Mutagenetix > Incidental Mutation

Incidental Mutation 'R5693:Vmn1r183'

443770

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r183

Ensembl Gene

ENSMUSG00000066723

Gene Name

vomeronasal 1 receptor 183

Synonyms

V1rd15, LOC209824

MMRRC Submission

043180-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R5693 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23754199-23755116 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23754227 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 10 (T10I)

Ref Sequence

ENSEMBL: ENSMUSP00000083176 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086012]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000086012
AA Change: T10I

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000083176
Gene: ENSMUSG00000066723
AA Change: T10I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	5.6e-15	PFAM
Pfam:7tm_1	31	285	1.4e-9	PFAM
Pfam:V1R	41	296	2.5e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000205855

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,266,233 (GRCm39)	I3071V	probably benign	Het
Abcb8	C	T	5: 24,605,137 (GRCm39)	R108C	possibly damaging	Het
Abr	T	C	11: 76,354,403 (GRCm39)	N236S	probably damaging	Het
Adcy6	T	C	15: 98,501,870 (GRCm39)	Y248C	probably damaging	Het
Armc8	A	G	9: 99,378,202 (GRCm39)		probably null	Het
Chd6	A	T	2: 160,807,185 (GRCm39)	S2010T	probably benign	Het
Dcc	G	A	18: 71,708,153 (GRCm39)	T521I	probably damaging	Het
Dmrtb1	G	A	4: 107,541,366 (GRCm39)		probably benign	Het
Evc	A	G	5: 37,477,584 (GRCm39)	V365A	possibly damaging	Het
Gata4	A	G	14: 63,478,594 (GRCm39)	Y2H	probably damaging	Het
Gpc1	A	G	1: 92,785,621 (GRCm39)	N437S	probably damaging	Het
Lifr	T	C	15: 7,205,041 (GRCm39)	V426A	probably damaging	Het
Lpin3	A	G	2: 160,737,320 (GRCm39)	I122M	probably benign	Het
Muc4	A	G	16: 32,597,181 (GRCm39)	N3174D	possibly damaging	Het
Myo6	G	A	9: 80,173,462 (GRCm39)	R534H	probably damaging	Het
Nectin2	T	C	7: 19,458,794 (GRCm39)	D339G	probably benign	Het
Oprd1	G	A	4: 131,871,721 (GRCm39)		probably benign	Het
Or6c66	T	C	10: 129,461,396 (GRCm39)	D178G	probably damaging	Het
Orc1	G	A	4: 108,470,276 (GRCm39)	V751I	probably benign	Het
Pacs2	T	C	12: 113,013,526 (GRCm39)	S175P	probably damaging	Het
Pik3r5	C	T	11: 68,385,077 (GRCm39)	R661C	probably damaging	Het
Plscr5	A	T	9: 92,087,564 (GRCm39)	K178*	probably null	Het
Prkar1b	A	G	5: 139,113,400 (GRCm39)	V40A	possibly damaging	Het
Ptprf	G	A	4: 118,093,374 (GRCm39)	R90*	probably null	Het
Rasef	T	C	4: 73,688,076 (GRCm39)	M26V	probably damaging	Het
Rfx1	C	A	8: 84,800,533 (GRCm39)	Q45K	unknown	Het
Rnf183	A	G	4: 62,346,753 (GRCm39)	V15A	possibly damaging	Het
Slc10a2	C	A	8: 5,155,128 (GRCm39)	C19F	probably damaging	Het
Slc14a2	T	A	18: 78,190,229 (GRCm39)	I907F	probably benign	Het
Snx16	T	C	3: 10,485,318 (GRCm39)	I293V	probably benign	Het
Srcap	C	A	7: 127,118,988 (GRCm39)	A97E	probably damaging	Het
Thyn1	G	T	9: 26,916,511 (GRCm39)		probably null	Het
Tiparp	T	C	3: 65,460,913 (GRCm39)	I634T	possibly damaging	Het
Tjp1	G	A	7: 64,992,411 (GRCm39)	A156V	possibly damaging	Het
Tmem168	T	C	6: 13,602,320 (GRCm39)	M349V	probably benign	Het
Tyro3	T	G	2: 119,641,349 (GRCm39)	F519L	probably damaging	Het
Vmn1r167	A	T	7: 23,204,646 (GRCm39)	Y123*	probably null	Het
Zfp654	T	C	16: 64,606,289 (GRCm39)	T97A	probably benign	Het

Other mutations in Vmn1r183

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00987:Vmn1r183	APN	7	23,754,649 (GRCm39)	missense	probably damaging	1.00
IGL01813:Vmn1r183	APN	7	23,754,985 (GRCm39)	missense	probably benign	0.19
IGL03377:Vmn1r183	APN	7	23,754,817 (GRCm39)	missense	possibly damaging	0.70
PIT4791001:Vmn1r183	UTSW	7	23,754,266 (GRCm39)	missense	probably damaging	0.99
R0463:Vmn1r183	UTSW	7	23,754,926 (GRCm39)	missense	probably damaging	1.00
R0616:Vmn1r183	UTSW	7	23,754,250 (GRCm39)	missense	probably benign	0.03
R0666:Vmn1r183	UTSW	7	23,754,601 (GRCm39)	missense	probably benign
R3928:Vmn1r183	UTSW	7	23,754,997 (GRCm39)	missense	probably damaging	0.98
R4425:Vmn1r183	UTSW	7	23,754,973 (GRCm39)	missense	probably benign	0.00
R4767:Vmn1r183	UTSW	7	23,754,531 (GRCm39)	frame shift	probably null
R4835:Vmn1r183	UTSW	7	23,754,564 (GRCm39)	missense	probably benign	0.07
R5267:Vmn1r183	UTSW	7	23,754,971 (GRCm39)	missense	possibly damaging	0.90
R6291:Vmn1r183	UTSW	7	23,754,982 (GRCm39)	missense	possibly damaging	0.70
R6439:Vmn1r183	UTSW	7	23,754,704 (GRCm39)	missense	possibly damaging	0.73
R7073:Vmn1r183	UTSW	7	23,754,926 (GRCm39)	missense	probably damaging	1.00
R8732:Vmn1r183	UTSW	7	23,754,890 (GRCm39)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- TGTTCTCCAGGCAAAGTTCC -3'
(R):5'- CTTGGAGCAAAAGCCATCATG -3'

Sequencing Primer
(F):5'- CCAGGCAAAGTTCCTTTATTGTG -3'
(R):5'- GGAGCAAAAGCCATCATGTTGTTTG -3'

Posted On

2016-11-09