Incidental Mutation 'R5693:Tmem168'
ID 443767
Institutional Source Beutler Lab
Gene Symbol Tmem168
Ensembl Gene ENSMUSG00000029569
Gene Name transmembrane protein 168
Synonyms 8430437G11Rik, 5730526F17Rik
MMRRC Submission 043180-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R5693 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 13580688-13608097 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13602320 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 349 (M349V)
Ref Sequence ENSEMBL: ENSMUSP00000031554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031554] [ENSMUST00000149123]
AlphaFold Q91VX9
Predicted Effect probably benign
Transcript: ENSMUST00000031554
AA Change: M349V

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000031554
Gene: ENSMUSG00000029569
AA Change: M349V

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 92 109 N/A INTRINSIC
low complexity region 152 163 N/A INTRINSIC
transmembrane domain 170 192 N/A INTRINSIC
transmembrane domain 199 216 N/A INTRINSIC
transmembrane domain 226 248 N/A INTRINSIC
transmembrane domain 261 283 N/A INTRINSIC
transmembrane domain 298 320 N/A INTRINSIC
transmembrane domain 359 378 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127050
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138637
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140750
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146139
Predicted Effect probably benign
Transcript: ENSMUST00000149123
SMART Domains Protein: ENSMUSP00000145372
Gene: ENSMUSG00000029569

DomainStartEndE-ValueType
SCOP:d1jxqa_ 29 167 8e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155179
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,266,233 (GRCm39) I3071V probably benign Het
Abcb8 C T 5: 24,605,137 (GRCm39) R108C possibly damaging Het
Abr T C 11: 76,354,403 (GRCm39) N236S probably damaging Het
Adcy6 T C 15: 98,501,870 (GRCm39) Y248C probably damaging Het
Armc8 A G 9: 99,378,202 (GRCm39) probably null Het
Chd6 A T 2: 160,807,185 (GRCm39) S2010T probably benign Het
Dcc G A 18: 71,708,153 (GRCm39) T521I probably damaging Het
Dmrtb1 G A 4: 107,541,366 (GRCm39) probably benign Het
Evc A G 5: 37,477,584 (GRCm39) V365A possibly damaging Het
Gata4 A G 14: 63,478,594 (GRCm39) Y2H probably damaging Het
Gpc1 A G 1: 92,785,621 (GRCm39) N437S probably damaging Het
Lifr T C 15: 7,205,041 (GRCm39) V426A probably damaging Het
Lpin3 A G 2: 160,737,320 (GRCm39) I122M probably benign Het
Muc4 A G 16: 32,597,181 (GRCm39) N3174D possibly damaging Het
Myo6 G A 9: 80,173,462 (GRCm39) R534H probably damaging Het
Nectin2 T C 7: 19,458,794 (GRCm39) D339G probably benign Het
Oprd1 G A 4: 131,871,721 (GRCm39) probably benign Het
Or6c66 T C 10: 129,461,396 (GRCm39) D178G probably damaging Het
Orc1 G A 4: 108,470,276 (GRCm39) V751I probably benign Het
Pacs2 T C 12: 113,013,526 (GRCm39) S175P probably damaging Het
Pik3r5 C T 11: 68,385,077 (GRCm39) R661C probably damaging Het
Plscr5 A T 9: 92,087,564 (GRCm39) K178* probably null Het
Prkar1b A G 5: 139,113,400 (GRCm39) V40A possibly damaging Het
Ptprf G A 4: 118,093,374 (GRCm39) R90* probably null Het
Rasef T C 4: 73,688,076 (GRCm39) M26V probably damaging Het
Rfx1 C A 8: 84,800,533 (GRCm39) Q45K unknown Het
Rnf183 A G 4: 62,346,753 (GRCm39) V15A possibly damaging Het
Slc10a2 C A 8: 5,155,128 (GRCm39) C19F probably damaging Het
Slc14a2 T A 18: 78,190,229 (GRCm39) I907F probably benign Het
Snx16 T C 3: 10,485,318 (GRCm39) I293V probably benign Het
Srcap C A 7: 127,118,988 (GRCm39) A97E probably damaging Het
Thyn1 G T 9: 26,916,511 (GRCm39) probably null Het
Tiparp T C 3: 65,460,913 (GRCm39) I634T possibly damaging Het
Tjp1 G A 7: 64,992,411 (GRCm39) A156V possibly damaging Het
Tyro3 T G 2: 119,641,349 (GRCm39) F519L probably damaging Het
Vmn1r167 A T 7: 23,204,646 (GRCm39) Y123* probably null Het
Vmn1r183 C T 7: 23,754,227 (GRCm39) T10I possibly damaging Het
Zfp654 T C 16: 64,606,289 (GRCm39) T97A probably benign Het
Other mutations in Tmem168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00786:Tmem168 APN 6 13,602,674 (GRCm39) missense probably benign 0.06
IGL01305:Tmem168 APN 6 13,583,045 (GRCm39) missense probably damaging 1.00
IGL01843:Tmem168 APN 6 13,582,940 (GRCm39) missense probably damaging 1.00
IGL02742:Tmem168 APN 6 13,603,261 (GRCm39) missense probably benign 0.04
IGL02863:Tmem168 APN 6 13,582,917 (GRCm39) missense probably damaging 0.98
ANU22:Tmem168 UTSW 6 13,583,045 (GRCm39) missense probably damaging 1.00
R0193:Tmem168 UTSW 6 13,583,312 (GRCm39) missense possibly damaging 0.81
R0537:Tmem168 UTSW 6 13,603,360 (GRCm39) missense probably damaging 1.00
R0630:Tmem168 UTSW 6 13,583,064 (GRCm39) missense probably benign
R0890:Tmem168 UTSW 6 13,603,271 (GRCm39) missense probably damaging 1.00
R1416:Tmem168 UTSW 6 13,591,400 (GRCm39) missense probably damaging 0.96
R1900:Tmem168 UTSW 6 13,583,070 (GRCm39) missense probably benign 0.02
R3947:Tmem168 UTSW 6 13,583,051 (GRCm39) missense probably damaging 1.00
R4362:Tmem168 UTSW 6 13,595,072 (GRCm39) missense probably benign 0.31
R4620:Tmem168 UTSW 6 13,594,952 (GRCm39) missense probably benign 0.03
R6142:Tmem168 UTSW 6 13,591,368 (GRCm39) missense probably benign
R6328:Tmem168 UTSW 6 13,602,710 (GRCm39) missense probably benign
R6438:Tmem168 UTSW 6 13,602,673 (GRCm39) missense probably benign 0.06
R6711:Tmem168 UTSW 6 13,603,120 (GRCm39) missense probably damaging 1.00
R6827:Tmem168 UTSW 6 13,582,837 (GRCm39) missense probably damaging 0.99
R6987:Tmem168 UTSW 6 13,591,476 (GRCm39) missense possibly damaging 0.82
R7696:Tmem168 UTSW 6 13,602,937 (GRCm39) missense probably benign 0.01
R8295:Tmem168 UTSW 6 13,602,850 (GRCm39) missense probably damaging 0.99
R8344:Tmem168 UTSW 6 13,583,324 (GRCm39) missense probably benign
R8432:Tmem168 UTSW 6 13,602,535 (GRCm39) missense probably benign 0.30
R8992:Tmem168 UTSW 6 13,602,849 (GRCm39) missense possibly damaging 0.72
R9003:Tmem168 UTSW 6 13,591,446 (GRCm39) missense probably benign 0.06
R9325:Tmem168 UTSW 6 13,583,253 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGCATAGGTATCCTGAGATCG -3'
(R):5'- GCTTTTCACTGCAATGATTGAGC -3'

Sequencing Primer
(F):5'- CTGAGATCGTCAGCATTTAGCAC -3'
(R):5'- GAGACACTCATCTCTGGTATTTTG -3'
Posted On 2016-11-09