Incidental Mutation 'R5678:Srpk2'
ID 442878
Institutional Source Beutler Lab
Gene Symbol Srpk2
Ensembl Gene ENSMUSG00000062604
Gene Name serine/arginine-rich protein specific kinase 2
Synonyms WBP6, mSRPK2
MMRRC Submission 043317-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5678 (G1)
Quality Score 217
Status Validated
Chromosome 5
Chromosomal Location 23708262-23889615 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) TCA to T at 23729604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000085734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088392] [ENSMUST00000196388] [ENSMUST00000196929]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000088392
SMART Domains Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
low complexity region 5 46 N/A INTRINSIC
Pfam:Pkinase 79 228 1.3e-22 PFAM
Pfam:Pkinase_Tyr 79 228 1e-9 PFAM
coiled coil region 263 314 N/A INTRINSIC
coiled coil region 339 373 N/A INTRINSIC
low complexity region 393 406 N/A INTRINSIC
Pfam:Pkinase 506 680 1.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196388
SMART Domains Protein: ENSMUSP00000143453
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
S_TKc 3 129 7.2e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000196929
SMART Domains Protein: ENSMUSP00000143216
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 131 2.6e-8 PFAM
Pfam:Pkinase 2 130 2.3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200173
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (55/55)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit normal phenotype. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted(3) Gene trapped(36)

Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T C 11: 23,466,529 (GRCm39) T168A probably damaging Het
3425401B19Rik T A 14: 32,384,010 (GRCm39) R652W probably damaging Het
A530016L24Rik T G 12: 112,463,306 (GRCm39) C43W probably damaging Het
Aatk T C 11: 119,900,980 (GRCm39) T1082A probably benign Het
Acsl1 T A 8: 46,945,887 (GRCm39) F7I probably benign Het
Adgb T G 10: 10,307,070 (GRCm39) S299R possibly damaging Het
Apob T C 12: 8,041,494 (GRCm39) F738L possibly damaging Het
Art3 T C 5: 92,540,409 (GRCm39) Y51H probably damaging Het
Atr C T 9: 95,833,540 (GRCm39) Q2597* probably null Het
Atrn T C 2: 130,811,936 (GRCm39) V627A probably damaging Het
Baz1a T C 12: 54,947,317 (GRCm39) K1111E probably damaging Het
Ccdc40 T C 11: 119,122,398 (GRCm39) S67P possibly damaging Het
Cd164 T C 10: 41,395,948 (GRCm39) probably null Het
Cep295 T C 9: 15,234,154 (GRCm39) D2214G probably damaging Het
Clcn1 A G 6: 42,284,199 (GRCm39) Y589C probably damaging Het
Col1a2 C T 6: 4,536,239 (GRCm39) A998V unknown Het
Csrnp2 T C 15: 100,379,685 (GRCm39) *535W probably null Het
Dhrs7 C T 12: 72,704,106 (GRCm39) G130D probably damaging Het
Dnah3 T C 7: 119,677,074 (GRCm39) T477A probably benign Het
Dscam A G 16: 96,592,100 (GRCm39) F725S probably benign Het
Dstyk T C 1: 132,381,029 (GRCm39) V508A probably benign Het
Eif4g3 A G 4: 137,879,053 (GRCm39) E595G probably damaging Het
Epha6 A T 16: 59,639,342 (GRCm39) V844E probably damaging Het
Esrp2 G A 8: 106,858,750 (GRCm39) A629V probably damaging Het
Fndc3b A G 3: 27,483,172 (GRCm39) S1009P probably benign Het
Gm8257 A T 14: 44,894,706 (GRCm39) I28N probably damaging Het
Ighv5-9-1 T C 12: 113,700,207 (GRCm39) E4G possibly damaging Het
Ints3 A G 3: 90,310,855 (GRCm39) V455A probably damaging Het
Lamtor2 A G 3: 88,458,101 (GRCm39) probably benign Het
Npy1r T C 8: 67,156,855 (GRCm39) C92R probably damaging Het
Nup210l T C 3: 90,098,266 (GRCm39) V1406A probably damaging Het
Or10g7 T C 9: 39,905,199 (GRCm39) V31A probably benign Het
Or4a75 A G 2: 89,447,625 (GRCm39) F304L probably benign Het
Or4c108 A T 2: 88,803,317 (GRCm39) L306* probably null Het
Prune2 A G 19: 17,096,032 (GRCm39) D512G probably damaging Het
Qdpr T C 5: 45,604,979 (GRCm39) E43G possibly damaging Het
Rps6ka5 T C 12: 100,691,135 (GRCm39) E2G unknown Het
Setd2 A G 9: 110,431,254 (GRCm39) T5A probably damaging Het
Slc66a2 T C 18: 80,300,249 (GRCm39) I40T probably damaging Het
Sympk T C 7: 18,783,397 (GRCm39) probably null Het
Tasor CGCGGCGGCGGCGGCGG CGCGGCGGCGGCGGCGGCGGCGG 14: 27,151,080 (GRCm39) probably benign Het
Tchh A T 3: 93,352,933 (GRCm39) Q791L unknown Het
Tmed11 T C 5: 108,934,031 (GRCm39) D55G probably benign Het
Tnrc18 T C 5: 142,719,319 (GRCm39) D1989G unknown Het
Utp20 A T 10: 88,644,979 (GRCm39) H582Q probably benign Het
Utrn A G 10: 12,317,762 (GRCm39) I554T probably damaging Het
Zfp1005 A T 2: 150,110,425 (GRCm39) R372* probably null Het
Zfp119a T C 17: 56,175,336 (GRCm39) E53G probably benign Het
Other mutations in Srpk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00697:Srpk2 APN 5 23,745,377 (GRCm39) missense probably benign 0.10
IGL02057:Srpk2 APN 5 23,723,705 (GRCm39) missense probably damaging 0.99
IGL02217:Srpk2 APN 5 23,750,568 (GRCm39) missense probably damaging 1.00
IGL03115:Srpk2 APN 5 23,729,616 (GRCm39) splice site probably null
FR4737:Srpk2 UTSW 5 23,750,194 (GRCm39) splice site probably null
P0008:Srpk2 UTSW 5 23,718,976 (GRCm39) missense probably damaging 1.00
R0142:Srpk2 UTSW 5 23,732,928 (GRCm39) missense probably damaging 0.97
R0462:Srpk2 UTSW 5 23,723,424 (GRCm39) missense probably damaging 1.00
R0992:Srpk2 UTSW 5 23,750,541 (GRCm39) missense probably damaging 0.99
R1569:Srpk2 UTSW 5 23,719,024 (GRCm39) missense probably damaging 1.00
R1677:Srpk2 UTSW 5 23,730,748 (GRCm39) splice site probably null
R1696:Srpk2 UTSW 5 23,753,492 (GRCm39) nonsense probably null
R1752:Srpk2 UTSW 5 23,733,017 (GRCm39) missense probably damaging 1.00
R1862:Srpk2 UTSW 5 23,729,148 (GRCm39) missense probably benign 0.32
R1989:Srpk2 UTSW 5 23,723,421 (GRCm39) missense probably damaging 1.00
R2173:Srpk2 UTSW 5 23,723,613 (GRCm39) splice site probably null
R4096:Srpk2 UTSW 5 23,745,500 (GRCm39) intron probably benign
R4271:Srpk2 UTSW 5 23,753,513 (GRCm39) missense possibly damaging 0.95
R4894:Srpk2 UTSW 5 23,750,527 (GRCm39) missense probably damaging 1.00
R5043:Srpk2 UTSW 5 23,729,515 (GRCm39) missense probably benign
R5044:Srpk2 UTSW 5 23,729,390 (GRCm39) missense possibly damaging 0.91
R5309:Srpk2 UTSW 5 23,730,716 (GRCm39) missense probably damaging 0.97
R5478:Srpk2 UTSW 5 23,729,181 (GRCm39) missense possibly damaging 0.71
R5568:Srpk2 UTSW 5 23,730,697 (GRCm39) missense possibly damaging 0.73
R5665:Srpk2 UTSW 5 23,723,475 (GRCm39) missense probably damaging 0.99
R6364:Srpk2 UTSW 5 23,745,465 (GRCm39) missense probably damaging 1.00
R7201:Srpk2 UTSW 5 23,712,626 (GRCm39) missense possibly damaging 0.64
R7597:Srpk2 UTSW 5 23,753,517 (GRCm39) missense possibly damaging 0.96
R8251:Srpk2 UTSW 5 23,729,266 (GRCm39) missense probably benign
R8477:Srpk2 UTSW 5 23,718,986 (GRCm39) missense probably benign 0.03
R9348:Srpk2 UTSW 5 23,719,671 (GRCm39) missense probably damaging 0.98
R9606:Srpk2 UTSW 5 23,729,604 (GRCm39) missense probably benign
R9745:Srpk2 UTSW 5 23,880,874 (GRCm39) intron probably benign
RF035:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
RF042:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
Predicted Primers PCR Primer
(F):5'- GGATTTGCACAGTCATCTTCATCG -3'
(R):5'- AGGTCCGTTAGAAGTGGCTC -3'

Sequencing Primer
(F):5'- GCACAGTCATCTTCATCGTCCTC -3'
(R):5'- AGACCGCCAGATCTCTGAGTTTG -3'
Posted On 2016-11-09