Incidental Mutation 'R5688:Dcp1b'
ID 443492
Institutional Source Beutler Lab
Gene Symbol Dcp1b
Ensembl Gene ENSMUSG00000041477
Gene Name decapping mRNA 1B
Synonyms B930050E02Rik
MMRRC Submission 043321-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.630) question?
Stock # R5688 (G1)
Quality Score 196
Status Not validated
Chromosome 6
Chromosomal Location 119152214-119198575 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119194872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 531 (S531P)
Ref Sequence ENSEMBL: ENSMUSP00000108397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073909] [ENSMUST00000112777]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000073909
AA Change: S498P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000073568
Gene: ENSMUSG00000041477
AA Change: S498P

low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 10 131 1.3e-53 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112777
AA Change: S531P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000108397
Gene: ENSMUSG00000041477
AA Change: S531P

low complexity region 2 8 N/A INTRINSIC
Pfam:DCP1 13 129 3e-46 PFAM
low complexity region 250 260 N/A INTRINSIC
low complexity region 451 462 N/A INTRINSIC
low complexity region 515 526 N/A INTRINSIC
Pfam:mRNA_decap_C 536 578 2.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136437
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149651
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 G A 7: 28,315,920 (GRCm39) A222V probably benign Het
Ahnak A G 19: 8,979,883 (GRCm39) D389G probably benign Het
Aldh1l2 A T 10: 83,337,789 (GRCm39) S559T possibly damaging Het
Alms1 T A 6: 85,576,877 (GRCm39) N144K possibly damaging Het
Anp32b T A 4: 46,469,868 (GRCm39) probably null Het
Atf7 C T 15: 102,459,944 (GRCm39) R57H probably damaging Het
Atp10b A T 11: 43,092,000 (GRCm39) H345L probably benign Het
Cacna2d1 A T 5: 16,563,950 (GRCm39) I859F probably damaging Het
Calcr T A 6: 3,714,730 (GRCm39) probably null Het
Cd248 A G 19: 5,119,963 (GRCm39) T604A probably benign Het
Cemip C T 7: 83,610,849 (GRCm39) V702M probably damaging Het
Cep295 G T 9: 15,243,282 (GRCm39) Q469K probably damaging Het
Cntn5 A G 9: 9,748,427 (GRCm39) W485R probably damaging Het
Cpe T C 8: 65,062,189 (GRCm39) N289S possibly damaging Het
Cyp2j11 G A 4: 96,233,358 (GRCm39) R113C probably damaging Het
Defb7 T G 8: 19,545,167 (GRCm39) L15R probably damaging Het
Dnah2 C T 11: 69,349,746 (GRCm39) R2399Q probably benign Het
Ednrb T C 14: 104,060,831 (GRCm39) D198G probably damaging Het
Engase A C 11: 118,378,146 (GRCm39) E312A possibly damaging Het
Evl G A 12: 108,639,612 (GRCm39) probably null Het
Faf1 C A 4: 109,652,010 (GRCm39) Q234K probably damaging Het
Garre1 T A 7: 33,953,416 (GRCm39) T449S possibly damaging Het
Garre1 T G 7: 33,984,134 (GRCm39) D163A probably damaging Het
Gm5460 C A 14: 33,767,752 (GRCm39) N453K possibly damaging Het
Gm7356 T A 17: 14,220,869 (GRCm39) I387F possibly damaging Het
H1f2 A G 13: 23,923,148 (GRCm39) K106R probably damaging Het
Hagh T C 17: 25,069,568 (GRCm39) M1T probably null Het
Hars1 A T 18: 36,905,369 (GRCm39) V155E probably damaging Het
Lca5 C A 9: 83,280,619 (GRCm39) D394Y probably benign Het
Lmtk3 T C 7: 45,440,834 (GRCm39) L280P probably damaging Het
Lrit1 C T 14: 36,784,385 (GRCm39) A571V possibly damaging Het
Map4k2 C A 19: 6,396,836 (GRCm39) P584H probably damaging Het
Mgst1 T C 6: 138,118,798 (GRCm39) probably benign Het
Mtrex A T 13: 113,009,590 (GRCm39) C936* probably null Het
Neb C T 2: 52,086,339 (GRCm39) V5245I probably damaging Het
Oas3 T C 5: 120,896,867 (GRCm39) N918S probably benign Het
Or4c106 C T 2: 88,683,023 (GRCm39) T243I probably benign Het
Or5d16 T A 2: 87,773,552 (GRCm39) Q140L probably benign Het
Or8b8 A C 9: 37,809,359 (GRCm39) I220L possibly damaging Het
Ovch2 A G 7: 107,393,201 (GRCm39) L224P probably damaging Het
Patj A T 4: 98,409,047 (GRCm39) K34* probably null Het
Pcf11 T A 7: 92,308,016 (GRCm39) R717S possibly damaging Het
Plcb1 A T 2: 135,177,400 (GRCm39) E577D probably benign Het
Plxnb2 T C 15: 89,042,899 (GRCm39) K1497E probably damaging Het
Pyroxd1 C A 6: 142,299,266 (GRCm39) L141I probably damaging Het
Rhobtb3 G T 13: 76,020,537 (GRCm39) N588K probably benign Het
Rnasel G A 1: 153,629,452 (GRCm39) probably benign Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Shank1 A T 7: 44,003,911 (GRCm39) I1868F possibly damaging Het
Slc28a3 A T 13: 58,706,463 (GRCm39) S593T probably damaging Het
Slc29a4 T C 5: 142,699,853 (GRCm39) I168T possibly damaging Het
Slc35f5 C T 1: 125,518,775 (GRCm39) P502L probably benign Het
Slco6d1 T C 1: 98,408,493 (GRCm39) I463T probably damaging Het
Slk A G 19: 47,608,451 (GRCm39) D468G probably benign Het
Spata31d1d G T 13: 59,874,322 (GRCm39) P1071Q probably damaging Het
Tert G A 13: 73,787,275 (GRCm39) V754I probably damaging Het
Thada T C 17: 84,759,155 (GRCm39) T235A probably benign Het
Ttn T C 2: 76,564,472 (GRCm39) D28555G probably damaging Het
Ttn T A 2: 76,710,328 (GRCm39) probably null Het
Ubqln4 T C 3: 88,472,575 (GRCm39) L464P probably damaging Het
Unc45b A T 11: 82,813,643 (GRCm39) N350I possibly damaging Het
Vmn2r65 T C 7: 84,589,900 (GRCm39) D672G probably benign Het
Zfp947 T A 17: 22,365,066 (GRCm39) I203L probably benign Het
Zfp964 T A 8: 70,116,766 (GRCm39) H454Q probably benign Het
Other mutations in Dcp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Dcp1b APN 6 119,192,319 (GRCm39) missense probably damaging 0.96
IGL01320:Dcp1b APN 6 119,192,036 (GRCm39) missense probably benign 0.29
IGL01348:Dcp1b APN 6 119,160,679 (GRCm39) missense probably damaging 1.00
IGL01635:Dcp1b APN 6 119,183,498 (GRCm39) missense probably damaging 1.00
IGL02888:Dcp1b APN 6 119,197,048 (GRCm39) utr 3 prime probably benign
IGL03280:Dcp1b APN 6 119,157,019 (GRCm39) intron probably benign
R1672:Dcp1b UTSW 6 119,194,872 (GRCm39) missense probably benign
R2395:Dcp1b UTSW 6 119,192,025 (GRCm39) missense probably benign
R2421:Dcp1b UTSW 6 119,192,227 (GRCm39) missense probably benign 0.28
R2512:Dcp1b UTSW 6 119,183,473 (GRCm39) missense possibly damaging 0.69
R2870:Dcp1b UTSW 6 119,191,735 (GRCm39) missense probably benign
R2870:Dcp1b UTSW 6 119,191,735 (GRCm39) missense probably benign
R4450:Dcp1b UTSW 6 119,183,437 (GRCm39) missense probably benign 0.01
R5394:Dcp1b UTSW 6 119,152,328 (GRCm39) missense probably damaging 1.00
R7734:Dcp1b UTSW 6 119,192,244 (GRCm39) missense probably benign 0.00
R7752:Dcp1b UTSW 6 119,152,318 (GRCm39) missense possibly damaging 0.64
R7847:Dcp1b UTSW 6 119,192,256 (GRCm39) missense probably benign
R8274:Dcp1b UTSW 6 119,160,612 (GRCm39) missense probably damaging 1.00
R8325:Dcp1b UTSW 6 119,192,397 (GRCm39) nonsense probably null
R9424:Dcp1b UTSW 6 119,196,993 (GRCm39) nonsense probably null
R9576:Dcp1b UTSW 6 119,196,993 (GRCm39) nonsense probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-11-09