Incidental Mutation 'R5689:Or10g3'
ID 443592
Institutional Source Beutler Lab
Gene Symbol Or10g3
Ensembl Gene ENSMUSG00000094140
Gene Name olfactory receptor family 10 subfamily G member 3
Synonyms GA_x6K02T2RJGY-622120-623061, MOR223-5, Olfr1512
MMRRC Submission 043322-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R5689 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 52609567-52610508 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 52610214 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 99 (V99M)
Ref Sequence ENSEMBL: ENSMUSP00000149717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071221] [ENSMUST00000214980]
AlphaFold Q8VF72
Predicted Effect possibly damaging
Transcript: ENSMUST00000071221
AA Change: V99M

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000071208
Gene: ENSMUSG00000094140
AA Change: V99M

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.1e-48 PFAM
Pfam:7tm_1 41 290 2.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192537
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200261
Predicted Effect possibly damaging
Transcript: ENSMUST00000214980
AA Change: V99M

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency 95% (63/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy7 G T 8: 89,051,412 (GRCm39) C844F probably benign Het
Afdn T C 17: 14,075,621 (GRCm39) V945A probably damaging Het
Aimp2 T C 5: 143,843,389 (GRCm39) D67G possibly damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Atp11b G T 3: 35,888,501 (GRCm39) V924F possibly damaging Het
Atp8b1 C T 18: 64,697,608 (GRCm39) R412H probably damaging Het
Cfb T A 17: 35,080,770 (GRCm39) T76S probably benign Het
Cmpk2 A T 12: 26,519,766 (GRCm39) H139L probably benign Het
Cypt4 T C 9: 24,536,542 (GRCm39) S11P possibly damaging Het
Dbx1 A G 7: 49,282,519 (GRCm39) F229L probably damaging Het
Dnah6 T A 6: 72,998,210 (GRCm39) M4071L probably benign Het
Dnah7a A G 1: 53,444,857 (GRCm39) V3949A possibly damaging Het
Dnajc25 A G 4: 59,017,716 (GRCm39) E6G probably damaging Het
Dync2h1 C A 9: 7,169,689 (GRCm39) V263F probably damaging Het
Eno4 T A 19: 58,959,088 (GRCm39) D403E probably benign Het
Evi5l C T 8: 4,255,460 (GRCm39) Q542* probably null Het
Fam135a A G 1: 24,068,134 (GRCm39) S12P probably benign Het
Flnc G A 6: 29,441,591 (GRCm39) A458T probably benign Het
Fnip1 T C 11: 54,393,115 (GRCm39) V517A probably damaging Het
Galc G T 12: 98,179,245 (GRCm39) H361N possibly damaging Het
Gask1a T C 9: 121,794,754 (GRCm39) F303L probably damaging Het
Gcnt1 T A 19: 17,306,768 (GRCm39) D319V probably damaging Het
Gm26996 T C 6: 130,555,258 (GRCm39) noncoding transcript Het
Gm5321 A T 7: 6,022,268 (GRCm39) noncoding transcript Het
Grin3b T C 10: 79,810,465 (GRCm39) L657P probably damaging Het
Gstm5 T C 3: 107,803,981 (GRCm39) F54S probably damaging Het
Ilk C A 7: 105,390,857 (GRCm39) L267I probably benign Het
Lifr A G 15: 7,214,285 (GRCm39) Y713C probably damaging Het
Lnx2 A T 5: 146,965,961 (GRCm39) V386E probably damaging Het
Lrch1 T C 14: 75,023,764 (GRCm39) E587G probably damaging Het
Osgin1 A G 8: 120,171,728 (GRCm39) *173W probably null Het
Pcdhga7 C A 18: 37,849,736 (GRCm39) P581H probably damaging Het
Pde4dip A T 3: 97,599,683 (GRCm39) L2384* probably null Het
Phf12 T A 11: 77,914,551 (GRCm39) N115K probably damaging Het
Pmel A G 10: 128,552,170 (GRCm39) T335A probably damaging Het
Polr3e C A 7: 120,539,912 (GRCm39) T579K possibly damaging Het
Ptprc A G 1: 138,045,515 (GRCm39) V164A probably benign Het
Rapsn T C 2: 90,866,269 (GRCm39) F43S probably damaging Het
Rarb T A 14: 16,434,177 (GRCm38) I334F probably damaging Het
Rev3l T C 10: 39,670,954 (GRCm39) Y167H probably damaging Het
Rnf146 T C 10: 29,223,800 (GRCm39) T29A probably benign Het
Rsf1 GC GCGGCGGCGCC 7: 97,229,141 (GRCm39) probably benign Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Slc5a10 C T 11: 61,598,710 (GRCm39) M223I probably benign Het
Slc7a11 C G 3: 50,326,780 (GRCm39) V494L probably benign Het
Slitrk6 C T 14: 110,989,558 (GRCm39) E50K probably benign Het
Smg8 A G 11: 86,975,949 (GRCm39) F544S probably damaging Het
Tnpo3 T C 6: 29,571,063 (GRCm39) M444V possibly damaging Het
Trav7d-4 G A 14: 53,007,651 (GRCm39) R48H probably damaging Het
Trim50 A T 5: 135,382,516 (GRCm39) T123S probably damaging Het
Trpc4ap C G 2: 155,512,955 (GRCm39) probably null Het
Ttn T A 2: 76,618,620 (GRCm39) R14475S probably damaging Het
Uts2 A T 4: 151,083,565 (GRCm39) T59S possibly damaging Het
Vmn1r52 T C 6: 90,156,232 (GRCm39) S179P possibly damaging Het
Vmn2r116 A G 17: 23,616,693 (GRCm39) H537R probably benign Het
Vps16 C T 2: 130,281,011 (GRCm39) Q226* probably null Het
Zfhx2 T C 14: 55,311,360 (GRCm39) T445A possibly damaging Het
Zfp638 T C 6: 83,906,054 (GRCm39) V73A probably damaging Het
Other mutations in Or10g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01328:Or10g3 APN 14 52,609,967 (GRCm39) missense probably damaging 1.00
IGL01375:Or10g3 APN 14 52,609,865 (GRCm39) missense probably damaging 0.99
IGL02343:Or10g3 APN 14 52,609,934 (GRCm39) missense probably damaging 1.00
R1443:Or10g3 UTSW 14 52,610,408 (GRCm39) missense probably damaging 1.00
R1902:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R1903:Or10g3 UTSW 14 52,610,174 (GRCm39) missense possibly damaging 0.81
R3115:Or10g3 UTSW 14 52,610,397 (GRCm39) missense probably damaging 1.00
R4752:Or10g3 UTSW 14 52,609,764 (GRCm39) missense probably damaging 1.00
R5345:Or10g3 UTSW 14 52,609,725 (GRCm39) nonsense probably null
R6185:Or10g3 UTSW 14 52,610,019 (GRCm39) missense possibly damaging 0.91
R6287:Or10g3 UTSW 14 52,609,748 (GRCm39) missense probably damaging 1.00
R6757:Or10g3 UTSW 14 52,610,172 (GRCm39) missense probably damaging 1.00
R8751:Or10g3 UTSW 14 52,610,420 (GRCm39) missense probably benign 0.03
R8855:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R8866:Or10g3 UTSW 14 52,610,196 (GRCm39) missense probably damaging 1.00
R9038:Or10g3 UTSW 14 52,609,716 (GRCm39) missense probably damaging 0.99
R9450:Or10g3 UTSW 14 52,610,110 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGATTGGGACCACAGTAGG -3'
(R):5'- TACATCCTGACTCAGCTGGG -3'

Sequencing Primer
(F):5'- CCACAGTAGGGCAAGCG -3'
(R):5'- GGAACGCGCTCATCCTGATC -3'
Posted On 2016-11-09