Mutagenetix > Incidental Mutation

Incidental Mutation 'R5662:Or1m1'

444137

Institutional Source

Beutler Lab

Gene Symbol

Or1m1

Ensembl Gene

ENSMUSG00000054141

Gene Name

olfactory receptor family 1 subfamily M member 1

Synonyms

GA_x6K02T2PVTD-12498544-12497603, MTPCR51, Olfr24, MOR132-1

MMRRC Submission

043305-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R5662 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18665988-18666929 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18666896 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 12 (F12L)

Ref Sequence

ENSEMBL: ENSMUSP00000149702 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066997] [ENSMUST00000216754]

AlphaFold

Q8VFM9

Predicted Effect

probably damaging
Transcript: ENSMUST00000066997
AA Change: F12L

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000064189
Gene: ENSMUSG00000054141
AA Change: F12L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.6e-64	PFAM
Pfam:7TM_GPCR_Srsx	35	304	9.2e-9	PFAM
Pfam:7tm_1	41	290	3.2e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212239
AA Change: F12L

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214366

Predicted Effect

probably damaging
Transcript: ENSMUST00000216754
AA Change: F12L

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acan	T	A	7: 78,749,855 (GRCm39)	V1542D	possibly damaging	Het
Acsm4	T	G	7: 119,294,023 (GRCm39)	N131K	possibly damaging	Het
Ankrd54	A	G	15: 78,946,814 (GRCm39)	S62P	possibly damaging	Het
Ccdc186	A	G	19: 56,781,920 (GRCm39)	I753T	probably benign	Het
Cers2	C	T	3: 95,228,295 (GRCm39)	R112C	probably damaging	Het
Col6a4	C	G	9: 105,945,200 (GRCm39)	R971S	probably damaging	Het
Ctsf	T	C	19: 4,906,606 (GRCm39)	S178P	probably damaging	Het
Dennd4c	C	T	4: 86,713,525 (GRCm39)	T492I	probably benign	Het
Dhx8	A	G	11: 101,657,584 (GRCm39)	K1212E	possibly damaging	Het
Dnah8	A	G	17: 30,956,307 (GRCm39)	T2096A	probably damaging	Het
Ephb4	A	T	5: 137,370,457 (GRCm39)	I886F	probably damaging	Het
Eprs1	T	G	1: 185,126,622 (GRCm39)	N519K	possibly damaging	Het
Fam3c	T	C	6: 22,355,061 (GRCm39)		probably benign	Het
Galnt17	G	A	5: 131,114,844 (GRCm39)	R219C	probably damaging	Het
Gm10645	A	G	8: 83,892,486 (GRCm39)		probably benign	Het
Gpr132	G	A	12: 112,816,416 (GRCm39)	R137C	probably damaging	Het
Hydin	T	G	8: 111,307,341 (GRCm39)	S3907A	probably benign	Het
Ighv1-49	A	T	12: 115,019,027 (GRCm39)	V56E	probably damaging	Het
Igtp	A	G	11: 58,097,105 (GRCm39)	D92G	probably damaging	Het
Itga1	C	T	13: 115,122,707 (GRCm39)	V750I	probably benign	Het
Katnip	A	G	7: 125,441,875 (GRCm39)	R595G	probably benign	Het
Kif3c	T	A	12: 3,417,031 (GRCm39)	Y351N	probably damaging	Het
Klhdc1	T	A	12: 69,329,939 (GRCm39)	I356N	probably benign	Het
Lrrc34	T	C	3: 30,685,473 (GRCm39)	Y292C	probably benign	Het
Ly75	G	A	2: 60,182,725 (GRCm39)	T526M	probably damaging	Het
Mroh4	A	T	15: 74,497,277 (GRCm39)	D181E	possibly damaging	Het
Nutm1	T	C	2: 112,079,645 (GRCm39)	N757D	probably benign	Het
Or1e25	T	C	11: 73,494,005 (GRCm39)	F200L	probably benign	Het
Or6c215	T	C	10: 129,638,176 (GRCm39)	T73A	possibly damaging	Het
Or9s18	T	C	13: 65,300,067 (GRCm39)	F10L	possibly damaging	Het
Paxbp1	G	A	16: 90,834,285 (GRCm39)	T167M	probably benign	Het
Pnpla7	A	G	2: 24,942,396 (GRCm39)	D1238G	probably damaging	Het
Pom121l2	T	C	13: 22,166,358 (GRCm39)	S210P	probably benign	Het
Ripor3	T	G	2: 167,835,476 (GRCm39)	N165T	probably benign	Het
Serpine3	T	G	14: 62,908,291 (GRCm39)	S106R	probably benign	Het
Slc25a11	G	A	11: 70,536,245 (GRCm39)	R158*	probably null	Het
Slc26a6	G	A	9: 108,736,538 (GRCm39)	V506M	possibly damaging	Het
Slc45a2	A	G	15: 11,022,169 (GRCm39)	K304E	probably benign	Het
Slc4a4	C	T	5: 89,176,103 (GRCm39)	L25F	probably damaging	Het
Smarcb1	T	C	10: 75,740,404 (GRCm39)	N267S	possibly damaging	Het
Spink6	C	A	18: 44,207,481 (GRCm39)	Q24K	possibly damaging	Het
Srebf2	T	C	15: 82,079,204 (GRCm39)	S811P	probably benign	Het
Ssc4d	A	G	5: 135,989,748 (GRCm39)	*587R	probably null	Het
Sult2a8	C	T	7: 14,161,765 (GRCm39)	R27H	probably benign	Het
Sun2	C	T	15: 79,623,069 (GRCm39)	A90T	probably benign	Het
Ubr7	T	C	12: 102,734,526 (GRCm39)	S267P	probably benign	Het
Wdr55	G	A	18: 36,893,448 (GRCm39)	V37M	possibly damaging	Het
Xdh	C	T	17: 74,248,110 (GRCm39)	G45S	probably damaging	Het
Zfp638	T	A	6: 83,920,111 (GRCm39)	S570T	probably damaging	Het

Other mutations in Or1m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02346:Or1m1	APN	9	18,666,065 (GRCm39)	missense	probably damaging	0.97
IGL02371:Or1m1	APN	9	18,666,000 (GRCm39)	missense	probably benign	0.07
IGL02555:Or1m1	APN	9	18,666,769 (GRCm39)	missense	probably benign	0.40
IGL03025:Or1m1	APN	9	18,666,665 (GRCm39)	missense	probably benign	0.00
IGL03259:Or1m1	APN	9	18,666,811 (GRCm39)	missense	probably benign
IGL03050:Or1m1	UTSW	9	18,666,750 (GRCm39)	nonsense	probably null
R0310:Or1m1	UTSW	9	18,666,629 (GRCm39)	missense	possibly damaging	0.91
R0410:Or1m1	UTSW	9	18,666,137 (GRCm39)	missense	probably damaging	0.96
R2152:Or1m1	UTSW	9	18,666,391 (GRCm39)	missense	probably damaging	1.00
R2153:Or1m1	UTSW	9	18,666,391 (GRCm39)	missense	probably damaging	1.00
R2918:Or1m1	UTSW	9	18,666,775 (GRCm39)	missense	probably damaging	1.00
R4552:Or1m1	UTSW	9	18,666,430 (GRCm39)	missense	possibly damaging	0.60
R5073:Or1m1	UTSW	9	18,666,118 (GRCm39)	missense	possibly damaging	0.89
R5539:Or1m1	UTSW	9	18,666,134 (GRCm39)	missense	probably damaging	0.99
R6145:Or1m1	UTSW	9	18,666,865 (GRCm39)	missense	probably benign	0.06
R7125:Or1m1	UTSW	9	18,666,174 (GRCm39)	nonsense	probably null
R7196:Or1m1	UTSW	9	18,666,886 (GRCm39)	nonsense	probably null
R7607:Or1m1	UTSW	9	18,666,178 (GRCm39)	missense	possibly damaging	0.93
R9136:Or1m1	UTSW	9	18,666,175 (GRCm39)	missense	probably damaging	1.00
Z1177:Or1m1	UTSW	9	18,666,815 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- CCAAGGAGAGATTGGCCAGG -3'
(R):5'- TTGTGTGAAATGGGAATATTCAGAAG -3'

Sequencing Primer
(F):5'- TTGGCCAGGAAGAAATACATAGG -3'
(R):5'- GCTCAGACAAGAACTGGA -3'

Posted On

2016-11-09