Incidental Mutation 'R5667:Slc22a6'
ID 444509
Institutional Source Beutler Lab
Gene Symbol Slc22a6
Ensembl Gene ENSMUSG00000024650
Gene Name solute carrier family 22 (organic anion transporter), member 6
Synonyms mOat1, Orctl1, NKT, Oat1
MMRRC Submission 043310-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5667 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 8595403-8605663 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to G at 8599148 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000010250 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010250]
AlphaFold Q8VC69
Predicted Effect probably null
Transcript: ENSMUST00000010250
SMART Domains Protein: ENSMUSP00000010250
Gene: ENSMUSG00000024650

DomainStartEndE-ValueType
Pfam:MFS_1 107 467 2.4e-25 PFAM
Pfam:Sugar_tr 107 512 8e-33 PFAM
low complexity region 520 531 N/A INTRINSIC
Meta Mutation Damage Score 0.9496 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 96% (54/56)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene may result in increased thymus weight or impaired renal organic anion excretion for a subset of organic anions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
Adamts16 A T 13: 70,984,494 (GRCm39) Y56* probably null Het
Ak2 T A 4: 128,902,040 (GRCm39) F238I probably damaging Het
Akap8l T C 17: 32,557,266 (GRCm39) Y115C probably damaging Het
Alms1 A G 6: 85,673,753 (GRCm39) D3116G probably damaging Het
Arhgap24 T G 5: 102,994,037 (GRCm39) probably null Het
Arhgap45 A G 10: 79,861,310 (GRCm39) E491G probably damaging Het
Atp8b1 C T 18: 64,714,994 (GRCm39) C86Y probably damaging Het
Atxn1 T C 13: 45,710,853 (GRCm39) K693R probably benign Het
Bltp1 A T 3: 36,971,826 (GRCm39) T520S probably benign Het
Btbd10 T C 7: 112,931,931 (GRCm39) K165R probably damaging Het
Capn11 C T 17: 45,950,600 (GRCm39) R293Q possibly damaging Het
Chordc1 T G 9: 18,206,628 (GRCm39) F33V probably damaging Het
Clca4b G A 3: 144,627,624 (GRCm39) T449I probably benign Het
Clip4 A C 17: 72,096,878 (GRCm39) M1L probably damaging Het
Cyfip1 C T 7: 55,523,478 (GRCm39) T90I probably benign Het
Cyp4v3 G T 8: 45,761,572 (GRCm39) T417K possibly damaging Het
Exoc3l4 T C 12: 111,389,851 (GRCm39) I142T probably damaging Het
Flnb T A 14: 7,890,843 (GRCm38) I575N probably benign Het
Foxa1 A T 12: 57,589,081 (GRCm39) S380T probably benign Het
Foxi2 A T 7: 135,012,668 (GRCm39) probably null Het
Gad1-ps A T 10: 99,280,395 (GRCm39) noncoding transcript Het
Gpa33 A G 1: 165,974,360 (GRCm39) T66A possibly damaging Het
Gpr45 A G 1: 43,072,218 (GRCm39) Y287C probably damaging Het
H2-Eb1 C A 17: 34,533,229 (GRCm39) Y150* probably null Het
Hsd17b8 T C 17: 34,245,435 (GRCm39) D233G probably null Het
Ifna6 A T 4: 88,745,906 (GRCm39) Q85L probably damaging Het
Ivns1abp G T 1: 151,229,760 (GRCm39) L149F probably benign Het
Kank4 A G 4: 98,653,698 (GRCm39) probably null Het
Katnip T A 7: 125,442,627 (GRCm39) probably null Het
Lama2 A T 10: 27,066,540 (GRCm39) C1114S probably damaging Het
Lmbr1l A C 15: 98,805,489 (GRCm39) D337E possibly damaging Het
Lrrn3 A C 12: 41,502,297 (GRCm39) S673R possibly damaging Het
Ly75 T C 2: 60,138,655 (GRCm39) D1404G probably damaging Het
Muc4 A G 16: 32,575,011 (GRCm39) T1199A probably benign Het
Mycn A T 12: 12,990,045 (GRCm39) M117K possibly damaging Het
Nalcn A G 14: 123,532,818 (GRCm39) I1314T probably damaging Het
Nod1 T C 6: 54,910,561 (GRCm39) T869A probably benign Het
Or2y16 T C 11: 49,335,140 (GRCm39) V154A probably benign Het
Or4k39 C T 2: 111,238,818 (GRCm39) noncoding transcript Het
Plekhg2 A T 7: 28,067,064 (GRCm39) I356N probably damaging Het
Ptpru T A 4: 131,547,501 (GRCm39) Y112F possibly damaging Het
Rpl36al G A 12: 69,229,897 (GRCm39) P5L possibly damaging Het
Ryr2 A G 13: 11,774,722 (GRCm39) W1145R probably damaging Het
Semp2l2b T A 10: 21,942,742 (GRCm39) T413S possibly damaging Het
Slc11a2 A G 15: 100,301,169 (GRCm39) Y295H probably damaging Het
Styxl1 A G 5: 135,785,977 (GRCm39) probably null Het
Tmc6 A G 11: 117,666,441 (GRCm39) S288P possibly damaging Het
Trpv4 A G 5: 114,772,617 (GRCm39) L371P probably damaging Het
Uqcc4 G A 17: 25,403,963 (GRCm39) S101N probably damaging Het
Usp8 A G 2: 126,584,345 (GRCm39) D518G probably benign Het
Washc4 T C 10: 83,405,892 (GRCm39) S463P probably damaging Het
Other mutations in Slc22a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00773:Slc22a6 APN 19 8,599,232 (GRCm39) missense probably benign 0.14
IGL00825:Slc22a6 APN 19 8,595,721 (GRCm39) missense possibly damaging 0.94
IGL01362:Slc22a6 APN 19 8,598,572 (GRCm39) missense possibly damaging 0.69
IGL01843:Slc22a6 APN 19 8,603,578 (GRCm39) utr 3 prime probably benign
IGL02583:Slc22a6 APN 19 8,600,980 (GRCm39) missense possibly damaging 0.79
R1004:Slc22a6 UTSW 19 8,595,763 (GRCm39) missense probably damaging 1.00
R1775:Slc22a6 UTSW 19 8,596,471 (GRCm39) critical splice donor site probably null
R1911:Slc22a6 UTSW 19 8,599,246 (GRCm39) missense probably benign
R2365:Slc22a6 UTSW 19 8,596,761 (GRCm39) missense probably benign
R3406:Slc22a6 UTSW 19 8,598,675 (GRCm39) missense probably damaging 1.00
R4106:Slc22a6 UTSW 19 8,595,874 (GRCm39) missense probably benign
R4693:Slc22a6 UTSW 19 8,601,016 (GRCm39) missense probably damaging 1.00
R5094:Slc22a6 UTSW 19 8,603,541 (GRCm39) missense probably damaging 1.00
R5347:Slc22a6 UTSW 19 8,595,917 (GRCm39) missense possibly damaging 0.94
R5360:Slc22a6 UTSW 19 8,596,786 (GRCm39) missense probably damaging 1.00
R5810:Slc22a6 UTSW 19 8,601,222 (GRCm39) missense probably damaging 1.00
R6176:Slc22a6 UTSW 19 8,599,161 (GRCm39) missense probably damaging 1.00
R6336:Slc22a6 UTSW 19 8,599,494 (GRCm39) missense probably benign 0.02
R6864:Slc22a6 UTSW 19 8,595,805 (GRCm39) missense probably damaging 1.00
R6954:Slc22a6 UTSW 19 8,599,460 (GRCm39) missense probably benign 0.02
R7298:Slc22a6 UTSW 19 8,598,684 (GRCm39) missense possibly damaging 0.49
R7305:Slc22a6 UTSW 19 8,599,522 (GRCm39) critical splice donor site probably null
R7681:Slc22a6 UTSW 19 8,603,493 (GRCm39) missense probably benign 0.03
R7749:Slc22a6 UTSW 19 8,599,260 (GRCm39) missense possibly damaging 0.48
R7937:Slc22a6 UTSW 19 8,601,253 (GRCm39) missense probably benign 0.07
R8346:Slc22a6 UTSW 19 8,599,169 (GRCm39) missense probably damaging 1.00
R8347:Slc22a6 UTSW 19 8,599,169 (GRCm39) missense probably damaging 1.00
R8348:Slc22a6 UTSW 19 8,599,169 (GRCm39) missense probably damaging 1.00
R8363:Slc22a6 UTSW 19 8,596,386 (GRCm39) missense probably benign
R8698:Slc22a6 UTSW 19 8,600,889 (GRCm39) missense probably benign
R9431:Slc22a6 UTSW 19 8,598,596 (GRCm39) missense probably benign 0.10
R9602:Slc22a6 UTSW 19 8,598,560 (GRCm39) nonsense probably null
R9774:Slc22a6 UTSW 19 8,603,134 (GRCm39) missense probably benign 0.00
Z1088:Slc22a6 UTSW 19 8,599,197 (GRCm39) missense probably benign 0.03
Z1176:Slc22a6 UTSW 19 8,600,907 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- AAGGAAGGTGGCAGTTCTCTG -3'
(R):5'- TAACCTCTGAGGCTTGGGTC -3'

Sequencing Primer
(F):5'- TGCTGGCATGCCTCTACACAG -3'
(R):5'- CTCTGAGGCTTGGGTCTTGGTAC -3'
Posted On 2016-11-09