Incidental Mutation 'R5652:Vmn2r88'
ID 441515
Institutional Source Beutler Lab
Gene Symbol Vmn2r88
Ensembl Gene ENSMUSG00000000606
Gene Name vomeronasal 2, receptor 88
Synonyms V2r3, V2r13
MMRRC Submission 043298-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # R5652 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 51410819-51419527 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 51418572 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 746 (V746A)
Ref Sequence ENSEMBL: ENSMUSP00000125126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022438] [ENSMUST00000159674] [ENSMUST00000162998] [ENSMUST00000228139]
AlphaFold L7N1W8
Predicted Effect possibly damaging
Transcript: ENSMUST00000022438
AA Change: V755A

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000022438
Gene: ENSMUSG00000000606
AA Change: V755A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 457 8.3e-27 PFAM
Pfam:NCD3G 516 570 1.2e-18 PFAM
Pfam:7tm_3 603 838 1.9e-55 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000159674
AA Change: V746A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000125126
Gene: ENSMUSG00000000606
AA Change: V746A

DomainStartEndE-ValueType
Pfam:ANF_receptor 30 408 3.2e-30 PFAM
Pfam:NCD3G 463 516 1.2e-19 PFAM
Pfam:7tm_3 546 785 3.7e-81 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161565
Predicted Effect probably benign
Transcript: ENSMUST00000162998
SMART Domains Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

DomainStartEndE-ValueType
Pfam:Takusan 35 115 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163019
SMART Domains Protein: ENSMUSP00000124837
Gene: ENSMUSG00000000606

DomainStartEndE-ValueType
Pfam:ANF_receptor 52 399 3.7e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000228139
AA Change: V747A

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530077C05Rik A G 9: 22,424,490 (GRCm38) T135A probably benign Het
Abcc4 T C 14: 118,618,927 (GRCm38) I334V probably benign Het
Adamts5 C T 16: 85,899,268 (GRCm38) A334T probably damaging Het
Adcy4 G C 14: 55,773,443 (GRCm38) F672L probably benign Het
Adgrl1 A G 8: 83,929,815 (GRCm38) Y254C probably damaging Het
Adnp2 A G 18: 80,130,850 (GRCm38) S115P probably damaging Het
Aox1 A T 1: 58,095,197 (GRCm38) S1110C probably damaging Het
Arhgap44 G T 11: 65,024,238 (GRCm38) N401K probably damaging Het
Atp23 A T 10: 126,899,625 (GRCm38) N63K possibly damaging Het
Atp8b1 G C 18: 64,531,382 (GRCm38) I1238M probably benign Het
Ccdc38 A T 10: 93,555,586 (GRCm38) probably null Het
Celsr2 T C 3: 108,396,735 (GRCm38) D2364G probably null Het
Celsr3 G A 9: 108,838,472 (GRCm38) D2116N probably benign Het
Cenpf A G 1: 189,657,082 (GRCm38) S1518P probably damaging Het
Clcn3 C A 8: 60,919,353 (GRCm38) V758L possibly damaging Het
Ctsf T C 19: 4,858,477 (GRCm38) L288P probably damaging Het
Cwh43 A G 5: 73,418,141 (GRCm38) T334A probably damaging Het
Cyp3a57 A T 5: 145,349,325 (GRCm38) probably null Het
Ddr1 C T 17: 35,686,508 (GRCm38) A531T probably benign Het
Dennd1a A G 2: 37,801,126 (GRCm38) I260T probably benign Het
Dgkh T C 14: 78,627,761 (GRCm38) H47R probably damaging Het
Dync1h1 G A 12: 110,665,988 (GRCm38) V4514I possibly damaging Het
Dync2h1 A T 9: 7,116,638 (GRCm38) M66K probably benign Het
Fam186a T G 15: 99,945,372 (GRCm38) Y997S possibly damaging Het
Fam8a1 T A 13: 46,674,338 (GRCm38) L334H probably damaging Het
Fat4 C T 3: 39,002,968 (GRCm38) T4271I probably damaging Het
Fdxacb1 T A 9: 50,768,405 (GRCm38) L41Q probably damaging Het
Fgfr2 C T 7: 130,261,863 (GRCm38) V18M probably damaging Het
Gpa33 A C 1: 166,165,145 (GRCm38) probably null Het
Gpr1 A G 1: 63,183,467 (GRCm38) V203A probably benign Het
Gpr107 A G 2: 31,185,589 (GRCm38) I371V probably benign Het
Hectd2 T C 19: 36,604,320 (GRCm38) V420A probably damaging Het
Hist1h1t A G 13: 23,696,236 (GRCm38) K124R probably benign Het
Iglc3 A G 16: 19,065,670 (GRCm38) probably benign Het
Igtp A G 11: 58,206,629 (GRCm38) T209A probably benign Het
Itgb7 T A 15: 102,216,203 (GRCm38) N793I possibly damaging Het
Kansl1 G A 11: 104,338,166 (GRCm38) R870C probably damaging Het
Kcnh6 C T 11: 106,008,985 (GRCm38) R27C probably damaging Het
Kif2b T A 11: 91,575,830 (GRCm38) E542D possibly damaging Het
Klhl24 C A 16: 20,120,247 (GRCm38) Y517* probably null Het
Klhl25 A G 7: 75,866,147 (GRCm38) D267G probably benign Het
Krr1 C A 10: 111,977,383 (GRCm38) F195L possibly damaging Het
Lsr C T 7: 30,959,031 (GRCm38) G95D probably damaging Het
Med15 A T 16: 17,655,191 (GRCm38) I504N probably damaging Het
Mug1 A G 6: 121,840,181 (GRCm38) R70G probably benign Het
Mypn T A 10: 63,135,801 (GRCm38) Q820L probably damaging Het
Nlrp4f A T 13: 65,182,989 (GRCm38) H863Q probably benign Het
Nudt9 G A 5: 104,059,780 (GRCm38) V213M probably benign Het
Olfr177 A G 16: 58,872,484 (GRCm38) L222P probably damaging Het
Olfr828 A G 9: 18,815,626 (GRCm38) S223P probably damaging Het
Olfr891 T C 9: 38,180,815 (GRCm38) T3A probably benign Het
Olfr987 T A 2: 85,331,373 (GRCm38) N175I probably damaging Het
Orc2 A G 1: 58,466,072 (GRCm38) F475L probably damaging Het
Oxa1l T A 14: 54,366,832 (GRCm38) L183* probably null Het
Pcdh20 T C 14: 88,467,324 (GRCm38) T847A probably damaging Het
Pcdha6 G A 18: 36,968,836 (GRCm38) probably null Het
Pip5k1a T C 3: 95,067,439 (GRCm38) N376S probably benign Het
Pkd1l1 T C 11: 8,909,889 (GRCm38) E573G probably benign Het
Pkp1 T A 1: 135,882,597 (GRCm38) probably null Het
Pum1 T C 4: 130,764,127 (GRCm38) I643T possibly damaging Het
Rapgef3 A G 15: 97,758,437 (GRCm38) S328P probably benign Het
Raver1 A G 9: 21,090,312 (GRCm38) V75A probably damaging Het
Rbm28 T C 6: 29,135,409 (GRCm38) E511G probably damaging Het
Satb1 T A 17: 51,742,795 (GRCm38) T544S probably damaging Het
Sdcbp2 T C 2: 151,589,215 (GRCm38) V248A probably benign Het
Sema7a A G 9: 57,960,659 (GRCm38) D506G probably damaging Het
Sept8 A G 11: 53,537,217 (GRCm38) E286G probably damaging Het
Sh3pxd2b A G 11: 32,422,812 (GRCm38) I660V probably damaging Het
Stk38l G T 6: 146,773,328 (GRCm38) D364Y possibly damaging Het
Sycp2 T C 2: 178,358,705 (GRCm38) probably null Het
Tbc1d31 T A 15: 57,951,666 (GRCm38) S580T probably damaging Het
Tcerg1l G A 7: 138,280,046 (GRCm38) R305C probably damaging Het
Tek T A 4: 94,855,324 (GRCm38) Y859N probably damaging Het
Tjp1 A T 7: 65,312,443 (GRCm38) probably null Het
Tmem132d A T 5: 127,784,795 (GRCm38) I754N possibly damaging Het
Togaram1 G A 12: 65,016,650 (GRCm38) V1580I probably benign Het
Troap A G 15: 99,082,264 (GRCm38) T442A probably benign Het
Ttn A T 2: 76,881,753 (GRCm38) probably benign Het
Twnk T A 19: 45,007,293 (GRCm38) V55E possibly damaging Het
Uggt1 A T 1: 36,216,153 (GRCm38) Y225* probably null Het
Vmn2r109 A G 17: 20,540,519 (GRCm38) *859Q probably null Het
Vmn2r17 A T 5: 109,429,564 (GRCm38) I494L probably benign Het
Yae1d1 A G 13: 17,991,706 (GRCm38) L57P probably damaging Het
Zfp26 G A 9: 20,437,841 (GRCm38) R476* probably null Het
Zmynd8 T A 2: 165,807,698 (GRCm38) Q816L probably damaging Het
Zswim8 A T 14: 20,713,427 (GRCm38) H414L possibly damaging Het
Other mutations in Vmn2r88
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Vmn2r88 APN 14 51,413,256 (GRCm38) missense probably benign 0.00
IGL00990:Vmn2r88 APN 14 51,413,060 (GRCm38) missense probably benign 0.00
IGL00990:Vmn2r88 APN 14 51,413,125 (GRCm38) missense probably benign 0.00
IGL00990:Vmn2r88 APN 14 51,416,802 (GRCm38) missense possibly damaging 0.59
IGL02308:Vmn2r88 APN 14 51,417,980 (GRCm38) missense possibly damaging 0.96
IGL02481:Vmn2r88 APN 14 51,414,154 (GRCm38) missense probably benign
IGL02483:Vmn2r88 APN 14 51,414,154 (GRCm38) missense probably benign
IGL03241:Vmn2r88 APN 14 51,418,373 (GRCm38) missense probably benign 0.03
R0052:Vmn2r88 UTSW 14 51,418,700 (GRCm38) missense possibly damaging 0.88
R0070:Vmn2r88 UTSW 14 51,414,140 (GRCm38) missense probably benign 0.08
R0799:Vmn2r88 UTSW 14 51,414,502 (GRCm38) missense possibly damaging 0.61
R0906:Vmn2r88 UTSW 14 51,418,209 (GRCm38) missense probably damaging 1.00
R1322:Vmn2r88 UTSW 14 51,414,108 (GRCm38) missense probably damaging 1.00
R1352:Vmn2r88 UTSW 14 51,418,550 (GRCm38) missense probably damaging 1.00
R1639:Vmn2r88 UTSW 14 51,416,787 (GRCm38) missense probably damaging 0.98
R1780:Vmn2r88 UTSW 14 51,418,572 (GRCm38) missense probably damaging 1.00
R1834:Vmn2r88 UTSW 14 51,413,030 (GRCm38) splice site probably benign
R1911:Vmn2r88 UTSW 14 51,418,214 (GRCm38) missense probably damaging 1.00
R2113:Vmn2r88 UTSW 14 51,418,194 (GRCm38) missense probably damaging 1.00
R2120:Vmn2r88 UTSW 14 51,413,208 (GRCm38) missense probably benign 0.00
R2126:Vmn2r88 UTSW 14 51,413,807 (GRCm38) missense probably benign 0.01
R2348:Vmn2r88 UTSW 14 51,414,004 (GRCm38) missense probably benign 0.00
R2881:Vmn2r88 UTSW 14 51,418,689 (GRCm38) missense probably damaging 0.97
R2884:Vmn2r88 UTSW 14 51,413,934 (GRCm38) missense probably damaging 1.00
R3081:Vmn2r88 UTSW 14 51,418,632 (GRCm38) missense probably damaging 0.99
R3933:Vmn2r88 UTSW 14 51,413,978 (GRCm38) missense probably benign 0.44
R3967:Vmn2r88 UTSW 14 51,413,190 (GRCm38) missense probably benign 0.06
R4091:Vmn2r88 UTSW 14 51,415,426 (GRCm38) missense probably damaging 1.00
R4378:Vmn2r88 UTSW 14 51,413,289 (GRCm38) nonsense probably null
R4397:Vmn2r88 UTSW 14 51,417,978 (GRCm38) missense probably damaging 1.00
R4418:Vmn2r88 UTSW 14 51,418,081 (GRCm38) missense probably damaging 1.00
R4609:Vmn2r88 UTSW 14 51,418,074 (GRCm38) missense probably damaging 0.98
R4647:Vmn2r88 UTSW 14 51,418,793 (GRCm38) missense probably benign 0.02
R4672:Vmn2r88 UTSW 14 51,418,155 (GRCm38) missense probably damaging 1.00
R4684:Vmn2r88 UTSW 14 51,413,334 (GRCm38) missense possibly damaging 0.95
R4686:Vmn2r88 UTSW 14 51,413,339 (GRCm38) missense probably benign 0.03
R4720:Vmn2r88 UTSW 14 51,413,245 (GRCm38) missense probably benign 0.01
R5046:Vmn2r88 UTSW 14 51,413,181 (GRCm38) missense probably benign 0.03
R5063:Vmn2r88 UTSW 14 51,411,146 (GRCm38) missense probably damaging 0.96
R5619:Vmn2r88 UTSW 14 51,413,910 (GRCm38) missense probably damaging 0.99
R6020:Vmn2r88 UTSW 14 51,418,149 (GRCm38) nonsense probably null
R6103:Vmn2r88 UTSW 14 51,415,369 (GRCm38) missense probably benign 0.17
R6674:Vmn2r88 UTSW 14 51,414,338 (GRCm38) missense probably benign 0.01
R6799:Vmn2r88 UTSW 14 51,413,969 (GRCm38) missense probably benign 0.05
R7089:Vmn2r88 UTSW 14 51,418,643 (GRCm38) missense
R7104:Vmn2r88 UTSW 14 51,413,796 (GRCm38) missense
R7265:Vmn2r88 UTSW 14 51,418,319 (GRCm38) missense
R7316:Vmn2r88 UTSW 14 51,414,255 (GRCm38) missense
R7552:Vmn2r88 UTSW 14 51,410,858 (GRCm38) splice site probably null
R7611:Vmn2r88 UTSW 14 51,413,997 (GRCm38) missense
R7667:Vmn2r88 UTSW 14 51,417,989 (GRCm38) missense
R7682:Vmn2r88 UTSW 14 51,418,449 (GRCm38) missense
R7755:Vmn2r88 UTSW 14 51,413,046 (GRCm38) missense probably benign 0.00
R7811:Vmn2r88 UTSW 14 51,418,703 (GRCm38) missense
R7882:Vmn2r88 UTSW 14 51,413,046 (GRCm38) missense probably benign 0.00
R7957:Vmn2r88 UTSW 14 51,413,132 (GRCm38) missense
R7998:Vmn2r88 UTSW 14 51,414,108 (GRCm38) missense
R8142:Vmn2r88 UTSW 14 51,414,107 (GRCm38) missense
R8186:Vmn2r88 UTSW 14 51,418,700 (GRCm38) missense
R8348:Vmn2r88 UTSW 14 51,418,796 (GRCm38) missense probably damaging 0.97
R8448:Vmn2r88 UTSW 14 51,418,796 (GRCm38) missense probably damaging 0.97
R8483:Vmn2r88 UTSW 14 51,413,073 (GRCm38) missense possibly damaging 0.48
R8783:Vmn2r88 UTSW 14 51,414,066 (GRCm38) missense
R8859:Vmn2r88 UTSW 14 51,418,806 (GRCm38) missense probably damaging 0.97
R8916:Vmn2r88 UTSW 14 51,411,136 (GRCm38) missense
R8936:Vmn2r88 UTSW 14 51,418,526 (GRCm38) missense possibly damaging 0.88
R9004:Vmn2r88 UTSW 14 51,413,167 (GRCm38) missense
R9038:Vmn2r88 UTSW 14 51,414,033 (GRCm38) missense
R9063:Vmn2r88 UTSW 14 51,410,872 (GRCm38) start gained probably benign
R9311:Vmn2r88 UTSW 14 51,413,046 (GRCm38) missense probably benign 0.00
R9382:Vmn2r88 UTSW 14 51,418,740 (GRCm38) missense
R9483:Vmn2r88 UTSW 14 51,411,184 (GRCm38) missense
R9602:Vmn2r88 UTSW 14 51,413,732 (GRCm38) missense
V5622:Vmn2r88 UTSW 14 51,413,127 (GRCm38) missense probably benign
X0024:Vmn2r88 UTSW 14 51,413,832 (GRCm38) missense possibly damaging 0.79
X0025:Vmn2r88 UTSW 14 51,416,802 (GRCm38) missense possibly damaging 0.59
Z1177:Vmn2r88 UTSW 14 51,418,187 (GRCm38) missense
Z1177:Vmn2r88 UTSW 14 51,418,046 (GRCm38) frame shift probably null
Z1190:Vmn2r88 UTSW 14 51,413,201 (GRCm38) missense
Predicted Primers PCR Primer
(F):5'- AGCTCACTACTCCAGGAAGAAG -3'
(R):5'- CCTGCACTAGAAGCCAAGATTG -3'

Sequencing Primer
(F):5'- CTCACTACTCCAGGAAGAAGAATGAG -3'
(R):5'- TAGAAGCCAAGATTGAGAAAACCTC -3'
Posted On 2016-11-08