Mutagenetix > Incidental Mutations

Incidental Mutation 'R5740:Vmn2r7'

444735

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

Synonyms

MMRRC Submission

043196-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R5740 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

64690660-64719602 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 64707233 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 387 (I387V)

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

Predicted Effect

probably benign
Transcript: ENSMUST00000161972
AA Change: I478V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: I478V

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168072
AA Change: I387V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: I387V

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177146

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921513I03Rik	G	A	10: 120,778,508		probably benign	Het
Arrdc5	T	A	17: 56,297,838	N150Y	probably benign	Het
Bag1	T	C	4: 40,941,526	Q269R	probably null	Het
C7	T	C	15: 5,057,040	N40D	probably benign	Het
Ccdc109b	A	T	3: 129,918,725	M167K	probably benign	Het
Ccnt1	T	C	15: 98,544,500	I296V	probably benign	Het
Col19a1	C	T	1: 24,337,915	G450S	probably damaging	Het
F13a1	T	C	13: 36,898,204	T509A	probably benign	Het
Fgg	A	T	3: 83,011,525	T282S	probably benign	Het
Fzd7	A	G	1: 59,483,680	M241V	probably benign	Het
Gja1	G	A	10: 56,388,189	V215M	probably damaging	Het
Golgb1	T	C	16: 36,919,000	L2567P	probably damaging	Het
Grik2	T	C	10: 49,113,477	N819D	probably damaging	Het
Grik4	C	T	9: 42,808,567	R3H	possibly damaging	Het
Hecw2	T	C	1: 53,887,603	Y1079C	probably benign	Het
Hivep3	A	G	4: 120,096,023	E512G	possibly damaging	Het
Ino80	T	C	2: 119,431,029	D718G	probably damaging	Het
Ints10	G	A	8: 68,804,922	R258K	probably damaging	Het
Jak2	A	G	19: 29,262,424	K73E	possibly damaging	Het
Lrba	A	G	3: 86,328,342	I918V	probably damaging	Het
M1ap	T	C	6: 82,981,922	V178A	probably damaging	Het
Mgat4c	A	T	10: 102,389,321	K465N	possibly damaging	Het
Naip1	T	A	13: 100,432,501		probably null	Het
Ncbp3	T	A	11: 73,053,497	N108K	possibly damaging	Het
Npepps	A	T	11: 97,236,068	D455E	possibly damaging	Het
Olfr1453	T	C	19: 13,027,562	M256V	probably benign	Het
Pan2	G	A	10: 128,308,164	G128S	probably damaging	Het
Ppp3cb	A	T	14: 20,501,596	I489N	possibly damaging	Het
Sdccag8	A	G	1: 176,831,150	T134A	probably benign	Het
Sh3tc1	T	C	5: 35,707,055	E596G	probably benign	Het
Shank1	T	C	7: 44,353,740	S1619P	possibly damaging	Het
Slc46a3	A	T	5: 147,879,833	C387*	probably null	Het
Slc5a5	G	T	8: 70,888,917		probably null	Het
Ttn	T	C	2: 76,891,374		probably benign	Het
Vangl1	T	C	3: 102,184,134	D212G	probably damaging	Het
Vmn1r52	T	A	6: 90,179,194	I160N	probably benign	Het
Vmn2r118	C	T	17: 55,593,103	M600I	probably benign	Het
Zfp369	A	G	13: 65,296,767	R575G	probably benign	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64715813	missense	possibly damaging	0.60
IGL01762:Vmn2r7	APN	3	64691435	missense	probably benign	0.39
IGL01903:Vmn2r7	APN	3	64719443	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64691447	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64693025	missense	probably damaging	0.97
IGL02593:Vmn2r7	APN	3	64693022	missense	probably damaging	1.00
IGL02797:Vmn2r7	APN	3	64691245	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64707218	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64715976	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64691039	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64691018	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64716479	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64716367	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64716579	missense	probably benign
R1065:Vmn2r7	UTSW	3	64707138	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64724802	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64707079	missense	probably benign
R1509:Vmn2r7	UTSW	3	64716460	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64716455	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64691459	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64724991	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64719611	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64719516	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64692993	missense	probably benign	0.08
R4117:Vmn2r7	UTSW	3	64715717	intron	probably benign
R4333:Vmn2r7	UTSW	3	64690778	missense	probably damaging	1.00
R4551:Vmn2r7	UTSW	3	64690689	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64716404	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64719443	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64690784	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64690667	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64716324	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64716237	missense	probably benign	0.07
R5977:Vmn2r7	UTSW	3	64716043	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64716222	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64725015	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64715918	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64707074	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64690827	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64691339	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64691121	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64716566	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64715777	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64690880	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64716593	missense	probably benign
R7557:Vmn2r7	UTSW	3	64724973	missense	probably benign
R7864:Vmn2r7	UTSW	3	64691526	missense	probably benign	0.10
R8046:Vmn2r7	UTSW	3	64707058	missense	probably damaging	1.00
R8068:Vmn2r7	UTSW	3	64716086	missense	probably benign	0.01
R8252:Vmn2r7	UTSW	3	64693106	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AACCCTTGAAGATTCAGTGTTCC -3'
(R):5'- TTTTCCAGGCTCTTGATACAGAG -3'

Sequencing Primer
(F):5'- CAGTGTTCCAAAATAATGTTGAGTTC -3'
(R):5'- CACCTGTGGCTAGAGGATATC -3'

Posted On

2016-11-21