Incidental Mutation 'R5691:Zfp90'
ID 443692
Institutional Source Beutler Lab
Gene Symbol Zfp90
Ensembl Gene ENSMUSG00000031907
Gene Name zinc finger protein 90
Synonyms Nk10 expressed protein, NK10, 6430515L01Rik, Zfp64, KRAB17, Zfp83
MMRRC Submission 043324-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.188) question?
Stock # R5691 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 107141959-107153230 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 107151710 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 474 (Y474*)
Ref Sequence ENSEMBL: ENSMUSP00000148744 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034382] [ENSMUST00000212606] [ENSMUST00000212874] [ENSMUST00000213045]
AlphaFold Q61967
Predicted Effect probably null
Transcript: ENSMUST00000034382
AA Change: Y474*
SMART Domains Protein: ENSMUSP00000034382
Gene: ENSMUSG00000031907
AA Change: Y474*

DomainStartEndE-ValueType
KRAB 14 74 4.83e-40 SMART
ZnF_C2H2 208 230 1.38e-3 SMART
ZnF_C2H2 250 272 2.75e-3 SMART
ZnF_C2H2 278 300 3.83e-2 SMART
ZnF_C2H2 306 328 1.13e-4 SMART
ZnF_C2H2 334 356 2.09e-3 SMART
ZnF_C2H2 362 384 3.16e-3 SMART
ZnF_C2H2 390 412 1.6e-4 SMART
ZnF_C2H2 446 468 1.92e-2 SMART
ZnF_C2H2 494 516 3.69e-4 SMART
ZnF_C2H2 522 544 5.59e-4 SMART
ZnF_C2H2 550 572 1.28e-3 SMART
ZnF_C2H2 578 600 1.28e-3 SMART
ZnF_C2H2 606 628 2.4e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180410
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211958
Predicted Effect probably benign
Transcript: ENSMUST00000212606
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212866
Predicted Effect probably null
Transcript: ENSMUST00000212874
AA Change: Y474*
Predicted Effect probably benign
Transcript: ENSMUST00000213045
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency 98% (60/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410022M11Rik A G 14: 57,049,830 (GRCm39) probably benign Het
Abcb5 A T 12: 118,890,970 (GRCm39) M509K probably damaging Het
Ap4m1 A G 5: 138,170,653 (GRCm39) Y34C probably damaging Het
Aqp7 G A 4: 41,035,510 (GRCm39) T115I probably benign Het
Bcl10 C T 3: 145,638,904 (GRCm39) T182I probably benign Het
Cdc123 T A 2: 5,827,986 (GRCm39) N87I probably benign Het
Cfap46 T C 7: 139,186,616 (GRCm39) E2431G possibly damaging Het
Dcc T C 18: 71,708,154 (GRCm39) T521A probably damaging Het
Defb46 T A 8: 19,292,149 (GRCm39) I55K probably benign Het
Dlgap4 A G 2: 156,546,390 (GRCm39) T353A probably benign Het
Eqtn C A 4: 94,811,965 (GRCm39) probably null Het
Ermn A T 2: 57,937,776 (GRCm39) M279K probably damaging Het
Fan1 C A 7: 64,004,118 (GRCm39) probably null Het
Fbxo17 G A 7: 28,436,897 (GRCm39) R284H probably damaging Het
Hectd4 A G 5: 121,486,878 (GRCm39) D3291G possibly damaging Het
Hid1 A G 11: 115,239,645 (GRCm39) W762R probably damaging Het
Idi2l A T 13: 8,992,693 (GRCm39) Y91* probably null Het
Ifi207 A G 1: 173,559,992 (GRCm39) I160T unknown Het
Inpp4b T A 8: 82,617,323 (GRCm39) probably benign Het
Iqcd C T 5: 120,740,571 (GRCm39) Q301* probably null Het
Jph1 T G 1: 17,074,587 (GRCm39) Q477P probably benign Het
Kdm4c A T 4: 74,252,965 (GRCm39) I511L probably benign Het
Lrp2 T C 2: 69,332,897 (GRCm39) D1540G probably damaging Het
Lrrc69 T A 4: 14,769,648 (GRCm39) I168F probably damaging Het
Mgat4e A T 1: 134,468,729 (GRCm39) probably benign Het
Mroh7 C A 4: 106,559,815 (GRCm39) G704V probably damaging Het
Nadsyn1 C T 7: 143,366,316 (GRCm39) probably null Het
Ncoa2 A T 1: 13,250,774 (GRCm39) C303S probably damaging Het
Nova1 T C 12: 46,863,738 (GRCm39) T71A unknown Het
Nrcam T C 12: 44,611,039 (GRCm39) Y554H probably damaging Het
Nubpl G A 12: 52,152,059 (GRCm39) probably benign Het
Oasl2 C A 5: 115,037,828 (GRCm39) T75K possibly damaging Het
Or8h9 A T 2: 86,789,616 (GRCm39) F62Y probably damaging Het
P3h3 C T 6: 124,832,116 (GRCm39) G257R probably damaging Het
Parp14 A G 16: 35,683,909 (GRCm39) V139A probably benign Het
Pgam5 G A 5: 110,414,959 (GRCm39) P85S probably damaging Het
Phpt1 T C 2: 25,463,707 (GRCm39) Y96C probably damaging Het
Plekhm2 A C 4: 141,355,600 (GRCm39) S867A possibly damaging Het
Pramel26 A T 4: 143,538,579 (GRCm39) W131R probably benign Het
Prss21 A G 17: 24,087,759 (GRCm39) probably null Het
Rabgap1l A T 1: 160,563,254 (GRCm39) Y108N probably damaging Het
Riox1 C T 12: 83,998,466 (GRCm39) T334I possibly damaging Het
Rps3a2 G T 14: 88,360,483 (GRCm39) noncoding transcript Het
Selenot C T 3: 58,493,447 (GRCm39) A108V probably benign Het
Setd3 A T 12: 108,126,544 (GRCm39) M98K probably benign Het
Slc22a27 T C 19: 7,904,035 (GRCm39) H34R possibly damaging Het
Slco1a8 A T 6: 141,940,581 (GRCm39) Y93* probably null Het
Sp3 A G 2: 72,801,803 (GRCm39) L70S probably damaging Het
Syne2 TCCAGGTAGGGCACACC TCC 12: 76,074,630 (GRCm39) probably null Het
Tcl1b4 C A 12: 105,168,806 (GRCm39) D23E possibly damaging Het
Tespa1 T A 10: 130,190,638 (GRCm39) probably null Het
Tmc7 T C 7: 118,141,116 (GRCm39) I672V probably benign Het
Trps1 T A 15: 50,690,700 (GRCm39) Q14L probably benign Het
Vmn2r73 A G 7: 85,507,299 (GRCm39) V671A probably damaging Het
Zfp106 G A 2: 120,354,952 (GRCm39) S1273F probably damaging Het
Other mutations in Zfp90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01753:Zfp90 APN 8 107,150,782 (GRCm39) missense probably benign 0.00
IGL02170:Zfp90 APN 8 107,146,156 (GRCm39) missense probably damaging 0.99
IGL02818:Zfp90 APN 8 107,150,841 (GRCm39) missense probably benign
R0378:Zfp90 UTSW 8 107,152,138 (GRCm39) missense possibly damaging 0.69
R0462:Zfp90 UTSW 8 107,151,892 (GRCm39) missense possibly damaging 0.89
R1555:Zfp90 UTSW 8 107,150,727 (GRCm39) missense probably benign
R1869:Zfp90 UTSW 8 107,145,755 (GRCm39) missense probably benign 0.00
R1870:Zfp90 UTSW 8 107,145,755 (GRCm39) missense probably benign 0.00
R2110:Zfp90 UTSW 8 107,152,120 (GRCm39) missense probably damaging 1.00
R2112:Zfp90 UTSW 8 107,152,120 (GRCm39) missense probably damaging 1.00
R3717:Zfp90 UTSW 8 107,150,682 (GRCm39) missense probably benign 0.12
R4506:Zfp90 UTSW 8 107,151,496 (GRCm39) missense possibly damaging 0.78
R5288:Zfp90 UTSW 8 107,152,000 (GRCm39) missense probably damaging 1.00
R5789:Zfp90 UTSW 8 107,150,605 (GRCm39) missense probably benign
R6283:Zfp90 UTSW 8 107,152,026 (GRCm39) missense probably damaging 1.00
R6560:Zfp90 UTSW 8 107,142,379 (GRCm39) missense probably damaging 0.99
R6977:Zfp90 UTSW 8 107,151,949 (GRCm39) missense probably damaging 0.99
R6977:Zfp90 UTSW 8 107,151,948 (GRCm39) missense probably damaging 1.00
R7040:Zfp90 UTSW 8 107,151,641 (GRCm39) nonsense probably null
R7196:Zfp90 UTSW 8 107,151,780 (GRCm39) missense probably damaging 0.99
R7523:Zfp90 UTSW 8 107,150,545 (GRCm39) missense probably benign 0.07
R7535:Zfp90 UTSW 8 107,150,900 (GRCm39) missense possibly damaging 0.94
R7546:Zfp90 UTSW 8 107,151,323 (GRCm39) missense probably benign 0.22
R7719:Zfp90 UTSW 8 107,145,725 (GRCm39) missense probably damaging 1.00
R8036:Zfp90 UTSW 8 107,145,760 (GRCm39) missense probably benign 0.21
R8056:Zfp90 UTSW 8 107,151,112 (GRCm39) missense probably damaging 1.00
R9370:Zfp90 UTSW 8 107,145,791 (GRCm39) missense probably damaging 1.00
R9581:Zfp90 UTSW 8 107,151,714 (GRCm39) missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- CATTTGGTCAGAGCCCATCC -3'
(R):5'- TTTATTCCGGGCGTGAACTC -3'

Sequencing Primer
(F):5'- GCCCATCCCTTTATAAACATATGAGG -3'
(R):5'- GCAAGCATAGGGTTTCTCTCCAG -3'
Posted On 2016-11-09