Incidental Mutation 'R5688:Or4c106'
ID 443477
Institutional Source Beutler Lab
Gene Symbol Or4c106
Ensembl Gene ENSMUSG00000061798
Gene Name olfactory receptor family 4 subfamily C member 106
Synonyms MOR232-6, Olfr1204, GA_x6K02T2Q125-50322618-50323547
MMRRC Submission 043321-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5688 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88682296-88683225 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 88683023 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 243 (T243I)
Ref Sequence ENSEMBL: ENSMUSP00000150111 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078631] [ENSMUST00000213283]
AlphaFold Q7TR10
Predicted Effect probably benign
Transcript: ENSMUST00000078631
AA Change: T243I

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000077701
Gene: ENSMUSG00000061798
AA Change: T243I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.5e-48 PFAM
Pfam:7tm_1 39 285 1.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213283
AA Change: T243I

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 G A 7: 28,315,920 (GRCm39) A222V probably benign Het
Ahnak A G 19: 8,979,883 (GRCm39) D389G probably benign Het
Aldh1l2 A T 10: 83,337,789 (GRCm39) S559T possibly damaging Het
Alms1 T A 6: 85,576,877 (GRCm39) N144K possibly damaging Het
Anp32b T A 4: 46,469,868 (GRCm39) probably null Het
Atf7 C T 15: 102,459,944 (GRCm39) R57H probably damaging Het
Atp10b A T 11: 43,092,000 (GRCm39) H345L probably benign Het
Cacna2d1 A T 5: 16,563,950 (GRCm39) I859F probably damaging Het
Calcr T A 6: 3,714,730 (GRCm39) probably null Het
Cd248 A G 19: 5,119,963 (GRCm39) T604A probably benign Het
Cemip C T 7: 83,610,849 (GRCm39) V702M probably damaging Het
Cep295 G T 9: 15,243,282 (GRCm39) Q469K probably damaging Het
Cntn5 A G 9: 9,748,427 (GRCm39) W485R probably damaging Het
Cpe T C 8: 65,062,189 (GRCm39) N289S possibly damaging Het
Cyp2j11 G A 4: 96,233,358 (GRCm39) R113C probably damaging Het
Dcp1b T C 6: 119,194,872 (GRCm39) S531P probably benign Het
Defb7 T G 8: 19,545,167 (GRCm39) L15R probably damaging Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Ednrb T C 14: 104,060,831 (GRCm39) D198G probably damaging Het
Engase A C 11: 118,378,146 (GRCm39) E312A possibly damaging Het
Evl G A 12: 108,639,612 (GRCm39) probably null Het
Faf1 C A 4: 109,652,010 (GRCm39) Q234K probably damaging Het
Garre1 T A 7: 33,953,416 (GRCm39) T449S possibly damaging Het
Garre1 T G 7: 33,984,134 (GRCm39) D163A probably damaging Het
Gm5460 C A 14: 33,767,752 (GRCm39) N453K possibly damaging Het
Gm7356 T A 17: 14,220,869 (GRCm39) I387F possibly damaging Het
H1f2 A G 13: 23,923,148 (GRCm39) K106R probably damaging Het
Hagh T C 17: 25,069,568 (GRCm39) M1T probably null Het
Hars1 A T 18: 36,905,369 (GRCm39) V155E probably damaging Het
Lca5 C A 9: 83,280,619 (GRCm39) D394Y probably benign Het
Lmtk3 T C 7: 45,440,834 (GRCm39) L280P probably damaging Het
Lrit1 C T 14: 36,784,385 (GRCm39) A571V possibly damaging Het
Map4k2 C A 19: 6,396,836 (GRCm39) P584H probably damaging Het
Mgst1 T C 6: 138,118,798 (GRCm39) probably benign Het
Mtrex A T 13: 113,009,590 (GRCm39) C936* probably null Het
Neb C T 2: 52,086,339 (GRCm39) V5245I probably damaging Het
Oas3 T C 5: 120,896,867 (GRCm39) N918S probably benign Het
Or5d16 T A 2: 87,773,552 (GRCm39) Q140L probably benign Het
Or8b8 A C 9: 37,809,359 (GRCm39) I220L possibly damaging Het
Ovch2 A G 7: 107,393,201 (GRCm39) L224P probably damaging Het
Patj A T 4: 98,409,047 (GRCm39) K34* probably null Het
Pcf11 T A 7: 92,308,016 (GRCm39) R717S possibly damaging Het
Plcb1 A T 2: 135,177,400 (GRCm39) E577D probably benign Het
Plxnb2 T C 15: 89,042,899 (GRCm39) K1497E probably damaging Het
Pyroxd1 C A 6: 142,299,266 (GRCm39) L141I probably damaging Het
Rhobtb3 G T 13: 76,020,537 (GRCm39) N588K probably benign Het
Rnasel G A 1: 153,629,452 (GRCm39) probably benign Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Shank1 A T 7: 44,003,911 (GRCm39) I1868F possibly damaging Het
Slc28a3 A T 13: 58,706,463 (GRCm39) S593T probably damaging Het
Slc29a4 T C 5: 142,699,853 (GRCm39) I168T possibly damaging Het
Slc35f5 C T 1: 125,518,775 (GRCm39) P502L probably benign Het
Slco6d1 T C 1: 98,408,493 (GRCm39) I463T probably damaging Het
Slk A G 19: 47,608,451 (GRCm39) D468G probably benign Het
Spata31d1d G T 13: 59,874,322 (GRCm39) P1071Q probably damaging Het
Tert G A 13: 73,787,275 (GRCm39) V754I probably damaging Het
Thada T C 17: 84,759,155 (GRCm39) T235A probably benign Het
Ttn T C 2: 76,564,472 (GRCm39) D28555G probably damaging Het
Ttn T A 2: 76,710,328 (GRCm39) probably null Het
Ubqln4 T C 3: 88,472,575 (GRCm39) L464P probably damaging Het
Unc45b A T 11: 82,813,643 (GRCm39) N350I possibly damaging Het
Vmn2r65 T C 7: 84,589,900 (GRCm39) D672G probably benign Het
Zfp947 T A 17: 22,365,066 (GRCm39) I203L probably benign Het
Zfp964 T A 8: 70,116,766 (GRCm39) H454Q probably benign Het
Other mutations in Or4c106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Or4c106 APN 2 88,682,669 (GRCm39) missense probably damaging 0.99
R1583:Or4c106 UTSW 2 88,682,606 (GRCm39) missense probably damaging 1.00
R2151:Or4c106 UTSW 2 88,683,128 (GRCm39) missense probably damaging 1.00
R2153:Or4c106 UTSW 2 88,683,128 (GRCm39) missense probably damaging 1.00
R4959:Or4c106 UTSW 2 88,682,516 (GRCm39) missense possibly damaging 0.79
R4973:Or4c106 UTSW 2 88,682,516 (GRCm39) missense possibly damaging 0.79
R5048:Or4c106 UTSW 2 88,682,807 (GRCm39) missense possibly damaging 0.91
R5164:Or4c106 UTSW 2 88,682,914 (GRCm39) missense probably benign 0.30
R5319:Or4c106 UTSW 2 88,683,122 (GRCm39) missense probably damaging 0.99
R5399:Or4c106 UTSW 2 88,682,999 (GRCm39) missense probably damaging 1.00
R6339:Or4c106 UTSW 2 88,683,215 (GRCm39) missense probably null
R6481:Or4c106 UTSW 2 88,682,863 (GRCm39) missense probably damaging 1.00
R7456:Or4c106 UTSW 2 88,682,563 (GRCm39) missense probably damaging 0.99
R7469:Or4c106 UTSW 2 88,682,847 (GRCm39) missense probably benign
R9517:Or4c106 UTSW 2 88,682,947 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CTAGCCTGTATTGACACCCAC -3'
(R):5'- TCTGAAGACACATGACTGTTCC -3'

Sequencing Primer
(F):5'- GTATTGACACCCACATCCTGG -3'
(R):5'- TGTCATCTGACTGAACTTTTACAC -3'
Posted On 2016-11-09