Incidental Mutation 'R5624:Or13p5'
ID 441724
Institutional Source Beutler Lab
Gene Symbol Or13p5
Ensembl Gene ENSMUSG00000070820
Gene Name olfactory receptor family 13 subfamily P member 5
Synonyms Olfr1339, MOR258-2, GA_x6K02T2QD9B-18815145-18814198
MMRRC Submission 043163-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5624 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 118591728-118592675 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 118592568 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 281 (Y281N)
Ref Sequence ENSEMBL: ENSMUSP00000148988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094832] [ENSMUST00000217522]
AlphaFold Q8VGB1
Predicted Effect probably damaging
Transcript: ENSMUST00000094832
AA Change: Y281N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092428
Gene: ENSMUSG00000070820
AA Change: Y281N

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 307 4.1e-7 PFAM
Pfam:7tm_1 44 293 3e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217522
AA Change: Y281N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad2 T A 8: 120,341,844 (GRCm39) probably null Het
Aoah A T 13: 21,179,649 (GRCm39) N372I probably damaging Het
Ash1l T A 3: 88,892,916 (GRCm39) D1598E probably damaging Het
Bcas2 T C 3: 103,080,577 (GRCm39) C72R probably benign Het
Car9 T A 4: 43,509,146 (GRCm39) F238Y probably benign Het
Ccnd1 T C 7: 144,491,749 (GRCm39) S97G probably benign Het
Cfap52 C G 11: 67,818,184 (GRCm39) C509S possibly damaging Het
Clcn4 C A 7: 7,291,943 (GRCm39) V623L probably benign Het
Dnajc11 T C 4: 152,063,967 (GRCm39) V483A probably benign Het
E2f8 G T 7: 48,527,709 (GRCm39) D144E probably damaging Het
Epb41l1 G A 2: 156,375,691 (GRCm39) probably benign Het
Fam186a A C 15: 99,839,628 (GRCm39) H2205Q possibly damaging Het
Fhit A G 14: 10,421,534 (GRCm38) S85P probably damaging Het
Fzd8 G A 18: 9,213,268 (GRCm39) G117S unknown Het
Gsdmc4 A G 15: 63,764,503 (GRCm39) M379T possibly damaging Het
Hemk1 T C 9: 107,208,727 (GRCm39) R157G probably benign Het
Il10 A G 1: 130,951,940 (GRCm39) M158V probably benign Het
Jmjd1c G A 10: 67,069,193 (GRCm39) M1656I probably damaging Het
Kit A T 5: 75,770,054 (GRCm39) K155N probably benign Het
Lmtk3 C A 7: 45,436,286 (GRCm39) A114E probably damaging Het
Lztr1 A G 16: 17,329,993 (GRCm39) probably benign Het
Mras A G 9: 99,293,538 (GRCm39) F34S probably damaging Het
Myo1c A G 11: 75,553,461 (GRCm39) T516A probably damaging Het
Nme8 A C 13: 19,862,038 (GRCm39) V197G possibly damaging Het
Or8k39 T C 2: 86,563,149 (GRCm39) D269G probably benign Het
Pcdhb9 A T 18: 37,534,459 (GRCm39) Y151F probably benign Het
Pcnx2 C T 8: 126,488,262 (GRCm39) probably null Het
Plekhg4 T C 8: 106,107,382 (GRCm39) F892S probably damaging Het
Prmt3 T A 7: 49,430,082 (GRCm39) F62I probably damaging Het
Ralgapa1 T C 12: 55,659,523 (GRCm39) Y1999C probably damaging Het
Rims2 A T 15: 39,208,809 (GRCm39) Q204L possibly damaging Het
Slc6a16 T G 7: 44,910,532 (GRCm39) H352Q probably benign Het
Snx9 T A 17: 5,942,084 (GRCm39) C70* probably null Het
Srprb A G 9: 103,074,800 (GRCm39) I114T probably damaging Het
Tas2r119 A T 15: 32,178,114 (GRCm39) I227F probably damaging Het
Tasor2 A G 13: 3,634,996 (GRCm39) S604P possibly damaging Het
Tg A T 15: 66,709,906 (GRCm39) Y163F probably benign Het
Tm2d2 A G 8: 25,512,784 (GRCm39) T211A probably damaging Het
Tmem132b A G 5: 125,699,710 (GRCm39) S83G probably benign Het
Trav9-4 T C 14: 53,913,886 (GRCm39) S47P probably benign Het
Vmn2r8 T A 5: 108,950,325 (GRCm39) H174L probably damaging Het
Xrcc1 A G 7: 24,259,270 (GRCm39) D85G possibly damaging Het
Zfp106 C G 2: 120,362,438 (GRCm39) A34P probably damaging Het
Zfp608 A T 18: 55,031,344 (GRCm39) N865K probably damaging Het
Zscan5b A G 7: 6,233,518 (GRCm39) D114G probably benign Het
Other mutations in Or13p5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Or13p5 APN 4 118,591,803 (GRCm39) missense probably benign 0.01
R0433:Or13p5 UTSW 4 118,592,287 (GRCm39) missense probably benign 0.20
R0600:Or13p5 UTSW 4 118,591,986 (GRCm39) missense probably damaging 0.99
R0737:Or13p5 UTSW 4 118,592,421 (GRCm39) missense probably benign 0.01
R1167:Or13p5 UTSW 4 118,591,829 (GRCm39) missense possibly damaging 0.83
R1655:Or13p5 UTSW 4 118,592,196 (GRCm39) missense probably benign 0.18
R2152:Or13p5 UTSW 4 118,592,446 (GRCm39) missense possibly damaging 0.90
R3883:Or13p5 UTSW 4 118,591,882 (GRCm39) missense probably benign 0.38
R4715:Or13p5 UTSW 4 118,591,852 (GRCm39) missense probably damaging 1.00
R4750:Or13p5 UTSW 4 118,591,930 (GRCm39) missense possibly damaging 0.66
R4887:Or13p5 UTSW 4 118,591,885 (GRCm39) missense probably benign 0.20
R4888:Or13p5 UTSW 4 118,591,885 (GRCm39) missense probably benign 0.20
R7268:Or13p5 UTSW 4 118,592,605 (GRCm39) missense probably damaging 1.00
R7783:Or13p5 UTSW 4 118,592,099 (GRCm39) missense probably damaging 1.00
R7796:Or13p5 UTSW 4 118,591,882 (GRCm39) missense probably damaging 0.97
R8676:Or13p5 UTSW 4 118,592,235 (GRCm39) missense probably damaging 1.00
Z1177:Or13p5 UTSW 4 118,592,653 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCCACCATTCTGAGAATCC -3'
(R):5'- GCGAGCCATGTCCTTTAACC -3'

Sequencing Primer
(F):5'- TGAGAATCCGCTCAGCCC -3'
(R):5'- AACCCTCAGTGAATGGTTCTTG -3'
Posted On 2016-11-08