Incidental Mutation 'R5693:Oprd1'
ID443763
Institutional Source Beutler Lab
Gene Symbol Oprd1
Ensembl Gene ENSMUSG00000050511
Gene Nameopioid receptor, delta 1
SynonymsDOR, mDOR, Nbor, DOR-1
MMRRC Submission 043180-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #R5693 (G1)
Quality Score145
Status Not validated
Chromosome4
Chromosomal Location132110726-132144486 bp(-) (GRCm38)
Type of Mutationstart gained
DNA Base Change (assembly) G to A at 132144410 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000050077 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056336]
PDB Structure
Structure of the delta opioid receptor bound to naltrindole [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000056336
SMART Domains Protein: ENSMUSP00000050077
Gene: ENSMUSG00000050511

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 58 288 8.2e-8 PFAM
Pfam:7TM_GPCR_Srsx 60 333 1.7e-11 PFAM
Pfam:7tm_1 66 318 4e-58 PFAM
Pfam:7TM_GPCR_Srv 69 335 3.7e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117559
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for one knock-out allele do not develop analgesic tolerance to morphine while mice homozygous for a different knock-out allele exhibit hyperactivity, increased anxiety, and decreased coping response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,316,233 I3071V probably benign Het
Abcb8 C T 5: 24,400,139 R108C possibly damaging Het
Abr T C 11: 76,463,577 N236S probably damaging Het
Adcy6 T C 15: 98,603,989 Y248C probably damaging Het
Armc8 A G 9: 99,496,149 probably null Het
Chd6 A T 2: 160,965,265 S2010T probably benign Het
Dcc G A 18: 71,575,082 T521I probably damaging Het
Dmrtb1 G A 4: 107,684,169 probably benign Het
Evc A G 5: 37,320,240 V365A possibly damaging Het
Gata4 A G 14: 63,241,145 Y2H probably damaging Het
Gpc1 A G 1: 92,857,899 N437S probably damaging Het
Lifr T C 15: 7,175,560 V426A probably damaging Het
Lpin3 A G 2: 160,895,400 I122M probably benign Het
Muc4 A G 16: 32,776,807 N3174D possibly damaging Het
Myo6 G A 9: 80,266,180 R534H probably damaging Het
Nectin2 T C 7: 19,724,869 D339G probably benign Het
Olfr798 T C 10: 129,625,527 D178G probably damaging Het
Orc1 G A 4: 108,613,079 V751I probably benign Het
Pacs2 T C 12: 113,049,906 S175P probably damaging Het
Pik3r5 C T 11: 68,494,251 R661C probably damaging Het
Plscr5 A T 9: 92,205,511 K178* probably null Het
Prkar1b A G 5: 139,127,645 V40A possibly damaging Het
Ptprf G A 4: 118,236,177 R90* probably null Het
Rasef T C 4: 73,769,839 M26V probably damaging Het
Rfx1 C A 8: 84,073,904 Q45K unknown Het
Rnf183 A G 4: 62,428,516 V15A possibly damaging Het
Slc10a2 C A 8: 5,105,128 C19F probably damaging Het
Slc14a2 T A 18: 78,147,014 I907F probably benign Het
Snx16 T C 3: 10,420,258 I293V probably benign Het
Srcap C A 7: 127,519,816 A97E probably damaging Het
Thyn1 G T 9: 27,005,215 probably null Het
Tiparp T C 3: 65,553,492 I634T possibly damaging Het
Tjp1 G A 7: 65,342,663 A156V possibly damaging Het
Tmem168 T C 6: 13,602,321 M349V probably benign Het
Tyro3 T G 2: 119,810,868 F519L probably damaging Het
Vmn1r167 A T 7: 23,505,221 Y123* probably null Het
Vmn1r183 C T 7: 24,054,802 T10I possibly damaging Het
Zfp654 T C 16: 64,785,926 T97A probably benign Het
Other mutations in Oprd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02825:Oprd1 APN 4 132117359 missense probably damaging 0.96
IGL03030:Oprd1 APN 4 132117385 missense possibly damaging 0.94
R0066:Oprd1 UTSW 4 132113988 missense probably benign 0.00
R0403:Oprd1 UTSW 4 132113768 missense probably benign 0.18
R1857:Oprd1 UTSW 4 132113681 missense probably damaging 1.00
R4808:Oprd1 UTSW 4 132117394 missense probably damaging 1.00
R5176:Oprd1 UTSW 4 132113793 missense probably benign 0.34
R5957:Oprd1 UTSW 4 132144163 missense probably benign 0.02
R6264:Oprd1 UTSW 4 132114054 missense possibly damaging 0.78
R6896:Oprd1 UTSW 4 132117301 missense probably damaging 0.97
R7205:Oprd1 UTSW 4 132113801 missense probably damaging 1.00
R7417:Oprd1 UTSW 4 132117452 missense probably damaging 1.00
R7426:Oprd1 UTSW 4 132114067 missense probably benign 0.02
R7480:Oprd1 UTSW 4 132117181 missense possibly damaging 0.92
R7552:Oprd1 UTSW 4 132113781 missense possibly damaging 0.80
Z1177:Oprd1 UTSW 4 132113729 missense probably damaging 1.00
Predicted Primers
Posted On2016-11-09