Incidental Mutation 'R5741:Zfp831'
ID 444775
Institutional Source Beutler Lab
Gene Symbol Zfp831
Ensembl Gene ENSMUSG00000050600
Gene Name zinc finger protein 831
Synonyms ENSMUSG00000050600, OTTMUSG00000017459
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5741 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 174485327-174552625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 174486945 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 540 (I540N)
Ref Sequence ENSEMBL: ENSMUSP00000060255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059452]
AlphaFold A2ADM8
Predicted Effect possibly damaging
Transcript: ENSMUST00000059452
AA Change: I540N

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: I540N

DomainStartEndE-ValueType
low complexity region 120 135 N/A INTRINSIC
ZnF_C2H2 143 165 5.06e-2 SMART
ZnF_C2H2 171 195 7.78e-3 SMART
low complexity region 201 216 N/A INTRINSIC
low complexity region 237 248 N/A INTRINSIC
low complexity region 345 371 N/A INTRINSIC
low complexity region 383 392 N/A INTRINSIC
low complexity region 447 459 N/A INTRINSIC
low complexity region 645 657 N/A INTRINSIC
low complexity region 717 736 N/A INTRINSIC
low complexity region 856 870 N/A INTRINSIC
low complexity region 1520 1529 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810010H24Rik T G 11: 106,919,315 (GRCm39) F220C probably damaging Het
Acox3 C T 5: 35,765,668 (GRCm39) H140Y probably benign Het
Ano3 A T 2: 110,488,618 (GRCm39) I938K probably benign Het
Ap3m1 A C 14: 21,095,788 (GRCm39) I14S possibly damaging Het
Arg1 T C 10: 24,793,897 (GRCm39) T127A probably benign Het
Asah2 A G 19: 31,986,015 (GRCm39) Y552H probably damaging Het
Cfap97d2 A T 8: 13,784,835 (GRCm39) Q32L possibly damaging Het
Chst12 A G 5: 140,509,688 (GRCm39) N105S probably benign Het
Cped1 G A 6: 22,123,620 (GRCm39) V458I probably benign Het
Cyld T G 8: 89,471,474 (GRCm39) I786S probably damaging Het
Cyp2j8 C T 4: 96,332,880 (GRCm39) V489I probably benign Het
Dlgap4 T C 2: 156,552,968 (GRCm39) Y462H probably damaging Het
Dnah5 C A 15: 28,246,513 (GRCm39) A617D probably benign Het
Erc2 T A 14: 28,024,826 (GRCm39) probably null Het
Fancm A G 12: 65,148,389 (GRCm39) N668S probably benign Het
Gm5592 A G 7: 40,938,625 (GRCm39) I636V probably benign Het
Gtf2h2 A T 13: 100,617,066 (GRCm39) C247S probably benign Het
Hyal5 T A 6: 24,876,494 (GRCm39) H122Q probably damaging Het
Ints10 G A 8: 69,257,574 (GRCm39) R258K probably damaging Het
Kir3dl1 G A X: 135,427,231 (GRCm39) D56N probably damaging Het
Lrguk T A 6: 34,025,802 (GRCm39) D199E probably damaging Het
Lyst A G 13: 13,808,615 (GRCm39) D95G probably benign Het
Map2k1 A T 9: 64,121,883 (GRCm39) L30Q possibly damaging Het
Nell1 G A 7: 50,210,638 (GRCm39) probably null Het
Nfatc3 T A 8: 106,805,698 (GRCm39) I181N probably damaging Het
Nipbl T C 15: 8,354,133 (GRCm39) K1668R possibly damaging Het
Or5b113 A G 19: 13,342,847 (GRCm39) N285S probably damaging Het
Or7e170 A G 9: 19,794,857 (GRCm39) V248A possibly damaging Het
Or8d2 T A 9: 38,759,899 (GRCm39) L163* probably null Het
Otud7b C T 3: 96,051,615 (GRCm39) T189I probably damaging Het
Pkia A T 3: 7,507,105 (GRCm39) E62D probably benign Het
Plcb3 G A 19: 6,931,790 (GRCm39) Q1154* probably null Het
Pole4 T C 6: 82,628,447 (GRCm39) E105G probably damaging Het
Ppp1r3a A G 6: 14,719,882 (GRCm39) V344A probably damaging Het
Ptpn21 A T 12: 98,645,548 (GRCm39) L1130Q probably damaging Het
Rapgef5 A G 12: 117,719,764 (GRCm39) D564G probably damaging Het
Samhd1 C T 2: 156,954,751 (GRCm39) R387H probably benign Het
Spag1 A G 15: 36,183,849 (GRCm39) K65E possibly damaging Het
Spata31d1d A T 13: 59,876,500 (GRCm39) V345D possibly damaging Het
Spin1 G A 13: 51,303,171 (GRCm39) V255I possibly damaging Het
Tmem171 A G 13: 98,828,559 (GRCm39) V197A probably benign Het
Tmigd1 T C 11: 76,797,916 (GRCm39) V86A possibly damaging Het
Ttn T C 2: 76,542,417 (GRCm39) D31777G probably damaging Het
Tymp T A 15: 89,260,639 (GRCm39) M60L probably benign Het
Ugdh T C 5: 65,584,866 (GRCm39) T19A probably damaging Het
Vmn1r234 G T 17: 21,449,731 (GRCm39) C215F probably benign Het
Wnt5b T C 6: 119,410,690 (GRCm39) D250G probably damaging Het
Xrn1 T A 9: 95,927,604 (GRCm39) C1463S probably benign Het
Zmynd8 T C 2: 165,681,937 (GRCm39) D189G probably damaging Het
Other mutations in Zfp831
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Zfp831 APN 2 174,488,078 (GRCm39) missense possibly damaging 0.86
IGL00091:Zfp831 APN 2 174,487,451 (GRCm39) missense possibly damaging 0.73
IGL00764:Zfp831 APN 2 174,487,701 (GRCm39) missense possibly damaging 0.72
IGL01538:Zfp831 APN 2 174,486,399 (GRCm39) missense possibly damaging 0.72
IGL01700:Zfp831 APN 2 174,486,711 (GRCm39) missense possibly damaging 0.86
IGL01718:Zfp831 APN 2 174,485,631 (GRCm39) missense possibly damaging 0.86
IGL02221:Zfp831 APN 2 174,485,519 (GRCm39) missense probably benign 0.33
IGL02250:Zfp831 APN 2 174,489,994 (GRCm39) missense possibly damaging 0.53
IGL03209:Zfp831 APN 2 174,487,059 (GRCm39) missense probably benign 0.40
D4043:Zfp831 UTSW 2 174,487,059 (GRCm39) missense probably benign 0.40
FR4304:Zfp831 UTSW 2 174,487,274 (GRCm39) small insertion probably benign
FR4340:Zfp831 UTSW 2 174,487,273 (GRCm39) small insertion probably benign
FR4449:Zfp831 UTSW 2 174,487,275 (GRCm39) small insertion probably benign
FR4449:Zfp831 UTSW 2 174,487,264 (GRCm39) small insertion probably benign
FR4589:Zfp831 UTSW 2 174,487,261 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,276 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,269 (GRCm39) small insertion probably benign
FR4737:Zfp831 UTSW 2 174,487,264 (GRCm39) small insertion probably benign
IGL02802:Zfp831 UTSW 2 174,486,945 (GRCm39) missense possibly damaging 0.73
P0028:Zfp831 UTSW 2 174,487,139 (GRCm39) missense possibly damaging 0.53
PIT4531001:Zfp831 UTSW 2 174,488,516 (GRCm39) missense possibly damaging 0.90
R0631:Zfp831 UTSW 2 174,487,083 (GRCm39) missense possibly damaging 0.53
R0644:Zfp831 UTSW 2 174,487,656 (GRCm39) missense probably benign 0.33
R0782:Zfp831 UTSW 2 174,488,423 (GRCm39) missense probably benign 0.06
R1156:Zfp831 UTSW 2 174,488,710 (GRCm39) missense possibly damaging 0.53
R1280:Zfp831 UTSW 2 174,545,852 (GRCm39) missense probably benign 0.00
R1709:Zfp831 UTSW 2 174,487,683 (GRCm39) missense probably benign 0.33
R1883:Zfp831 UTSW 2 174,545,870 (GRCm39) missense possibly damaging 0.53
R1884:Zfp831 UTSW 2 174,545,870 (GRCm39) missense possibly damaging 0.53
R2127:Zfp831 UTSW 2 174,489,917 (GRCm39) missense probably benign 0.33
R2137:Zfp831 UTSW 2 174,547,539 (GRCm39) missense possibly damaging 0.53
R2268:Zfp831 UTSW 2 174,486,034 (GRCm39) missense probably benign 0.01
R2330:Zfp831 UTSW 2 174,489,882 (GRCm39) nonsense probably null
R3547:Zfp831 UTSW 2 174,499,476 (GRCm39) missense probably benign
R3821:Zfp831 UTSW 2 174,485,816 (GRCm39) missense possibly damaging 0.73
R4163:Zfp831 UTSW 2 174,485,822 (GRCm39) missense possibly damaging 0.53
R4232:Zfp831 UTSW 2 174,547,447 (GRCm39) missense possibly damaging 0.96
R4778:Zfp831 UTSW 2 174,488,600 (GRCm39) missense possibly damaging 0.53
R4820:Zfp831 UTSW 2 174,547,097 (GRCm39) missense possibly damaging 0.73
R4912:Zfp831 UTSW 2 174,486,417 (GRCm39) missense probably damaging 1.00
R5119:Zfp831 UTSW 2 174,547,103 (GRCm39) missense probably benign 0.18
R5152:Zfp831 UTSW 2 174,486,357 (GRCm39) missense probably benign 0.33
R5723:Zfp831 UTSW 2 174,487,200 (GRCm39) missense probably benign 0.23
R5888:Zfp831 UTSW 2 174,485,420 (GRCm39) missense probably benign 0.18
R5975:Zfp831 UTSW 2 174,485,885 (GRCm39) missense possibly damaging 0.93
R6092:Zfp831 UTSW 2 174,547,299 (GRCm39) missense probably damaging 0.98
R6158:Zfp831 UTSW 2 174,485,651 (GRCm39) missense possibly damaging 0.53
R6212:Zfp831 UTSW 2 174,487,661 (GRCm39) missense possibly damaging 0.53
R6233:Zfp831 UTSW 2 174,488,490 (GRCm39) missense possibly damaging 0.85
R6248:Zfp831 UTSW 2 174,486,308 (GRCm39) missense possibly damaging 0.53
R6255:Zfp831 UTSW 2 174,488,214 (GRCm39) missense possibly damaging 0.96
R6460:Zfp831 UTSW 2 174,488,360 (GRCm39) missense possibly damaging 0.46
R6477:Zfp831 UTSW 2 174,545,960 (GRCm39) missense probably benign
R6864:Zfp831 UTSW 2 174,488,533 (GRCm39) missense possibly damaging 0.72
R7396:Zfp831 UTSW 2 174,487,002 (GRCm39) missense possibly damaging 0.73
R7447:Zfp831 UTSW 2 174,487,896 (GRCm39) missense possibly damaging 0.88
R7499:Zfp831 UTSW 2 174,485,816 (GRCm39) missense possibly damaging 0.73
R7662:Zfp831 UTSW 2 174,487,934 (GRCm39) missense possibly damaging 0.85
R7857:Zfp831 UTSW 2 174,547,035 (GRCm39) missense probably benign 0.33
R7889:Zfp831 UTSW 2 174,487,097 (GRCm39) missense possibly damaging 0.53
R7896:Zfp831 UTSW 2 174,488,921 (GRCm39) missense possibly damaging 0.53
R8074:Zfp831 UTSW 2 174,486,528 (GRCm39) missense possibly damaging 0.72
R8089:Zfp831 UTSW 2 174,486,717 (GRCm39) missense possibly damaging 0.96
R8438:Zfp831 UTSW 2 174,486,796 (GRCm39) missense possibly damaging 0.53
R8716:Zfp831 UTSW 2 174,547,049 (GRCm39) missense possibly damaging 0.53
R8757:Zfp831 UTSW 2 174,487,874 (GRCm39) missense probably benign
R8759:Zfp831 UTSW 2 174,487,874 (GRCm39) missense probably benign
R8899:Zfp831 UTSW 2 174,485,978 (GRCm39) missense probably damaging 0.97
R8976:Zfp831 UTSW 2 174,487,079 (GRCm39) missense possibly damaging 0.76
R9146:Zfp831 UTSW 2 174,487,461 (GRCm39) missense possibly damaging 0.72
R9257:Zfp831 UTSW 2 174,488,156 (GRCm39) missense possibly damaging 0.53
R9324:Zfp831 UTSW 2 174,547,113 (GRCm39) missense probably benign 0.33
R9467:Zfp831 UTSW 2 174,486,789 (GRCm39) missense probably benign 0.33
R9729:Zfp831 UTSW 2 174,487,938 (GRCm39) missense possibly damaging 0.96
X0021:Zfp831 UTSW 2 174,547,662 (GRCm39) missense possibly damaging 0.85
Z1177:Zfp831 UTSW 2 174,485,981 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- ACTACAGTGGAGTGTGTCCC -3'
(R):5'- AAAGTCTCATTTCCATACACTTGCC -3'

Sequencing Primer
(F):5'- AGTGTGTCCCTGTCACCAGAAG -3'
(R):5'- ATACACTTGCCATTTCTCCTGGGAG -3'
Posted On 2016-11-21