Incidental Mutation 'R5669:Or10ag53'
ID 442490
Institutional Source Beutler Lab
Gene Symbol Or10ag53
Ensembl Gene ENSMUSG00000070856
Gene Name olfactory receptor family 10 subfamily AG member 53
Synonyms GA_x6K02T2Q125-48736906-48737886, MOR273-4P, MOR273-4P, Olfr1530-ps1, MOR264-20, Olfr1115
MMRRC Submission 043312-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5669 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87082184-87083285 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87082785 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 168 (V168A)
Ref Sequence ENSEMBL: ENSMUSP00000150996 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081986] [ENSMUST00000213513] [ENSMUST00000214119] [ENSMUST00000217196]
AlphaFold Q7TR53
Predicted Effect probably benign
Transcript: ENSMUST00000081986
AA Change: V168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000080647
Gene: ENSMUSG00000070856
AA Change: V168A

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 5e-54 PFAM
Pfam:7tm_1 56 305 3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183480
Predicted Effect probably benign
Transcript: ENSMUST00000213513
AA Change: V168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000214119
AA Change: V168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000217196
AA Change: V168A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Akap9 T A 5: 4,100,540 (GRCm39) L2734* probably null Het
Aldh1a1 T C 19: 20,588,284 (GRCm39) I25T probably damaging Het
Astl G T 2: 127,189,199 (GRCm39) R175L probably damaging Het
BC035947 A T 1: 78,474,550 (GRCm39) C661S probably damaging Het
Cd160 C T 3: 96,716,214 (GRCm39) probably benign Het
Cdc42bpb C T 12: 111,268,447 (GRCm39) probably null Het
Cdip1 T A 16: 4,586,679 (GRCm39) I149F probably damaging Het
Cfap65 T C 1: 74,964,127 (GRCm39) Y607C probably damaging Het
Col6a5 A G 9: 105,803,197 (GRCm39) I1256T unknown Het
Copb1 A G 7: 113,836,820 (GRCm39) V336A probably damaging Het
Ddx42 A T 11: 106,132,645 (GRCm39) D556V probably damaging Het
Dlk1 T C 12: 109,425,964 (GRCm39) V279A probably benign Het
Fbll1 T C 11: 35,688,411 (GRCm39) N284S probably benign Het
Fbxw21 A T 9: 108,974,578 (GRCm39) I314N probably benign Het
Foxa3 T C 7: 18,748,176 (GRCm39) T317A probably benign Het
Gpr37 A T 6: 25,669,351 (GRCm39) C498S probably benign Het
Hapln3 G T 7: 78,767,244 (GRCm39) probably null Het
Igkv4-54 A G 6: 69,608,832 (GRCm39) V29A possibly damaging Het
Itgb8 T A 12: 119,154,363 (GRCm39) I225F probably damaging Het
Kcnk3 A G 5: 30,779,693 (GRCm39) T248A probably damaging Het
Kcnv1 T C 15: 44,977,648 (GRCm39) Q130R possibly damaging Het
Lrp1b T C 2: 41,001,050 (GRCm39) H2058R probably damaging Het
Macf1 T A 4: 123,370,018 (GRCm39) E1581V probably damaging Het
Mga A G 2: 119,733,907 (GRCm39) N252D probably damaging Het
Nadsyn1 C T 7: 143,361,168 (GRCm39) G335S probably damaging Het
Or7e165 T C 9: 19,695,053 (GRCm39) F208S probably benign Het
Pak5 G A 2: 135,958,204 (GRCm39) P295S probably damaging Het
Pcsk1 T A 13: 75,278,221 (GRCm39) S595T probably benign Het
Pepd T C 7: 34,740,099 (GRCm39) V324A probably benign Het
Pml C T 9: 58,154,346 (GRCm39) D176N probably benign Het
Popdc3 T A 10: 45,192,529 (GRCm39) I163N probably damaging Het
Ppp1r13l A C 7: 19,106,947 (GRCm39) T481P probably benign Het
Pramel13 T C 4: 144,122,413 (GRCm39) I44V probably benign Het
Prlh A G 1: 90,880,842 (GRCm39) T5A probably benign Het
Prom1 A G 5: 44,170,285 (GRCm39) F638S possibly damaging Het
Prpf8 T A 11: 75,395,564 (GRCm39) L1897H probably damaging Het
Ret T C 6: 118,161,204 (GRCm39) T91A probably benign Het
Retsat A G 6: 72,582,993 (GRCm39) S176G probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rnf213 T C 11: 119,349,611 (GRCm39) L3823P possibly damaging Het
Rnf31 C T 14: 55,834,161 (GRCm39) A653V probably damaging Het
Rps6kl1 T C 12: 85,194,641 (GRCm39) D90G probably damaging Het
Scarb1 A G 5: 125,377,451 (GRCm39) Y194H probably damaging Het
Scube2 C T 7: 109,424,646 (GRCm39) A556T probably benign Het
Serpinb1a A G 13: 33,029,299 (GRCm39) L243P probably damaging Het
Slc39a4 A C 15: 76,498,363 (GRCm39) L358R probably damaging Het
Slitrk5 A G 14: 111,919,055 (GRCm39) D893G probably damaging Het
Srgap1 C A 10: 121,640,755 (GRCm39) V681L probably benign Het
Tmprss6 A T 15: 78,339,156 (GRCm39) M262K possibly damaging Het
Ttf2 T A 3: 100,858,433 (GRCm39) K719* probably null Het
Vmn1r62 T A 7: 5,678,736 (GRCm39) L139* probably null Het
Zfp1004 A G 2: 150,034,098 (GRCm39) I140V probably benign Het
Other mutations in Or10ag53
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Or10ag53 APN 2 87,082,806 (GRCm39) missense probably damaging 1.00
IGL01376:Or10ag53 APN 2 87,083,217 (GRCm39) missense possibly damaging 0.58
IGL02167:Or10ag53 APN 2 87,082,542 (GRCm39) missense probably benign 0.18
IGL02224:Or10ag53 APN 2 87,082,821 (GRCm39) missense probably benign 0.42
IGL02388:Or10ag53 APN 2 87,082,295 (GRCm39) missense probably benign
IGL02596:Or10ag53 APN 2 87,082,473 (GRCm39) missense probably damaging 0.98
PIT4131001:Or10ag53 UTSW 2 87,082,973 (GRCm39) missense probably benign 0.01
R0140:Or10ag53 UTSW 2 87,082,969 (GRCm39) missense probably damaging 1.00
R0468:Or10ag53 UTSW 2 87,082,599 (GRCm39) missense probably benign 0.04
R1222:Or10ag53 UTSW 2 87,082,766 (GRCm39) missense probably benign 0.04
R1418:Or10ag53 UTSW 2 87,082,766 (GRCm39) missense probably benign 0.04
R1742:Or10ag53 UTSW 2 87,083,122 (GRCm39) missense probably benign 0.01
R1822:Or10ag53 UTSW 2 87,083,054 (GRCm39) missense possibly damaging 0.91
R2332:Or10ag53 UTSW 2 87,083,217 (GRCm39) missense possibly damaging 0.58
R3123:Or10ag53 UTSW 2 87,083,135 (GRCm39) missense possibly damaging 0.67
R3407:Or10ag53 UTSW 2 87,083,243 (GRCm39) missense probably benign 0.00
R4571:Or10ag53 UTSW 2 87,082,802 (GRCm39) missense possibly damaging 0.67
R4710:Or10ag53 UTSW 2 87,082,384 (GRCm39) missense possibly damaging 0.64
R4889:Or10ag53 UTSW 2 87,082,991 (GRCm39) missense probably damaging 0.97
R5031:Or10ag53 UTSW 2 87,082,426 (GRCm39) missense probably benign
R5288:Or10ag53 UTSW 2 87,082,827 (GRCm39) missense probably benign 0.06
R5385:Or10ag53 UTSW 2 87,082,827 (GRCm39) missense probably benign 0.06
R5386:Or10ag53 UTSW 2 87,082,827 (GRCm39) missense probably benign 0.06
R6187:Or10ag53 UTSW 2 87,083,042 (GRCm39) missense probably damaging 1.00
R6226:Or10ag53 UTSW 2 87,082,736 (GRCm39) missense probably benign 0.27
R6598:Or10ag53 UTSW 2 87,083,100 (GRCm39) missense probably damaging 0.96
R8208:Or10ag53 UTSW 2 87,083,007 (GRCm39) missense probably benign 0.24
R8493:Or10ag53 UTSW 2 87,083,215 (GRCm39) missense probably benign 0.24
R8724:Or10ag53 UTSW 2 87,082,704 (GRCm39) missense probably damaging 1.00
R8965:Or10ag53 UTSW 2 87,082,901 (GRCm39) missense possibly damaging 0.86
R9015:Or10ag53 UTSW 2 87,082,546 (GRCm39) nonsense probably null
R9302:Or10ag53 UTSW 2 87,082,906 (GRCm39) missense probably benign 0.10
R9742:Or10ag53 UTSW 2 87,082,376 (GRCm39) missense probably benign 0.29
R9758:Or10ag53 UTSW 2 87,082,439 (GRCm39) missense possibly damaging 0.79
R9775:Or10ag53 UTSW 2 87,082,568 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GCCTGTGCTACACAAATGTG -3'
(R):5'- TGATGGCAACTTCAAGATAGTTGAG -3'

Sequencing Primer
(F):5'- CAAATGTGTTTATTCCTTATCCTGGG -3'
(R):5'- TGATCCTGCTGTAAGATGCAAG -3'
Posted On 2016-11-09