Incidental Mutation 'R5626:Cpxm2'
ID 441839
Institutional Source Beutler Lab
Gene Symbol Cpxm2
Ensembl Gene ENSMUSG00000030862
Gene Name carboxypeptidase X, M14 family member 2
Synonyms 4632435C11Rik
MMRRC Submission 043165-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5626 (G1)
Quality Score 113
Status Not validated
Chromosome 7
Chromosomal Location 131634416-131756468 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) TGCAGCAGCAGCAGCAGCAG to TGCAGCAGCAGCAGCAG at 131661581 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033149] [ENSMUST00000124096]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000033149
SMART Domains Protein: ENSMUSP00000033149
Gene: ENSMUSG00000030862

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 52 59 N/A INTRINSIC
low complexity region 72 82 N/A INTRINSIC
low complexity region 87 98 N/A INTRINSIC
FA58C 143 301 2.18e-46 SMART
Zn_pept 448 736 9.21e-58 SMART
low complexity region 751 764 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122681
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127039
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150405
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh1 G C 3: 137,986,171 (GRCm39) V53L probably benign Het
Arfgap2 C T 2: 91,105,737 (GRCm39) Q514* probably null Het
Calhm2 A C 19: 47,121,558 (GRCm39) C204G probably damaging Het
Carhsp1 T C 16: 8,478,897 (GRCm39) N119D probably benign Het
Cfap57 A G 4: 118,471,980 (GRCm39) L133P probably damaging Het
Clcn4 A T 7: 7,292,017 (GRCm39) V598E probably damaging Het
Ddi1 T C 9: 6,266,003 (GRCm39) H122R probably benign Het
Dync1h1 A G 12: 110,607,575 (GRCm39) T2697A probably benign Het
Ednrb T A 14: 104,080,564 (GRCm39) I117F probably damaging Het
Egflam A G 15: 7,280,688 (GRCm39) S446P possibly damaging Het
F5 A G 1: 164,036,604 (GRCm39) I1922V probably damaging Het
Gpc1 T A 1: 92,784,841 (GRCm39) probably null Het
Gphn A C 12: 78,730,671 (GRCm39) I769L probably benign Het
Grid2 T C 6: 64,053,929 (GRCm39) probably null Het
Hira G T 16: 18,746,262 (GRCm39) Q468H probably damaging Het
Hmcn1 C T 1: 150,532,318 (GRCm39) G3154E probably damaging Het
Ighv16-1 G A 12: 114,032,472 (GRCm39) T92M probably damaging Het
Lcmt2 T C 2: 120,969,943 (GRCm39) E380G probably benign Het
Ms4a14 A G 19: 11,281,419 (GRCm39) F380L probably benign Het
Myof T C 19: 37,911,438 (GRCm39) N1511D probably benign Het
Ncbp1 G A 4: 46,161,290 (GRCm39) S422N probably damaging Het
Pcolce T A 5: 137,608,661 (GRCm39) T26S probably damaging Het
Pitpnm3 T C 11: 72,003,158 (GRCm39) I51V probably benign Het
Plcb3 T C 19: 6,932,643 (GRCm39) S1041G probably benign Het
Ppp5c T C 7: 16,761,629 (GRCm39) D37G probably benign Het
Prkca T C 11: 107,948,641 (GRCm39) D116G possibly damaging Het
Qrsl1 A T 10: 43,757,516 (GRCm39) D367E probably benign Het
Rbm26 T C 14: 105,381,667 (GRCm39) T493A probably benign Het
Saxo1 T C 4: 86,363,826 (GRCm39) E219G probably damaging Het
Slc22a16 A T 10: 40,460,849 (GRCm39) probably null Het
Tmem30c T C 16: 57,096,506 (GRCm39) N205S possibly damaging Het
Trp53i11 A G 2: 93,029,723 (GRCm39) N119S possibly damaging Het
Wnt3a A T 11: 59,181,409 (GRCm39) I22N probably benign Het
Zfp998 A G 13: 66,580,040 (GRCm39) Y148H probably benign Het
Other mutations in Cpxm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01862:Cpxm2 APN 7 131,661,540 (GRCm39) missense probably benign 0.01
IGL02039:Cpxm2 APN 7 131,649,482 (GRCm39) missense probably damaging 1.00
IGL03011:Cpxm2 APN 7 131,650,807 (GRCm39) missense possibly damaging 0.46
R0033:Cpxm2 UTSW 7 131,663,886 (GRCm39) missense possibly damaging 0.55
R0100:Cpxm2 UTSW 7 131,656,600 (GRCm39) missense possibly damaging 0.90
R0100:Cpxm2 UTSW 7 131,656,600 (GRCm39) missense possibly damaging 0.90
R0453:Cpxm2 UTSW 7 131,730,134 (GRCm39) missense probably damaging 1.00
R0555:Cpxm2 UTSW 7 131,645,772 (GRCm39) nonsense probably null
R0655:Cpxm2 UTSW 7 131,656,549 (GRCm39) missense possibly damaging 0.87
R0834:Cpxm2 UTSW 7 131,756,342 (GRCm39) intron probably benign
R1145:Cpxm2 UTSW 7 131,659,377 (GRCm39) missense probably damaging 0.99
R1145:Cpxm2 UTSW 7 131,659,377 (GRCm39) missense probably damaging 0.99
R1249:Cpxm2 UTSW 7 131,730,079 (GRCm39) critical splice donor site probably null
R1563:Cpxm2 UTSW 7 131,745,411 (GRCm39) missense probably benign 0.00
R1565:Cpxm2 UTSW 7 131,663,874 (GRCm39) missense probably damaging 1.00
R1709:Cpxm2 UTSW 7 131,661,563 (GRCm39) missense probably damaging 1.00
R1863:Cpxm2 UTSW 7 131,745,392 (GRCm39) splice site probably null
R1874:Cpxm2 UTSW 7 131,661,563 (GRCm39) missense probably damaging 1.00
R1958:Cpxm2 UTSW 7 131,663,876 (GRCm39) missense probably damaging 1.00
R2273:Cpxm2 UTSW 7 131,661,581 (GRCm39) intron probably benign
R3806:Cpxm2 UTSW 7 131,681,820 (GRCm39) missense probably benign 0.12
R3861:Cpxm2 UTSW 7 131,656,648 (GRCm39) missense probably benign 0.00
R4570:Cpxm2 UTSW 7 131,745,435 (GRCm39) missense probably benign 0.11
R4642:Cpxm2 UTSW 7 131,672,610 (GRCm39) missense probably benign 0.11
R4684:Cpxm2 UTSW 7 131,650,767 (GRCm39) missense possibly damaging 0.92
R4717:Cpxm2 UTSW 7 131,656,574 (GRCm39) missense possibly damaging 0.61
R4863:Cpxm2 UTSW 7 131,661,476 (GRCm39) missense probably benign 0.13
R5079:Cpxm2 UTSW 7 131,756,014 (GRCm39) critical splice donor site probably null
R5341:Cpxm2 UTSW 7 131,756,342 (GRCm39) intron probably benign
R5666:Cpxm2 UTSW 7 131,656,625 (GRCm39) missense probably benign 0.44
R5815:Cpxm2 UTSW 7 131,645,839 (GRCm39) missense probably damaging 1.00
R6114:Cpxm2 UTSW 7 131,756,035 (GRCm39) missense probably benign
R6133:Cpxm2 UTSW 7 131,730,182 (GRCm39) missense probably damaging 1.00
R6224:Cpxm2 UTSW 7 131,745,460 (GRCm39) missense probably benign
R6468:Cpxm2 UTSW 7 131,672,589 (GRCm39) missense probably damaging 1.00
R6657:Cpxm2 UTSW 7 131,650,806 (GRCm39) missense probably damaging 1.00
R7058:Cpxm2 UTSW 7 131,745,408 (GRCm39) missense probably benign 0.32
R7100:Cpxm2 UTSW 7 131,656,544 (GRCm39) missense probably benign 0.06
R7198:Cpxm2 UTSW 7 131,681,813 (GRCm39) missense probably damaging 1.00
R7712:Cpxm2 UTSW 7 131,756,107 (GRCm39) missense possibly damaging 0.69
R7855:Cpxm2 UTSW 7 131,659,424 (GRCm39) missense possibly damaging 0.56
R7867:Cpxm2 UTSW 7 131,650,800 (GRCm39) missense probably damaging 1.00
R8513:Cpxm2 UTSW 7 131,745,431 (GRCm39) missense probably benign 0.01
R8694:Cpxm2 UTSW 7 131,681,783 (GRCm39) missense probably benign 0.03
R8874:Cpxm2 UTSW 7 131,708,010 (GRCm39) critical splice donor site probably null
R8967:Cpxm2 UTSW 7 131,661,564 (GRCm39) missense probably damaging 1.00
R9680:Cpxm2 UTSW 7 131,661,651 (GRCm39) missense probably damaging 1.00
R9759:Cpxm2 UTSW 7 131,756,242 (GRCm39) missense probably benign 0.03
RF014:Cpxm2 UTSW 7 131,672,592 (GRCm39) missense possibly damaging 0.85
Z1177:Cpxm2 UTSW 7 131,656,730 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAGCACACCCTTAGAGTTGG -3'
(R):5'- TGGCTCTAGTCATTCAGGCTTG -3'

Sequencing Primer
(F):5'- GCACACCCTTAGAGTTGGGATAC -3'
(R):5'- AGTCATTCAGGCTTGCTATCTACAG -3'
Posted On 2016-11-08