Incidental Mutation 'R5663:Phlpp2'
ID 444209
Institutional Source Beutler Lab
Gene Symbol Phlpp2
Ensembl Gene ENSMUSG00000031732
Gene Name PH domain and leucine rich repeat protein phosphatase 2
Synonyms C130044A18Rik, Phlppl
MMRRC Submission 043306-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.249) question?
Stock # R5663 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 110595174-110671303 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 110630976 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 207 (V207I)
Ref Sequence ENSEMBL: ENSMUSP00000136166 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034175] [ENSMUST00000179721]
AlphaFold Q8BXA7
Predicted Effect probably benign
Transcript: ENSMUST00000034175
AA Change: V172I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000034175
Gene: ENSMUSG00000031732
AA Change: V172I

DomainStartEndE-ValueType
low complexity region 40 57 N/A INTRINSIC
Blast:PH 148 247 3e-61 BLAST
LRR 295 314 1.12e2 SMART
Pfam:LRR_7 319 335 3.5e-2 PFAM
LRR 341 363 2.82e0 SMART
LRR 364 387 9.75e0 SMART
LRR 456 479 2.68e1 SMART
LRR 498 517 1.35e1 SMART
LRR 521 540 5.59e1 SMART
LRR 544 563 2.79e1 SMART
LRR 569 589 1.62e1 SMART
LRR 590 609 1.67e1 SMART
LRR 616 641 1.33e2 SMART
LRR 640 659 1.4e1 SMART
LRR_TYP 664 687 6.78e-3 SMART
LRR 709 733 2.15e2 SMART
PP2Cc 772 1028 2.98e-30 SMART
low complexity region 1061 1095 N/A INTRINSIC
Blast:PP2Cc 1109 1175 8e-15 BLAST
low complexity region 1297 1315 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154262
Predicted Effect probably benign
Transcript: ENSMUST00000179721
AA Change: V207I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000136166
Gene: ENSMUSG00000031732
AA Change: V207I

DomainStartEndE-ValueType
low complexity region 2 28 N/A INTRINSIC
low complexity region 75 92 N/A INTRINSIC
Blast:PH 183 282 4e-61 BLAST
LRR 330 349 1.12e2 SMART
LRR 376 398 2.82e0 SMART
LRR 399 422 9.75e0 SMART
LRR 491 514 2.68e1 SMART
LRR 533 552 1.35e1 SMART
LRR 556 575 5.59e1 SMART
LRR 579 598 2.79e1 SMART
LRR 604 624 1.62e1 SMART
LRR 625 644 1.67e1 SMART
LRR 651 676 1.33e2 SMART
LRR 675 694 1.4e1 SMART
LRR_TYP 699 722 6.78e-3 SMART
LRR 744 768 2.15e2 SMART
PP2Cc 807 1063 2.98e-30 SMART
low complexity region 1096 1130 N/A INTRINSIC
Blast:PP2Cc 1144 1210 8e-15 BLAST
low complexity region 1332 1350 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 T C 5: 50,156,627 (GRCm39) N368D probably benign Het
Agfg1 T A 1: 82,871,173 (GRCm39) S444R probably damaging Het
Arhgap44 A T 11: 64,915,117 (GRCm39) F384I probably damaging Het
Atp8b2 T C 3: 89,849,101 (GRCm39) N1078D probably benign Het
Bcan G A 3: 87,902,920 (GRCm39) T286I probably damaging Het
Cacna1d A G 14: 29,845,297 (GRCm39) L624P probably damaging Het
Ccn5 G A 2: 163,667,173 (GRCm39) R58Q probably damaging Het
Cimip1 C T 2: 173,369,690 (GRCm39) P68L probably damaging Het
Dnah7c C A 1: 46,574,308 (GRCm39) F994L probably damaging Het
Dpp6 A G 5: 27,254,620 (GRCm39) I12V possibly damaging Het
Edil3 A G 13: 89,190,627 (GRCm39) I101M probably damaging Het
Elapor1 T C 3: 108,399,399 (GRCm39) T64A probably benign Het
Farp2 T C 1: 93,497,735 (GRCm39) V255A probably damaging Het
Fhip1a T C 3: 85,579,740 (GRCm39) T822A probably benign Het
Fzr1 A G 10: 81,206,360 (GRCm39) S137P probably benign Het
H2-Eb2 T C 17: 34,552,382 (GRCm39) F76L possibly damaging Het
Helb A G 10: 119,941,698 (GRCm39) I330T possibly damaging Het
Il18rap T A 1: 40,570,717 (GRCm39) C220S probably damaging Het
Kdm4c T C 4: 74,317,585 (GRCm39) V966A probably damaging Het
Kdm5b T C 1: 134,558,373 (GRCm39) V1460A probably benign Het
Kif15 T A 9: 122,820,916 (GRCm39) probably null Het
Liat1 A G 11: 75,891,047 (GRCm39) K54E probably damaging Het
Lrrc37 A G 11: 103,503,949 (GRCm39) V497A probably benign Het
Masp1 T C 16: 23,271,688 (GRCm39) E621G possibly damaging Het
Mier1 T A 4: 103,007,739 (GRCm39) S285T probably damaging Het
Mroh6 A G 15: 75,760,437 (GRCm39) S46P probably benign Het
Myo1h A T 5: 114,472,155 (GRCm39) Q395L probably damaging Het
Ndufb5 T C 3: 32,801,898 (GRCm39) I86T possibly damaging Het
Nelfb T A 2: 25,093,501 (GRCm39) E417V probably benign Het
Nfkb1 T G 3: 135,309,612 (GRCm39) D494A possibly damaging Het
Nid1 G A 13: 13,647,419 (GRCm39) C395Y probably damaging Het
Nr4a3 G T 4: 48,055,931 (GRCm39) R319I probably damaging Het
Or2ag13 T A 7: 106,472,877 (GRCm39) T192S probably benign Het
Or4e1 A T 14: 52,701,052 (GRCm39) I138K probably benign Het
Or6f2 G A 7: 139,756,234 (GRCm39) C67Y probably damaging Het
Paqr5 A G 9: 61,876,144 (GRCm39) V130A probably benign Het
Pik3ca C T 3: 32,516,928 (GRCm39) T1052M probably damaging Het
Pikfyve T C 1: 65,255,187 (GRCm39) Y347H probably benign Het
Ptprz1 A G 6: 23,035,142 (GRCm39) H1964R probably damaging Het
Rassf7 C T 7: 140,797,003 (GRCm39) T72I probably damaging Het
Rfx3 A G 19: 27,771,017 (GRCm39) F603S probably damaging Het
Slc27a4 T A 2: 29,702,382 (GRCm39) V477D probably damaging Het
Slc9a3 A C 13: 74,311,831 (GRCm39) D593A probably damaging Het
Smyd1 A G 6: 71,216,705 (GRCm39) I14T probably benign Het
Sox6 T A 7: 115,149,289 (GRCm39) I404L probably benign Het
Tas2r121 G A 6: 132,677,520 (GRCm39) H151Y probably benign Het
Tgfb1 C T 7: 25,393,706 (GRCm39) T192M possibly damaging Het
Ubr4 T C 4: 139,155,894 (GRCm39) Y2240H possibly damaging Het
Whrn T A 4: 63,336,685 (GRCm39) N626Y probably damaging Het
Xrra1 T A 7: 99,535,250 (GRCm39) I185N probably damaging Het
Zfp94 G A 7: 24,002,252 (GRCm39) R397W probably damaging Het
Other mutations in Phlpp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00467:Phlpp2 APN 8 110,652,422 (GRCm39) missense probably benign 0.01
IGL01363:Phlpp2 APN 8 110,663,729 (GRCm39) missense probably benign 0.22
IGL01535:Phlpp2 APN 8 110,660,697 (GRCm39) missense possibly damaging 0.82
IGL01815:Phlpp2 APN 8 110,666,491 (GRCm39) missense probably benign
IGL02105:Phlpp2 APN 8 110,631,040 (GRCm39) missense probably damaging 1.00
IGL02257:Phlpp2 APN 8 110,646,731 (GRCm39) missense possibly damaging 0.88
IGL02318:Phlpp2 APN 8 110,666,505 (GRCm39) missense probably benign 0.04
IGL02500:Phlpp2 APN 8 110,640,250 (GRCm39) missense probably benign
IGL03356:Phlpp2 APN 8 110,662,249 (GRCm39) missense probably benign 0.00
IGL03366:Phlpp2 APN 8 110,667,467 (GRCm39) missense probably benign 0.44
R0142:Phlpp2 UTSW 8 110,634,145 (GRCm39) missense probably damaging 1.00
R0144:Phlpp2 UTSW 8 110,634,145 (GRCm39) missense probably damaging 1.00
R0374:Phlpp2 UTSW 8 110,634,145 (GRCm39) missense probably damaging 1.00
R0420:Phlpp2 UTSW 8 110,666,567 (GRCm39) missense probably damaging 0.99
R0426:Phlpp2 UTSW 8 110,655,095 (GRCm39) missense probably benign 0.01
R0477:Phlpp2 UTSW 8 110,622,138 (GRCm39) critical splice acceptor site probably null
R0529:Phlpp2 UTSW 8 110,603,603 (GRCm39) missense probably benign 0.00
R0605:Phlpp2 UTSW 8 110,659,843 (GRCm39) missense probably benign 0.00
R0655:Phlpp2 UTSW 8 110,622,219 (GRCm39) missense probably benign 0.00
R0833:Phlpp2 UTSW 8 110,663,738 (GRCm39) missense probably damaging 1.00
R0836:Phlpp2 UTSW 8 110,663,738 (GRCm39) missense probably damaging 1.00
R1394:Phlpp2 UTSW 8 110,603,662 (GRCm39) nonsense probably null
R1417:Phlpp2 UTSW 8 110,667,313 (GRCm39) nonsense probably null
R1602:Phlpp2 UTSW 8 110,660,655 (GRCm39) missense possibly damaging 0.96
R1650:Phlpp2 UTSW 8 110,660,587 (GRCm39) splice site probably benign
R1815:Phlpp2 UTSW 8 110,666,855 (GRCm39) missense probably damaging 1.00
R2045:Phlpp2 UTSW 8 110,634,232 (GRCm39) missense probably damaging 1.00
R2072:Phlpp2 UTSW 8 110,655,124 (GRCm39) missense possibly damaging 0.88
R2074:Phlpp2 UTSW 8 110,655,124 (GRCm39) missense possibly damaging 0.88
R2075:Phlpp2 UTSW 8 110,655,124 (GRCm39) missense possibly damaging 0.88
R2433:Phlpp2 UTSW 8 110,666,634 (GRCm39) missense probably damaging 1.00
R3028:Phlpp2 UTSW 8 110,634,245 (GRCm39) missense probably damaging 1.00
R4611:Phlpp2 UTSW 8 110,603,515 (GRCm39) missense possibly damaging 0.79
R4718:Phlpp2 UTSW 8 110,667,452 (GRCm39) missense probably benign 0.31
R4739:Phlpp2 UTSW 8 110,667,052 (GRCm39) missense probably damaging 1.00
R4857:Phlpp2 UTSW 8 110,603,642 (GRCm39) missense probably damaging 1.00
R5020:Phlpp2 UTSW 8 110,666,714 (GRCm39) missense probably damaging 1.00
R5047:Phlpp2 UTSW 8 110,640,251 (GRCm39) missense probably benign 0.04
R5074:Phlpp2 UTSW 8 110,652,461 (GRCm39) missense probably damaging 0.99
R5330:Phlpp2 UTSW 8 110,660,667 (GRCm39) missense probably damaging 0.99
R5668:Phlpp2 UTSW 8 110,655,205 (GRCm39) missense possibly damaging 0.67
R6433:Phlpp2 UTSW 8 110,661,317 (GRCm39) missense probably benign
R6470:Phlpp2 UTSW 8 110,663,826 (GRCm39) missense probably benign 0.45
R6804:Phlpp2 UTSW 8 110,655,197 (GRCm39) missense probably damaging 1.00
R7012:Phlpp2 UTSW 8 110,603,486 (GRCm39) missense possibly damaging 0.95
R7183:Phlpp2 UTSW 8 110,666,585 (GRCm39) missense probably damaging 1.00
R7257:Phlpp2 UTSW 8 110,666,820 (GRCm39) missense probably benign
R7312:Phlpp2 UTSW 8 110,666,785 (GRCm39) missense probably damaging 0.96
R7349:Phlpp2 UTSW 8 110,655,278 (GRCm39) missense probably damaging 0.98
R7801:Phlpp2 UTSW 8 110,652,474 (GRCm39) missense possibly damaging 0.56
R8059:Phlpp2 UTSW 8 110,622,189 (GRCm39) missense probably benign 0.00
R8174:Phlpp2 UTSW 8 110,595,321 (GRCm39) missense unknown
R8242:Phlpp2 UTSW 8 110,666,834 (GRCm39) missense probably benign 0.03
R8488:Phlpp2 UTSW 8 110,640,202 (GRCm39) missense probably benign
R8688:Phlpp2 UTSW 8 110,631,012 (GRCm39) missense probably damaging 1.00
R8843:Phlpp2 UTSW 8 110,652,431 (GRCm39) missense probably benign 0.18
R9154:Phlpp2 UTSW 8 110,666,590 (GRCm39) missense possibly damaging 0.82
R9556:Phlpp2 UTSW 8 110,666,758 (GRCm39) missense probably benign
R9737:Phlpp2 UTSW 8 110,663,714 (GRCm39) missense probably damaging 0.99
R9781:Phlpp2 UTSW 8 110,662,178 (GRCm39) missense possibly damaging 0.95
R9786:Phlpp2 UTSW 8 110,660,655 (GRCm39) nonsense probably null
X0018:Phlpp2 UTSW 8 110,639,001 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAAATAGGGCTACTGGATGTTGGC -3'
(R):5'- GCTCTGAAGATCAAATGGAGGC -3'

Sequencing Primer
(F):5'- TACTGGATGTTGGCACACAC -3'
(R):5'- ATGGAGGCCCCCACATC -3'
Posted On 2016-11-09