Incidental Mutation 'R5738:Olfr131'
ID444650
Institutional Source Beutler Lab
Gene Symbol Olfr131
Ensembl Gene ENSMUSG00000043312
Gene Nameolfactory receptor 131
SynonymsGA_x6K02T2PSCP-2531299-2530355, MOR256-4
MMRRC Submission 043350-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R5738 (G1)
Quality Score225
Status Validated
Chromosome17
Chromosomal Location38081624-38088693 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 38082456 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 174 (Y174C)
Ref Sequence ENSEMBL: ENSMUSP00000150562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059560] [ENSMUST00000172933] [ENSMUST00000215940] [ENSMUST00000216523]
Predicted Effect probably damaging
Transcript: ENSMUST00000059560
AA Change: Y174C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000061861
Gene: ENSMUSG00000043312
AA Change: Y174C

DomainStartEndE-ValueType
Pfam:7tm_1 43 294 4e-35 PFAM
Pfam:7tm_4 141 287 2.7e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172933
AA Change: Y174C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000134532
Gene: ENSMUSG00000043312
AA Change: Y174C

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 9.5e-57 PFAM
Pfam:7tm_1 43 294 1.2e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173218
Predicted Effect probably damaging
Transcript: ENSMUST00000215940
AA Change: Y174C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216523
AA Change: Y174C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,621,917 D4826V probably damaging Het
Acoxl G A 2: 127,877,766 C149Y probably benign Het
Adamts3 G T 5: 89,708,668 H349N probably damaging Het
Ap2b1 A G 11: 83,336,430 probably null Het
Ap3m2 T C 8: 22,803,861 S58G possibly damaging Het
Bhmt2 A T 13: 93,663,290 W213R probably benign Het
Cacna1h T G 17: 25,387,049 D1092A probably damaging Het
Cbfb A C 8: 105,202,561 Q170P probably damaging Het
Ccdc73 A C 2: 104,930,986 K110N possibly damaging Het
Cep350 C A 1: 155,866,078 R2149L probably damaging Het
Cog2 A G 8: 124,546,038 T525A probably benign Het
Dnah8 G A 17: 30,748,568 D2585N probably benign Het
Fbxl5 A G 5: 43,762,828 I251T probably benign Het
Fscn3 A G 6: 28,430,031 K67E possibly damaging Het
Glmp T A 3: 88,326,138 N133K probably benign Het
Gpr179 T C 11: 97,351,406 N204S probably damaging Het
Gtf2ird1 C T 5: 134,383,818 R613Q probably damaging Het
Hepacam A G 9: 37,383,425 D285G possibly damaging Het
Hipk4 G A 7: 27,528,416 V196M probably damaging Het
Hlx A T 1: 184,731,557 probably null Het
Igf2r A T 17: 12,717,367 D597E probably benign Het
Ighm T C 12: 113,421,495 T282A unknown Het
Igsf9b T C 9: 27,328,530 C624R probably damaging Het
Ksr2 T C 5: 117,748,799 V800A probably damaging Het
Lyn A T 4: 3,782,987 I386F probably damaging Het
Melk A G 4: 44,310,333 D102G probably damaging Het
Mettl1 G T 10: 127,041,994 E4* probably null Het
Mybl2 C T 2: 163,068,283 Q210* probably null Het
Naga C T 15: 82,334,853 W231* probably null Het
Olfr730 C T 14: 50,186,648 V190I probably benign Het
Olfr828 T C 9: 18,815,829 N155S possibly damaging Het
Otud4 T C 8: 79,673,461 S935P probably benign Het
P2rx7 C T 5: 122,652,789 T63I probably damaging Het
Pga5 A T 19: 10,669,660 N260K probably benign Het
Phka2 ACC AC X: 160,559,866 probably null Het
Plch1 T A 3: 63,773,655 R184W probably damaging Het
Ppm1b T C 17: 84,993,946 F85L probably benign Het
Prtg T A 9: 72,912,006 F1094I probably benign Het
Ralgds G A 2: 28,542,526 probably benign Het
Rgs17 A C 10: 5,833,140 V149G probably damaging Het
Rnf168 A G 16: 32,282,374 E124G probably damaging Het
Sav1 T C 12: 69,976,043 E245G possibly damaging Het
Slc25a19 T C 11: 115,624,234 I33V probably benign Het
Sptbn1 T C 11: 30,145,941 I318V probably damaging Het
Tas2r136 A G 6: 132,777,744 L140P probably damaging Het
Tbc1d9 A G 8: 83,271,026 I1071V probably benign Het
Tecta G T 9: 42,373,178 N870K possibly damaging Het
Tmem230 G A 2: 132,244,128 P38L possibly damaging Het
Trpa1 G T 1: 14,875,950 H986N probably damaging Het
Wdr41 A T 13: 94,978,488 I24L possibly damaging Het
Other mutations in Olfr131
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01063:Olfr131 APN 17 38082653 missense possibly damaging 0.48
IGL01287:Olfr131 APN 17 38082107 missense probably damaging 1.00
IGL01637:Olfr131 APN 17 38082103 missense possibly damaging 0.90
IGL02833:Olfr131 APN 17 38082352 missense possibly damaging 0.84
IGL02927:Olfr131 APN 17 38082223 missense probably benign 0.00
R0662:Olfr131 UTSW 17 38082933 missense probably benign 0.09
R0755:Olfr131 UTSW 17 38082194 nonsense probably null
R1526:Olfr131 UTSW 17 38082595 missense probably damaging 0.99
R2155:Olfr131 UTSW 17 38082180 missense probably damaging 1.00
R3123:Olfr131 UTSW 17 38082012 utr 3 prime probably null
R3125:Olfr131 UTSW 17 38082012 utr 3 prime probably null
R4135:Olfr131 UTSW 17 38082357 missense possibly damaging 0.52
R4244:Olfr131 UTSW 17 38082430 missense probably benign 0.12
R5104:Olfr131 UTSW 17 38082283 missense possibly damaging 0.47
R5182:Olfr131 UTSW 17 38082114 missense probably benign 0.03
R5293:Olfr131 UTSW 17 38082240 missense probably damaging 1.00
R5924:Olfr131 UTSW 17 38082363 missense probably benign 0.01
R6218:Olfr131 UTSW 17 38082729 missense probably damaging 0.98
R6362:Olfr131 UTSW 17 38082729 missense probably damaging 0.99
R6961:Olfr131 UTSW 17 38082205 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCCTTCTTTCGACCTTCAGAAG -3'
(R):5'- TCCTTAGCTTGGGGTCTACAG -3'

Sequencing Primer
(F):5'- CTTTCGACCTTCAGAAGATTGTATC -3'
(R):5'- ACAGAGTGTGTGCTTCTCTCCG -3'
Posted On2016-11-21