Incidental Mutation 'R5744:Metrn'
ID 445737
Institutional Source Beutler Lab
Gene Symbol Metrn
Ensembl Gene ENSMUSG00000002274
Gene Name meteorin, glial cell differentiation regulator
Synonyms 1810034B16Rik
MMRRC Submission 043197-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R5744 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 26013545-26016019 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 26014211 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 205 (V205A)
Ref Sequence ENSEMBL: ENSMUSP00000127275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002344] [ENSMUST00000072735] [ENSMUST00000095500] [ENSMUST00000165838]
AlphaFold Q8C1Q4
Predicted Effect probably damaging
Transcript: ENSMUST00000002344
AA Change: V205A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000002344
Gene: ENSMUSG00000002274
AA Change: V205A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072735
SMART Domains Protein: ENSMUSP00000072518
Gene: ENSMUSG00000057411

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
SCOP:d1f3la_ 65 141 2e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000095500
SMART Domains Protein: ENSMUSP00000093155
Gene: ENSMUSG00000071202

DomainStartEndE-ValueType
Pfam:DUF4472 63 190 5.5e-23 PFAM
coiled coil region 364 408 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000165838
AA Change: V205A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000127275
Gene: ENSMUSG00000002274
AA Change: V205A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldoart2 A G 12: 55,612,131 (GRCm39) I19V possibly damaging Het
Ascc3 T C 10: 50,586,977 (GRCm39) I943T probably benign Het
Btaf1 T C 19: 36,981,890 (GRCm39) V1640A probably benign Het
Cep250 T C 2: 155,823,394 (GRCm39) F1015S possibly damaging Het
Cgnl1 G T 9: 71,537,957 (GRCm39) probably null Het
Csgalnact2 C T 6: 118,103,197 (GRCm39) G255E probably damaging Het
Ctla2a C T 13: 61,083,767 (GRCm39) probably null Het
Dip2c A T 13: 9,618,441 (GRCm39) I497F probably damaging Het
Eif3f C A 7: 108,537,624 (GRCm39) T179K probably damaging Het
Frem2 A G 3: 53,563,380 (GRCm39) F376L probably damaging Het
Gemin4 A T 11: 76,102,991 (GRCm39) F590Y probably damaging Het
Gemin5 C A 11: 58,046,009 (GRCm39) C433F possibly damaging Het
Gm7694 C T 1: 170,130,075 (GRCm39) probably null Het
Gpr158 G A 2: 21,373,331 (GRCm39) G89R probably damaging Het
Herc1 C T 9: 66,415,475 (GRCm39) P4817S probably damaging Het
Hs6st3 T C 14: 119,375,852 (GRCm39) L9P possibly damaging Het
Igdcc3 TGCCGCCGCCGCCGCCGCCGC TGCCGCCGCCGCCGCCGC 9: 65,048,770 (GRCm39) probably benign Het
Il1rap A C 16: 26,498,974 (GRCm39) I158L probably benign Het
Itpr2 A G 6: 146,277,649 (GRCm39) S640P probably damaging Het
Mfhas1 C A 8: 36,056,636 (GRCm39) D370E probably damaging Het
Mn1 T C 5: 111,568,402 (GRCm39) S791P possibly damaging Het
Mtmr3 A G 11: 4,437,679 (GRCm39) V925A possibly damaging Het
Neil1 T C 9: 57,051,485 (GRCm39) T278A probably damaging Het
Nol8 A G 13: 49,815,802 (GRCm39) N619D possibly damaging Het
Nup214 T C 2: 31,900,308 (GRCm39) L879P probably damaging Het
Or2l5 A G 16: 19,334,086 (GRCm39) I100T probably benign Het
Or7a37 T C 10: 78,806,017 (GRCm39) F178S probably damaging Het
Or9k2 T C 10: 129,998,661 (GRCm39) D178G possibly damaging Het
Plxna1 C T 6: 89,311,664 (GRCm39) R947Q possibly damaging Het
Prdm16 A G 4: 154,613,161 (GRCm39) S89P probably damaging Het
Reln A C 5: 22,311,081 (GRCm39) S277R probably null Het
Sel1l A T 12: 91,776,754 (GRCm39) I746N possibly damaging Het
Slc2a8 C T 2: 32,866,040 (GRCm39) D291N probably benign Het
Slc7a5 T C 8: 122,615,121 (GRCm39) N242S probably benign Het
Smco3 T C 6: 136,808,763 (GRCm39) N37S probably damaging Het
Sult1c2 T A 17: 54,280,990 (GRCm39) K38* probably null Het
Tfap2b T C 1: 19,289,445 (GRCm39) M190T probably benign Het
Tnpo2 T A 8: 85,778,523 (GRCm39) Y623* probably null Het
Tomm70a G T 16: 56,942,202 (GRCm39) probably benign Het
Ttyh2 T C 11: 114,593,136 (GRCm39) probably null Het
Zbtb10 A G 3: 9,329,623 (GRCm39) Y327C probably damaging Het
Other mutations in Metrn
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0008:Metrn UTSW 17 26,015,479 (GRCm39) missense possibly damaging 0.94
R0280:Metrn UTSW 17 26,014,109 (GRCm39) missense probably benign 0.08
R0729:Metrn UTSW 17 26,015,202 (GRCm39) splice site probably benign
R1523:Metrn UTSW 17 26,013,951 (GRCm39) makesense probably null
R2119:Metrn UTSW 17 26,014,197 (GRCm39) missense probably benign 0.03
R2146:Metrn UTSW 17 26,015,601 (GRCm39) missense probably damaging 0.99
R4036:Metrn UTSW 17 26,013,984 (GRCm39) missense probably benign
R4037:Metrn UTSW 17 26,013,984 (GRCm39) missense probably benign
R4038:Metrn UTSW 17 26,013,984 (GRCm39) missense probably benign
R4230:Metrn UTSW 17 26,015,915 (GRCm39) unclassified probably benign
R5074:Metrn UTSW 17 26,015,613 (GRCm39) missense probably damaging 1.00
R5259:Metrn UTSW 17 26,015,514 (GRCm39) missense probably damaging 1.00
R5686:Metrn UTSW 17 26,014,191 (GRCm39) missense probably damaging 1.00
R7707:Metrn UTSW 17 26,014,384 (GRCm39) missense probably benign 0.17
R8108:Metrn UTSW 17 26,014,004 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACACGGCTGAACTCTTGGAAG -3'
(R):5'- GATGACCTGCCTTGCATGCTAG -3'

Sequencing Primer
(F):5'- CTGAACTCTTGGAAGCGGGG -3'
(R):5'- CCTTGCATGCTAGGTGCCTG -3'
Posted On 2016-11-21