Mutagenetix > Incidental Mutation

Incidental Mutation 'R5739:Vmn2r26'

444684

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

043351-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R5739 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 124025966 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 112 (N112Y)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: N112Y

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: N112Y

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 95.0%

Validation Efficiency

100% (82/82)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931429L15Rik	A	T	9: 46,309,419 (GRCm38)	S50T	probably benign	Het
A930011G23Rik	A	G	5: 99,221,430 (GRCm38)	L529P	probably damaging	Het
Acer2	A	T	4: 86,900,555 (GRCm38)	N147Y	probably damaging	Het
Adamtsl1	A	G	4: 86,232,664 (GRCm38)	E353G	probably damaging	Het
Alg6	T	C	4: 99,744,500 (GRCm38)	F60L	probably benign	Het
Ano6	A	T	15: 95,913,379 (GRCm38)	D120V	probably damaging	Het
Armc3	A	G	2: 19,253,917 (GRCm38)	D265G	possibly damaging	Het
Aurkc	A	T	7: 7,002,860 (GRCm38)	Y249F	probably benign	Het
Bmal1	G	A	7: 113,285,031 (GRCm38)	R92Q	probably damaging	Het
Cacna2d2	A	G	9: 107,512,329 (GRCm38)	I274V	probably benign	Het
Camk2n2	C	A	16: 20,621,080 (GRCm38)	G39C	probably damaging	Het
Ccdc39	A	G	3: 33,826,561 (GRCm38)	L419P	possibly damaging	Het
Cdh23	T	C	10: 60,305,609 (GRCm38)	M3117V	probably damaging	Het
Celsr3	A	G	9: 108,827,158 (GRCm38)	E280G	probably benign	Het
Cherp	TGCTGGTGGTGGGG	TG	8: 72,467,815 (GRCm38)		probably benign	Het
Clcn6	A	G	4: 148,014,189 (GRCm38)	V494A	probably damaging	Het
Col19a1	C	T	1: 24,337,915 (GRCm38)	G450S	probably damaging	Het
Crb2	T	G	2: 37,793,654 (GRCm38)	V1056G	probably damaging	Het
Crtac1	A	G	19: 42,302,173 (GRCm38)	F363S	probably damaging	Het
Dipk2a	A	T	9: 94,520,541 (GRCm38)	V356E	possibly damaging	Het
Dnaaf2	T	C	12: 69,196,941 (GRCm38)	S449G	probably benign	Het
Dnah7b	A	T	1: 46,233,992 (GRCm38)	I2427F	probably damaging	Het
Dnah8	T	A	17: 30,719,007 (GRCm38)	D1619E	probably benign	Het
Dock3	A	T	9: 106,973,796 (GRCm38)	S836T	possibly damaging	Het
Donson	A	T	16: 91,681,229 (GRCm38)		probably null	Het
Drc3	G	A	11: 60,375,130 (GRCm38)	R215H	possibly damaging	Het
Entpd2	T	C	2: 25,399,492 (GRCm38)	S329P	possibly damaging	Het
Eya2	T	C	2: 165,761,937 (GRCm38)	S332P	probably damaging	Het
Fam83f	T	A	15: 80,692,005 (GRCm38)	Y286N	probably damaging	Het
Fat4	T	C	3: 38,983,134 (GRCm38)	V3645A	probably benign	Het
G2e3	T	C	12: 51,372,504 (GRCm38)	F668L	possibly damaging	Het
Gm14403	T	A	2: 177,509,247 (GRCm38)	C329S	probably damaging	Het
Hmcn1	A	T	1: 150,758,474 (GRCm38)		probably null	Het
Hmcn1	G	A	1: 150,808,697 (GRCm38)	T374I	probably benign	Het
Hrnr	T	C	3: 93,323,129 (GRCm38)	S225P	unknown	Het
Ifi202b	C	T	1: 173,971,352 (GRCm38)		probably null	Het
Il10ra	A	T	9: 45,256,070 (GRCm38)	D394E	possibly damaging	Het
Itga2b	A	T	11: 102,465,909 (GRCm38)	D275E	probably benign	Het
Jaml	A	T	9: 45,088,728 (GRCm38)	D108V	probably damaging	Het
Kir3dl1	G	A	X: 136,526,482 (GRCm38)	D56N	probably damaging	Het
Lrrtm1	T	C	6: 77,244,889 (GRCm38)	V443A	probably damaging	Het
Mkln1	T	A	6: 31,496,702 (GRCm38)	S126R	probably benign	Het
Myo19	T	C	11: 84,897,624 (GRCm38)	I354T	probably damaging	Het
Nucb1	A	T	7: 45,501,660 (GRCm38)	L99Q	probably damaging	Het
Or4f59	A	G	2: 112,042,783 (GRCm38)	F83S	probably damaging	Het
Pask	A	G	1: 93,322,056 (GRCm38)	S541P	probably benign	Het
Pdpr	A	T	8: 111,134,620 (GRCm38)	I749F	possibly damaging	Het
Pgap6	T	A	17: 26,120,451 (GRCm38)	F580I	probably damaging	Het
Phyhipl	T	C	10: 70,559,569 (GRCm38)	D269G	possibly damaging	Het
Pkdcc	A	G	17: 83,215,794 (GRCm38)	D110G	probably benign	Het
Ppox	A	G	1: 171,279,996 (GRCm38)	L115P	probably damaging	Het
Ppp1r12c	A	G	7: 4,497,282 (GRCm38)	L94P	probably damaging	Het
Ppp6r2	T	A	15: 89,259,073 (GRCm38)	M141K	probably benign	Het
Prl3d1	A	T	13: 27,100,012 (GRCm38)	H188L	probably benign	Het
Psmb3	T	A	11: 97,713,470 (GRCm38)		probably benign	Het
Pxdn	T	A	12: 29,982,334 (GRCm38)	S150T	probably benign	Het
Ripor3	T	C	2: 167,981,283 (GRCm38)	T903A	probably damaging	Het
Rnase4	T	C	14: 51,104,849 (GRCm38)	L10S	probably benign	Het
Rnf224	T	C	2: 25,236,000 (GRCm38)	T114A	probably benign	Het
Rp1l1	A	T	14: 64,032,170 (GRCm38)	E1735V	probably benign	Het
Rrp1b	T	A	17: 32,045,976 (GRCm38)	Y60N	probably damaging	Het
Rsbn1l	A	T	5: 20,905,816 (GRCm38)	V508E	probably damaging	Het
Rubcnl	T	C	14: 75,040,941 (GRCm38)		probably null	Het
Rxfp4	A	G	3: 88,651,902 (GRCm38)		probably benign	Het
Sdccag8	A	G	1: 176,826,231 (GRCm38)	T85A	probably benign	Het
Slc46a1	A	T	11: 78,467,149 (GRCm38)	I343F	possibly damaging	Het
Ssh2	A	G	11: 77,449,813 (GRCm38)	D597G	probably damaging	Het
Syne2	T	A	12: 75,997,465 (GRCm38)	V3942E	possibly damaging	Het
Timd4	T	C	11: 46,817,746 (GRCm38)	S200P	probably benign	Het
Tmc5	G	A	7: 118,666,611 (GRCm38)		probably null	Het
Trbv16	A	G	6: 41,152,079 (GRCm38)	T66A	probably benign	Het
Ttc3	A	T	16: 94,439,324 (GRCm38)	K1103*	probably null	Het
Ttc7b	A	G	12: 100,384,233 (GRCm38)	V458A	probably damaging	Het
Ubxn10	A	G	4: 138,720,823 (GRCm38)	S181P	probably benign	Het
Vmn2r11	A	G	5: 109,059,248 (GRCm38)		probably null	Het
Vmn2r5	T	C	3: 64,504,076 (GRCm38)	D357G	probably damaging	Het
Zc3h10	T	C	10: 128,544,801 (GRCm38)	N229S	probably benign	Het
Zfp407	T	C	18: 84,208,742 (GRCm38)	*2247W	probably null	Het
Zfyve1	C	A	12: 83,575,136 (GRCm38)	V162L	possibly damaging	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,061,607 (GRCm38)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,061,756 (GRCm38)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,053,874 (GRCm38)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,050,673 (GRCm38)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,061,625 (GRCm38)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,061,818 (GRCm38)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,026,141 (GRCm38)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,026,132 (GRCm38)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,039,795 (GRCm38)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,050,819 (GRCm38)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,039,899 (GRCm38)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,062,033 (GRCm38)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,053,981 (GRCm38)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,061,170 (GRCm38)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,061,644 (GRCm38)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,053,913 (GRCm38)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,050,708 (GRCm38)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,039,747 (GRCm38)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,061,472 (GRCm38)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,061,410 (GRCm38)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,024,771 (GRCm38)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,053,887 (GRCm38)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,061,185 (GRCm38)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,061,237 (GRCm38)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,039,749 (GRCm38)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,061,350 (GRCm38)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,025,979 (GRCm38)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,050,738 (GRCm38)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,061,191 (GRCm38)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,061,416 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,053,965 (GRCm38)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,026,111 (GRCm38)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,061,873 (GRCm38)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,061,326 (GRCm38)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,050,717 (GRCm38)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,039,449 (GRCm38)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,061,674 (GRCm38)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,039,871 (GRCm38)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,039,560 (GRCm38)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,061,485 (GRCm38)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,061,389 (GRCm38)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,026,080 (GRCm38)	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124,061,691 (GRCm38)	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124,039,098 (GRCm38)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,039,782 (GRCm38)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,061,296 (GRCm38)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,039,768 (GRCm38)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,061,989 (GRCm38)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,025,955 (GRCm38)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,039,741 (GRCm38)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,039,647 (GRCm38)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,039,362 (GRCm38)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,061,535 (GRCm38)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,061,745 (GRCm38)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,039,799 (GRCm38)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,024,955 (GRCm38)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,061,928 (GRCm38)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,026,036 (GRCm38)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,039,618 (GRCm38)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,024,918 (GRCm38)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,062,024 (GRCm38)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,026,050 (GRCm38)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,039,374 (GRCm38)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,025,867 (GRCm38)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,061,178 (GRCm38)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,039,489 (GRCm38)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- GCTCTTTATATGCCTTAGATTGCTG -3'
(R):5'- CGTTGTAGAGACTTAGAACTCGGG -3'

Sequencing Primer
(F):5'- TCCAAAATTTGAGAGGGAGCACTG -3'
(R):5'- CTTAGAACTCGGGAGATCTGAATG -3'

Posted On

2016-11-21