Mutagenetix > Incidental Mutation

Incidental Mutation 'R5656:Nav3'

442337

Institutional Source

Beutler Lab

Gene Symbol

Nav3

Ensembl Gene

ENSMUSG00000020181

Gene Name

neuron navigator 3

Synonyms

POMFIL1, 9630020C08Rik, 4732483H20Rik, unc53H3, steerin 3, Pomfil1p

MMRRC Submission

043302-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5656 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109681259-110456204 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 109764633 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 1378 (S1378A)

Ref Sequence

ENSEMBL: ENSMUSP00000032719 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032719]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000032719
AA Change: S1378A

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000032719
Gene: ENSMUSG00000020181
AA Change: S1378A

Domain	Start	End	E-Value	Type
CH	79	182	4.41e-12	SMART
low complexity region	184	194	N/A	INTRINSIC
low complexity region	318	329	N/A	INTRINSIC
low complexity region	353	363	N/A	INTRINSIC
low complexity region	427	439	N/A	INTRINSIC
low complexity region	522	536	N/A	INTRINSIC
low complexity region	713	724	N/A	INTRINSIC
low complexity region	807	818	N/A	INTRINSIC
low complexity region	873	896	N/A	INTRINSIC
low complexity region	904	916	N/A	INTRINSIC
low complexity region	1077	1095	N/A	INTRINSIC
low complexity region	1160	1173	N/A	INTRINSIC
low complexity region	1207	1229	N/A	INTRINSIC
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1274	1285	N/A	INTRINSIC
low complexity region	1293	1312	N/A	INTRINSIC
low complexity region	1327	1341	N/A	INTRINSIC
low complexity region	1383	1397	N/A	INTRINSIC
low complexity region	1462	1474	N/A	INTRINSIC
low complexity region	1550	1563	N/A	INTRINSIC
coiled coil region	1565	1656	N/A	INTRINSIC
low complexity region	1675	1692	N/A	INTRINSIC
low complexity region	1722	1733	N/A	INTRINSIC
low complexity region	1756	1781	N/A	INTRINSIC
low complexity region	1782	1795	N/A	INTRINSIC
coiled coil region	1801	1842	N/A	INTRINSIC
low complexity region	1848	1871	N/A	INTRINSIC
AAA	2029	2184	4.94e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161582

SMART Domains

Protein: ENSMUSP00000124591
Gene: ENSMUSG00000020181

Domain	Start	End	E-Value	Type
low complexity region	84	95	N/A	INTRINSIC
low complexity region	150	173	N/A	INTRINSIC
low complexity region	181	193	N/A	INTRINSIC
low complexity region	354	372	N/A	INTRINSIC
low complexity region	437	450	N/A	INTRINSIC
low complexity region	484	506	N/A	INTRINSIC
low complexity region	533	543	N/A	INTRINSIC
low complexity region	551	562	N/A	INTRINSIC
low complexity region	570	589	N/A	INTRINSIC
low complexity region	604	618	N/A	INTRINSIC
low complexity region	660	674	N/A	INTRINSIC
low complexity region	739	751	N/A	INTRINSIC
low complexity region	827	840	N/A	INTRINSIC
coiled coil region	842	933	N/A	INTRINSIC
low complexity region	952	969	N/A	INTRINSIC
low complexity region	992	1003	N/A	INTRINSIC
low complexity region	1026	1051	N/A	INTRINSIC
low complexity region	1052	1065	N/A	INTRINSIC
coiled coil region	1071	1112	N/A	INTRINSIC
low complexity region	1118	1141	N/A	INTRINSIC
AAA	1299	1454	4.94e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163071

SMART Domains

Protein: ENSMUSP00000124856
Gene: ENSMUSG00000020181

Domain	Start	End	E-Value	Type
low complexity region	19	33	N/A	INTRINSIC
low complexity region	75	89	N/A	INTRINSIC
low complexity region	140	152	N/A	INTRINSIC

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933405L10Rik	A	G	8: 105,709,512 (GRCm38)	S139G	probably benign	Het
Adrb3	T	C	8: 27,227,377 (GRCm38)	D348G	probably damaging	Het
Atg2b	A	G	12: 105,621,328 (GRCm38)	V1959A	probably benign	Het
Bicral	G	A	17: 46,808,369 (GRCm38)	T742M	probably damaging	Het
Bub1b	T	A	2: 118,605,431 (GRCm38)	I60N	probably damaging	Het
Ccdc162	A	G	10: 41,569,934 (GRCm38)	V414A	probably benign	Het
Cd22	T	G	7: 30,869,773 (GRCm38)	Y612S	probably damaging	Het
Cd68	T	A	11: 69,664,421 (GRCm38)	I320F	probably damaging	Het
Clca3a2	A	T	3: 144,797,632 (GRCm38)	N852K	probably benign	Het
Cpa6	T	A	1: 10,329,514 (GRCm38)	H363L	probably benign	Het
Ddx18	A	T	1: 121,561,358 (GRCm38)	L320Q	probably damaging	Het
Dnah5	A	G	15: 28,421,064 (GRCm38)	D3849G	probably benign	Het
Eci1	T	A	17: 24,437,309 (GRCm38)	N164K	probably damaging	Het
Efs	T	C	14: 54,917,127 (GRCm38)	T552A	probably damaging	Het
Fbp1	C	A	13: 62,875,196 (GRCm38)	V96L	probably damaging	Het
Gtf3c1	T	A	7: 125,662,654 (GRCm38)	N1139I	probably benign	Het
Gucy1b2	T	C	14: 62,422,981 (GRCm38)	Y152C	probably damaging	Het
Gxylt1	A	T	15: 93,245,661 (GRCm38)	L362Q	probably damaging	Het
Iqcd	A	G	5: 120,605,126 (GRCm38)		probably null	Het
Klhl41	T	A	2: 69,683,532 (GRCm38)	I585N	possibly damaging	Het
Map6	A	G	7: 99,336,298 (GRCm38)	K470E	probably damaging	Het
Mast3	T	C	8: 70,786,221 (GRCm38)	T496A	probably damaging	Het
Mbd6	A	T	10: 127,285,286 (GRCm38)		probably benign	Het
Melk	A	G	4: 44,312,237 (GRCm38)	K183R	possibly damaging	Het
Mta1	T	C	12: 113,123,139 (GRCm38)	V152A	probably damaging	Het
Naa35	G	A	13: 59,622,866 (GRCm38)		probably benign	Het
Ncapd3	T	A	9: 27,051,645 (GRCm38)	D415E	possibly damaging	Het
Nlrp4f	G	A	13: 65,190,871 (GRCm38)	R651*	probably null	Het
Olfr1480	A	G	19: 13,530,380 (GRCm38)	T280A	probably benign	Het
Olfr397	T	A	11: 73,964,710 (GRCm38)	M34K	probably damaging	Het
Olfr497	A	G	7: 108,422,618 (GRCm38)	I16V	probably benign	Het
P2rx7	A	T	5: 122,673,717 (GRCm38)	R364W	probably damaging	Het
Phactr2	T	C	10: 13,388,703 (GRCm38)	D2G	probably benign	Het
Phc3	G	T	3: 30,965,866 (GRCm38)	S28R	probably damaging	Het
Ppfia1	A	T	7: 144,519,974 (GRCm38)		probably null	Het
Prdm10	C	T	9: 31,353,417 (GRCm38)	T667M	probably benign	Het
Pwwp2b	T	A	7: 139,255,971 (GRCm38)	S443T	possibly damaging	Het
Pzp	T	C	6: 128,490,072 (GRCm38)	T1113A	probably damaging	Het
Rapgef6	A	G	11: 54,636,136 (GRCm38)	E551G	possibly damaging	Het
Sec23ip	A	G	7: 128,776,784 (GRCm38)	Y774C	probably damaging	Het
Setdb2	T	C	14: 59,419,118 (GRCm38)	D266G	probably damaging	Het
Shank1	T	C	7: 44,352,886 (GRCm38)	V1343A	probably benign	Het
Slf2	T	A	19: 44,973,235 (GRCm38)	D1064E	probably benign	Het
Slu7	A	G	11: 43,443,418 (GRCm38)	K424E	probably benign	Het
Smg1	A	T	7: 118,154,664 (GRCm38)		probably benign	Het
Sptlc2	A	T	12: 87,346,761 (GRCm38)	L264Q	probably damaging	Het
Sra1	A	G	18: 36,678,407 (GRCm38)	S93P	probably damaging	Het
Sult1c1	T	C	17: 53,964,652 (GRCm38)	E169G	probably benign	Het
Sv2a	A	G	3: 96,185,572 (GRCm38)	D196G	probably damaging	Het
Tbc1d22b	A	G	17: 29,594,780 (GRCm38)	I362M	probably damaging	Het
Tenm3	T	C	8: 48,228,762 (GRCm38)	D2611G	probably damaging	Het
Tmem43	T	C	6: 91,480,708 (GRCm38)	F191L	probably benign	Het
Trbv13-2	T	A	6: 41,121,694 (GRCm38)	Y68N	probably benign	Het
Ttn	T	G	2: 76,774,654 (GRCm38)	D18312A	possibly damaging	Het
Ublcp1	A	G	11: 44,465,606 (GRCm38)	V95A	probably damaging	Het
Usp17ld	A	G	7: 103,250,840 (GRCm38)	V295A	probably damaging	Het
Vmn1r29	T	A	6: 58,308,167 (GRCm38)	L291M	possibly damaging	Het
Vsig10l	C	T	7: 43,464,151 (GRCm38)	R176*	probably null	Het
Zbtb46	A	G	2: 181,423,417 (GRCm38)		probably null	Het
Zfp644	A	G	5: 106,637,982 (GRCm38)	V233A	probably benign	Het

Other mutations in Nav3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00095:Nav3	APN	10	109,841,733 (GRCm38)	missense	probably damaging	0.99
IGL00425:Nav3	APN	10	109,703,507 (GRCm38)	missense	probably benign	0.13
IGL00465:Nav3	APN	10	109,852,746 (GRCm38)	missense	probably damaging	0.99
IGL00531:Nav3	APN	10	109,703,310 (GRCm38)	missense	probably null	0.99
IGL00575:Nav3	APN	10	109,764,765 (GRCm38)	missense	probably damaging	0.98
IGL00770:Nav3	APN	10	109,816,263 (GRCm38)	missense	probably damaging	1.00
IGL00774:Nav3	APN	10	109,816,263 (GRCm38)	missense	probably damaging	1.00
IGL00858:Nav3	APN	10	109,742,632 (GRCm38)	missense	probably damaging	0.98
IGL00935:Nav3	APN	10	109,705,666 (GRCm38)	missense	probably benign
IGL01638:Nav3	APN	10	109,852,863 (GRCm38)	missense	probably damaging	1.00
IGL01662:Nav3	APN	10	109,769,258 (GRCm38)	missense	possibly damaging	0.56
IGL01670:Nav3	APN	10	109,714,241 (GRCm38)	missense	possibly damaging	0.92
IGL01885:Nav3	APN	10	109,742,660 (GRCm38)	nonsense	probably null
IGL01979:Nav3	APN	10	109,704,929 (GRCm38)	missense	probably benign	0.01
IGL02121:Nav3	APN	10	109,759,036 (GRCm38)	missense	probably damaging	0.99
IGL02210:Nav3	APN	10	109,766,990 (GRCm38)	missense	probably benign
IGL02523:Nav3	APN	10	109,769,296 (GRCm38)	missense	probably damaging	1.00
IGL02573:Nav3	APN	10	109,866,974 (GRCm38)	missense	probably benign	0.23
IGL02633:Nav3	APN	10	109,692,136 (GRCm38)	missense	probably benign	0.09
IGL02810:Nav3	APN	10	109,816,274 (GRCm38)	missense	probably damaging	1.00
IGL02964:Nav3	APN	10	109,736,953 (GRCm38)	missense	probably damaging	0.99
IGL03015:Nav3	APN	10	109,718,297 (GRCm38)	missense	probably damaging	0.98
IGL03288:Nav3	APN	10	109,759,017 (GRCm38)	missense	probably damaging	1.00
IGL03310:Nav3	APN	10	109,824,572 (GRCm38)	critical splice donor site	probably null
PIT4377001:Nav3	UTSW	10	109,716,605 (GRCm38)	missense	probably damaging	0.99
R0010:Nav3	UTSW	10	109,823,226 (GRCm38)	splice site	probably benign
R0043:Nav3	UTSW	10	109,767,518 (GRCm38)	missense	possibly damaging	0.95
R0053:Nav3	UTSW	10	109,766,917 (GRCm38)	splice site	probably benign
R0053:Nav3	UTSW	10	109,766,917 (GRCm38)	splice site	probably benign
R0077:Nav3	UTSW	10	109,716,642 (GRCm38)	missense	possibly damaging	0.87
R0219:Nav3	UTSW	10	109,866,930 (GRCm38)	critical splice donor site	probably null
R0310:Nav3	UTSW	10	109,767,128 (GRCm38)	missense	possibly damaging	0.82
R0380:Nav3	UTSW	10	109,758,879 (GRCm38)	splice site	probably benign
R0403:Nav3	UTSW	10	109,767,103 (GRCm38)	missense	probably damaging	0.98
R0480:Nav3	UTSW	10	109,853,300 (GRCm38)	missense	probably damaging	1.00
R0626:Nav3	UTSW	10	109,823,464 (GRCm38)	missense	probably damaging	1.00
R0637:Nav3	UTSW	10	109,770,197 (GRCm38)	missense	probably benign	0.25
R0847:Nav3	UTSW	10	109,903,857 (GRCm38)	missense	possibly damaging	0.94
R0988:Nav3	UTSW	10	109,716,528 (GRCm38)	missense	probably damaging	1.00
R1272:Nav3	UTSW	10	109,736,999 (GRCm38)	missense	probably damaging	0.98
R1295:Nav3	UTSW	10	109,692,102 (GRCm38)	missense	probably damaging	1.00
R1405:Nav3	UTSW	10	109,770,333 (GRCm38)	splice site	probably benign
R1406:Nav3	UTSW	10	109,883,634 (GRCm38)	missense	possibly damaging	0.64
R1406:Nav3	UTSW	10	109,883,634 (GRCm38)	missense	possibly damaging	0.64
R1420:Nav3	UTSW	10	109,823,254 (GRCm38)	missense	probably benign	0.02
R1449:Nav3	UTSW	10	109,853,511 (GRCm38)	missense	probably benign	0.13
R1458:Nav3	UTSW	10	109,720,044 (GRCm38)	missense	probably damaging	1.00
R1469:Nav3	UTSW	10	109,760,508 (GRCm38)	missense	probably damaging	1.00
R1469:Nav3	UTSW	10	109,760,508 (GRCm38)	missense	probably damaging	1.00
R1472:Nav3	UTSW	10	109,727,941 (GRCm38)	missense	probably damaging	0.99
R1537:Nav3	UTSW	10	109,866,985 (GRCm38)	missense	probably damaging	1.00
R1539:Nav3	UTSW	10	109,767,170 (GRCm38)	missense	probably damaging	0.99
R1581:Nav3	UTSW	10	109,823,428 (GRCm38)	missense	probably damaging	1.00
R1586:Nav3	UTSW	10	109,853,254 (GRCm38)	missense	probably damaging	1.00
R1654:Nav3	UTSW	10	109,853,123 (GRCm38)	missense	possibly damaging	0.85
R1725:Nav3	UTSW	10	109,823,590 (GRCm38)	missense	probably damaging	1.00
R1742:Nav3	UTSW	10	109,769,213 (GRCm38)	missense	probably benign
R1793:Nav3	UTSW	10	109,703,372 (GRCm38)	missense	probably benign	0.00
R1830:Nav3	UTSW	10	109,823,323 (GRCm38)	missense	probably damaging	1.00
R1834:Nav3	UTSW	10	109,720,022 (GRCm38)	missense	probably damaging	0.99
R1881:Nav3	UTSW	10	109,852,559 (GRCm38)	missense	probably damaging	0.96
R1922:Nav3	UTSW	10	109,705,606 (GRCm38)	missense	probably benign	0.43
R1944:Nav3	UTSW	10	109,716,530 (GRCm38)	missense	probably damaging	0.99
R1981:Nav3	UTSW	10	109,719,090 (GRCm38)	splice site	probably benign
R1985:Nav3	UTSW	10	109,770,184 (GRCm38)	splice site	probably benign
R1996:Nav3	UTSW	10	109,853,401 (GRCm38)	missense	probably damaging	1.00
R2051:Nav3	UTSW	10	109,824,675 (GRCm38)	missense	probably damaging	0.99
R2062:Nav3	UTSW	10	109,720,021 (GRCm38)	missense	probably damaging	1.00
R2139:Nav3	UTSW	10	109,853,135 (GRCm38)	missense	probably benign	0.22
R2248:Nav3	UTSW	10	109,696,227 (GRCm38)	missense	probably damaging	1.00
R2420:Nav3	UTSW	10	109,863,813 (GRCm38)	missense	probably damaging	0.98
R2444:Nav3	UTSW	10	109,764,915 (GRCm38)	missense	probably benign	0.09
R3026:Nav3	UTSW	10	109,824,604 (GRCm38)	missense	probably damaging	0.99
R3052:Nav3	UTSW	10	109,903,752 (GRCm38)	missense	probably damaging	0.99
R3441:Nav3	UTSW	10	109,704,928 (GRCm38)	missense	probably benign	0.01
R3845:Nav3	UTSW	10	109,853,376 (GRCm38)	missense	possibly damaging	0.82
R3929:Nav3	UTSW	10	109,684,203 (GRCm38)	missense	probably damaging	1.00
R3932:Nav3	UTSW	10	109,694,035 (GRCm38)	missense	probably damaging	0.99
R4056:Nav3	UTSW	10	109,880,533 (GRCm38)	critical splice donor site	probably null
R4057:Nav3	UTSW	10	109,880,533 (GRCm38)	critical splice donor site	probably null
R4120:Nav3	UTSW	10	109,903,744 (GRCm38)	critical splice donor site	probably null
R4244:Nav3	UTSW	10	109,769,296 (GRCm38)	missense	probably damaging	1.00
R4361:Nav3	UTSW	10	109,852,986 (GRCm38)	missense	probably damaging	1.00
R4512:Nav3	UTSW	10	109,694,082 (GRCm38)	missense	possibly damaging	0.89
R4514:Nav3	UTSW	10	109,694,082 (GRCm38)	missense	possibly damaging	0.89
R4700:Nav3	UTSW	10	109,764,935 (GRCm38)	missense	probably benign	0.10
R4815:Nav3	UTSW	10	109,823,552 (GRCm38)	missense	probably benign
R4981:Nav3	UTSW	10	109,880,692 (GRCm38)	missense	probably benign
R5042:Nav3	UTSW	10	109,769,268 (GRCm38)	missense	probably benign	0.27
R5251:Nav3	UTSW	10	109,853,253 (GRCm38)	missense	probably damaging	0.99
R5252:Nav3	UTSW	10	109,714,291 (GRCm38)	small deletion	probably benign
R5273:Nav3	UTSW	10	109,693,038 (GRCm38)	critical splice donor site	probably null
R5288:Nav3	UTSW	10	109,853,105 (GRCm38)	missense	probably benign	0.10
R5407:Nav3	UTSW	10	109,866,935 (GRCm38)	missense	probably benign	0.28
R5533:Nav3	UTSW	10	109,883,678 (GRCm38)	missense	possibly damaging	0.61
R5561:Nav3	UTSW	10	109,716,552 (GRCm38)	missense	probably damaging	1.00
R5577:Nav3	UTSW	10	109,769,403 (GRCm38)	missense	probably damaging	1.00
R5872:Nav3	UTSW	10	109,764,787 (GRCm38)	missense	probably damaging	1.00
R6023:Nav3	UTSW	10	109,823,515 (GRCm38)	missense	possibly damaging	0.95
R6061:Nav3	UTSW	10	109,866,984 (GRCm38)	nonsense	probably null
R6189:Nav3	UTSW	10	109,720,019 (GRCm38)	missense	probably damaging	0.98
R6214:Nav3	UTSW	10	109,852,565 (GRCm38)	missense	probably damaging	1.00
R6215:Nav3	UTSW	10	109,852,565 (GRCm38)	missense	probably damaging	1.00
R6264:Nav3	UTSW	10	109,688,833 (GRCm38)	missense	probably damaging	0.97
R6500:Nav3	UTSW	10	109,764,756 (GRCm38)	missense	probably damaging	1.00
R6524:Nav3	UTSW	10	109,720,030 (GRCm38)	missense	probably damaging	0.99
R6868:Nav3	UTSW	10	109,693,166 (GRCm38)	missense	possibly damaging	0.49
R7079:Nav3	UTSW	10	109,767,292 (GRCm38)	missense	probably benign	0.16
R7099:Nav3	UTSW	10	109,703,334 (GRCm38)	missense	probably benign	0.11
R7139:Nav3	UTSW	10	109,853,477 (GRCm38)	missense	probably benign	0.44
R7238:Nav3	UTSW	10	109,853,324 (GRCm38)	missense	possibly damaging	0.75
R7338:Nav3	UTSW	10	109,769,212 (GRCm38)	missense	probably benign	0.04
R7343:Nav3	UTSW	10	109,903,758 (GRCm38)	missense	probably damaging	0.98
R7383:Nav3	UTSW	10	109,716,671 (GRCm38)	missense	probably damaging	0.98
R7391:Nav3	UTSW	10	109,703,456 (GRCm38)	missense	probably benign	0.07
R7399:Nav3	UTSW	10	109,852,934 (GRCm38)	missense	possibly damaging	0.74
R7457:Nav3	UTSW	10	109,696,328 (GRCm38)	nonsense	probably null
R7462:Nav3	UTSW	10	109,823,578 (GRCm38)	missense	probably damaging	1.00
R7542:Nav3	UTSW	10	109,823,533 (GRCm38)	missense	possibly damaging	0.89
R7659:Nav3	UTSW	10	109,766,990 (GRCm38)	missense	probably benign	0.09
R7749:Nav3	UTSW	10	109,703,352 (GRCm38)	missense	probably damaging	0.99
R7794:Nav3	UTSW	10	109,688,856 (GRCm38)	missense	probably benign	0.08
R7876:Nav3	UTSW	10	109,853,498 (GRCm38)	missense	probably benign	0.26
R8048:Nav3	UTSW	10	109,764,918 (GRCm38)	missense	probably benign	0.13
R8104:Nav3	UTSW	10	109,758,967 (GRCm38)	missense	probably damaging	0.99
R8125:Nav3	UTSW	10	109,852,659 (GRCm38)	missense	probably damaging	0.99
R8275:Nav3	UTSW	10	109,692,123 (GRCm38)	missense	noncoding transcript
R8325:Nav3	UTSW	10	109,705,603 (GRCm38)	missense	probably benign	0.24
R8336:Nav3	UTSW	10	109,767,569 (GRCm38)	missense	probably damaging	0.99
R8523:Nav3	UTSW	10	109,823,277 (GRCm38)	missense	probably damaging	1.00
R8529:Nav3	UTSW	10	109,853,331 (GRCm38)	missense	probably benign	0.09
R8745:Nav3	UTSW	10	109,823,450 (GRCm38)	missense	probably benign	0.08
R8752:Nav3	UTSW	10	109,760,304 (GRCm38)	intron	probably benign
R8794:Nav3	UTSW	10	109,769,171 (GRCm38)	nonsense	probably null
R8816:Nav3	UTSW	10	109,863,860 (GRCm38)	missense	possibly damaging	0.69
R9029:Nav3	UTSW	10	109,863,752 (GRCm38)	missense	possibly damaging	0.68
R9117:Nav3	UTSW	10	109,684,239 (GRCm38)	missense	probably benign	0.41
R9126:Nav3	UTSW	10	109,705,663 (GRCm38)	missense	probably benign
R9258:Nav3	UTSW	10	109,714,382 (GRCm38)	missense	probably damaging	0.99
R9347:Nav3	UTSW	10	109,903,094 (GRCm38)	missense	probably damaging	0.98
R9353:Nav3	UTSW	10	109,718,204 (GRCm38)	missense	probably damaging	0.99
R9366:Nav3	UTSW	10	109,823,503 (GRCm38)	missense	probably damaging	0.99
R9384:Nav3	UTSW	10	109,718,297 (GRCm38)	missense	probably damaging	0.98
R9428:Nav3	UTSW	10	109,769,315 (GRCm38)	missense	probably benign
R9454:Nav3	UTSW	10	110,000,003 (GRCm38)	missense	probably benign	0.01
R9516:Nav3	UTSW	10	109,684,154 (GRCm38)	missense	probably damaging	1.00
R9521:Nav3	UTSW	10	109,999,984 (GRCm38)	missense	possibly damaging	0.95
R9622:Nav3	UTSW	10	109,767,242 (GRCm38)	missense	probably benign
R9689:Nav3	UTSW	10	109,769,173 (GRCm38)	missense	probably damaging	1.00
R9796:Nav3	UTSW	10	109,692,108 (GRCm38)	missense	probably damaging	0.99
X0012:Nav3	UTSW	10	109,692,097 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TTAGTCACAGTGGGGATCGG -3'
(R):5'- ACAAGGCAGTCTGGAGTCAC -3'

Sequencing Primer
(F):5'- ATCGGGGGAATTTAGTAGGGTAG -3'
(R):5'- AGTCTGGAGTCACCGTCGTC -3'

Posted On

2016-11-09