Incidental Mutation 'R5654:Or5m11b'
ID 442149
Institutional Source Beutler Lab
Gene Symbol Or5m11b
Ensembl Gene ENSMUSG00000059873
Gene Name olfactory receptor family 5 subfamily M member 11B
Synonyms GA_x6K02T2Q125-47454152-47455126, Olfr1029, MOR198-1P
MMRRC Submission 043300-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5654 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85805557-85806617 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85806500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 304 (I304M)
Ref Sequence ENSEMBL: ENSMUSP00000150637 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849] [ENSMUST00000082191] [ENSMUST00000217244]
AlphaFold A2ATE0
Predicted Effect probably benign
Transcript: ENSMUST00000056849
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000082191
AA Change: I304M

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000080828
Gene: ENSMUSG00000059873
AA Change: I304M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.2e-56 PFAM
Pfam:7tm_1 41 290 2.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217244
AA Change: I304M

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 96% (69/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 T C 1: 75,151,479 (GRCm39) probably null Het
Abcc9 G A 6: 142,571,371 (GRCm39) probably benign Het
Acss2 T C 2: 155,416,575 (GRCm39) probably benign Het
Atp8b4 G A 2: 126,217,725 (GRCm39) T597I probably damaging Het
Btaf1 A T 19: 36,961,015 (GRCm39) N796I probably benign Het
Caskin2 T C 11: 115,690,905 (GRCm39) probably null Het
Cdhr2 A G 13: 54,884,349 (GRCm39) N1295D probably benign Het
Cog3 G A 14: 75,962,239 (GRCm39) T534M probably benign Het
Cpne1 A G 2: 155,919,561 (GRCm39) S303P probably damaging Het
Cs G A 10: 128,187,086 (GRCm39) G74S possibly damaging Het
Cyb5r4 G T 9: 86,929,533 (GRCm39) S229I probably damaging Het
Ddr1 C T 17: 35,997,400 (GRCm39) A531T probably benign Het
Ect2l C T 10: 18,018,810 (GRCm39) V529M probably damaging Het
Edaradd C A 13: 12,493,161 (GRCm39) R177L possibly damaging Het
Esf1 T C 2: 140,006,148 (GRCm39) D333G possibly damaging Het
Fam8a1 T A 13: 46,827,814 (GRCm39) L334H probably damaging Het
Fbxl18 A G 5: 142,871,558 (GRCm39) I559T probably damaging Het
Fcrl2 A C 3: 87,164,851 (GRCm39) V225G probably benign Het
Ido1 C T 8: 25,077,819 (GRCm39) V83M probably damaging Het
Iffo1 T G 6: 125,130,030 (GRCm39) C419G probably damaging Het
Igfals A T 17: 25,100,439 (GRCm39) Y510F probably benign Het
Ipo9 A T 1: 135,313,210 (GRCm39) Y1006* probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Jmjd1c T A 10: 67,065,785 (GRCm39) S1737T probably benign Het
Klhl32 C T 4: 24,800,805 (GRCm39) probably null Het
Klk1b11 T A 7: 43,427,810 (GRCm39) C173S probably damaging Het
Klk1b24 A T 7: 43,840,889 (GRCm39) M106L probably benign Het
Lamp1 G A 8: 13,221,388 (GRCm39) probably null Het
Mapk4 A T 18: 74,103,365 (GRCm39) V48E probably damaging Het
Marchf6 A T 15: 31,486,082 (GRCm39) D395E probably damaging Het
Mdp1 A G 14: 55,896,465 (GRCm39) F157S probably damaging Het
Mettl21e A T 1: 44,250,255 (GRCm39) F50L probably damaging Het
Mrgpra2a A G 7: 47,077,153 (GRCm39) I35T probably benign Het
Natd1 T C 11: 60,796,892 (GRCm39) Y91C probably damaging Het
Nbas T A 12: 13,633,476 (GRCm39) Y2294N probably damaging Het
Nrcam A G 12: 44,610,841 (GRCm39) T520A probably benign Het
Nrf1 A G 6: 30,117,061 (GRCm39) T324A probably benign Het
Or10a2 G A 7: 106,673,394 (GRCm39) A120T probably damaging Het
Or4k51 T A 2: 111,585,326 (GRCm39) I244N probably damaging Het
Or52a5 A C 7: 103,427,182 (GRCm39) D123E probably damaging Het
Pam C T 1: 97,792,123 (GRCm39) V433I probably benign Het
Pck1 T A 2: 173,000,353 (GRCm39) Y595N probably damaging Het
Per2 C T 1: 91,373,223 (GRCm39) probably null Het
Piezo2 G C 18: 63,278,162 (GRCm39) F247L possibly damaging Het
Pkdcc A G 17: 83,523,337 (GRCm39) Y148C probably damaging Het
Plod2 A G 9: 92,475,876 (GRCm39) T320A probably benign Het
Ppip5k1 G A 2: 121,147,157 (GRCm39) R1155C probably benign Het
Ppp1r15b C T 1: 133,059,382 (GRCm39) probably benign Het
Prkn C T 17: 11,456,536 (GRCm39) A119V probably damaging Het
Ptprz1 G T 6: 22,986,133 (GRCm39) C311F probably damaging Het
Rab11fip3 A T 17: 26,235,038 (GRCm39) V44E probably damaging Het
Rpl5 T A 5: 108,051,514 (GRCm39) probably benign Het
Rttn G A 18: 89,066,556 (GRCm39) V1201I probably benign Het
Sdk1 A G 5: 141,921,853 (GRCm39) N283S probably damaging Het
Shank3 T A 15: 89,405,529 (GRCm39) N418K probably benign Het
Shmt2 T C 10: 127,353,668 (GRCm39) D499G probably benign Het
Slc25a46 A G 18: 31,716,293 (GRCm39) L403S probably damaging Het
Slc5a1 A G 5: 33,303,955 (GRCm39) T257A probably benign Het
Snrnp35 T C 5: 124,628,535 (GRCm39) V116A probably benign Het
Spag9 T A 11: 93,981,538 (GRCm39) F593I probably damaging Het
Tmem171 C A 13: 98,828,574 (GRCm39) R192L probably benign Het
Trappc3l T A 10: 33,978,703 (GRCm39) L169Q unknown Het
Ube2s T C 7: 4,811,431 (GRCm39) E148G probably damaging Het
Uspl1 T C 5: 149,146,521 (GRCm39) F424S probably damaging Het
Vmn1r2 T C 4: 3,172,261 (GRCm39) V60A probably benign Het
Wdfy4 T C 14: 32,829,575 (GRCm39) probably null Het
Zfp735 C T 11: 73,602,964 (GRCm39) S636L possibly damaging Het
Zswim9 G A 7: 12,995,094 (GRCm39) S354F probably damaging Het
Other mutations in Or5m11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02020:Or5m11b APN 2 85,805,579 (GRCm39) utr 5 prime probably benign
IGL02126:Or5m11b APN 2 85,806,517 (GRCm39) missense probably benign 0.00
IGL02584:Or5m11b APN 2 85,806,219 (GRCm39) missense probably damaging 0.96
IGL03410:Or5m11b APN 2 85,805,764 (GRCm39) missense probably damaging 0.99
R1466:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R1466:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R1499:Or5m11b UTSW 2 85,806,372 (GRCm39) missense possibly damaging 0.62
R1584:Or5m11b UTSW 2 85,806,339 (GRCm39) missense probably damaging 1.00
R2925:Or5m11b UTSW 2 85,806,125 (GRCm39) nonsense probably null
R2970:Or5m11b UTSW 2 85,806,454 (GRCm39) missense possibly damaging 0.75
R4571:Or5m11b UTSW 2 85,806,175 (GRCm39) missense probably damaging 0.97
R5533:Or5m11b UTSW 2 85,805,797 (GRCm39) missense possibly damaging 0.78
R5827:Or5m11b UTSW 2 85,805,650 (GRCm39) missense probably benign 0.00
R5967:Or5m11b UTSW 2 85,806,535 (GRCm39) missense probably benign 0.01
R6291:Or5m11b UTSW 2 85,805,926 (GRCm39) missense probably damaging 1.00
R6735:Or5m11b UTSW 2 85,805,778 (GRCm39) missense possibly damaging 0.81
R6897:Or5m11b UTSW 2 85,805,700 (GRCm39) missense possibly damaging 0.45
R7053:Or5m11b UTSW 2 85,806,358 (GRCm39) missense possibly damaging 0.64
R7163:Or5m11b UTSW 2 85,805,932 (GRCm39) missense probably damaging 1.00
R7358:Or5m11b UTSW 2 85,805,780 (GRCm39) missense possibly damaging 0.81
R8047:Or5m11b UTSW 2 85,806,271 (GRCm39) missense possibly damaging 0.52
R8271:Or5m11b UTSW 2 85,806,085 (GRCm39) missense probably benign 0.40
R8271:Or5m11b UTSW 2 85,805,766 (GRCm39) missense probably damaging 1.00
R8364:Or5m11b UTSW 2 85,806,358 (GRCm39) missense possibly damaging 0.64
R9100:Or5m11b UTSW 2 85,806,096 (GRCm39) missense probably benign 0.00
R9190:Or5m11b UTSW 2 85,805,884 (GRCm39) missense possibly damaging 0.66
R9646:Or5m11b UTSW 2 85,806,446 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- CAAGGCATTCTCTACTTGTGGTTCC -3'
(R):5'- GGTCCATGAAGTACAGGCTG -3'

Sequencing Primer
(F):5'- CACATGATGGCTGTCACATTG -3'
(R):5'- TCCATGAAGTACAGGCTGTAAAATAG -3'
Posted On 2016-11-09