Mutagenetix > Incidental Mutation

Incidental Mutation 'R5652:Celsr3'

441495

Institutional Source

Beutler Lab

Gene Symbol

Celsr3

Ensembl Gene

ENSMUSG00000023473

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3

Synonyms

Fmi1, flamingo, Adgrc3

MMRRC Submission

043298-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5652 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

108703519-108730168 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 108715671 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 2116 (D2116N)

Ref Sequence

ENSEMBL: ENSMUSP00000024238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024238] [ENSMUST00000194079] [ENSMUST00000213524]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000024238
AA Change: D2116N

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000024238
Gene: ENSMUSG00000023473
AA Change: D2116N

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	264	293	N/A	INTRINSIC
CA	338	422	2.25e-27	SMART
CA	446	534	5.05e-30	SMART
CA	558	640	7.6e-25	SMART
CA	664	745	7.36e-32	SMART
CA	769	847	5.95e-18	SMART
CA	871	950	5.25e-28	SMART
CA	974	1056	2.67e-29	SMART
CA	1080	1158	1.18e-21	SMART
CA	1186	1262	3.2e-1	SMART
low complexity region	1328	1335	N/A	INTRINSIC
low complexity region	1350	1360	N/A	INTRINSIC
EGF	1369	1424	1.02e-2	SMART
EGF	1429	1464	3.23e0	SMART
EGF	1467	1503	8.78e-2	SMART
LamG	1524	1691	2.27e-35	SMART
EGF	1714	1747	4.22e-4	SMART
LamG	1774	1913	9.02e-21	SMART
EGF	1938	1971	2.43e-4	SMART
EGF	1973	2009	1.3e-4	SMART
EGF_Lam	2066	2111	5.08e-7	SMART
HormR	2114	2176	3.42e-21	SMART
Pfam:GAIN	2188	2441	1.1e-57	PFAM
GPS	2467	2520	7.92e-20	SMART
Pfam:7tm_2	2527	2758	1.5e-56	PFAM
low complexity region	2813	2829	N/A	INTRINSIC
low complexity region	2882	2906	N/A	INTRINSIC
low complexity region	3058	3072	N/A	INTRINSIC
low complexity region	3149	3189	N/A	INTRINSIC
low complexity region	3239	3261	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193726

Predicted Effect

probably benign
Transcript: ENSMUST00000194079

SMART Domains

Protein: ENSMUSP00000141789
Gene: ENSMUSG00000023473

Domain	Start	End	E-Value	Type
Pfam:7tm_2	1	185	6.9e-45	PFAM
low complexity region	240	256	N/A	INTRINSIC
low complexity region	309	333	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195255

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195857

Predicted Effect

probably benign
Transcript: ENSMUST00000213524
AA Change: D2118N

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, abnormal neurvous system development, and abnormal respiratory system development. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(2) Targeted, other(2)

Other mutations in this stock

Total: 86 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	T	C	14: 118,856,339 (GRCm39)	I334V	probably benign	Het
Adamts5	C	T	16: 85,696,156 (GRCm39)	A334T	probably damaging	Het
Adcy4	G	C	14: 56,010,900 (GRCm39)	F672L	probably benign	Het
Adgrl1	A	G	8: 84,656,444 (GRCm39)	Y254C	probably damaging	Het
Adnp2	A	G	18: 80,174,065 (GRCm39)	S115P	probably damaging	Het
Aox1	A	T	1: 58,134,356 (GRCm39)	S1110C	probably damaging	Het
Arhgap44	G	T	11: 64,915,064 (GRCm39)	N401K	probably damaging	Het
Atp23	A	T	10: 126,735,494 (GRCm39)	N63K	possibly damaging	Het
Atp8b1	G	C	18: 64,664,453 (GRCm39)	I1238M	probably benign	Het
Ccdc38	A	T	10: 93,391,448 (GRCm39)		probably null	Het
Celsr2	T	C	3: 108,304,051 (GRCm39)	D2364G	probably null	Het
Cenpf	A	G	1: 189,389,279 (GRCm39)	S1518P	probably damaging	Het
Clcn3	C	A	8: 61,372,387 (GRCm39)	V758L	possibly damaging	Het
Cmklr2	A	G	1: 63,222,626 (GRCm39)	V203A	probably benign	Het
Ctsf	T	C	19: 4,908,505 (GRCm39)	L288P	probably damaging	Het
Cwh43	A	G	5: 73,575,484 (GRCm39)	T334A	probably damaging	Het
Cyp3a57	A	T	5: 145,286,135 (GRCm39)		probably null	Het
Ddr1	C	T	17: 35,997,400 (GRCm39)	A531T	probably benign	Het
Dennd1a	A	G	2: 37,691,138 (GRCm39)	I260T	probably benign	Het
Dgkh	T	C	14: 78,865,201 (GRCm39)	H47R	probably damaging	Het
Dync1h1	G	A	12: 110,632,422 (GRCm39)	V4514I	possibly damaging	Het
Dync2h1	A	T	9: 7,116,638 (GRCm39)	M66K	probably benign	Het
Fam186a	T	G	15: 99,843,253 (GRCm39)	Y997S	possibly damaging	Het
Fam8a1	T	A	13: 46,827,814 (GRCm39)	L334H	probably damaging	Het
Fat4	C	T	3: 39,057,117 (GRCm39)	T4271I	probably damaging	Het
Fdxacb1	T	A	9: 50,679,705 (GRCm39)	L41Q	probably damaging	Het
Fgfr2	C	T	7: 129,863,593 (GRCm39)	V18M	probably damaging	Het
Gpa33	A	C	1: 165,992,714 (GRCm39)		probably null	Het
Gpr107	A	G	2: 31,075,601 (GRCm39)	I371V	probably benign	Het
H1f6	A	G	13: 23,880,219 (GRCm39)	K124R	probably benign	Het
Hectd2	T	C	19: 36,581,720 (GRCm39)	V420A	probably damaging	Het
Iglc3	A	G	16: 18,884,420 (GRCm39)		probably benign	Het
Igtp	A	G	11: 58,097,455 (GRCm39)	T209A	probably benign	Het
Itgb7	T	A	15: 102,124,638 (GRCm39)	N793I	possibly damaging	Het
Kansl1	G	A	11: 104,228,992 (GRCm39)	R870C	probably damaging	Het
Kcnh6	C	T	11: 105,899,811 (GRCm39)	R27C	probably damaging	Het
Kif2b	T	A	11: 91,466,656 (GRCm39)	E542D	possibly damaging	Het
Klhl24	C	A	16: 19,938,997 (GRCm39)	Y517*	probably null	Het
Klhl25	A	G	7: 75,515,895 (GRCm39)	D267G	probably benign	Het
Krr1	C	A	10: 111,813,288 (GRCm39)	F195L	possibly damaging	Het
Lsr	C	T	7: 30,658,456 (GRCm39)	G95D	probably damaging	Het
Matcap2	A	G	9: 22,335,786 (GRCm39)	T135A	probably benign	Het
Med15	A	T	16: 17,473,055 (GRCm39)	I504N	probably damaging	Het
Mug1	A	G	6: 121,817,140 (GRCm39)	R70G	probably benign	Het
Mypn	T	A	10: 62,971,580 (GRCm39)	Q820L	probably damaging	Het
Nlrp4f	A	T	13: 65,330,803 (GRCm39)	H863Q	probably benign	Het
Nudt9	G	A	5: 104,207,646 (GRCm39)	V213M	probably benign	Het
Or5ak4	T	A	2: 85,161,717 (GRCm39)	N175I	probably damaging	Het
Or5k14	A	G	16: 58,692,847 (GRCm39)	L222P	probably damaging	Het
Or7g16	A	G	9: 18,726,922 (GRCm39)	S223P	probably damaging	Het
Or8c13	T	C	9: 38,092,111 (GRCm39)	T3A	probably benign	Het
Orc2	A	G	1: 58,505,231 (GRCm39)	F475L	probably damaging	Het
Oxa1l	T	A	14: 54,604,289 (GRCm39)	L183*	probably null	Het
Pcdh20	T	C	14: 88,704,760 (GRCm39)	T847A	probably damaging	Het
Pcdha6	G	A	18: 37,101,889 (GRCm39)		probably null	Het
Pip5k1a	T	C	3: 94,974,750 (GRCm39)	N376S	probably benign	Het
Pkd1l1	T	C	11: 8,859,889 (GRCm39)	E573G	probably benign	Het
Pkp1	T	A	1: 135,810,335 (GRCm39)		probably null	Het
Pum1	T	C	4: 130,491,438 (GRCm39)	I643T	possibly damaging	Het
Rapgef3	A	G	15: 97,656,318 (GRCm39)	S328P	probably benign	Het
Raver1	A	G	9: 21,001,608 (GRCm39)	V75A	probably damaging	Het
Rbm28	T	C	6: 29,135,408 (GRCm39)	E511G	probably damaging	Het
Satb1	T	A	17: 52,049,823 (GRCm39)	T544S	probably damaging	Het
Sdcbp2	T	C	2: 151,431,135 (GRCm39)	V248A	probably benign	Het
Sema7a	A	G	9: 57,867,942 (GRCm39)	D506G	probably damaging	Het
Septin8	A	G	11: 53,428,044 (GRCm39)	E286G	probably damaging	Het
Sh3pxd2b	A	G	11: 32,372,812 (GRCm39)	I660V	probably damaging	Het
Stk38l	G	T	6: 146,674,826 (GRCm39)	D364Y	possibly damaging	Het
Sycp2	T	C	2: 178,000,498 (GRCm39)		probably null	Het
Tbc1d31	T	A	15: 57,815,062 (GRCm39)	S580T	probably damaging	Het
Tcerg1l	G	A	7: 137,881,775 (GRCm39)	R305C	probably damaging	Het
Tek	T	A	4: 94,743,561 (GRCm39)	Y859N	probably damaging	Het
Tjp1	A	T	7: 64,962,191 (GRCm39)		probably null	Het
Tmem132d	A	T	5: 127,861,859 (GRCm39)	I754N	possibly damaging	Het
Togaram1	G	A	12: 65,063,424 (GRCm39)	V1580I	probably benign	Het
Troap	A	G	15: 98,980,145 (GRCm39)	T442A	probably benign	Het
Ttn	A	T	2: 76,712,097 (GRCm39)		probably benign	Het
Twnk	T	A	19: 44,995,732 (GRCm39)	V55E	possibly damaging	Het
Uggt1	A	T	1: 36,255,234 (GRCm39)	Y225*	probably null	Het
Vmn2r109	A	G	17: 20,760,781 (GRCm39)	*859Q	probably null	Het
Vmn2r17	A	T	5: 109,577,430 (GRCm39)	I494L	probably benign	Het
Vmn2r88	T	C	14: 51,656,029 (GRCm39)	V746A	probably damaging	Het
Yae1d1	A	G	13: 18,166,291 (GRCm39)	L57P	probably damaging	Het
Zfp26	G	A	9: 20,349,137 (GRCm39)	R476*	probably null	Het
Zmynd8	T	A	2: 165,649,618 (GRCm39)	Q816L	probably damaging	Het
Zswim8	A	T	14: 20,763,495 (GRCm39)	H414L	possibly damaging	Het

Other mutations in Celsr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Celsr3	APN	9	108,726,124 (GRCm39)	missense	probably damaging	1.00
IGL00536:Celsr3	APN	9	108,706,391 (GRCm39)	missense	probably benign	0.33
IGL00552:Celsr3	APN	9	108,718,462 (GRCm39)	missense	possibly damaging	0.88
IGL00801:Celsr3	APN	9	108,719,775 (GRCm39)	missense	probably benign
IGL01420:Celsr3	APN	9	108,718,389 (GRCm39)	critical splice acceptor site	probably null
IGL01541:Celsr3	APN	9	108,708,907 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,711,756 (GRCm39)	missense	probably damaging	1.00
IGL01619:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01631:Celsr3	APN	9	108,714,603 (GRCm39)	missense	probably benign	0.00
IGL01777:Celsr3	APN	9	108,713,141 (GRCm39)	missense	probably benign	0.08
IGL01938:Celsr3	APN	9	108,705,614 (GRCm39)	missense	probably benign	0.34
IGL02135:Celsr3	APN	9	108,704,755 (GRCm39)	missense	probably benign	0.11
IGL02231:Celsr3	APN	9	108,719,709 (GRCm39)	missense	probably damaging	1.00
IGL02234:Celsr3	APN	9	108,707,159 (GRCm39)	missense	probably benign
IGL02392:Celsr3	APN	9	108,711,920 (GRCm39)	splice site	probably benign
IGL02416:Celsr3	APN	9	108,709,318 (GRCm39)	missense	probably damaging	1.00
IGL02421:Celsr3	APN	9	108,717,662 (GRCm39)	missense	probably damaging	1.00
IGL02455:Celsr3	APN	9	108,720,092 (GRCm39)	missense	probably benign	0.15
IGL02798:Celsr3	APN	9	108,720,774 (GRCm39)	missense	probably damaging	1.00
IGL02939:Celsr3	APN	9	108,726,652 (GRCm39)	missense	probably damaging	1.00
IGL02947:Celsr3	APN	9	108,723,134 (GRCm39)	missense	probably benign	0.12
IGL02986:Celsr3	APN	9	108,718,454 (GRCm39)	splice site	probably null
IGL03089:Celsr3	APN	9	108,703,806 (GRCm39)	missense	probably benign	0.04
IGL03162:Celsr3	APN	9	108,719,757 (GRCm39)	missense	probably damaging	1.00
IGL03267:Celsr3	APN	9	108,713,724 (GRCm39)	splice site	probably benign
Diminishment	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
little_d	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
nogal	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
F6893:Celsr3	UTSW	9	108,712,266 (GRCm39)	missense	probably benign	0.00
PIT4243001:Celsr3	UTSW	9	108,709,507 (GRCm39)	missense	probably benign	0.13
PIT4810001:Celsr3	UTSW	9	108,722,932 (GRCm39)	missense	probably damaging	1.00
R0110:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0243:Celsr3	UTSW	9	108,720,923 (GRCm39)	splice site	probably benign
R0382:Celsr3	UTSW	9	108,706,417 (GRCm39)	missense	probably damaging	1.00
R0482:Celsr3	UTSW	9	108,706,272 (GRCm39)	nonsense	probably null
R0510:Celsr3	UTSW	9	108,704,204 (GRCm39)	missense	possibly damaging	0.62
R0630:Celsr3	UTSW	9	108,704,891 (GRCm39)	missense	probably damaging	0.98
R0656:Celsr3	UTSW	9	108,711,854 (GRCm39)	missense	possibly damaging	0.89
R0764:Celsr3	UTSW	9	108,705,017 (GRCm39)	missense	probably damaging	1.00
R0883:Celsr3	UTSW	9	108,719,832 (GRCm39)	missense	probably damaging	1.00
R0924:Celsr3	UTSW	9	108,723,224 (GRCm39)	missense	possibly damaging	0.78
R1015:Celsr3	UTSW	9	108,710,375 (GRCm39)	missense	probably benign	0.17
R1321:Celsr3	UTSW	9	108,713,069 (GRCm39)	missense	probably damaging	1.00
R1423:Celsr3	UTSW	9	108,704,104 (GRCm39)	missense	probably benign	0.00
R1497:Celsr3	UTSW	9	108,726,064 (GRCm39)	missense	probably benign	0.14
R1520:Celsr3	UTSW	9	108,725,857 (GRCm39)	missense	probably damaging	1.00
R1534:Celsr3	UTSW	9	108,726,083 (GRCm39)	missense	probably damaging	0.99
R1569:Celsr3	UTSW	9	108,706,267 (GRCm39)	missense	probably damaging	1.00
R1657:Celsr3	UTSW	9	108,720,151 (GRCm39)	nonsense	probably null
R1753:Celsr3	UTSW	9	108,709,056 (GRCm39)	missense	probably damaging	0.99
R1764:Celsr3	UTSW	9	108,706,157 (GRCm39)	missense	probably damaging	1.00
R1801:Celsr3	UTSW	9	108,711,825 (GRCm39)	missense	possibly damaging	0.88
R1838:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1839:Celsr3	UTSW	9	108,707,105 (GRCm39)	missense	probably benign
R1874:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1875:Celsr3	UTSW	9	108,713,037 (GRCm39)	missense	probably benign
R1953:Celsr3	UTSW	9	108,720,381 (GRCm39)	missense	probably benign	0.19
R1960:Celsr3	UTSW	9	108,723,016 (GRCm39)	missense	probably benign
R2113:Celsr3	UTSW	9	108,715,669 (GRCm39)	missense	probably damaging	1.00
R2290:Celsr3	UTSW	9	108,720,423 (GRCm39)	missense	probably damaging	1.00
R2369:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2373:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2374:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2375:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R2844:Celsr3	UTSW	9	108,706,507 (GRCm39)	missense	probably damaging	1.00
R2968:Celsr3	UTSW	9	108,709,390 (GRCm39)	missense	probably damaging	1.00
R3103:Celsr3	UTSW	9	108,714,338 (GRCm39)	missense	probably benign	0.31
R3159:Celsr3	UTSW	9	108,704,909 (GRCm39)	missense	possibly damaging	0.94
R3791:Celsr3	UTSW	9	108,719,751 (GRCm39)	missense	probably benign
R4194:Celsr3	UTSW	9	108,720,501 (GRCm39)	critical splice donor site	probably null
R4329:Celsr3	UTSW	9	108,723,248 (GRCm39)	missense	probably benign	0.00
R4365:Celsr3	UTSW	9	108,707,046 (GRCm39)	missense	possibly damaging	0.47
R4419:Celsr3	UTSW	9	108,720,443 (GRCm39)	missense	possibly damaging	0.84
R4484:Celsr3	UTSW	9	108,723,262 (GRCm39)	critical splice donor site	probably null
R4582:Celsr3	UTSW	9	108,722,922 (GRCm39)	missense	probably damaging	1.00
R4681:Celsr3	UTSW	9	108,704,953 (GRCm39)	missense	possibly damaging	0.58
R4729:Celsr3	UTSW	9	108,724,851 (GRCm39)	missense	probably benign	0.05
R4881:Celsr3	UTSW	9	108,721,140 (GRCm39)	missense	probably damaging	1.00
R4893:Celsr3	UTSW	9	108,726,620 (GRCm39)	missense	probably damaging	1.00
R5183:Celsr3	UTSW	9	108,714,759 (GRCm39)	missense	probably damaging	0.99
R5207:Celsr3	UTSW	9	108,709,958 (GRCm39)	missense	probably benign	0.01
R5290:Celsr3	UTSW	9	108,720,357 (GRCm39)	missense	probably benign	0.01
R5327:Celsr3	UTSW	9	108,719,907 (GRCm39)	intron	probably benign
R5345:Celsr3	UTSW	9	108,709,323 (GRCm39)	missense	probably damaging	1.00
R5358:Celsr3	UTSW	9	108,709,224 (GRCm39)	missense	possibly damaging	0.96
R5396:Celsr3	UTSW	9	108,705,781 (GRCm39)	missense	probably damaging	1.00
R5414:Celsr3	UTSW	9	108,717,241 (GRCm39)	missense	possibly damaging	0.88
R5452:Celsr3	UTSW	9	108,721,233 (GRCm39)	missense	possibly damaging	0.68
R5467:Celsr3	UTSW	9	108,705,836 (GRCm39)	missense	probably damaging	1.00
R5479:Celsr3	UTSW	9	108,721,743 (GRCm39)	critical splice donor site	probably null
R5629:Celsr3	UTSW	9	108,726,266 (GRCm39)	missense	probably benign	0.41
R5637:Celsr3	UTSW	9	108,714,332 (GRCm39)	missense	probably damaging	1.00
R5739:Celsr3	UTSW	9	108,704,357 (GRCm39)	missense	probably benign
R5785:Celsr3	UTSW	9	108,704,996 (GRCm39)	missense	probably damaging	1.00
R5877:Celsr3	UTSW	9	108,722,926 (GRCm39)	missense	probably damaging	0.98
R5961:Celsr3	UTSW	9	108,708,993 (GRCm39)	missense	probably damaging	1.00
R6046:Celsr3	UTSW	9	108,714,350 (GRCm39)	missense	probably benign	0.01
R6176:Celsr3	UTSW	9	108,705,554 (GRCm39)	missense	probably damaging	1.00
R6291:Celsr3	UTSW	9	108,706,041 (GRCm39)	missense	probably damaging	1.00
R6468:Celsr3	UTSW	9	108,712,989 (GRCm39)	missense	probably benign	0.08
R6481:Celsr3	UTSW	9	108,714,283 (GRCm39)	missense	possibly damaging	0.92
R6547:Celsr3	UTSW	9	108,706,327 (GRCm39)	missense	probably damaging	1.00
R6763:Celsr3	UTSW	9	108,704,549 (GRCm39)	missense	probably damaging	1.00
R6870:Celsr3	UTSW	9	108,706,390 (GRCm39)	missense	probably benign	0.02
R6977:Celsr3	UTSW	9	108,704,914 (GRCm39)	missense	probably benign
R7061:Celsr3	UTSW	9	108,724,793 (GRCm39)	nonsense	probably null
R7122:Celsr3	UTSW	9	108,705,766 (GRCm39)	missense	possibly damaging	0.90
R7156:Celsr3	UTSW	9	108,715,203 (GRCm39)	missense	possibly damaging	0.95
R7166:Celsr3	UTSW	9	108,720,150 (GRCm39)	missense	probably damaging	1.00
R7176:Celsr3	UTSW	9	108,722,961 (GRCm39)	missense	probably benign
R7213:Celsr3	UTSW	9	108,726,239 (GRCm39)	missense	probably damaging	0.98
R7314:Celsr3	UTSW	9	108,706,343 (GRCm39)	missense	probably damaging	1.00
R7478:Celsr3	UTSW	9	108,720,777 (GRCm39)	missense	probably benign	0.37
R7508:Celsr3	UTSW	9	108,713,821 (GRCm39)	missense	probably benign
R7554:Celsr3	UTSW	9	108,718,408 (GRCm39)	missense	probably benign
R7615:Celsr3	UTSW	9	108,714,851 (GRCm39)	missense	possibly damaging	0.75
R7653:Celsr3	UTSW	9	108,712,269 (GRCm39)	nonsense	probably null
R7747:Celsr3	UTSW	9	108,707,177 (GRCm39)	missense	possibly damaging	0.61
R7881:Celsr3	UTSW	9	108,705,271 (GRCm39)	missense	probably benign	0.28
R7935:Celsr3	UTSW	9	108,706,840 (GRCm39)	missense	probably benign	0.01
R7995:Celsr3	UTSW	9	108,722,282 (GRCm39)	missense	probably damaging	0.99
R8006:Celsr3	UTSW	9	108,706,306 (GRCm39)	missense	probably damaging	1.00
R8077:Celsr3	UTSW	9	108,705,530 (GRCm39)	missense	probably benign	0.15
R8284:Celsr3	UTSW	9	108,723,612 (GRCm39)	missense	probably damaging	0.99
R8291:Celsr3	UTSW	9	108,715,169 (GRCm39)	missense	probably damaging	1.00
R8322:Celsr3	UTSW	9	108,725,993 (GRCm39)	missense	probably damaging	1.00
R8334:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8337:Celsr3	UTSW	9	108,718,471 (GRCm39)	frame shift	probably null
R8338:Celsr3	UTSW	9	108,704,539 (GRCm39)	nonsense	probably null
R8353:Celsr3	UTSW	9	108,703,734 (GRCm39)	missense	probably benign	0.00
R8407:Celsr3	UTSW	9	108,706,256 (GRCm39)	missense	probably damaging	1.00
R8408:Celsr3	UTSW	9	108,708,988 (GRCm39)	missense	probably damaging	1.00
R8459:Celsr3	UTSW	9	108,706,829 (GRCm39)	missense	probably damaging	1.00
R8510:Celsr3	UTSW	9	108,715,319 (GRCm39)	missense	possibly damaging	0.93
R8713:Celsr3	UTSW	9	108,707,062 (GRCm39)	missense	probably benign
R8728:Celsr3	UTSW	9	108,723,940 (GRCm39)	missense	probably benign	0.24
R8829:Celsr3	UTSW	9	108,717,582 (GRCm39)	missense	probably benign
R8877:Celsr3	UTSW	9	108,706,877 (GRCm39)	missense	probably damaging	1.00
R8905:Celsr3	UTSW	9	108,718,501 (GRCm39)	missense	probably damaging	1.00
R9008:Celsr3	UTSW	9	108,706,151 (GRCm39)	missense	possibly damaging	0.94
R9072:Celsr3	UTSW	9	108,704,293 (GRCm39)	missense	probably benign
R9157:Celsr3	UTSW	9	108,707,185 (GRCm39)	missense	probably damaging	1.00
R9183:Celsr3	UTSW	9	108,706,595 (GRCm39)	missense	probably damaging	1.00
R9275:Celsr3	UTSW	9	108,715,689 (GRCm39)	missense	probably benign	0.27
R9361:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9382:Celsr3	UTSW	9	108,706,961 (GRCm39)	missense	possibly damaging	0.60
R9407:Celsr3	UTSW	9	108,723,596 (GRCm39)	missense	probably damaging	1.00
R9432:Celsr3	UTSW	9	108,726,032 (GRCm39)	missense	probably benign	0.00
R9607:Celsr3	UTSW	9	108,717,701 (GRCm39)	critical splice donor site	probably null
R9626:Celsr3	UTSW	9	108,726,521 (GRCm39)	missense	probably damaging	1.00
R9628:Celsr3	UTSW	9	108,703,559 (GRCm39)	nonsense	probably null
R9630:Celsr3	UTSW	9	108,704,296 (GRCm39)	missense	probably benign
R9645:Celsr3	UTSW	9	108,704,691 (GRCm39)	nonsense	probably null
R9683:Celsr3	UTSW	9	108,704,522 (GRCm39)	missense	probably damaging	1.00
R9794:Celsr3	UTSW	9	108,728,502 (GRCm39)	missense	probably benign	0.00
R9798:Celsr3	UTSW	9	108,705,794 (GRCm39)	missense	probably damaging	1.00
RF020:Celsr3	UTSW	9	108,726,256 (GRCm39)	missense	probably benign
X0018:Celsr3	UTSW	9	108,717,611 (GRCm39)	missense	probably benign	0.01
X0018:Celsr3	UTSW	9	108,704,977 (GRCm39)	missense	possibly damaging	0.65
X0026:Celsr3	UTSW	9	108,706,129 (GRCm39)	missense	probably damaging	0.99
Z1177:Celsr3	UTSW	9	108,703,676 (GRCm39)	missense	probably benign	0.34

Predicted Primers

PCR Primer
(F):5'- AAGCTCTTCCTGAGGGAGAC -3'
(R):5'- TTCACTTGGTAAAAGAGGAGACTG -3'

Sequencing Primer
(F):5'- ACAGTCAGCTGGCATACTTG -3'
(R):5'- CTGCAAGAATCAGAAGAGACCTGTC -3'

Posted On

2016-11-08