|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 119|
|Synonyms||mGR19, T2R19, mt2r19, Tas2r19|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5624 (G1)|
|Chromosomal Location||32177289-32178294 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 32177968 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 227 (I227F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000050277 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000057633]|
|Predicted Effect||probably damaging
AA Change: I227F
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: I227F
|Meta Mutation Damage Score||0.6386|
|Coding Region Coverage||
|Validation Efficiency||98% (47/48)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r119||
(F):5'- GCATGCCACACTACTCTCAGTC -3'
(R):5'- TTGAGGTGACCCAAGCTCTTG -3'
(F):5'- ACACTACTCTCAGTCTTTGTCTTTGG -3'
(R):5'- GTGACCCAAGCTCTTGCACAATG -3'