|Institutional Source||Beutler Lab|
|Gene Name||triggering receptor expressed on myeloid cells 1|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5623 (G1)|
|Chromosomal Location||48232768-48246924 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 48237055 bp (GRCm38)|
|Amino Acid Change||Threonine to Isoleucine at position 36 (T36I)|
|Ref Sequence||ENSEMBL: ENSMUSP00000038636 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000048782] [ENSMUST00000113251]|
|PDB Structure||Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76 [X-RAY DIFFRACTION]|
AA Change: T36I
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: T36I
|Meta Mutation Damage Score||0.6447|
|Coding Region Coverage||
|Validation Efficiency||98% (65/66)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for a reporter allele exhibit decreased susceptibility to DEN induced tumors and liver damage. Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Trem1||
(F):5'- GTTCAGTTTCCACAGACCACAAATC -3'
(R):5'- AGTCTGTCACTTGAAGGTCAGTC -3'
(F):5'- GACCACAAATCATTGACTCTTGTAC -3'
(R):5'- GAACTTGTAGCATGGCCTCACTAG -3'