Mutagenetix > Incidental Mutation

Incidental Mutation 'R5681:Olfr855'

443046

Institutional Source

Beutler Lab

Gene Symbol

Olfr855

Ensembl Gene

ENSMUSG00000043087

Gene Name

olfactory receptor 855

Synonyms

MOR148-1, GA_x6K02T2PVTD-13330461-13331399

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R5681 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19582617-19586030 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 19584899 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Asparagine at position 121 (D121N)

Ref Sequence

ENSEMBL: ENSMUSP00000150218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061693] [ENSMUST00000215587]

AlphaFold

Q7TRF8

Predicted Effect

probably damaging
Transcript: ENSMUST00000061693
AA Change: D121N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000054790
Gene: ENSMUSG00000043087
AA Change: D121N

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	310	1.7e-54	PFAM
Pfam:7TM_GPCR_Srsx	37	182	5.2e-8	PFAM
Pfam:7tm_1	43	292	2.5e-24	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215587
AA Change: D121N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.6%
3x: 98.8%
10x: 97.0%
20x: 94.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330182L06Rik	T	A	5: 9,459,308		probably null	Het
Acoxl	T	C	2: 127,972,639	F45S	possibly damaging	Het
Adora2b	T	A	11: 62,249,241	V47E	probably damaging	Het
Amdhd2	A	G	17: 24,156,040	I396T	probably damaging	Het
Arhgap5	G	A	12: 52,519,779	D1178N	probably benign	Het
Atp10d	T	C	5: 72,246,946		probably benign	Het
Baiap3	A	G	17: 25,249,373	S264P	probably damaging	Het
BC055324	T	C	1: 163,962,085	N627S	probably damaging	Het
Brinp3	A	T	1: 146,901,746	I644F	probably benign	Het
Ccdc66	T	C	14: 27,486,741	R675G	probably benign	Het
Cnr2	T	G	4: 135,916,689	M26R	probably damaging	Het
Col6a2	A	T	10: 76,609,251		probably null	Het
Cux1	A	G	5: 136,308,184	W696R	probably damaging	Het
D6Ertd527e	A	G	6: 87,111,206	N117S	unknown	Het
Dnah12	T	C	14: 26,815,495	C2234R	probably benign	Het
Dnhd1	G	A	7: 105,703,209	R2523Q	probably damaging	Het
Dock2	T	G	11: 34,249,836	I1405L	probably benign	Het
Dsg1c	T	C	18: 20,283,213	F724L	probably damaging	Het
Enoph1	T	C	5: 100,062,277		probably null	Het
Epha10	A	T	4: 124,902,566	Q356L	unknown	Het
Fbln2	G	T	6: 91,271,796	V1148L	probably damaging	Het
Gm11397	G	A	13: 33,395,829	C20Y	probably damaging	Het
Gm8251	A	T	1: 44,061,464	V158D	possibly damaging	Het
Gp2	C	T	7: 119,452,294	V233M	possibly damaging	Het
Gtf2ird1	T	A	5: 134,363,318	S800C	probably damaging	Het
Hat1	A	G	2: 71,434,209		probably null	Het
Hpdl	A	T	4: 116,820,842	S141T	probably benign	Het
Klhl29	A	G	12: 5,090,669	S658P	possibly damaging	Het
Lifr	T	A	15: 7,191,084	I1065N	probably damaging	Het
Lrrn2	G	T	1: 132,937,161		probably benign	Het
March9	T	A	10: 127,058,303	I144F	probably benign	Het
Mtnr1a	A	G	8: 45,087,937	I312V	possibly damaging	Het
Ngf	T	A	3: 102,520,353	F139L	probably damaging	Het
Nipbl	T	C	15: 8,301,382	I2318V	probably benign	Het
Nkpd1	C	T	7: 19,523,573	Q276*	probably null	Het
Nphs1	A	G	7: 30,486,625	D1227G	probably benign	Het
Olfm3	C	A	3: 115,122,275	N285K	probably benign	Het
Olfr1313	T	A	2: 112,072,377	I69F	probably benign	Het
Olfr3	C	A	2: 36,812,681	S137I	probably benign	Het
Olfr870	A	G	9: 20,170,795	Y259H	probably damaging	Het
Olfr887	C	T	9: 38,085,631	S265F	possibly damaging	Het
Osbp2	A	G	11: 3,863,486	S128P	probably benign	Het
Otop2	A	T	11: 115,326,859	M174L	probably damaging	Het
Pard3	A	G	8: 127,389,433	T668A	possibly damaging	Het
Pkhd1	T	C	1: 20,547,461	T967A	possibly damaging	Het
Pls1	A	G	9: 95,787,012	V52A	probably damaging	Het
Ptcd3	T	C	6: 71,907,659	K64R	probably damaging	Het
Pxn	T	C	5: 115,544,534	W69R	possibly damaging	Het
Rai14	T	C	15: 10,575,120	D584G	probably damaging	Het
Safb	G	A	17: 56,599,000		probably benign	Het
Serinc2	A	C	4: 130,265,076	L10R	probably damaging	Het
Serpinb12	A	T	1: 106,946,701	H52L	probably benign	Het
Serpinf2	A	G	11: 75,435,939	Y273H	probably damaging	Het
Slc2a10	T	A	2: 165,514,740	S107T	probably benign	Het
Slc41a3	T	C	6: 90,640,946	L318P	probably damaging	Het
Slc6a3	A	T	13: 73,538,735	I74F	probably damaging	Het
Snrnp200	G	A	2: 127,225,135	G788D	probably damaging	Het
Snx7	A	G	3: 117,846,623	I79T	probably benign	Het
Sox11	G	T	12: 27,341,824	D195E	probably benign	Het
Ssc4d	A	G	5: 135,970,220	L43P	probably damaging	Het
Tab2	A	G	10: 7,920,073	I215T	probably damaging	Het
Ttn	C	T	2: 76,830,598	V7422I	possibly damaging	Het
Unc13c	A	T	9: 73,546,075		probably null	Het
Wdr17	T	C	8: 54,662,869	D633G	probably damaging	Het
Wdsub1	A	T	2: 59,852,895	M445K	probably damaging	Het
Xpc	A	G	6: 91,504,120	F257L	probably damaging	Het

Other mutations in Olfr855

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr855	APN	9	19585320	missense	possibly damaging	0.74
IGL01405:Olfr855	APN	9	19585205	missense	probably benign	0.23
IGL01775:Olfr855	APN	9	19584705	missense	probably benign	0.04
IGL01920:Olfr855	APN	9	19585022	missense	probably benign	0.01
R0501:Olfr855	UTSW	9	19584618	missense	probably damaging	1.00
R0600:Olfr855	UTSW	9	19585304	missense	possibly damaging	0.47
R0667:Olfr855	UTSW	9	19585447	missense	probably benign
R1769:Olfr855	UTSW	9	19585386	missense	probably damaging	0.98
R3117:Olfr855	UTSW	9	19584941	missense	probably damaging	0.99
R4002:Olfr855	UTSW	9	19584714	missense	probably damaging	1.00
R4003:Olfr855	UTSW	9	19584714	missense	probably damaging	1.00
R4043:Olfr855	UTSW	9	19584995	missense	probably benign	0.16
R4243:Olfr855	UTSW	9	19584558	missense	probably damaging	1.00
R4672:Olfr855	UTSW	9	19585430	missense	possibly damaging	0.74
R4673:Olfr855	UTSW	9	19585430	missense	possibly damaging	0.74
R4959:Olfr855	UTSW	9	19585208	missense	probably benign
R4973:Olfr855	UTSW	9	19585208	missense	probably benign
R5223:Olfr855	UTSW	9	19585026	missense	probably benign	0.16
R6005:Olfr855	UTSW	9	19584885	missense	probably benign	0.45
R6017:Olfr855	UTSW	9	19585434	missense	probably benign	0.00
R6145:Olfr855	UTSW	9	19584888	missense	probably benign	0.02
R6615:Olfr855	UTSW	9	19584989	missense	probably benign	0.05
R6771:Olfr855	UTSW	9	19585379	missense	probably benign	0.16
R6969:Olfr855	UTSW	9	19584590	missense	possibly damaging	0.77
R7239:Olfr855	UTSW	9	19585191	missense	probably damaging	1.00
R7313:Olfr855	UTSW	9	19584642	missense	probably damaging	1.00
R7361:Olfr855	UTSW	9	19584560	missense	probably benign	0.00
R8112:Olfr855	UTSW	9	19584724	missense	probably benign	0.44
R8470:Olfr855	UTSW	9	19584969	missense	probably damaging	0.99
R9155:Olfr855	UTSW	9	19585083	missense	probably benign	0.00
R9187:Olfr855	UTSW	9	19584654	missense	probably benign	0.03
R9422:Olfr855	UTSW	9	19584672	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATAAGCTCTGAGTCCCACCTC -3'
(R):5'- CTGATCAAGCTCACAGAAGAAGTG -3'

Sequencing Primer
(F):5'- GCTCTGAGTCCCACCTCCAAAC -3'
(R):5'- AAGTGAGGGATTTCCAGATCTG -3'

Posted On

2016-11-09