Incidental Mutation 'R5625:Wdr93'
ID441799
Institutional Source Beutler Lab
Gene Symbol Wdr93
Ensembl Gene ENSMUSG00000039099
Gene NameWD repeat domain 93
SynonymsEG626359
MMRRC Submission 043164-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R5625 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location79743163-79785950 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 79771018 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 376 (T376A)
Ref Sequence ENSEMBL: ENSMUSP00000037467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035622]
Predicted Effect probably benign
Transcript: ENSMUST00000035622
AA Change: T376A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000037467
Gene: ENSMUSG00000039099
AA Change: T376A

DomainStartEndE-ValueType
low complexity region 240 251 N/A INTRINSIC
low complexity region 265 274 N/A INTRINSIC
SCOP:d1jofa_ 389 607 7e-4 SMART
Blast:WD40 413 451 2e-11 BLAST
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 T G 9: 44,278,036 D388A probably benign Het
Ampd3 A C 7: 110,802,523 E408A probably damaging Het
BC027072 T A 17: 71,751,326 D452V probably damaging Het
Bmp1 G T 14: 70,486,166 N743K probably benign Het
Brsk1 A G 7: 4,706,400 K398E probably damaging Het
Ccdc157 A T 11: 4,151,888 M11K probably damaging Het
Cep295 A C 9: 15,340,891 M394R probably damaging Het
Cfap44 G T 16: 44,460,347 probably null Het
Col13a1 C T 10: 61,843,609 G713R unknown Het
Cxcr2 A T 1: 74,158,832 K162* probably null Het
Cyp3a44 C T 5: 145,779,566 D405N possibly damaging Het
Exo1 G T 1: 175,893,814 D340Y possibly damaging Het
Farp2 T G 1: 93,528,748 L51R probably damaging Het
Fat4 A T 3: 38,888,934 I659F possibly damaging Het
Gbp2b T A 3: 142,599,045 W81R probably damaging Het
Gipc2 C T 3: 152,165,904 probably benign Het
Gm10941 G T 10: 77,258,836 probably benign Het
Gm1988 A T 7: 39,173,805 noncoding transcript Het
Hapln3 G T 7: 79,117,258 probably null Het
Ifi213 A G 1: 173,569,063 S482P possibly damaging Het
Insc A G 7: 114,829,067 T92A probably damaging Het
Lrrn1 T A 6: 107,567,354 C38S probably damaging Het
Mycbpap T C 11: 94,505,693 E107G probably damaging Het
Neb A T 2: 52,177,535 L5848* probably null Het
Nrg3 A T 14: 38,370,993 M545K probably damaging Het
Nudt3 A G 17: 27,583,228 L28P probably damaging Het
Olfr955 T A 9: 39,469,803 M308L probably benign Het
Otop1 A T 5: 38,302,761 Y557F probably damaging Het
Pdgfra G A 5: 75,189,337 probably null Het
Pi4kb A G 3: 94,984,677 M223V probably benign Het
Piezo1 T C 8: 122,482,960 T2335A probably benign Het
Ppp6c A G 2: 39,197,441 V251A probably benign Het
Prkg1 C T 19: 31,764,762 E21K possibly damaging Het
Ptpru T C 4: 131,803,380 E521G probably null Het
Rasl10b G T 11: 83,418,814 R199L probably damaging Het
Rhbdf2 G A 11: 116,605,377 R111C probably damaging Het
Sec23ip G T 7: 128,744,983 probably benign Het
Sptbn5 A T 2: 120,079,792 noncoding transcript Het
Srsf11 C T 3: 158,023,344 probably benign Het
Syne2 T C 12: 76,095,112 S6141P probably benign Het
Szt2 A G 4: 118,373,217 V2653A unknown Het
Tex46 T C 4: 136,610,614 F39S probably damaging Het
Tmem50a AACCA AA 4: 134,898,467 probably benign Het
Tmem62 G T 2: 120,990,393 W180L probably damaging Het
Tnxb G A 17: 34,685,211 A1232T probably benign Het
Tubgcp3 T C 8: 12,624,888 H744R possibly damaging Het
Uggt2 A G 14: 119,077,724 I311T probably damaging Het
Usp8 C T 2: 126,742,277 R469C probably damaging Het
Vmn1r19 T C 6: 57,405,296 L278S probably damaging Het
Vmn2r59 A T 7: 42,046,460 I176N probably benign Het
Vmn2r-ps159 A T 4: 156,334,210 noncoding transcript Het
Zfp575 G A 7: 24,585,652 A188V possibly damaging Het
Other mutations in Wdr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00928:Wdr93 APN 7 79775553 missense probably damaging 1.00
IGL01910:Wdr93 APN 7 79771573 missense probably damaging 1.00
IGL01977:Wdr93 APN 7 79752505 missense probably damaging 1.00
IGL01979:Wdr93 APN 7 79776652 missense probably benign 0.03
IGL02191:Wdr93 APN 7 79749220 missense probably damaging 0.98
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R1136:Wdr93 UTSW 7 79773448 missense probably damaging 1.00
R1168:Wdr93 UTSW 7 79749174 missense probably damaging 0.99
R1586:Wdr93 UTSW 7 79768361 missense probably damaging 0.99
R1605:Wdr93 UTSW 7 79771509 splice site probably null
R1651:Wdr93 UTSW 7 79750082 missense probably benign 0.00
R3078:Wdr93 UTSW 7 79752493 missense possibly damaging 0.81
R3689:Wdr93 UTSW 7 79771585 missense possibly damaging 0.91
R4013:Wdr93 UTSW 7 79768411 missense possibly damaging 0.90
R4771:Wdr93 UTSW 7 79776763 missense probably damaging 0.99
R4824:Wdr93 UTSW 7 79750069 nonsense probably null
R4887:Wdr93 UTSW 7 79785774 missense probably damaging 1.00
R5172:Wdr93 UTSW 7 79752493 missense probably damaging 0.97
R5510:Wdr93 UTSW 7 79750031 missense probably damaging 1.00
R5648:Wdr93 UTSW 7 79777226 missense probably benign 0.04
R5950:Wdr93 UTSW 7 79773431 missense probably damaging 0.99
R6147:Wdr93 UTSW 7 79758497 missense probably benign
R6530:Wdr93 UTSW 7 79755993 missense probably damaging 1.00
R7056:Wdr93 UTSW 7 79749340 missense probably damaging 1.00
R7079:Wdr93 UTSW 7 79749292 missense probably damaging 1.00
R7309:Wdr93 UTSW 7 79773355 missense possibly damaging 0.86
R7397:Wdr93 UTSW 7 79766424 missense probably null 0.01
R7426:Wdr93 UTSW 7 79777307 critical splice donor site probably null
R7455:Wdr93 UTSW 7 79775519 missense probably benign 0.09
R7618:Wdr93 UTSW 7 79785726 missense probably benign 0.02
R8360:Wdr93 UTSW 7 79749226 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTAAAGCTGGGGTCTCCTTTGG -3'
(R):5'- CCATCTTAGGGAAACTGGGC -3'

Sequencing Primer
(F):5'- ATGTCCAAGGTCTGTTCGGCC -3'
(R):5'- CATCTTAGGGAAACTGGGCTCAGG -3'
Posted On2016-11-08