Mutagenetix > Incidental Mutations

Incidental Mutation 'R5688:Olfr1155'

443476

Institutional Source

Beutler Lab

Gene Symbol

Olfr1155

Ensembl Gene

ENSMUSG00000075145

Gene Name

olfactory receptor 1155

Synonyms

GA_x6K02T2Q125-49426894-49425950, MOR174-10

MMRRC Submission

043321-MU

Accession Numbers

Genbank: NM_146643; MGI: 3030989

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R5688 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

87941645-87945137 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 87943208 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 140 (Q140L)

Ref Sequence

ENSEMBL: ENSMUSP00000149428 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099843] [ENSMUST00000214641] [ENSMUST00000215903] [ENSMUST00000216191] [ENSMUST00000216726]

Predicted Effect

probably benign
Transcript: ENSMUST00000099843
AA Change: Q140L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000097431
Gene: ENSMUSG00000075145
AA Change: Q140L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	310	2.7e-44	PFAM
Pfam:7tm_1	43	292	5.3e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214641
AA Change: Q140L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000215903
AA Change: Q140L

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000216191

Predicted Effect

probably benign
Transcript: ENSMUST00000216726

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.3%
20x: 95.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406P16Rik	T	A	7: 34,253,991	T449S	possibly damaging	Het
4931406P16Rik	T	G	7: 34,284,709	D163A	probably damaging	Het
Acp7	G	A	7: 28,616,495	A222V	probably benign	Het
Ahnak	A	G	19: 9,002,519	D389G	probably benign	Het
Aldh1l2	A	T	10: 83,501,925	S559T	possibly damaging	Het
Alms1	T	A	6: 85,599,895	N144K	possibly damaging	Het
Anp32b	T	A	4: 46,469,868		probably null	Het
Atf7	C	T	15: 102,551,509	R57H	probably damaging	Het
Atp10b	A	T	11: 43,201,173	H345L	probably benign	Het
Cacna2d1	A	T	5: 16,358,952	I859F	probably damaging	Het
Calcr	T	A	6: 3,714,730		probably null	Het
Cd248	A	G	19: 5,069,935	T604A	probably benign	Het
Cemip	C	T	7: 83,961,641	V702M	probably damaging	Het
Cep295	G	T	9: 15,331,986	Q469K	probably damaging	Het
Cntn5	A	G	9: 9,748,422	W485R	probably damaging	Het
Cpe	T	C	8: 64,609,155	N289S	possibly damaging	Het
Cyp2j11	G	A	4: 96,345,121	R113C	probably damaging	Het
Dcp1b	T	C	6: 119,217,911	S531P	probably benign	Het
Defb7	T	G	8: 19,495,151	L15R	probably damaging	Het
Dnah2	C	T	11: 69,458,920	R2399Q	probably benign	Het
Ednrb	T	C	14: 103,823,395	D198G	probably damaging	Het
Engase	A	C	11: 118,487,320	E312A	possibly damaging	Het
Evl	G	A	12: 108,673,353		probably null	Het
Faf1	C	A	4: 109,794,813	Q234K	probably damaging	Het
Gm5460	C	A	14: 34,045,795	N453K	possibly damaging	Het
Gm7356	T	A	17: 14,000,607	I387F	possibly damaging	Het
Hagh	T	C	17: 24,850,594	M1T	probably null	Het
Hars	A	T	18: 36,772,316	V155E	probably damaging	Het
Hist1h1c	A	G	13: 23,739,165	K106R	probably damaging	Het
Lca5	C	A	9: 83,398,566	D394Y	probably benign	Het
Lmtk3	T	C	7: 45,791,410	L280P	probably damaging	Het
Lrit1	C	T	14: 37,062,428	A571V	possibly damaging	Het
Map4k2	C	A	19: 6,346,806	P584H	probably damaging	Het
Mgst1	T	C	6: 138,141,800		probably benign	Het
Neb	C	T	2: 52,196,327	V5245I	probably damaging	Het
Oas3	T	C	5: 120,758,802	N918S	probably benign	Het
Olfr1204	C	T	2: 88,852,679	T243I	probably benign	Het
Olfr145	A	C	9: 37,898,063	I220L	possibly damaging	Het
Ovch2	A	G	7: 107,793,994	L224P	probably damaging	Het
Patj	A	T	4: 98,520,810	K34*	probably null	Het
Pcf11	T	A	7: 92,658,808	R717S	possibly damaging	Het
Plcb1	A	T	2: 135,335,480	E577D	probably benign	Het
Plxnb2	T	C	15: 89,158,696	K1497E	probably damaging	Het
Pyroxd1	C	A	6: 142,353,540	L141I	probably damaging	Het
Rhobtb3	G	T	13: 75,872,418	N588K	probably benign	Het
Rnasel	G	A	1: 153,753,706		probably benign	Het
Sh3bp5	C	A	14: 31,377,495	R265L	probably benign	Het
Shank1	A	T	7: 44,354,487	I1868F	possibly damaging	Het
Skiv2l2	A	T	13: 112,873,056	C936*	probably null	Het
Slc28a3	A	T	13: 58,558,649	S593T	probably damaging	Het
Slc29a4	T	C	5: 142,714,098	I168T	possibly damaging	Het
Slc35f5	C	T	1: 125,591,038	P502L	probably benign	Het
Slco6d1	T	C	1: 98,480,768	I463T	probably damaging	Het
Slk	A	G	19: 47,620,012	D468G	probably benign	Het
Spata31d1d	G	T	13: 59,726,508	P1071Q	probably damaging	Het
Tert	G	A	13: 73,639,156	V754I	probably damaging	Het
Thada	T	C	17: 84,451,727	T235A	probably benign	Het
Ttn	T	C	2: 76,734,128	D28555G	probably damaging	Het
Ttn	T	A	2: 76,879,984		probably null	Het
Ubqln4	T	C	3: 88,565,268	L464P	probably damaging	Het
Unc45b	A	T	11: 82,922,817	N350I	possibly damaging	Het
Vmn2r65	T	C	7: 84,940,692	D672G	probably benign	Het
Zfp947	T	A	17: 22,146,085	I203L	probably benign	Het
Zfp964	T	A	8: 69,664,116	H454Q	probably benign	Het

Other mutations in Olfr1155

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02507:Olfr1155	APN	2	87942918	nonsense	probably null
IGL03245:Olfr1155	APN	2	87942742	missense	possibly damaging	0.75
B5639:Olfr1155	UTSW	2	87943598	missense	probably benign	0.03
PIT4531001:Olfr1155	UTSW	2	87943227	missense	probably damaging	1.00
R0212:Olfr1155	UTSW	2	87943091	missense	probably damaging	1.00
R0393:Olfr1155	UTSW	2	87943565	missense	possibly damaging	0.62
R1178:Olfr1155	UTSW	2	87943146	missense	probably benign	0.02
R1180:Olfr1155	UTSW	2	87943146	missense	probably benign	0.02
R1181:Olfr1155	UTSW	2	87943146	missense	probably benign	0.02
R1266:Olfr1155	UTSW	2	87943533	missense	probably benign	0.01
R1847:Olfr1155	UTSW	2	87942721	splice site	probably null
R1998:Olfr1155	UTSW	2	87943146	missense	probably benign	0.02
R2000:Olfr1155	UTSW	2	87943146	missense	probably benign	0.02
R4119:Olfr1155	UTSW	2	87943443	missense	probably damaging	1.00
R4213:Olfr1155	UTSW	2	87943121	missense	probably benign	0.00
R5157:Olfr1155	UTSW	2	87942888	missense	probably benign
R5731:Olfr1155	UTSW	2	87943427	missense	possibly damaging	0.89
R6064:Olfr1155	UTSW	2	87943484	missense	probably benign	0.00
R6372:Olfr1155	UTSW	2	87942975	missense	probably benign	0.00
R6505:Olfr1155	UTSW	2	87943174	nonsense	probably null
R6555:Olfr1155	UTSW	2	87943288	missense	probably damaging	1.00
R6909:Olfr1155	UTSW	2	87942690	missense	probably benign	0.27
R7257:Olfr1155	UTSW	2	87943571	missense	probably damaging	1.00
R8037:Olfr1155	UTSW	2	87942975	missense	probably benign	0.00
R8367:Olfr1155	UTSW	2	87943097	missense	possibly damaging	0.75
Z1088:Olfr1155	UTSW	2	87943448	missense	probably damaging	1.00
Z1176:Olfr1155	UTSW	2	87943209	missense	possibly damaging	0.57
Z1176:Olfr1155	UTSW	2	87943467	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAGGGCAGTGACAACAATG -3'
(R):5'- CTCCCAAGATGCTGGTGAAC -3'

Sequencing Primer
(F):5'- GTGCTTATTTCATTGAAAGTGGCAAC -3'
(R):5'- ACCTTGTTGTAGAAGATAGGACC -3'

Posted On

2016-11-09