Incidental Mutation 'R5624:Tas2r119'
ID 441754
Institutional Source Beutler Lab
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mt2r19, mGR19, Tas2r19, T2R19
MMRRC Submission 043163-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5624 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 32177435-32178440 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32178114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 227 (I227F)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057633
AA Change: I227F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: I227F

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.1e-90 PFAM
Meta Mutation Damage Score 0.6386 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad2 T A 8: 120,341,844 (GRCm39) probably null Het
Aoah A T 13: 21,179,649 (GRCm39) N372I probably damaging Het
Ash1l T A 3: 88,892,916 (GRCm39) D1598E probably damaging Het
Bcas2 T C 3: 103,080,577 (GRCm39) C72R probably benign Het
Car9 T A 4: 43,509,146 (GRCm39) F238Y probably benign Het
Ccnd1 T C 7: 144,491,749 (GRCm39) S97G probably benign Het
Cfap52 C G 11: 67,818,184 (GRCm39) C509S possibly damaging Het
Clcn4 C A 7: 7,291,943 (GRCm39) V623L probably benign Het
Dnajc11 T C 4: 152,063,967 (GRCm39) V483A probably benign Het
E2f8 G T 7: 48,527,709 (GRCm39) D144E probably damaging Het
Epb41l1 G A 2: 156,375,691 (GRCm39) probably benign Het
Fam186a A C 15: 99,839,628 (GRCm39) H2205Q possibly damaging Het
Fhit A G 14: 10,421,534 (GRCm38) S85P probably damaging Het
Fzd8 G A 18: 9,213,268 (GRCm39) G117S unknown Het
Gsdmc4 A G 15: 63,764,503 (GRCm39) M379T possibly damaging Het
Hemk1 T C 9: 107,208,727 (GRCm39) R157G probably benign Het
Il10 A G 1: 130,951,940 (GRCm39) M158V probably benign Het
Jmjd1c G A 10: 67,069,193 (GRCm39) M1656I probably damaging Het
Kit A T 5: 75,770,054 (GRCm39) K155N probably benign Het
Lmtk3 C A 7: 45,436,286 (GRCm39) A114E probably damaging Het
Lztr1 A G 16: 17,329,993 (GRCm39) probably benign Het
Mras A G 9: 99,293,538 (GRCm39) F34S probably damaging Het
Myo1c A G 11: 75,553,461 (GRCm39) T516A probably damaging Het
Nme8 A C 13: 19,862,038 (GRCm39) V197G possibly damaging Het
Or13p5 T A 4: 118,592,568 (GRCm39) Y281N probably damaging Het
Or8k39 T C 2: 86,563,149 (GRCm39) D269G probably benign Het
Pcdhb9 A T 18: 37,534,459 (GRCm39) Y151F probably benign Het
Pcnx2 C T 8: 126,488,262 (GRCm39) probably null Het
Plekhg4 T C 8: 106,107,382 (GRCm39) F892S probably damaging Het
Prmt3 T A 7: 49,430,082 (GRCm39) F62I probably damaging Het
Ralgapa1 T C 12: 55,659,523 (GRCm39) Y1999C probably damaging Het
Rims2 A T 15: 39,208,809 (GRCm39) Q204L possibly damaging Het
Slc6a16 T G 7: 44,910,532 (GRCm39) H352Q probably benign Het
Snx9 T A 17: 5,942,084 (GRCm39) C70* probably null Het
Srprb A G 9: 103,074,800 (GRCm39) I114T probably damaging Het
Tasor2 A G 13: 3,634,996 (GRCm39) S604P possibly damaging Het
Tg A T 15: 66,709,906 (GRCm39) Y163F probably benign Het
Tm2d2 A G 8: 25,512,784 (GRCm39) T211A probably damaging Het
Tmem132b A G 5: 125,699,710 (GRCm39) S83G probably benign Het
Trav9-4 T C 14: 53,913,886 (GRCm39) S47P probably benign Het
Vmn2r8 T A 5: 108,950,325 (GRCm39) H174L probably damaging Het
Xrcc1 A G 7: 24,259,270 (GRCm39) D85G possibly damaging Het
Zfp106 C G 2: 120,362,438 (GRCm39) A34P probably damaging Het
Zfp608 A T 18: 55,031,344 (GRCm39) N865K probably damaging Het
Zscan5b A G 7: 6,233,518 (GRCm39) D114G probably benign Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Tas2r119 APN 15 32,177,599 (GRCm39) missense probably damaging 0.97
IGL01522:Tas2r119 APN 15 32,178,339 (GRCm39) missense probably benign 0.15
IGL01548:Tas2r119 APN 15 32,178,123 (GRCm39) missense probably damaging 1.00
IGL01826:Tas2r119 APN 15 32,177,548 (GRCm39) missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32,177,853 (GRCm39) missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32,177,679 (GRCm39) missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32,178,297 (GRCm39) missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32,178,165 (GRCm39) missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32,178,228 (GRCm39) missense probably benign 0.03
R5819:Tas2r119 UTSW 15 32,177,452 (GRCm39) missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32,178,034 (GRCm39) missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32,177,676 (GRCm39) missense probably benign
R6521:Tas2r119 UTSW 15 32,178,319 (GRCm39) missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32,178,279 (GRCm39) missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32,178,109 (GRCm39) missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32,178,226 (GRCm39) missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32,177,932 (GRCm39) missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32,178,301 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCATGCCACACTACTCTCAGTC -3'
(R):5'- TTGAGGTGACCCAAGCTCTTG -3'

Sequencing Primer
(F):5'- ACACTACTCTCAGTCTTTGTCTTTGG -3'
(R):5'- GTGACCCAAGCTCTTGCACAATG -3'
Posted On 2016-11-08