|Institutional Source||Beutler Lab|
|Gene Name||brain glycogen phosphorylase|
|Is this an essential gene?||Probably non essential (E-score: 0.195)|
|Stock #||R5665 (G1)|
|Chromosomal Location||150786735-150831758 bp(+) (GRCm38)|
|Type of Mutation||splice site (6 bp from exon)|
|DNA Base Change (assembly)||T to C at 150820888 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000035743 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045441]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pygb||
(F):5'- TCCTGTGTCGGTATAGCCAC -3'
(R):5'- TCCCATGTTCCAGGGATCGTAG -3'
(F):5'- ACCGTCTTCCATTTCTCAGGAAAAC -3'
(R):5'- AGGGATCGTAGGTTCTCCAAC -3'