Mutagenetix > Incidental Mutation

Incidental Mutation 'R5692:Vmn2r18'

443728

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r18

Ensembl Gene

ENSMUSG00000091794

Gene Name

vomeronasal 2, receptor 18

Synonyms

EG632671

MMRRC Submission

043179-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

R5692 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

151485126-151529232 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 151485724 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 590 (I590T)

Ref Sequence

ENSEMBL: ENSMUSP00000127506 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165928]

AlphaFold

A0A3B2WB67

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165928
AA Change: I590T

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000127506
Gene: ENSMUSG00000091794
AA Change: I590T

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	403	5.7e-39	PFAM
Pfam:NCD3G	446	499	5.5e-20	PFAM
Pfam:7tm_3	531	767	5e-53	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700128F08Rik	G	A	9: 8,221,991 (GRCm39)		noncoding transcript	Het
Adcy10	A	G	1: 165,342,875 (GRCm39)	N247S	probably benign	Het
Ago3	T	C	4: 126,248,862 (GRCm39)		probably null	Het
Aldh16a1	A	G	7: 44,797,223 (GRCm39)	V168A	probably damaging	Het
Aqp7	G	A	4: 41,035,510 (GRCm39)	T115I	probably benign	Het
Arhgap26	T	A	18: 39,254,945 (GRCm39)	V274E	probably damaging	Het
Clec4d	T	C	6: 123,245,104 (GRCm39)		probably null	Het
Dennd4b	T	C	3: 90,185,090 (GRCm39)	Y1166H	probably damaging	Het
Egln3	T	C	12: 54,227,447 (GRCm39)		probably null	Het
Fetub	C	T	16: 22,751,081 (GRCm39)	R143C	probably damaging	Het
Fhad1	T	A	4: 141,690,768 (GRCm39)	M434L	probably benign	Het
Gfm1	T	G	3: 67,342,955 (GRCm39)	M163R	probably damaging	Het
Isg15	A	T	4: 156,284,279 (GRCm39)	L83Q	probably damaging	Het
Ly9	GCCTTTGGGGGACAATTCC	GCC	1: 171,432,755 (GRCm39)		probably null	Het
Med1	G	T	11: 98,047,206 (GRCm39)		probably benign	Het
Mrc2	T	A	11: 105,227,468 (GRCm39)	V567D	probably damaging	Het
Nnmt	G	T	9: 48,514,780 (GRCm39)	T79K	probably benign	Het
Opn1sw	G	A	6: 29,379,840 (GRCm39)		probably benign	Het
Optc	G	T	1: 133,828,714 (GRCm39)		probably benign	Het
Pcdh17	C	T	14: 84,685,980 (GRCm39)	P816S	probably benign	Het
Pcdhb15	T	C	18: 37,607,502 (GRCm39)	S245P	probably benign	Het
Pcdhb18	G	A	18: 37,623,537 (GRCm39)	R289Q	probably benign	Het
Sacs	T	C	14: 61,445,288 (GRCm39)	F2445L	probably benign	Het
Sel1l	T	C	12: 91,778,652 (GRCm39)	N721S	probably benign	Het
Slc35e2	C	T	4: 155,694,483 (GRCm39)	P10L	probably benign	Het
Slc7a11	C	G	3: 50,326,780 (GRCm39)	V494L	probably benign	Het
Sulf2	C	A	2: 165,923,426 (GRCm39)	A598S	probably benign	Het
Tph2	A	T	10: 115,020,732 (GRCm39)	D21E	probably damaging	Het
Trf	T	C	9: 103,103,324 (GRCm39)	Y110C	possibly damaging	Het
Ttn	C	T	2: 76,628,202 (GRCm39)	E14653K	possibly damaging	Het
Zfp607b	G	T	7: 27,402,889 (GRCm39)	K448N	probably benign	Het
Zfp689	T	C	7: 127,048,071 (GRCm39)		probably benign	Het
Zfp709	C	T	8: 72,643,999 (GRCm39)	P476L	probably damaging	Het

Other mutations in Vmn2r18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01098:Vmn2r18	APN	5	151,496,296 (GRCm39)	missense	probably damaging	0.99
IGL01564:Vmn2r18	APN	5	151,508,633 (GRCm39)	missense	possibly damaging	0.69
IGL01602:Vmn2r18	APN	5	151,510,106 (GRCm39)	missense	possibly damaging	0.64
IGL01605:Vmn2r18	APN	5	151,510,106 (GRCm39)	missense	possibly damaging	0.64
IGL01619:Vmn2r18	APN	5	151,510,229 (GRCm39)	missense	probably benign	0.25
IGL02177:Vmn2r18	APN	5	151,510,274 (GRCm39)	missense	possibly damaging	0.76
IGL02682:Vmn2r18	APN	5	151,508,102 (GRCm39)	missense	probably damaging	0.99
IGL02751:Vmn2r18	APN	5	151,508,072 (GRCm39)	missense	probably benign	0.09
IGL02977:Vmn2r18	APN	5	151,510,149 (GRCm39)	missense	probably damaging	1.00
R0089:Vmn2r18	UTSW	5	151,508,269 (GRCm39)	missense	probably benign	0.00
R0282:Vmn2r18	UTSW	5	151,508,668 (GRCm39)	missense	probably benign	0.02
R0529:Vmn2r18	UTSW	5	151,485,988 (GRCm39)	missense	probably damaging	0.99
R0812:Vmn2r18	UTSW	5	151,496,395 (GRCm39)	splice site	probably benign
R1467:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	possibly damaging	0.48
R1467:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	possibly damaging	0.48
R1506:Vmn2r18	UTSW	5	151,499,099 (GRCm39)	splice site	probably null
R1562:Vmn2r18	UTSW	5	151,510,301 (GRCm39)	missense	probably benign	0.12
R1637:Vmn2r18	UTSW	5	151,508,222 (GRCm39)	missense	probably damaging	1.00
R1651:Vmn2r18	UTSW	5	151,485,464 (GRCm39)	missense	probably damaging	1.00
R1883:Vmn2r18	UTSW	5	151,499,190 (GRCm39)	missense	probably benign	0.37
R1884:Vmn2r18	UTSW	5	151,499,190 (GRCm39)	missense	probably benign	0.37
R1914:Vmn2r18	UTSW	5	151,499,286 (GRCm39)	missense	probably benign	0.02
R2051:Vmn2r18	UTSW	5	151,486,016 (GRCm39)	missense	possibly damaging	0.90
R2056:Vmn2r18	UTSW	5	151,508,160 (GRCm39)	missense	probably damaging	0.98
R2252:Vmn2r18	UTSW	5	151,508,441 (GRCm39)	missense	possibly damaging	0.59
R2265:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2266:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2267:Vmn2r18	UTSW	5	151,510,127 (GRCm39)	missense	probably damaging	1.00
R2843:Vmn2r18	UTSW	5	151,485,749 (GRCm39)	missense	probably damaging	1.00
R3023:Vmn2r18	UTSW	5	151,485,148 (GRCm39)	missense	probably benign	0.13
R3694:Vmn2r18	UTSW	5	151,508,033 (GRCm39)	missense	probably benign	0.00
R3763:Vmn2r18	UTSW	5	151,508,644 (GRCm39)	missense	probably damaging	1.00
R3816:Vmn2r18	UTSW	5	151,485,148 (GRCm39)	missense	probably benign	0.13
R4007:Vmn2r18	UTSW	5	151,508,711 (GRCm39)	missense	probably damaging	0.99
R4152:Vmn2r18	UTSW	5	151,485,730 (GRCm39)	missense	probably damaging	1.00
R4308:Vmn2r18	UTSW	5	151,508,268 (GRCm39)	nonsense	probably null
R4362:Vmn2r18	UTSW	5	151,496,368 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r18	UTSW	5	151,508,424 (GRCm39)	missense	possibly damaging	0.64
R4716:Vmn2r18	UTSW	5	151,485,602 (GRCm39)	missense	possibly damaging	0.87
R4817:Vmn2r18	UTSW	5	151,508,897 (GRCm39)	splice site	probably null
R5111:Vmn2r18	UTSW	5	151,485,913 (GRCm39)	missense	possibly damaging	0.85
R6115:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	possibly damaging	0.81
R6244:Vmn2r18	UTSW	5	151,508,116 (GRCm39)	missense	probably damaging	1.00
R6595:Vmn2r18	UTSW	5	151,485,889 (GRCm39)	missense	probably damaging	1.00
R6997:Vmn2r18	UTSW	5	151,485,338 (GRCm39)	missense	possibly damaging	0.95
R7227:Vmn2r18	UTSW	5	151,496,264 (GRCm39)	missense	probably damaging	1.00
R7349:Vmn2r18	UTSW	5	151,485,682 (GRCm39)	nonsense	probably null
R7506:Vmn2r18	UTSW	5	151,508,485 (GRCm39)	missense	possibly damaging	0.51
R7590:Vmn2r18	UTSW	5	151,485,194 (GRCm39)	missense	probably damaging	1.00
R7721:Vmn2r18	UTSW	5	151,510,158 (GRCm39)	missense	possibly damaging	0.53
R7877:Vmn2r18	UTSW	5	151,508,437 (GRCm39)	missense	probably damaging	1.00
R7882:Vmn2r18	UTSW	5	151,485,329 (GRCm39)	missense	probably damaging	1.00
R7984:Vmn2r18	UTSW	5	151,485,526 (GRCm39)	missense	probably damaging	1.00
R8295:Vmn2r18	UTSW	5	151,508,621 (GRCm39)	missense	probably damaging	0.97
R8353:Vmn2r18	UTSW	5	151,485,373 (GRCm39)	missense	probably damaging	1.00
R8453:Vmn2r18	UTSW	5	151,485,373 (GRCm39)	missense	probably damaging	1.00
R8670:Vmn2r18	UTSW	5	151,485,854 (GRCm39)	missense	probably damaging	1.00
R8725:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	probably damaging	0.99
R8727:Vmn2r18	UTSW	5	151,508,462 (GRCm39)	missense	probably damaging	0.99
R8895:Vmn2r18	UTSW	5	151,485,140 (GRCm39)	missense	possibly damaging	0.46
R9286:Vmn2r18	UTSW	5	151,499,175 (GRCm39)	missense	probably benign	0.00
R9339:Vmn2r18	UTSW	5	151,485,132 (GRCm39)	missense	probably damaging	0.99
Z1176:Vmn2r18	UTSW	5	151,508,498 (GRCm39)	missense	probably damaging	0.99
Z1187:Vmn2r18	UTSW	5	151,508,497 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ATGCCAGAGGTAATAAGTTGGATC -3'
(R):5'- TTGAGGATCCTCTGGGCATG -3'

Sequencing Primer
(F):5'- CCAGAGGTAATAAGTTGGATCAGGAC -3'
(R):5'- CATGTCTCTGGCCTGCATGG -3'

Posted On

2016-11-09