Incidental Mutation 'R5621:Or4c15b'
ID 441550
Institutional Source Beutler Lab
Gene Symbol Or4c15b
Ensembl Gene ENSMUSG00000075095
Gene Name olfactory receptor family 4 subfamily C member 15B
Synonyms Olfr1229, GA_x6K02T2Q125-50727797-50726862, MOR233-19, MOR233-22
MMRRC Submission 043279-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5621 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89112540-89113475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 89112697 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 281 (P281L)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099788] [ENSMUST00000213883] [ENSMUST00000214593]
AlphaFold Q7TQZ9
Predicted Effect possibly damaging
Transcript: ENSMUST00000099788
AA Change: P260L

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097376
Gene: ENSMUSG00000075095
AA Change: P260L

DomainStartEndE-ValueType
Pfam:7tm_1 39 286 2.9e-29 PFAM
Pfam:7tm_4 138 279 1.7e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111549
AA Change: P281L

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107174
Gene: ENSMUSG00000075095
AA Change: P281L

DomainStartEndE-ValueType
transmembrane domain 2 19 N/A INTRINSIC
Pfam:7tm_4 49 324 9.6e-51 PFAM
Pfam:7tm_1 60 307 7.3e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213883
AA Change: P260L

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214593
AA Change: P260L

PolyPhen 2 Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
Meta Mutation Damage Score 0.4847 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 T G 17: 85,003,421 (GRCm39) L417R probably damaging Het
Adrm1b G A 3: 92,335,664 (GRCm39) A346V probably damaging Het
Als2 A G 1: 59,231,049 (GRCm39) V854A probably benign Het
Bbox1 C T 2: 110,122,868 (GRCm39) W140* probably null Het
Ccdc28a A T 10: 18,092,016 (GRCm39) N110K probably benign Het
Chrna6 C T 8: 27,897,068 (GRCm39) E270K probably damaging Het
Cilp A G 9: 65,186,073 (GRCm39) K723E possibly damaging Het
Ciz1 C A 2: 32,261,753 (GRCm39) A455E probably damaging Het
Csmd3 T G 15: 48,177,374 (GRCm39) H388P possibly damaging Het
Dnajc8 A G 4: 132,280,563 (GRCm39) probably benign Het
Dnase1 G T 16: 3,856,982 (GRCm39) C164F probably benign Het
Dync2h1 A T 9: 7,120,909 (GRCm39) I2126K possibly damaging Het
Epha4 G T 1: 77,491,686 (GRCm39) probably benign Het
Fer1l6 T C 15: 58,430,175 (GRCm39) C201R probably damaging Het
Fgf8 T C 19: 45,730,821 (GRCm39) Y68C probably benign Het
Gabrb1 A T 5: 72,266,071 (GRCm39) I243F probably damaging Het
Gpam A C 19: 55,067,692 (GRCm39) S484A probably damaging Het
Hectd2 T A 19: 36,596,151 (GRCm39) N745K probably damaging Het
Hspa13 T C 16: 75,563,651 (GRCm39) probably benign Het
Ints2 A G 11: 86,133,773 (GRCm39) F426L probably benign Het
Ism1 A G 2: 139,520,641 (GRCm39) T18A probably damaging Het
Itih2 T A 2: 10,107,616 (GRCm39) Q650L probably benign Het
Jmjd4 T C 11: 59,341,219 (GRCm39) F50S probably damaging Het
Kif5b T C 18: 6,226,883 (GRCm39) N125S probably benign Het
Lonp1 G C 17: 56,927,263 (GRCm39) A330G probably benign Het
Lrfn1 A G 7: 28,166,261 (GRCm39) I552V probably damaging Het
Mcph1 A G 8: 18,682,186 (GRCm39) E441G probably damaging Het
Mdn1 T A 4: 32,716,371 (GRCm39) H2144Q possibly damaging Het
Mms19 A G 19: 41,954,752 (GRCm39) S56P probably benign Het
Mrgprb3 A G 7: 48,293,116 (GRCm39) I145T probably benign Het
Myh11 G A 16: 14,062,719 (GRCm39) T287I probably damaging Het
Npas2 A G 1: 39,398,794 (GRCm39) T730A probably benign Het
Or4c108 T C 2: 88,803,810 (GRCm39) I142V probably benign Het
Pcdhgb1 A G 18: 37,815,222 (GRCm39) E571G possibly damaging Het
Pcx T A 19: 4,669,195 (GRCm39) V731E possibly damaging Het
Pgm2 T A 5: 64,269,381 (GRCm39) Y489* probably null Het
Rrp12 T C 19: 41,868,856 (GRCm39) T541A probably benign Het
Ryr3 C T 2: 112,731,329 (GRCm39) W660* probably null Het
Sertad2 T A 11: 20,598,061 (GRCm39) F86I possibly damaging Het
Slc11a1 G A 1: 74,420,065 (GRCm39) G191D probably damaging Het
Slc22a22 G T 15: 57,122,547 (GRCm39) F143L probably benign Het
Slc22a28 C T 19: 8,048,376 (GRCm39) V424I probably benign Het
Slc7a11 T G 3: 50,393,324 (GRCm39) K106N probably damaging Het
Smgc A T 15: 91,728,623 (GRCm39) D121V probably damaging Het
Sphk1 C T 11: 116,427,192 (GRCm39) probably benign Het
Spock3 A T 8: 63,597,040 (GRCm39) T118S probably benign Het
Stk17b G T 1: 53,810,943 (GRCm39) S54* probably null Het
Sycp2 A G 2: 178,023,711 (GRCm39) I435T probably benign Het
Tm2d3 G T 7: 65,351,366 (GRCm39) D207Y probably damaging Het
Top2b A T 14: 16,387,280 (GRCm38) N123Y probably damaging Het
Unc80 A G 1: 66,677,202 (GRCm39) T2044A possibly damaging Het
Usp6nl A G 2: 6,445,243 (GRCm39) S407G probably benign Het
Vmn1r195 G A 13: 22,462,559 (GRCm39) V10I probably benign Het
Zfp292 C T 4: 34,811,703 (GRCm39) R447H probably damaging Het
Other mutations in Or4c15b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02982:Or4c15b APN 2 89,113,453 (GRCm39) missense probably damaging 0.98
R1535:Or4c15b UTSW 2 89,113,401 (GRCm39) missense probably benign 0.14
R1610:Or4c15b UTSW 2 89,113,165 (GRCm39) missense probably damaging 1.00
R3896:Or4c15b UTSW 2 89,113,441 (GRCm39) missense possibly damaging 0.78
R4516:Or4c15b UTSW 2 89,113,187 (GRCm39) missense probably benign 0.05
R4922:Or4c15b UTSW 2 89,112,811 (GRCm39) missense possibly damaging 0.93
R4990:Or4c15b UTSW 2 89,113,671 (GRCm39) splice site probably null
R5267:Or4c15b UTSW 2 89,112,574 (GRCm39) nonsense probably null
R5271:Or4c15b UTSW 2 89,113,297 (GRCm39) missense probably benign 0.39
R5514:Or4c15b UTSW 2 89,112,817 (GRCm39) missense probably damaging 1.00
R7154:Or4c15b UTSW 2 89,113,204 (GRCm39) missense probably damaging 1.00
R7992:Or4c15b UTSW 2 89,113,082 (GRCm39) missense probably benign 0.01
R9028:Or4c15b UTSW 2 89,112,676 (GRCm39) missense probably damaging 1.00
Z1176:Or4c15b UTSW 2 89,113,241 (GRCm39) frame shift probably null
Z1176:Or4c15b UTSW 2 89,112,881 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CTCCAAAGTAATGCTAGTTCTGTAC -3'
(R):5'- CCAACAGTGGCTTTATCTGC -3'

Sequencing Primer
(F):5'- GAATGAAATGGTTTTGACCTCTTTCC -3'
(R):5'- CAGTGGCTTTATCTGCATCATAATC -3'
Posted On 2016-11-08