Incidental Mutation 'R5679:Scrt1'
ID 442945
Institutional Source Beutler Lab
Gene Symbol Scrt1
Ensembl Gene ENSMUSG00000048385
Gene Name scratch family zinc finger 1
Synonyms
MMRRC Submission 043176-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.740) question?
Stock # R5679 (G1)
Quality Score 172
Status Not validated
Chromosome 15
Chromosomal Location 76516203-76522499 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 76519062 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 243 (T243S)
Ref Sequence ENSEMBL: ENSMUSP00000131152 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096365] [ENSMUST00000164703]
AlphaFold Q99M85
Predicted Effect unknown
Transcript: ENSMUST00000096365
AA Change: T243S
SMART Domains Protein: ENSMUSP00000094093
Gene: ENSMUSG00000048385
AA Change: T243S

DomainStartEndE-ValueType
low complexity region 78 92 N/A INTRINSIC
ZnF_C2H2 191 213 9.58e-3 SMART
ZnF_C2H2 222 244 5.06e-2 SMART
ZnF_C2H2 248 270 6.42e-4 SMART
ZnF_C2H2 276 298 7.9e-4 SMART
ZnF_C2H2 304 324 3.47e1 SMART
low complexity region 330 341 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000164703
AA Change: T243S
SMART Domains Protein: ENSMUSP00000131152
Gene: ENSMUSG00000048385
AA Change: T243S

DomainStartEndE-ValueType
low complexity region 78 92 N/A INTRINSIC
ZnF_C2H2 191 213 9.58e-3 SMART
ZnF_C2H2 222 244 5.06e-2 SMART
ZnF_C2H2 248 270 6.42e-4 SMART
ZnF_C2H2 276 298 7.9e-4 SMART
ZnF_C2H2 304 324 3.47e1 SMART
low complexity region 330 341 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh3a1 G A 11: 61,217,168 R346Q probably benign Het
Bcat1 A T 6: 145,007,748 F304L probably damaging Het
Ccdc178 T G 18: 22,067,429 K439N probably benign Het
Cdkn2a T C 4: 89,276,861 D84G possibly damaging Het
Chst8 T A 7: 34,675,304 H370L probably damaging Het
Dimt1 A G 13: 106,947,600 T32A possibly damaging Het
Dph6 T C 2: 114,567,941 I162V probably benign Het
E230025N22Rik C T 18: 36,685,382 G465R possibly damaging Het
Fbxw7 T A 3: 84,977,487 N612K probably damaging Het
Gpr179 A G 11: 97,336,745 V1528A probably benign Het
Gucy2g T A 19: 55,231,079 K370N possibly damaging Het
Ipo13 A T 4: 117,894,832 W903R probably damaging Het
Itgax T A 7: 128,134,990 H311Q probably benign Het
Kmt2d T C 15: 98,854,272 probably benign Het
Lox T C 18: 52,528,917 N138S probably benign Het
Mre11a T A 9: 14,786,919 I21N probably damaging Het
Ncan T G 8: 70,112,626 Y217S probably damaging Het
Nfil3 A G 13: 52,968,491 F126L possibly damaging Het
Nfu1 T C 6: 87,019,397 V110A probably damaging Het
Oit1 T C 14: 8,349,305 E215G probably damaging Het
Olfr1009 A T 2: 85,722,046 I214F probably damaging Het
Olfr1120 T C 2: 87,357,545 F34L possibly damaging Het
Olfr513 A G 7: 108,754,996 I47V probably damaging Het
Palld T C 8: 61,684,945 Q592R possibly damaging Het
Pcdhac1 T A 18: 37,092,477 L781Q probably damaging Het
Rcl1 A G 19: 29,121,258 probably null Het
Saxo1 C T 4: 86,445,035 V404I possibly damaging Het
Slc22a30 G T 19: 8,335,771 T550K possibly damaging Het
Strc A G 2: 121,368,100 S1437P probably benign Het
Tecpr1 T A 5: 144,207,423 I654F possibly damaging Het
Tfcp2l1 A G 1: 118,668,647 M371V probably benign Het
Vmn2r11 T C 5: 109,054,842 N123S probably benign Het
Wdr81 T C 11: 75,452,923 D506G probably damaging Het
Xylt1 A G 7: 117,643,650 D640G probably damaging Het
Zfp148 T G 16: 33,495,786 M276R probably damaging Het
Zfp329 G A 7: 12,810,031 T522I probably damaging Het
Other mutations in Scrt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01695:Scrt1 APN 15 76518950 missense unknown
R4676:Scrt1 UTSW 15 76521668 missense possibly damaging 0.92
R5321:Scrt1 UTSW 15 76519170 missense unknown
R7591:Scrt1 UTSW 15 76519494 missense probably damaging 1.00
R7920:Scrt1 UTSW 15 76519217 missense unknown
R8558:Scrt1 UTSW 15 76519643 nonsense probably null
R8804:Scrt1 UTSW 15 76519211 missense unknown
R8846:Scrt1 UTSW 15 76521608 missense possibly damaging 0.84
R9507:Scrt1 UTSW 15 76519092 missense unknown
Z1177:Scrt1 UTSW 15 76518914 missense unknown
Predicted Primers PCR Primer
(F):5'- ACTGGAAGTGCTTGAAGGCG -3'
(R):5'- TTCTTCATCACTGACGGGC -3'

Sequencing Primer
(F):5'- GCTTGAAGGCGGAGTGC -3'
(R):5'- TGCTAATGCCAACGCTGC -3'
Posted On 2016-11-09