Mutagenetix > Incidental Mutation

Incidental Mutation 'R5623:Pkd1l3'

441686

Institutional Source

Beutler Lab

Gene Symbol

Pkd1l3

Ensembl Gene

ENSMUSG00000048827

Gene Name

polycystic kidney disease 1 like 3

Synonyms

MMRRC Submission

043162-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5623 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110340828-110399305 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 110350351 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 399 (T399S)

Ref Sequence

ENSEMBL: ENSMUSP00000148592 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057344] [ENSMUST00000109242] [ENSMUST00000212537]

AlphaFold

Q2EG98

Predicted Effect

possibly damaging
Transcript: ENSMUST00000057344
AA Change: T399S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000051512
Gene: ENSMUSG00000048827
AA Change: T399S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CLECT	26	142	4.25e-1	SMART
internal_repeat_2	143	245	2.25e-8	PROSPERO
low complexity region	246	270	N/A	INTRINSIC
low complexity region	272	296	N/A	INTRINSIC
low complexity region	298	322	N/A	INTRINSIC
low complexity region	324	348	N/A	INTRINSIC
internal_repeat_1	349	431	1.22e-8	PROSPERO
internal_repeat_2	378	466	2.25e-8	PROSPERO
internal_repeat_1	518	731	1.22e-8	PROSPERO
GPS	1007	1056	3.62e-5	SMART
transmembrane domain	1075	1094	N/A	INTRINSIC
LH2	1119	1238	1.01e-9	SMART
transmembrane domain	1282	1304	N/A	INTRINSIC
transmembrane domain	1319	1341	N/A	INTRINSIC
low complexity region	1398	1408	N/A	INTRINSIC
low complexity region	1451	1460	N/A	INTRINSIC
low complexity region	1484	1497	N/A	INTRINSIC
transmembrane domain	1534	1556	N/A	INTRINSIC
transmembrane domain	1576	1595	N/A	INTRINSIC
Pfam:PKD_channel	1695	2110	2.8e-86	PFAM
Pfam:Ion_trans	1858	2114	2.9e-9	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109242
AA Change: T399S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000104865
Gene: ENSMUSG00000048827
AA Change: T399S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
CLECT	26	142	4.25e-1	SMART
internal_repeat_2	143	245	2.63e-8	PROSPERO
low complexity region	246	270	N/A	INTRINSIC
low complexity region	272	296	N/A	INTRINSIC
low complexity region	298	322	N/A	INTRINSIC
low complexity region	324	348	N/A	INTRINSIC
internal_repeat_1	349	440	3.96e-14	PROSPERO
internal_repeat_2	378	466	2.63e-8	PROSPERO
internal_repeat_1	518	724	3.96e-14	PROSPERO
GPS	1017	1066	3.62e-5	SMART
transmembrane domain	1085	1104	N/A	INTRINSIC
LH2	1129	1248	1.01e-9	SMART
transmembrane domain	1292	1314	N/A	INTRINSIC
transmembrane domain	1329	1351	N/A	INTRINSIC
low complexity region	1408	1418	N/A	INTRINSIC
low complexity region	1461	1470	N/A	INTRINSIC
low complexity region	1494	1507	N/A	INTRINSIC
transmembrane domain	1544	1566	N/A	INTRINSIC
transmembrane domain	1586	1605	N/A	INTRINSIC
Pfam:PKD_channel	1705	2120	1.3e-86	PFAM
Pfam:Ion_trans	1868	2124	4.3e-9	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000212537
AA Change: T399S

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212609

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.2%
20x: 95.0%

Validation Efficiency

98% (65/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and grossly normal and exhibit normal taste responsiveness in various behavioral and electrophysiological tests of taste function. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp8b1	T	G	18: 64,679,165 (GRCm39)	Q772P	possibly damaging	Het
B3gnt2	C	G	11: 22,787,018 (GRCm39)	A57P	probably damaging	Het
Birc6	T	G	17: 74,835,651 (GRCm39)	D63E	probably damaging	Het
Ccdc13	T	C	9: 121,662,799 (GRCm39)	E72G	probably damaging	Het
Cfap221	C	T	1: 119,881,898 (GRCm39)	A297T	probably benign	Het
Chd1	T	A	17: 15,975,194 (GRCm39)	N1081K	probably damaging	Het
Chrm3	C	A	13: 9,927,423 (GRCm39)	V538L	possibly damaging	Het
Clec16a	T	A	16: 10,428,985 (GRCm39)	N37K	probably benign	Het
Cnksr3	T	A	10: 7,070,548 (GRCm39)	I229F	probably damaging	Het
Cspg4b	T	C	13: 113,483,168 (GRCm39)	I1590T	possibly damaging	Het
Dchs1	T	C	7: 105,421,976 (GRCm39)	E148G	probably damaging	Het
Diaph1	A	T	18: 38,029,146 (GRCm39)		probably benign	Het
Dis3l	A	G	9: 64,214,885 (GRCm39)	F895L	possibly damaging	Het
Dnah1	G	T	14: 31,007,980 (GRCm39)	D2142E	possibly damaging	Het
Dst	T	C	1: 34,229,214 (GRCm39)	V1944A	possibly damaging	Het
Eif4a2	C	T	16: 22,928,969 (GRCm39)		probably benign	Het
Ephb6	T	A	6: 41,593,415 (GRCm39)	M487K	probably benign	Het
Fgf18	T	G	11: 33,084,272 (GRCm39)	T61P	probably damaging	Het
G6pc2	A	G	2: 69,056,927 (GRCm39)	E191G	probably damaging	Het
Gm10717	C	T	9: 3,026,318 (GRCm39)	S55L	probably benign	Het
Gm5414	A	G	15: 101,534,246 (GRCm39)	F286S	probably damaging	Het
Gpcpd1	G	T	2: 132,376,637 (GRCm39)	A553E	probably damaging	Het
Gpr153	A	G	4: 152,366,398 (GRCm39)	D321G	possibly damaging	Het
Hecw2	T	A	1: 53,871,782 (GRCm39)	Q1388L	probably null	Het
Ighv14-3	A	C	12: 114,023,710 (GRCm39)	S36A	probably damaging	Het
Inpp5j	C	A	11: 3,444,766 (GRCm39)	G969V	probably damaging	Het
Kat5	G	A	19: 5,657,590 (GRCm39)	R307W	probably damaging	Het
Klk1b21	A	G	7: 43,754,989 (GRCm39)	S95G	probably damaging	Het
Mdm1	G	A	10: 117,986,694 (GRCm39)	V171I	possibly damaging	Het
Nfu1	TCGC	T	6: 86,993,188 (GRCm39)		probably benign	Het
Or5k8	C	T	16: 58,644,706 (GRCm39)	R122H	probably benign	Het
Or6c206	G	A	10: 129,096,901 (GRCm39)	V24M	probably benign	Het
Phkb	T	A	8: 86,569,677 (GRCm39)		probably benign	Het
Prr14l	A	T	5: 33,001,852 (GRCm39)		probably benign	Het
Psg21	A	C	7: 18,388,939 (GRCm39)	L51R	probably damaging	Het
Ptprg	T	A	14: 12,153,857 (GRCm38)	I526N	probably damaging	Het
Rab1a	T	C	11: 20,151,626 (GRCm39)		probably benign	Het
Rims2	A	T	15: 39,342,011 (GRCm39)	Q620L	probably damaging	Het
Rnf215	T	G	11: 4,085,453 (GRCm39)	S58A	probably benign	Het
Scaper	A	C	9: 55,771,791 (GRCm39)	V375G	probably benign	Het
Sgk3	A	T	1: 9,872,520 (GRCm39)		probably benign	Het
Skic2	T	C	17: 35,066,408 (GRCm39)	K192E	probably benign	Het
Slc34a3	T	A	2: 25,123,312 (GRCm39)		probably null	Het
Sspn	T	A	6: 145,906,952 (GRCm39)	C52S	probably damaging	Het
Strip1	T	C	3: 107,534,142 (GRCm39)	E164G	possibly damaging	Het
Sult5a1	A	C	8: 123,884,181 (GRCm39)	S47A	probably damaging	Het
Svep1	T	C	4: 58,091,964 (GRCm39)	D1557G	possibly damaging	Het
Tdrd6	T	C	17: 43,940,224 (GRCm39)	I275V	probably damaging	Het
Thada	C	T	17: 84,499,411 (GRCm39)	V1929I	probably benign	Het
Tmem132b	G	A	5: 125,700,416 (GRCm39)	R318Q	probably damaging	Het
Tmem176b	T	G	6: 48,811,004 (GRCm39)	I259L	probably benign	Het
Tmppe	C	A	9: 114,234,964 (GRCm39)	P421Q	possibly damaging	Het
Tmprss11e	G	A	5: 86,857,315 (GRCm39)	Q333*	probably null	Het
Tpcn2	T	A	7: 144,821,071 (GRCm39)	R328W	possibly damaging	Het
Trem1	C	T	17: 48,544,083 (GRCm39)	T36I	probably damaging	Het
Trpm2	C	A	10: 77,767,973 (GRCm39)	R842L	probably damaging	Het
Zfp319	A	G	8: 96,052,199 (GRCm39)		probably benign	Het

Other mutations in Pkd1l3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Pkd1l3	APN	8	110,356,869 (GRCm39)	missense	possibly damaging	0.53
IGL00562:Pkd1l3	APN	8	110,382,779 (GRCm39)	missense	possibly damaging	0.53
IGL00563:Pkd1l3	APN	8	110,382,779 (GRCm39)	missense	possibly damaging	0.53
IGL01061:Pkd1l3	APN	8	110,365,338 (GRCm39)	missense	probably damaging	1.00
IGL01105:Pkd1l3	APN	8	110,388,873 (GRCm39)	missense	possibly damaging	0.81
IGL01574:Pkd1l3	APN	8	110,350,403 (GRCm39)	missense	probably benign	0.01
IGL01597:Pkd1l3	APN	8	110,350,153 (GRCm39)	missense	probably benign	0.33
IGL01634:Pkd1l3	APN	8	110,394,157 (GRCm39)	critical splice acceptor site	probably null
IGL01645:Pkd1l3	APN	8	110,361,934 (GRCm39)	missense	possibly damaging	0.59
IGL01770:Pkd1l3	APN	8	110,375,134 (GRCm39)	critical splice acceptor site	probably null
IGL01837:Pkd1l3	APN	8	110,356,798 (GRCm39)	missense	possibly damaging	0.85
IGL01862:Pkd1l3	APN	8	110,357,908 (GRCm39)	critical splice acceptor site	probably null
IGL01938:Pkd1l3	APN	8	110,361,933 (GRCm39)	missense	probably benign	0.00
IGL01990:Pkd1l3	APN	8	110,387,438 (GRCm39)	missense	probably damaging	1.00
IGL02056:Pkd1l3	APN	8	110,358,010 (GRCm39)	missense	probably benign	0.14
IGL02069:Pkd1l3	APN	8	110,362,012 (GRCm39)	missense	probably damaging	1.00
IGL02086:Pkd1l3	APN	8	110,392,217 (GRCm39)	missense	probably damaging	1.00
IGL02152:Pkd1l3	APN	8	110,395,924 (GRCm39)	missense	probably damaging	1.00
IGL02209:Pkd1l3	APN	8	110,365,296 (GRCm39)	missense	probably damaging	1.00
IGL02213:Pkd1l3	APN	8	110,357,977 (GRCm39)	missense	probably damaging	1.00
IGL02218:Pkd1l3	APN	8	110,387,434 (GRCm39)	missense	possibly damaging	0.92
IGL02225:Pkd1l3	APN	8	110,365,310 (GRCm39)	missense	probably damaging	1.00
IGL02252:Pkd1l3	APN	8	110,357,708 (GRCm39)	missense	possibly damaging	0.92
IGL02351:Pkd1l3	APN	8	110,373,129 (GRCm39)	unclassified	probably benign
IGL02358:Pkd1l3	APN	8	110,373,129 (GRCm39)	unclassified	probably benign
IGL02369:Pkd1l3	APN	8	110,342,977 (GRCm39)	missense	unknown
IGL02481:Pkd1l3	APN	8	110,341,414 (GRCm39)	missense	unknown
IGL02505:Pkd1l3	APN	8	110,359,848 (GRCm39)	missense	probably damaging	1.00
IGL02506:Pkd1l3	APN	8	110,374,132 (GRCm39)	missense	probably damaging	1.00
IGL02535:Pkd1l3	APN	8	110,367,522 (GRCm39)	nonsense	probably null
IGL02715:Pkd1l3	APN	8	110,353,458 (GRCm39)	missense	probably damaging	0.96
IGL02979:Pkd1l3	APN	8	110,388,736 (GRCm39)	splice site	probably benign
IGL03059:Pkd1l3	APN	8	110,374,999 (GRCm39)	missense	probably damaging	1.00
IGL03090:Pkd1l3	APN	8	110,382,165 (GRCm39)	nonsense	probably null
IGL03206:Pkd1l3	APN	8	110,350,345 (GRCm39)	missense	probably benign	0.18
IGL03328:Pkd1l3	APN	8	110,388,738 (GRCm39)	splice site	probably benign
BB006:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
PIT4453001:Pkd1l3	UTSW	8	110,387,433 (GRCm39)	missense	probably damaging	0.99
PIT4468001:Pkd1l3	UTSW	8	110,391,131 (GRCm39)	missense	possibly damaging	0.85
R0001:Pkd1l3	UTSW	8	110,355,265 (GRCm39)	splice site	probably benign
R0066:Pkd1l3	UTSW	8	110,347,103 (GRCm39)	missense	unknown
R0066:Pkd1l3	UTSW	8	110,347,103 (GRCm39)	missense	unknown
R0233:Pkd1l3	UTSW	8	110,377,412 (GRCm39)	nonsense	probably null
R0233:Pkd1l3	UTSW	8	110,377,412 (GRCm39)	nonsense	probably null
R0255:Pkd1l3	UTSW	8	110,365,386 (GRCm39)	missense	probably damaging	1.00
R0288:Pkd1l3	UTSW	8	110,373,131 (GRCm39)	splice site	probably null
R0311:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0311:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0403:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0403:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0441:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0446:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0465:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0465:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0466:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0467:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0468:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0488:Pkd1l3	UTSW	8	110,350,295 (GRCm39)	missense	probably benign	0.33
R0488:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0515:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0534:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0650:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R0689:Pkd1l3	UTSW	8	110,350,281 (GRCm39)	missense	possibly damaging	0.70
R1422:Pkd1l3	UTSW	8	110,348,340 (GRCm39)	missense	unknown
R1464:Pkd1l3	UTSW	8	110,363,059 (GRCm39)	splice site	probably benign
R1467:Pkd1l3	UTSW	8	110,343,000 (GRCm39)	missense	unknown
R1467:Pkd1l3	UTSW	8	110,343,000 (GRCm39)	missense	unknown
R1469:Pkd1l3	UTSW	8	110,373,585 (GRCm39)	missense	possibly damaging	0.72
R1469:Pkd1l3	UTSW	8	110,373,585 (GRCm39)	missense	possibly damaging	0.72
R1509:Pkd1l3	UTSW	8	110,367,402 (GRCm39)	missense	probably damaging	0.99
R1561:Pkd1l3	UTSW	8	110,341,445 (GRCm39)	missense	unknown
R1574:Pkd1l3	UTSW	8	110,341,445 (GRCm39)	missense	unknown
R1599:Pkd1l3	UTSW	8	110,363,016 (GRCm39)	missense	probably benign	0.01
R1688:Pkd1l3	UTSW	8	110,350,450 (GRCm39)	missense	probably benign	0.18
R1792:Pkd1l3	UTSW	8	110,359,237 (GRCm39)	missense	probably damaging	1.00
R1818:Pkd1l3	UTSW	8	110,375,038 (GRCm39)	missense	probably benign	0.03
R1896:Pkd1l3	UTSW	8	110,350,831 (GRCm39)	missense	possibly damaging	0.92
R2105:Pkd1l3	UTSW	8	110,374,205 (GRCm39)	nonsense	probably null
R2185:Pkd1l3	UTSW	8	110,359,827 (GRCm39)	missense	possibly damaging	0.95
R2192:Pkd1l3	UTSW	8	110,347,156 (GRCm39)	missense	unknown
R2260:Pkd1l3	UTSW	8	110,350,268 (GRCm39)	missense	probably benign	0.18
R2363:Pkd1l3	UTSW	8	110,355,341 (GRCm39)	missense	probably benign	0.01
R2418:Pkd1l3	UTSW	8	110,397,353 (GRCm39)	makesense	probably null
R2435:Pkd1l3	UTSW	8	110,377,334 (GRCm39)	missense	probably benign	0.07
R2443:Pkd1l3	UTSW	8	110,350,447 (GRCm39)	missense	probably benign	0.18
R2850:Pkd1l3	UTSW	8	110,350,622 (GRCm39)	missense	possibly damaging	0.92
R2910:Pkd1l3	UTSW	8	110,394,268 (GRCm39)	splice site	probably benign
R3755:Pkd1l3	UTSW	8	110,359,171 (GRCm39)	missense	probably damaging	1.00
R3791:Pkd1l3	UTSW	8	110,362,949 (GRCm39)	missense	probably damaging	0.99
R3905:Pkd1l3	UTSW	8	110,373,511 (GRCm39)	missense	probably benign	0.02
R4027:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4028:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4029:Pkd1l3	UTSW	8	110,350,603 (GRCm39)	missense	possibly damaging	0.68
R4274:Pkd1l3	UTSW	8	110,350,751 (GRCm39)	missense	possibly damaging	0.92
R4461:Pkd1l3	UTSW	8	110,359,345 (GRCm39)	splice site	probably null
R4893:Pkd1l3	UTSW	8	110,365,026 (GRCm39)	missense	probably benign	0.15
R4907:Pkd1l3	UTSW	8	110,367,475 (GRCm39)	missense	probably damaging	0.99
R5037:Pkd1l3	UTSW	8	110,392,268 (GRCm39)	missense	probably damaging	1.00
R5045:Pkd1l3	UTSW	8	110,349,787 (GRCm39)	missense	unknown
R5207:Pkd1l3	UTSW	8	110,359,823 (GRCm39)	missense	probably damaging	1.00
R5307:Pkd1l3	UTSW	8	110,367,424 (GRCm39)	missense	probably damaging	1.00
R5408:Pkd1l3	UTSW	8	110,393,684 (GRCm39)	missense	probably damaging	1.00
R5595:Pkd1l3	UTSW	8	110,382,152 (GRCm39)	missense	probably damaging	1.00
R5615:Pkd1l3	UTSW	8	110,356,842 (GRCm39)	missense	probably benign
R5896:Pkd1l3	UTSW	8	110,353,468 (GRCm39)	missense	probably damaging	1.00
R6101:Pkd1l3	UTSW	8	110,367,478 (GRCm39)	missense	probably damaging	1.00
R6105:Pkd1l3	UTSW	8	110,367,478 (GRCm39)	missense	probably damaging	1.00
R6170:Pkd1l3	UTSW	8	110,349,811 (GRCm39)	missense	unknown
R6330:Pkd1l3	UTSW	8	110,373,541 (GRCm39)	missense	probably benign	0.00
R6346:Pkd1l3	UTSW	8	110,358,016 (GRCm39)	missense	probably damaging	0.98
R6395:Pkd1l3	UTSW	8	110,350,595 (GRCm39)	missense	probably benign	0.20
R6475:Pkd1l3	UTSW	8	110,349,844 (GRCm39)	missense	unknown
R6480:Pkd1l3	UTSW	8	110,365,019 (GRCm39)	nonsense	probably null
R6519:Pkd1l3	UTSW	8	110,355,404 (GRCm39)	missense	probably benign
R6654:Pkd1l3	UTSW	8	110,350,915 (GRCm39)	missense	probably benign	0.23
R6717:Pkd1l3	UTSW	8	110,341,401 (GRCm39)	missense	unknown
R6733:Pkd1l3	UTSW	8	110,375,126 (GRCm39)	splice site	probably null
R6753:Pkd1l3	UTSW	8	110,351,081 (GRCm39)	missense	probably damaging	1.00
R6777:Pkd1l3	UTSW	8	110,353,446 (GRCm39)	missense	probably benign	0.00
R6901:Pkd1l3	UTSW	8	110,341,246 (GRCm39)	missense	unknown
R6975:Pkd1l3	UTSW	8	110,387,539 (GRCm39)	missense	possibly damaging	0.73
R6991:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7018:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7083:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7139:Pkd1l3	UTSW	8	110,362,972 (GRCm39)	missense	probably damaging	0.96
R7153:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7235:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7238:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7252:Pkd1l3	UTSW	8	110,387,330 (GRCm39)	missense	probably benign	0.01
R7296:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7309:Pkd1l3	UTSW	8	110,374,893 (GRCm39)	splice site	probably null
R7362:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7462:Pkd1l3	UTSW	8	110,355,409 (GRCm39)	missense	probably benign	0.00
R7470:Pkd1l3	UTSW	8	110,365,008 (GRCm39)	missense	probably benign	0.09
R7478:Pkd1l3	UTSW	8	110,359,947 (GRCm39)	missense	probably damaging	1.00
R7483:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7516:Pkd1l3	UTSW	8	110,361,861 (GRCm39)	missense	probably damaging	1.00
R7553:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7559:Pkd1l3	UTSW	8	110,351,072 (GRCm39)	missense	probably benign	0.03
R7650:Pkd1l3	UTSW	8	110,399,217 (GRCm39)	missense	probably benign	0.23
R7654:Pkd1l3	UTSW	8	110,365,049 (GRCm39)	missense	probably damaging	1.00
R7742:Pkd1l3	UTSW	8	110,341,204 (GRCm39)	missense	unknown
R7749:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7751:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7755:Pkd1l3	UTSW	8	110,356,798 (GRCm39)	missense	possibly damaging	0.85
R7816:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7831:Pkd1l3	UTSW	8	110,357,990 (GRCm39)	missense	possibly damaging	0.47
R7835:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7849:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R7917:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7929:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R7952:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8054:Pkd1l3	UTSW	8	110,373,008 (GRCm39)	missense	probably damaging	1.00
R8098:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8099:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8276:Pkd1l3	UTSW	8	110,397,353 (GRCm39)	makesense	probably null
R8352:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8376:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R8377:Pkd1l3	UTSW	8	110,361,982 (GRCm39)	missense	probably benign	0.08
R8398:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8399:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8400:Pkd1l3	UTSW	8	110,350,520 (GRCm39)	missense	possibly damaging	0.93
R8412:Pkd1l3	UTSW	8	110,360,022 (GRCm39)	missense	possibly damaging	0.85
R8530:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8539:Pkd1l3	UTSW	8	110,362,919 (GRCm39)	missense	probably damaging	1.00
R8546:Pkd1l3	UTSW	8	110,393,615 (GRCm39)	missense	possibly damaging	0.52
R8558:Pkd1l3	UTSW	8	110,362,012 (GRCm39)	missense	probably damaging	1.00
R8719:Pkd1l3	UTSW	8	110,341,255 (GRCm39)	missense	unknown
R8769:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8797:Pkd1l3	UTSW	8	110,374,946 (GRCm39)	missense	probably benign	0.15
R8840:Pkd1l3	UTSW	8	110,349,842 (GRCm39)	missense	unknown
R8846:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8874:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8893:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8956:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8963:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R8968:Pkd1l3	UTSW	8	110,350,420 (GRCm39)	small deletion	probably benign
R9035:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9054:Pkd1l3	UTSW	8	110,392,304 (GRCm39)	missense	probably benign	0.08
R9058:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9119:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9134:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9138:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9158:Pkd1l3	UTSW	8	110,394,207 (GRCm39)	nonsense	probably null
R9180:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9181:Pkd1l3	UTSW	8	110,375,318 (GRCm39)	missense	probably damaging	0.98
R9218:Pkd1l3	UTSW	8	110,382,128 (GRCm39)	nonsense	probably null
R9249:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9269:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9338:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9383:Pkd1l3	UTSW	8	110,350,601 (GRCm39)	small deletion	probably benign
R9396:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9423:Pkd1l3	UTSW	8	110,350,312 (GRCm39)	missense	possibly damaging	0.53
R9514:Pkd1l3	UTSW	8	110,395,849 (GRCm39)	missense	probably damaging	1.00
R9515:Pkd1l3	UTSW	8	110,395,849 (GRCm39)	missense	probably damaging	1.00
R9567:Pkd1l3	UTSW	8	110,394,173 (GRCm39)	missense	probably damaging	0.99
R9668:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9684:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
R9748:Pkd1l3	UTSW	8	110,373,555 (GRCm39)	missense	probably benign	0.00
R9778:Pkd1l3	UTSW	8	110,357,937 (GRCm39)	missense	probably benign	0.00
RF016:Pkd1l3	UTSW	8	110,350,174 (GRCm39)	missense	probably benign	0.18
RF029:Pkd1l3	UTSW	8	110,350,827 (GRCm39)	small deletion	probably benign
X0026:Pkd1l3	UTSW	8	110,341,185 (GRCm39)	missense	probably null
Z1176:Pkd1l3	UTSW	8	110,349,874 (GRCm39)	missense	unknown
Z31818:Pkd1l3	UTSW	8	110,395,924 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAGCCACATCTGCATCTAGC -3'
(R):5'- AATCCAGGTGTGTCTGATGTC -3'

Sequencing Primer
(F):5'- TCTAGCAGCCCACCACAGG -3'
(R):5'- CAGGTGTGTCTGATGTCCCCTG -3'

Posted On

2016-11-08