Incidental Mutation 'R5628:Or5m10b'
ID 441911
Institutional Source Beutler Lab
Gene Symbol Or5m10b
Ensembl Gene ENSMUSG00000057761
Gene Name olfactory receptor family 5 subfamily M member 10B
Synonyms GA_x6K02T2Q125-47347069-47348016, Olfr1022, MOR196-1
MMRRC Submission 043167-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5628 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 85698938-85699885 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85699149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 71 (I71N)
Ref Sequence ENSEMBL: ENSMUSP00000059312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054736] [ENSMUST00000121914]
AlphaFold L7MTT3
Predicted Effect probably damaging
Transcript: ENSMUST00000054736
AA Change: I71N

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000059312
Gene: ENSMUSG00000057761
AA Change: I71N

DomainStartEndE-ValueType
Pfam:7tm_4 31 312 4.8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 304 8e-6 PFAM
Pfam:7tm_1 41 290 9.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121914
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 A G 8: 41,208,747 (GRCm39) D671G probably benign Het
Ap3b1 A G 13: 94,613,556 (GRCm39) D685G unknown Het
Atp6v1h G A 1: 5,206,112 (GRCm39) W358* probably null Het
Atr T A 9: 95,756,279 (GRCm39) Y830* probably null Het
B3galnt2 A T 13: 14,169,737 (GRCm39) probably null Het
Casz1 T C 4: 149,030,553 (GRCm39) Y1191H probably damaging Het
Cdc40 T G 10: 40,727,049 (GRCm39) E169D probably benign Het
Cep55 C T 19: 38,058,396 (GRCm39) Q330* probably null Het
Clcn1 T C 6: 42,275,823 (GRCm39) V315A probably damaging Het
Cmya5 A G 13: 93,226,218 (GRCm39) F2957L probably damaging Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Dync1li2 T C 8: 105,147,224 (GRCm39) N490S possibly damaging Het
Ephb3 T C 16: 21,036,869 (GRCm39) Y111H probably damaging Het
Fam186a A C 15: 99,839,628 (GRCm39) H2205Q possibly damaging Het
Fat3 T C 9: 15,877,392 (GRCm39) Y3407C probably damaging Het
Fbxw8 A G 5: 118,230,622 (GRCm39) V393A probably damaging Het
Fnip1 A T 11: 54,394,459 (GRCm39) D965V probably benign Het
Gramd2a T C 9: 59,615,006 (GRCm39) M3T probably benign Het
Kctd15 T C 7: 34,339,720 (GRCm39) D283G probably damaging Het
Kif9 C T 9: 110,343,621 (GRCm39) R547* probably null Het
Map4 A G 9: 109,910,915 (GRCm39) T245A probably benign Het
Mindy4 C T 6: 55,237,579 (GRCm39) L385F probably damaging Het
Myo7b A G 18: 32,107,240 (GRCm39) C1252R probably benign Het
Myt1l T A 12: 29,861,620 (GRCm39) I134N unknown Het
Osgin2 T A 4: 15,998,998 (GRCm39) N208I probably benign Het
Polr2b G A 5: 77,461,063 (GRCm39) V29M probably damaging Het
Prdm15 T A 16: 97,600,823 (GRCm39) M812L probably damaging Het
Prr36 TGCTTTGCTGGTCTGTGGAAGAGCGGCTTTGCTGGTCTGTGGAAGAGCGGCTTTGCTGGTCTGTGGAAGAGCGGCTTTGC TGCTTTGCTGGTCTGTGGAAGAGCGGCTTTGCTGGTCTGTGGAAGAGCGGCTTTGC 8: 4,266,273 (GRCm39) probably benign Het
Rev3l T A 10: 39,698,963 (GRCm39) N1153K probably damaging Het
Rnf17 A G 14: 56,724,409 (GRCm39) probably null Het
Rusc2 C T 4: 43,425,348 (GRCm39) T1151M probably damaging Het
Scrib T C 15: 75,921,389 (GRCm39) T30A possibly damaging Het
Sephs1 T C 2: 4,894,018 (GRCm39) I73T probably benign Het
Sf3b1 C T 1: 55,037,334 (GRCm39) A861T probably benign Het
Shq1 A G 6: 100,607,964 (GRCm39) W316R probably damaging Het
Slc26a5 T A 5: 22,021,974 (GRCm39) D484V probably benign Het
Smg1 C T 7: 117,753,924 (GRCm39) probably benign Het
Stard5 T C 7: 83,282,355 (GRCm39) I56T probably benign Het
Szt2 A G 4: 118,230,414 (GRCm39) V2653A unknown Het
Tmem217 A T 17: 29,745,430 (GRCm39) I100N probably damaging Het
Trpm2 C T 10: 77,748,470 (GRCm39) R1400Q probably benign Het
Vmn1r82 T G 7: 12,039,205 (GRCm39) N41K probably damaging Het
Zfp236 T C 18: 82,675,247 (GRCm39) D367G probably damaging Het
Zfyve1 A T 12: 83,621,663 (GRCm39) V244E probably benign Het
Other mutations in Or5m10b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02701:Or5m10b APN 2 85,699,802 (GRCm39) missense probably benign 0.22
IGL03265:Or5m10b APN 2 85,699,494 (GRCm39) missense possibly damaging 0.80
PIT4366001:Or5m10b UTSW 2 85,699,226 (GRCm39) missense probably damaging 1.00
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0057:Or5m10b UTSW 2 85,699,597 (GRCm39) nonsense probably null
R0554:Or5m10b UTSW 2 85,699,863 (GRCm39) missense probably benign 0.00
R3873:Or5m10b UTSW 2 85,699,306 (GRCm39) nonsense probably null
R3913:Or5m10b UTSW 2 85,699,115 (GRCm39) missense probably damaging 1.00
R4698:Or5m10b UTSW 2 85,699,596 (GRCm39) missense possibly damaging 0.90
R6467:Or5m10b UTSW 2 85,699,714 (GRCm39) nonsense probably null
R6947:Or5m10b UTSW 2 85,699,271 (GRCm39) missense probably benign 0.01
R7092:Or5m10b UTSW 2 85,698,951 (GRCm39) missense probably damaging 1.00
R7351:Or5m10b UTSW 2 85,694,415 (GRCm39) unclassified probably benign
R7574:Or5m10b UTSW 2 85,699,350 (GRCm39) missense probably benign 0.03
R8430:Or5m10b UTSW 2 85,699,526 (GRCm39) missense probably benign 0.00
R8771:Or5m10b UTSW 2 85,699,712 (GRCm39) missense probably damaging 0.99
R8969:Or5m10b UTSW 2 85,699,832 (GRCm39) missense probably benign 0.19
R9101:Or5m10b UTSW 2 85,694,523 (GRCm39) unclassified probably benign
R9630:Or5m10b UTSW 2 85,699,493 (GRCm39) missense probably benign 0.00
R9649:Or5m10b UTSW 2 85,699,819 (GRCm39) missense probably damaging 1.00
R9649:Or5m10b UTSW 2 85,699,278 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- GTCACTTTCAGCTTGCAAGG -3'
(R):5'- ACTGTAATGCAAGGGGCTGC -3'

Sequencing Primer
(F):5'- ACTGCAGTGATGGATTTCATTC -3'
(R):5'- CTGTAATGCAAGGGGCTGCAAATAG -3'
Posted On 2016-11-08