Mutagenetix > Incidental Mutation

Incidental Mutation 'R5684:Vmn2r103'

443251

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

043178-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R5684 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 19792989 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 124 (I124S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: I124S

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I124S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.6%
3x: 98.8%
10x: 97.0%
20x: 94.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930519G04Rik	A	G	5: 114,879,560 (GRCm38)	D144G	possibly damaging	Het
4933406M09Rik	A	G	1: 134,389,922 (GRCm38)	D144G	probably benign	Het
AU040320	A	G	4: 126,792,146 (GRCm38)	T172A	probably benign	Het
Bspry	T	C	4: 62,496,282 (GRCm38)	F371L	possibly damaging	Het
Cacna1c	A	G	6: 118,687,044 (GRCm38)	F555L	probably damaging	Het
Colec12	T	C	18: 9,849,009 (GRCm38)	S396P	probably damaging	Het
Creb3l1	A	G	2: 91,990,731 (GRCm38)	V336A	probably damaging	Het
Crocc	T	C	4: 141,051,144 (GRCm38)	N85S	probably damaging	Het
Dcbld2	T	C	16: 58,449,809 (GRCm38)	S278P	possibly damaging	Het
Dnhd1	G	A	7: 105,703,209 (GRCm38)	R2523Q	probably damaging	Het
Ercc4	T	A	16: 13,130,601 (GRCm38)	C561S	probably benign	Het
Gab1	T	C	8: 80,769,670 (GRCm38)	K637R	probably damaging	Het
Grm5	T	C	7: 88,130,645 (GRCm38)	S1130P	probably benign	Het
H2-M10.6	A	T	17: 36,813,854 (GRCm38)	N221I	probably damaging	Het
Htr7	C	A	19: 35,969,871 (GRCm38)	A248S	probably damaging	Het
Kcnh5	T	A	12: 75,137,649 (GRCm38)	K100I	probably damaging	Het
Naip6	T	A	13: 100,300,380 (GRCm38)	Q545L	probably damaging	Het
Nkpd1	C	T	7: 19,523,573 (GRCm38)	Q276*	probably null	Het
Olfr159	T	C	4: 43,770,624 (GRCm38)	N129S	probably benign	Het
Olfr487	A	T	7: 108,212,072 (GRCm38)	Y152*	probably null	Het
Olfr488	A	T	7: 108,256,039 (GRCm38)	I33N	possibly damaging	Het
Pidd1	A	T	7: 141,441,111 (GRCm38)		probably null	Het
Plec	A	G	15: 76,205,596 (GRCm38)		probably null	Het
Plekhh2	C	T	17: 84,597,918 (GRCm38)	A1080V	probably damaging	Het
Plppr3	A	T	10: 79,865,317 (GRCm38)	S564T	possibly damaging	Het
Ppp2ca	A	G	11: 52,113,327 (GRCm38)	K104E	probably damaging	Het
Rad54l	T	A	4: 116,100,563 (GRCm38)	K407M	probably damaging	Het
Sfn	T	A	4: 133,601,292 (GRCm38)	K160*	probably null	Het
Slc22a15	A	G	3: 101,862,955 (GRCm38)	S439P	probably damaging	Het
Slc6a2	T	A	8: 92,989,053 (GRCm38)	V273D	probably damaging	Het
Slc9a9	T	C	9: 95,055,508 (GRCm38)	F471S	possibly damaging	Het
Smc3	A	G	19: 53,640,804 (GRCm38)	E896G	probably benign	Het
Sorbs3	C	T	14: 70,181,222 (GRCm38)	R717Q	probably damaging	Het
Spg11	T	C	2: 122,093,503 (GRCm38)	E779G	probably damaging	Het
Spg7	T	C	8: 123,073,884 (GRCm38)	V66A	probably damaging	Het
Trmt11	A	G	10: 30,547,710 (GRCm38)	S400P	probably damaging	Het
Trpc6	T	C	9: 8,653,128 (GRCm38)	V567A	probably damaging	Het
Vps13a	A	T	19: 16,699,045 (GRCm38)	M1188K	probably benign	Het
Vtn	G	A	11: 78,500,558 (GRCm38)	G266S	probably damaging	Het
Yeats2	T	C	16: 20,193,803 (GRCm38)	S640P	possibly damaging	Het
Zc3hav1	A	T	6: 38,311,279 (GRCm38)	M874K	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19,793,102 (GRCm38)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19,794,965 (GRCm38)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19,792,997 (GRCm38)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19,792,967 (GRCm38)	missense	probably benign
IGL01404:Vmn2r103	APN	17	19,812,434 (GRCm38)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19,794,068 (GRCm38)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19,799,208 (GRCm38)	missense	probably benign
IGL02251:Vmn2r103	APN	17	19,793,969 (GRCm38)	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19,773,369 (GRCm38)	missense	probably benign
IGL02555:Vmn2r103	APN	17	19,811,611 (GRCm38)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19,794,127 (GRCm38)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19,793,956 (GRCm38)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19,812,248 (GRCm38)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,773,520 (GRCm38)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19,811,979 (GRCm38)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19,811,641 (GRCm38)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19,793,464 (GRCm38)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	19,792,859 (GRCm38)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,773,568 (GRCm38)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19,793,927 (GRCm38)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19,794,247 (GRCm38)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19,792,968 (GRCm38)	missense	probably benign
R1488:Vmn2r103	UTSW	17	19,793,660 (GRCm38)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,773,400 (GRCm38)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19,794,234 (GRCm38)	missense	probably benign
R1928:Vmn2r103	UTSW	17	19,811,767 (GRCm38)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19,812,300 (GRCm38)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19,793,794 (GRCm38)	missense	probably benign
R2219:Vmn2r103	UTSW	17	19,793,647 (GRCm38)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,773,531 (GRCm38)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19,793,600 (GRCm38)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19,812,149 (GRCm38)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19,794,233 (GRCm38)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19,811,815 (GRCm38)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19,811,769 (GRCm38)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19,812,171 (GRCm38)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19,793,642 (GRCm38)	missense	probably damaging	0.99
R5715:Vmn2r103	UTSW	17	19,794,939 (GRCm38)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19,812,453 (GRCm38)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19,794,216 (GRCm38)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19,812,325 (GRCm38)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19,812,144 (GRCm38)	missense	probably benign
R6292:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19,794,082 (GRCm38)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19,811,904 (GRCm38)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19,811,977 (GRCm38)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19,793,477 (GRCm38)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19,812,052 (GRCm38)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19,794,214 (GRCm38)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19,793,123 (GRCm38)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19,799,249 (GRCm38)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19,793,497 (GRCm38)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19,811,796 (GRCm38)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19,811,943 (GRCm38)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19,812,384 (GRCm38)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19,811,896 (GRCm38)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19,811,659 (GRCm38)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19,793,765 (GRCm38)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19,799,263 (GRCm38)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19,812,213 (GRCm38)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19,795,047 (GRCm38)	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- GTGATTTTATGCCACTTTCACAGG -3'
(R):5'- TTAGACCTGTAAGTCTCAAGGAC -3'

Sequencing Primer
(F):5'- TTATGCCACTTTCACAGGTATAAC -3'
(R):5'- CCAACCTTTATTTTACAAGGGAGAG -3'

Posted On

2016-11-09