Mutagenetix > Incidental Mutation

Incidental Mutation 'R5693:Vmn1r167'

443769

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r167

Ensembl Gene

ENSMUSG00000090715

Gene Name

vomeronasal 1 receptor 167

Synonyms

Gm6279

MMRRC Submission

043180-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R5693 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23204067-23205014 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 23204646 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 123 (Y123*)

Ref Sequence

ENSEMBL: ENSMUSP00000153774 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164527] [ENSMUST00000227713]

AlphaFold

G3UW71

Predicted Effect

probably null
Transcript: ENSMUST00000164527
AA Change: Y123*

SMART Domains

Protein: ENSMUSP00000129193
Gene: ENSMUSG00000090715
AA Change: Y123*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	19	307	1.5e-13	PFAM
Pfam:7tm_1	41	299	3.8e-6	PFAM
Pfam:V1R	52	306	2.1e-18	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000227713
AA Change: Y123*

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,266,233 (GRCm39)	I3071V	probably benign	Het
Abcb8	C	T	5: 24,605,137 (GRCm39)	R108C	possibly damaging	Het
Abr	T	C	11: 76,354,403 (GRCm39)	N236S	probably damaging	Het
Adcy6	T	C	15: 98,501,870 (GRCm39)	Y248C	probably damaging	Het
Armc8	A	G	9: 99,378,202 (GRCm39)		probably null	Het
Chd6	A	T	2: 160,807,185 (GRCm39)	S2010T	probably benign	Het
Dcc	G	A	18: 71,708,153 (GRCm39)	T521I	probably damaging	Het
Dmrtb1	G	A	4: 107,541,366 (GRCm39)		probably benign	Het
Evc	A	G	5: 37,477,584 (GRCm39)	V365A	possibly damaging	Het
Gata4	A	G	14: 63,478,594 (GRCm39)	Y2H	probably damaging	Het
Gpc1	A	G	1: 92,785,621 (GRCm39)	N437S	probably damaging	Het
Lifr	T	C	15: 7,205,041 (GRCm39)	V426A	probably damaging	Het
Lpin3	A	G	2: 160,737,320 (GRCm39)	I122M	probably benign	Het
Muc4	A	G	16: 32,597,181 (GRCm39)	N3174D	possibly damaging	Het
Myo6	G	A	9: 80,173,462 (GRCm39)	R534H	probably damaging	Het
Nectin2	T	C	7: 19,458,794 (GRCm39)	D339G	probably benign	Het
Oprd1	G	A	4: 131,871,721 (GRCm39)		probably benign	Het
Or6c66	T	C	10: 129,461,396 (GRCm39)	D178G	probably damaging	Het
Orc1	G	A	4: 108,470,276 (GRCm39)	V751I	probably benign	Het
Pacs2	T	C	12: 113,013,526 (GRCm39)	S175P	probably damaging	Het
Pik3r5	C	T	11: 68,385,077 (GRCm39)	R661C	probably damaging	Het
Plscr5	A	T	9: 92,087,564 (GRCm39)	K178*	probably null	Het
Prkar1b	A	G	5: 139,113,400 (GRCm39)	V40A	possibly damaging	Het
Ptprf	G	A	4: 118,093,374 (GRCm39)	R90*	probably null	Het
Rasef	T	C	4: 73,688,076 (GRCm39)	M26V	probably damaging	Het
Rfx1	C	A	8: 84,800,533 (GRCm39)	Q45K	unknown	Het
Rnf183	A	G	4: 62,346,753 (GRCm39)	V15A	possibly damaging	Het
Slc10a2	C	A	8: 5,155,128 (GRCm39)	C19F	probably damaging	Het
Slc14a2	T	A	18: 78,190,229 (GRCm39)	I907F	probably benign	Het
Snx16	T	C	3: 10,485,318 (GRCm39)	I293V	probably benign	Het
Srcap	C	A	7: 127,118,988 (GRCm39)	A97E	probably damaging	Het
Thyn1	G	T	9: 26,916,511 (GRCm39)		probably null	Het
Tiparp	T	C	3: 65,460,913 (GRCm39)	I634T	possibly damaging	Het
Tjp1	G	A	7: 64,992,411 (GRCm39)	A156V	possibly damaging	Het
Tmem168	T	C	6: 13,602,320 (GRCm39)	M349V	probably benign	Het
Tyro3	T	G	2: 119,641,349 (GRCm39)	F519L	probably damaging	Het
Vmn1r183	C	T	7: 23,754,227 (GRCm39)	T10I	possibly damaging	Het
Zfp654	T	C	16: 64,606,289 (GRCm39)	T97A	probably benign	Het

Other mutations in Vmn1r167

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02137:Vmn1r167	APN	7	23,204,864 (GRCm39)	missense	probably damaging	0.98
IGL02261:Vmn1r167	APN	7	23,204,261 (GRCm39)	missense	probably benign	0.17
IGL02963:Vmn1r167	APN	7	23,204,975 (GRCm39)	missense	possibly damaging	0.60
R0054:Vmn1r167	UTSW	7	23,204,334 (GRCm39)	missense	possibly damaging	0.89
R0555:Vmn1r167	UTSW	7	23,204,512 (GRCm39)	missense	probably damaging	1.00
R0766:Vmn1r167	UTSW	7	23,204,548 (GRCm39)	missense	probably benign	0.01
R1312:Vmn1r167	UTSW	7	23,204,548 (GRCm39)	missense	probably benign	0.01
R1464:Vmn1r167	UTSW	7	23,204,681 (GRCm39)	missense	possibly damaging	0.62
R1464:Vmn1r167	UTSW	7	23,204,681 (GRCm39)	missense	possibly damaging	0.62
R1532:Vmn1r167	UTSW	7	23,204,204 (GRCm39)	missense	probably benign	0.01
R1937:Vmn1r167	UTSW	7	23,204,452 (GRCm39)	missense	probably benign	0.25
R2162:Vmn1r167	UTSW	7	23,204,224 (GRCm39)	missense	possibly damaging	0.91
R4639:Vmn1r167	UTSW	7	23,205,011 (GRCm39)	missense	probably benign	0.00
R4661:Vmn1r167	UTSW	7	23,204,117 (GRCm39)	missense	probably damaging	1.00
R4845:Vmn1r167	UTSW	7	23,204,158 (GRCm39)	missense	probably benign	0.01
R4868:Vmn1r167	UTSW	7	23,204,161 (GRCm39)	missense	probably benign
R4993:Vmn1r167	UTSW	7	23,204,653 (GRCm39)	missense	probably damaging	1.00
R6622:Vmn1r167	UTSW	7	23,205,014 (GRCm39)	start codon destroyed	probably null
R7800:Vmn1r167	UTSW	7	23,204,069 (GRCm39)	makesense	probably null
R8297:Vmn1r167	UTSW	7	23,204,215 (GRCm39)	missense	probably damaging	1.00
R8365:Vmn1r167	UTSW	7	23,204,200 (GRCm39)	missense	probably benign	0.03
R8411:Vmn1r167	UTSW	7	23,204,981 (GRCm39)	missense	possibly damaging	0.86
R9667:Vmn1r167	UTSW	7	23,204,990 (GRCm39)	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- GATGCGCATGCCTATACTGAAAC -3'
(R):5'- CATTCTAGCCAACTTAGCTGTGG -3'

Sequencing Primer
(F):5'- CATGCCTATACTGAAACCAGAGGTAG -3'
(R):5'- ACTTAGCTGTGGGCAATACC -3'

Posted On

2016-11-09