Mutagenetix > Incidental Mutation

Incidental Mutation 'R5761:Vmn2r23'

445296

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

043363-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R5761 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 123712759 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 198 (T198K)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably benign
Transcript: ENSMUST00000172391
AA Change: T198K

PolyPhen 2 Score 0.386 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: T198K

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.5%
3x: 98.8%
10x: 97.3%
20x: 95.2%

Validation Efficiency

99% (67/68)

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	A	T	11: 110,210,101	V953D	probably damaging	Het
Abcb8	T	C	5: 24,405,881		probably benign	Het
Acad12	A	T	5: 121,604,180		probably benign	Het
Adam2	A	T	14: 66,046,146	C436S	probably damaging	Het
Aebp2	T	C	6: 140,624,217		probably benign	Het
AI314180	T	C	4: 58,853,131	I401M	probably damaging	Het
Akap8	A	T	17: 32,317,185	C85S	possibly damaging	Het
Aldh1a3	C	A	7: 66,419,179	R19L	probably damaging	Het
Baz2a	A	G	10: 128,119,690	T848A	possibly damaging	Het
Bud13	C	T	9: 46,288,052	A237V	probably benign	Het
Cbarp	CGCCTCTGCTGCCTCT	CGCCTCT	10: 80,132,233		probably benign	Het
Ccdc187	G	A	2: 26,276,092	P775L	possibly damaging	Het
Ccz1	C	T	5: 143,992,510	G367R	probably damaging	Het
Cep104	T	C	4: 153,981,224	V56A	possibly damaging	Het
Chd6	C	A	2: 160,957,078	R2362S	probably damaging	Het
Chd6	C	T	2: 160,957,079	R2362K	probably damaging	Het
Cmc1	T	C	9: 118,115,375	E25G	probably benign	Het
Cntnap5b	T	C	1: 100,446,894	S1123P	probably damaging	Het
Col4a3	T	A	1: 82,716,057	L66*	probably null	Het
Crmp1	A	G	5: 37,282,868	T329A	probably benign	Het
Cybb	C	G	X: 9,450,750	D246H	probably benign	Het
Cyp3a16	A	G	5: 145,442,033	S393P	possibly damaging	Het
Cyp4f18	T	A	8: 71,996,131	I225F	probably damaging	Het
Ddhd2	A	G	8: 25,741,699	V432A	probably benign	Het
Foxq1	G	A	13: 31,559,331	A139T	probably damaging	Het
Gm10428	G	T	11: 62,753,343		probably benign	Het
Gpr89	A	G	3: 96,892,880	L134P	probably damaging	Het
Hfe2	T	C	3: 96,528,622	S399P	probably benign	Het
Hrc	A	T	7: 45,336,601		probably null	Het
Igf1r	T	A	7: 68,207,253	Y988N	probably damaging	Het
Igf2r	A	C	17: 12,698,352		probably null	Het
Itga2b	A	G	11: 102,466,274	F260S	probably benign	Het
Kif2a	T	A	13: 106,962,164	N698I	probably benign	Het
Lap3	A	C	5: 45,504,805	I316L	probably benign	Het
Map2k6	T	G	11: 110,399,371		probably benign	Het
Myh1	A	G	11: 67,219,252	E1422G	probably damaging	Het
Ncoa6	A	G	2: 155,408,141	V1081A	probably benign	Het
Nom1	A	G	5: 29,437,641	E380G	probably damaging	Het
Nwd2	A	T	5: 63,725,230	Y75F	probably damaging	Het
Olfr401	T	A	11: 74,121,509	D73E	probably damaging	Het
Olfr645	G	A	7: 104,084,169	R304W	probably benign	Het
Pkd1l1	A	G	11: 8,916,301	V518A	probably damaging	Het
Ptgs2	A	G	1: 150,105,528	M521V	probably benign	Het
Qsox1	T	A	1: 155,779,528	M630L	probably benign	Het
Skiv2l2	T	A	13: 112,917,662	I146F	probably damaging	Het
Spty2d1	A	G	7: 46,998,284	L299P	probably damaging	Het
St6gal1	T	G	16: 23,321,055		probably benign	Het
Sult2a6	T	C	7: 14,250,358	Y149C	probably damaging	Het
Tlr3	G	A	8: 45,402,771	T124M	probably benign	Het
Tmem171	A	G	13: 98,692,511	Y44H	probably damaging	Het
Usp35	C	T	7: 97,312,351	V623I	probably benign	Het
Vangl2	T	A	1: 172,006,127	H463L	probably damaging	Het
Vmn1r175	A	C	7: 23,808,480	L241V	probably benign	Het
Vmn1r19	A	T	6: 57,405,353	K297I	unknown	Het
Vmn2r-ps69	T	A	7: 85,304,015		noncoding transcript	Het
Xirp2	A	G	2: 67,510,967	Y1184C	probably benign	Het
Ythdc1	A	G	5: 86,835,951		probably benign	Het
Zbtb39	C	T	10: 127,742,646	A363V	probably damaging	Het
Zmiz1	T	A	14: 25,651,304	I527K	possibly damaging	Het
Zmiz1	C	A	14: 25,651,306	P534T	probably damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123741823	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- CCTGTGAGCAGTTAGAAGACAG -3'
(R):5'- CAGGAAATTCTGGAACCTTTTCTG -3'

Sequencing Primer
(F):5'- CCTAGAGTTCATAAACAGAGAAG -3'
(R):5'- TGGAACCTTTTCTGCAAATGC -3'

Posted On

2016-11-21