Mutagenetix > Incidental Mutations

Incidental Mutation 'R5741:Vmn1r234'

444817

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r234

Ensembl Gene

ENSMUSG00000057203

Gene Name

vomeronasal 1 receptor 234

Synonyms

V1rf1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R5741 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

21228826-21229815 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 21229469 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 215 (C215F)

Ref Sequence

ENSEMBL: ENSMUSP00000078579 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079633]

Predicted Effect

probably benign
Transcript: ENSMUST00000079633
AA Change: C215F

PolyPhen 2 Score 0.214 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000078579
Gene: ENSMUSG00000057203
AA Change: C215F

Domain	Start	End	E-Value	Type
Pfam:TAS2R	25	315	2.8e-14	PFAM
Pfam:V1R	57	318	2.3e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177028

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810010H24Rik	T	G	11: 107,028,489	F220C	probably damaging	Het
4932443I19Rik	A	T	8: 13,734,835	Q32L	possibly damaging	Het
Acox3	C	T	5: 35,608,324	H140Y	probably benign	Het
Ano3	A	T	2: 110,658,273	I938K	probably benign	Het
Ap3m1	A	C	14: 21,045,720	I14S	possibly damaging	Het
Arg1	T	C	10: 24,917,999	T127A	probably benign	Het
Asah2	A	G	19: 32,008,615	Y552H	probably damaging	Het
Chst12	A	G	5: 140,523,933	N105S	probably benign	Het
Cped1	G	A	6: 22,123,621	V458I	probably benign	Het
Cyld	T	G	8: 88,744,846	I786S	probably damaging	Het
Cyp2j8	C	T	4: 96,444,643	V489I	probably benign	Het
Dlgap4	T	C	2: 156,711,048	Y462H	probably damaging	Het
Dnah5	C	A	15: 28,246,367	A617D	probably benign	Het
Erc2	T	A	14: 28,302,869		probably null	Het
Fancm	A	G	12: 65,101,615	N668S	probably benign	Het
Gm5592	A	G	7: 41,289,201	I636V	probably benign	Het
Gtf2h2	A	T	13: 100,480,558	C247S	probably benign	Het
Hyal5	T	A	6: 24,876,495	H122Q	probably damaging	Het
Ints10	G	A	8: 68,804,922	R258K	probably damaging	Het
Kir3dl1	G	A	X: 136,526,482	D56N	probably damaging	Het
Lrguk	T	A	6: 34,048,867	D199E	probably damaging	Het
Lyst	A	G	13: 13,634,030	D95G	probably benign	Het
Map2k1	A	T	9: 64,214,601	L30Q	possibly damaging	Het
Nell1	G	A	7: 50,560,890		probably null	Het
Nfatc3	T	A	8: 106,079,066	I181N	probably damaging	Het
Nipbl	T	C	15: 8,324,649	K1668R	possibly damaging	Het
Olfr1467	A	G	19: 13,365,483	N285S	probably damaging	Het
Olfr862	A	G	9: 19,883,561	V248A	possibly damaging	Het
Olfr924	T	A	9: 38,848,603	L163*	probably null	Het
Otud7b	C	T	3: 96,144,304	T189I	probably damaging	Het
Pkia	A	T	3: 7,442,045	E62D	probably benign	Het
Plcb3	G	A	19: 6,954,422	Q1154*	probably null	Het
Pole4	T	C	6: 82,651,466	E105G	probably damaging	Het
Ppp1r3a	A	G	6: 14,719,883	V344A	probably damaging	Het
Ptpn21	A	T	12: 98,679,289	L1130Q	probably damaging	Het
Rapgef5	A	G	12: 117,756,029	D564G	probably damaging	Het
Samhd1	C	T	2: 157,112,831	R387H	probably benign	Het
Spag1	A	G	15: 36,183,703	K65E	possibly damaging	Het
Spata31d1d	A	T	13: 59,728,686	V345D	possibly damaging	Het
Spin1	G	A	13: 51,149,135	V255I	possibly damaging	Het
Tmem171	A	G	13: 98,692,051	V197A	probably benign	Het
Tmigd1	T	C	11: 76,907,090	V86A	possibly damaging	Het
Ttn	T	C	2: 76,712,073	D31777G	probably damaging	Het
Tymp	T	A	15: 89,376,436	M60L	probably benign	Het
Ugdh	T	C	5: 65,427,523	T19A	probably damaging	Het
Wnt5b	T	C	6: 119,433,729	D250G	probably damaging	Het
Xrn1	T	A	9: 96,045,551	C1463S	probably benign	Het
Zfp831	T	A	2: 174,645,152	I540N	possibly damaging	Het
Zmynd8	T	C	2: 165,840,017	D189G	probably damaging	Het

Other mutations in Vmn1r234

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Vmn1r234	APN	17	21229598	missense	possibly damaging	0.95
IGL01485:Vmn1r234	APN	17	21228909	missense	possibly damaging	0.53
IGL02149:Vmn1r234	APN	17	21229007	missense	probably benign	0.00
IGL02291:Vmn1r234	APN	17	21228931	missense	probably benign	0.28
IGL02993:Vmn1r234	APN	17	21229703	missense	probably damaging	0.99
IGL03223:Vmn1r234	APN	17	21229391	missense	probably damaging	0.98
R0626:Vmn1r234	UTSW	17	21229745	missense	probably benign	0.17
R1274:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1275:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1288:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1289:Vmn1r234	UTSW	17	21229251	frame shift	probably null
R1319:Vmn1r234	UTSW	17	21228910	missense	probably benign	0.01
R1412:Vmn1r234	UTSW	17	21229250	missense	probably benign	0.01
R2323:Vmn1r234	UTSW	17	21229703	missense	probably benign	0.10
R3755:Vmn1r234	UTSW	17	21229009	missense	probably damaging	0.98
R4299:Vmn1r234	UTSW	17	21229021	missense	probably benign	0.03
R5301:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.11
R6197:Vmn1r234	UTSW	17	21229327	missense	probably benign	0.04
R6218:Vmn1r234	UTSW	17	21229721	missense	possibly damaging	0.71
R6486:Vmn1r234	UTSW	17	21229342	missense	probably benign	0.11
R7482:Vmn1r234	UTSW	17	21229375	missense	probably benign	0.07
R7635:Vmn1r234	UTSW	17	21229217	missense	probably damaging	1.00
R8295:Vmn1r234	UTSW	17	21228839	missense	probably benign	0.01
X0028:Vmn1r234	UTSW	17	21228890	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- CAGAGGATGCCATTTGGACAATC -3'
(R):5'- ATGGATACTCACTAGATGCCAGG -3'

Sequencing Primer
(F):5'- AGTGCATCAGCTCTTCCCTATAC -3'
(R):5'- CTCACTAGATGCCAGGTAAGATTAAC -3'

Posted On

2016-11-21