|Institutional Source||Beutler Lab|
|Gene Name||chemokine (C-C motif) ligand 1|
|Synonyms||Scya1, CCR8 ligand, Tca-3, I-309|
|Is this an essential gene?||Probably non essential (E-score: 0.112)|
|Stock #||R5743 (G1)|
|Chromosomal Location||82176657-82305690 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to G at 82176886 bp|
|Amino Acid Change||Serine to Arginine at position 73 (S73R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000103824 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000021043] [ENSMUST00000108189]|
|Predicted Effect||probably benign
|Predicted Effect||possibly damaging
AA Change: S73R
PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
AA Change: S73R
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccl1||
(F):5'- ATGACTGAGGTCTGTGAGCC -3'
(R):5'- TAGTCTCCACGGTAGGCTTC -3'
(F):5'- AGGTCTGTGAGCCTGCAG -3'
(R):5'- GGGTCCCCATTAATAAGCTTCCAATG -3'