Incidental Mutation 'R5621:Slc22a28'
ID 441591
Institutional Source Beutler Lab
Gene Symbol Slc22a28
Ensembl Gene ENSMUSG00000063590
Gene Name solute carrier family 22, member 28
Synonyms Gm5631
MMRRC Submission 043279-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.299) question?
Stock # R5621 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 8039574-8109346 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 8048376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 424 (V424I)
Ref Sequence ENSEMBL: ENSMUSP00000067114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065651]
AlphaFold B2RT89
Predicted Effect probably benign
Transcript: ENSMUST00000065651
AA Change: V424I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000067114
Gene: ENSMUSG00000063590
AA Change: V424I

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 527 1.4e-26 PFAM
Pfam:MFS_1 140 375 1.1e-15 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 T G 17: 85,003,421 (GRCm39) L417R probably damaging Het
Adrm1b G A 3: 92,335,664 (GRCm39) A346V probably damaging Het
Als2 A G 1: 59,231,049 (GRCm39) V854A probably benign Het
Bbox1 C T 2: 110,122,868 (GRCm39) W140* probably null Het
Ccdc28a A T 10: 18,092,016 (GRCm39) N110K probably benign Het
Chrna6 C T 8: 27,897,068 (GRCm39) E270K probably damaging Het
Cilp A G 9: 65,186,073 (GRCm39) K723E possibly damaging Het
Ciz1 C A 2: 32,261,753 (GRCm39) A455E probably damaging Het
Csmd3 T G 15: 48,177,374 (GRCm39) H388P possibly damaging Het
Dnajc8 A G 4: 132,280,563 (GRCm39) probably benign Het
Dnase1 G T 16: 3,856,982 (GRCm39) C164F probably benign Het
Dync2h1 A T 9: 7,120,909 (GRCm39) I2126K possibly damaging Het
Epha4 G T 1: 77,491,686 (GRCm39) probably benign Het
Fer1l6 T C 15: 58,430,175 (GRCm39) C201R probably damaging Het
Fgf8 T C 19: 45,730,821 (GRCm39) Y68C probably benign Het
Gabrb1 A T 5: 72,266,071 (GRCm39) I243F probably damaging Het
Gpam A C 19: 55,067,692 (GRCm39) S484A probably damaging Het
Hectd2 T A 19: 36,596,151 (GRCm39) N745K probably damaging Het
Hspa13 T C 16: 75,563,651 (GRCm39) probably benign Het
Ints2 A G 11: 86,133,773 (GRCm39) F426L probably benign Het
Ism1 A G 2: 139,520,641 (GRCm39) T18A probably damaging Het
Itih2 T A 2: 10,107,616 (GRCm39) Q650L probably benign Het
Jmjd4 T C 11: 59,341,219 (GRCm39) F50S probably damaging Het
Kif5b T C 18: 6,226,883 (GRCm39) N125S probably benign Het
Lonp1 G C 17: 56,927,263 (GRCm39) A330G probably benign Het
Lrfn1 A G 7: 28,166,261 (GRCm39) I552V probably damaging Het
Mcph1 A G 8: 18,682,186 (GRCm39) E441G probably damaging Het
Mdn1 T A 4: 32,716,371 (GRCm39) H2144Q possibly damaging Het
Mms19 A G 19: 41,954,752 (GRCm39) S56P probably benign Het
Mrgprb3 A G 7: 48,293,116 (GRCm39) I145T probably benign Het
Myh11 G A 16: 14,062,719 (GRCm39) T287I probably damaging Het
Npas2 A G 1: 39,398,794 (GRCm39) T730A probably benign Het
Or4c108 T C 2: 88,803,810 (GRCm39) I142V probably benign Het
Or4c15b G A 2: 89,112,697 (GRCm39) P281L probably damaging Het
Pcdhgb1 A G 18: 37,815,222 (GRCm39) E571G possibly damaging Het
Pcx T A 19: 4,669,195 (GRCm39) V731E possibly damaging Het
Pgm2 T A 5: 64,269,381 (GRCm39) Y489* probably null Het
Rrp12 T C 19: 41,868,856 (GRCm39) T541A probably benign Het
Ryr3 C T 2: 112,731,329 (GRCm39) W660* probably null Het
Sertad2 T A 11: 20,598,061 (GRCm39) F86I possibly damaging Het
Slc11a1 G A 1: 74,420,065 (GRCm39) G191D probably damaging Het
Slc22a22 G T 15: 57,122,547 (GRCm39) F143L probably benign Het
Slc7a11 T G 3: 50,393,324 (GRCm39) K106N probably damaging Het
Smgc A T 15: 91,728,623 (GRCm39) D121V probably damaging Het
Sphk1 C T 11: 116,427,192 (GRCm39) probably benign Het
Spock3 A T 8: 63,597,040 (GRCm39) T118S probably benign Het
Stk17b G T 1: 53,810,943 (GRCm39) S54* probably null Het
Sycp2 A G 2: 178,023,711 (GRCm39) I435T probably benign Het
Tm2d3 G T 7: 65,351,366 (GRCm39) D207Y probably damaging Het
Top2b A T 14: 16,387,280 (GRCm38) N123Y probably damaging Het
Unc80 A G 1: 66,677,202 (GRCm39) T2044A possibly damaging Het
Usp6nl A G 2: 6,445,243 (GRCm39) S407G probably benign Het
Vmn1r195 G A 13: 22,462,559 (GRCm39) V10I probably benign Het
Zfp292 C T 4: 34,811,703 (GRCm39) R447H probably damaging Het
Other mutations in Slc22a28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Slc22a28 APN 19 8,107,567 (GRCm39) missense possibly damaging 0.89
IGL00515:Slc22a28 APN 19 8,094,428 (GRCm39) missense probably benign 0.34
IGL01025:Slc22a28 APN 19 8,094,272 (GRCm39) splice site probably benign
IGL02697:Slc22a28 APN 19 8,094,491 (GRCm39) missense probably benign 0.06
PIT4378001:Slc22a28 UTSW 19 8,049,279 (GRCm39) missense probably damaging 0.96
R0744:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R0836:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R1398:Slc22a28 UTSW 19 8,107,566 (GRCm39) nonsense probably null
R1456:Slc22a28 UTSW 19 8,049,223 (GRCm39) missense possibly damaging 0.50
R1603:Slc22a28 UTSW 19 8,040,674 (GRCm39) missense probably damaging 1.00
R1993:Slc22a28 UTSW 19 8,094,488 (GRCm39) missense possibly damaging 0.79
R2254:Slc22a28 UTSW 19 8,041,858 (GRCm39) missense probably benign
R2262:Slc22a28 UTSW 19 8,048,573 (GRCm39) missense probably benign 0.00
R4078:Slc22a28 UTSW 19 8,078,777 (GRCm39) missense probably benign 0.15
R4165:Slc22a28 UTSW 19 8,040,773 (GRCm39) missense possibly damaging 0.95
R4612:Slc22a28 UTSW 19 8,078,770 (GRCm39) missense probably damaging 1.00
R4947:Slc22a28 UTSW 19 8,108,816 (GRCm39) missense probably benign 0.03
R5573:Slc22a28 UTSW 19 8,048,462 (GRCm39) missense possibly damaging 0.50
R5611:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R5671:Slc22a28 UTSW 19 8,108,795 (GRCm39) missense probably damaging 1.00
R6063:Slc22a28 UTSW 19 8,094,386 (GRCm39) missense probably benign 0.01
R6358:Slc22a28 UTSW 19 8,049,253 (GRCm39) missense probably damaging 0.99
R6385:Slc22a28 UTSW 19 8,078,844 (GRCm39) missense probably damaging 0.99
R6680:Slc22a28 UTSW 19 8,078,757 (GRCm39) missense probably benign 0.07
R6767:Slc22a28 UTSW 19 8,094,409 (GRCm39) missense probably damaging 1.00
R6865:Slc22a28 UTSW 19 8,041,856 (GRCm39) nonsense probably null
R6947:Slc22a28 UTSW 19 8,041,875 (GRCm39) missense possibly damaging 0.58
R7049:Slc22a28 UTSW 19 8,049,270 (GRCm39) missense probably benign
R7269:Slc22a28 UTSW 19 8,094,491 (GRCm39) missense probably benign 0.06
R7484:Slc22a28 UTSW 19 8,048,492 (GRCm39) missense probably benign
R7823:Slc22a28 UTSW 19 8,041,890 (GRCm39) missense probably benign 0.38
R7856:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R7980:Slc22a28 UTSW 19 8,078,837 (GRCm39) missense probably damaging 0.99
R8323:Slc22a28 UTSW 19 8,108,788 (GRCm39) missense probably damaging 1.00
R8404:Slc22a28 UTSW 19 8,108,793 (GRCm39) nonsense probably null
R8435:Slc22a28 UTSW 19 8,048,565 (GRCm39) missense probably benign 0.13
R8529:Slc22a28 UTSW 19 8,040,778 (GRCm39) missense probably benign 0.01
R9149:Slc22a28 UTSW 19 8,049,205 (GRCm39) missense probably benign 0.00
R9727:Slc22a28 UTSW 19 8,108,818 (GRCm39) missense probably benign
R9782:Slc22a28 UTSW 19 8,041,813 (GRCm39) missense probably null 1.00
Z1088:Slc22a28 UTSW 19 8,039,763 (GRCm39) missense probably damaging 0.96
Z1176:Slc22a28 UTSW 19 8,039,748 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAGTTTCCAGCATGGCAACC -3'
(R):5'- CGATGTGATCACTCATTACACAATG -3'

Sequencing Primer
(F):5'- CCAGCATGGCAACCAGAAATTATTTG -3'
(R):5'- TCATTACACAATGATTCTTGGTAGC -3'
Posted On 2016-11-08