656,426 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9695:Adgrl1
|
UTSW |
8 |
84,665,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9785:Adgrl1
|
UTSW |
8 |
84,665,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF007:Adgrl1
|
UTSW |
8 |
84,661,401 (GRCm39) |
missense |
probably benign |
0.14 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACTGAATATGCCTCATGGGAG -3'
(R):5'- ACCATGAAGGCATTGGAGGC -3'
Sequencing Primer
(F):5'- CTCATGGGAGGACTATGTAGCC -3'
(R):5'- CGAGCGCTTGTCATAGCCTG -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation