Incidental Mutation 'R5679:Ipo13'
ID 442925
Institutional Source Beutler Lab
Gene Symbol Ipo13
Ensembl Gene ENSMUSG00000033365
Gene Name importin 13
Synonyms Imp13, Kap13
MMRRC Submission 043176-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.959) question?
Stock # R5679 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 117751683-117772196 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 117752029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 903 (W903R)
Ref Sequence ENSEMBL: ENSMUSP00000035989 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030265] [ENSMUST00000036156] [ENSMUST00000183773]
AlphaFold Q8K0C1
Predicted Effect probably benign
Transcript: ENSMUST00000030265
SMART Domains Protein: ENSMUSP00000030265
Gene: ENSMUSG00000028540

DomainStartEndE-ValueType
Pfam:Diphthamide_syn 54 375 2.8e-64 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000036156
AA Change: W903R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035989
Gene: ENSMUSG00000033365
AA Change: W903R

DomainStartEndE-ValueType
low complexity region 9 18 N/A INTRINSIC
IBN_N 45 111 2.05e-7 SMART
Pfam:Xpo1 116 263 4.8e-29 PFAM
low complexity region 668 692 N/A INTRINSIC
low complexity region 767 779 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126554
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136670
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139332
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155524
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140661
Predicted Effect probably benign
Transcript: ENSMUST00000183773
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a gene trap insertion die prior to genotyping age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh3a1 G A 11: 61,107,994 (GRCm39) R346Q probably benign Het
Bcat1 A T 6: 144,953,474 (GRCm39) F304L probably damaging Het
Ccdc178 T G 18: 22,200,486 (GRCm39) K439N probably benign Het
Cdkn2a T C 4: 89,195,098 (GRCm39) D84G possibly damaging Het
Chst8 T A 7: 34,374,729 (GRCm39) H370L probably damaging Het
Dimt1 A G 13: 107,084,108 (GRCm39) T32A possibly damaging Het
Dph6 T C 2: 114,398,422 (GRCm39) I162V probably benign Het
E230025N22Rik C T 18: 36,818,435 (GRCm39) G465R possibly damaging Het
Fam3d T C 14: 8,349,305 (GRCm38) E215G probably damaging Het
Fbxw7 T A 3: 84,884,794 (GRCm39) N612K probably damaging Het
Gpr179 A G 11: 97,227,571 (GRCm39) V1528A probably benign Het
Gucy2g T A 19: 55,219,511 (GRCm39) K370N possibly damaging Het
Itgax T A 7: 127,734,162 (GRCm39) H311Q probably benign Het
Kmt2d T C 15: 98,752,153 (GRCm39) probably benign Het
Lox T C 18: 52,661,989 (GRCm39) N138S probably benign Het
Mre11a T A 9: 14,698,215 (GRCm39) I21N probably damaging Het
Ncan T G 8: 70,565,276 (GRCm39) Y217S probably damaging Het
Nfil3 A G 13: 53,122,527 (GRCm39) F126L possibly damaging Het
Nfu1 T C 6: 86,996,379 (GRCm39) V110A probably damaging Het
Or12e8 T C 2: 87,187,889 (GRCm39) F34L possibly damaging Het
Or5e1 A G 7: 108,354,203 (GRCm39) I47V probably damaging Het
Or5g9 A T 2: 85,552,390 (GRCm39) I214F probably damaging Het
Palld T C 8: 62,137,979 (GRCm39) Q592R possibly damaging Het
Pcdhac1 T A 18: 37,225,530 (GRCm39) L781Q probably damaging Het
Rcl1 A G 19: 29,098,658 (GRCm39) probably null Het
Saxo1 C T 4: 86,363,272 (GRCm39) V404I possibly damaging Het
Scrt1 T A 15: 76,403,262 (GRCm39) T243S unknown Het
Slc22a30 G T 19: 8,313,135 (GRCm39) T550K possibly damaging Het
Strc A G 2: 121,198,581 (GRCm39) S1437P probably benign Het
Tecpr1 T A 5: 144,144,241 (GRCm39) I654F possibly damaging Het
Tfcp2l1 A G 1: 118,596,377 (GRCm39) M371V probably benign Het
Vmn2r11 T C 5: 109,202,708 (GRCm39) N123S probably benign Het
Wdr81 T C 11: 75,343,749 (GRCm39) D506G probably damaging Het
Xylt1 A G 7: 117,242,877 (GRCm39) D640G probably damaging Het
Zfp148 T G 16: 33,316,156 (GRCm39) M276R probably damaging Het
Zfp329 G A 7: 12,543,958 (GRCm39) T522I probably damaging Het
Other mutations in Ipo13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Ipo13 APN 4 117,760,602 (GRCm39) missense probably benign 0.10
IGL00800:Ipo13 APN 4 117,769,505 (GRCm39) missense probably benign 0.31
IGL00971:Ipo13 APN 4 117,771,564 (GRCm39) missense possibly damaging 0.83
IGL01552:Ipo13 APN 4 117,758,161 (GRCm39) missense probably benign 0.16
IGL01957:Ipo13 APN 4 117,761,078 (GRCm39) missense probably damaging 0.99
IGL02262:Ipo13 APN 4 117,761,010 (GRCm39) missense probably damaging 1.00
R0109:Ipo13 UTSW 4 117,762,213 (GRCm39) missense possibly damaging 0.92
R0142:Ipo13 UTSW 4 117,762,766 (GRCm39) missense probably damaging 1.00
R0771:Ipo13 UTSW 4 117,751,843 (GRCm39) missense possibly damaging 0.78
R1248:Ipo13 UTSW 4 117,758,228 (GRCm39) missense probably damaging 1.00
R1381:Ipo13 UTSW 4 117,761,592 (GRCm39) missense probably damaging 1.00
R1497:Ipo13 UTSW 4 117,761,856 (GRCm39) missense probably benign 0.04
R1614:Ipo13 UTSW 4 117,761,815 (GRCm39) missense probably benign 0.00
R1711:Ipo13 UTSW 4 117,761,719 (GRCm39) missense probably benign 0.38
R2037:Ipo13 UTSW 4 117,761,858 (GRCm39) nonsense probably null
R2200:Ipo13 UTSW 4 117,762,100 (GRCm39) critical splice donor site probably null
R3698:Ipo13 UTSW 4 117,757,890 (GRCm39) missense probably damaging 1.00
R3949:Ipo13 UTSW 4 117,758,239 (GRCm39) missense probably benign 0.10
R4687:Ipo13 UTSW 4 117,758,773 (GRCm39) missense probably benign 0.06
R4894:Ipo13 UTSW 4 117,761,687 (GRCm39) missense possibly damaging 0.84
R4894:Ipo13 UTSW 4 117,760,638 (GRCm39) missense probably damaging 0.99
R4956:Ipo13 UTSW 4 117,758,768 (GRCm39) missense probably benign 0.00
R5879:Ipo13 UTSW 4 117,760,400 (GRCm39) missense possibly damaging 0.67
R5921:Ipo13 UTSW 4 117,769,286 (GRCm39) missense probably benign 0.14
R6250:Ipo13 UTSW 4 117,769,351 (GRCm39) missense possibly damaging 0.93
R6875:Ipo13 UTSW 4 117,762,108 (GRCm39) missense possibly damaging 0.90
R7178:Ipo13 UTSW 4 117,761,081 (GRCm39) missense possibly damaging 0.83
R7412:Ipo13 UTSW 4 117,752,068 (GRCm39) missense probably benign
R7687:Ipo13 UTSW 4 117,769,088 (GRCm39) missense probably benign 0.01
R7774:Ipo13 UTSW 4 117,771,494 (GRCm39) missense probably benign 0.11
R8390:Ipo13 UTSW 4 117,769,534 (GRCm39) missense probably damaging 0.99
R8489:Ipo13 UTSW 4 117,758,219 (GRCm39) missense probably damaging 0.98
R8525:Ipo13 UTSW 4 117,762,126 (GRCm39) missense probably damaging 0.99
R9039:Ipo13 UTSW 4 117,758,185 (GRCm39) missense probably damaging 0.98
R9229:Ipo13 UTSW 4 117,758,801 (GRCm39) missense probably damaging 0.96
R9319:Ipo13 UTSW 4 117,769,585 (GRCm39) missense probably benign 0.00
R9760:Ipo13 UTSW 4 117,762,778 (GRCm39) missense probably benign 0.05
Z1088:Ipo13 UTSW 4 117,761,877 (GRCm39) missense probably benign 0.14
Z1176:Ipo13 UTSW 4 117,761,827 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGTTTACTCGCTCACTGTAGGG -3'
(R):5'- GACAGTGCTCACTTACACAGC -3'

Sequencing Primer
(F):5'- TCGCTCACTGTAGGGAAGGG -3'
(R):5'- CTGTGGACGTATCCCAGAGAG -3'
Posted On 2016-11-09